Vaccines for malaria: how close are we?Mahamadou A Thera
Malaria Research and Training Center, Faculty of Medicine, University of Bamako, Bamako, Mali, West Africa
Annu Rev Med 63:345-57. 2012
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- Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial
Mahamadou A Thera
Malaria Research and Training Center, University of Bamako, Bamako, Mali
PLoS ONE 5:e9041. 2010
..The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A) in children exposed to seasonal falciparum malaria...
- Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial
Mahamadou A Thera
Malaria Research and Training Center, University of Bamako, Bamako, Mali
PLoS ONE 3:e1465. 2008
..The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria...
- A field trial to assess a blood-stage malaria vaccine
Mahamadou A Thera
Malaria Research and Training Center, University of Bamako, Bamako, Mali
N Engl J Med 365:1004-13. 2011
..1/AS02(A), a recombinant protein based on apical membrane antigen 1 (AMA1) from the 3D7 strain of Plasmodium falciparum, has previously been shown to have immunogenicity and acceptable safety in Malian adults and children...
- Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein
Kavita Gandhi
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Am J Trop Med Hyg 86:775-81. 2012
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- Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians
Alassane Dicko
Malaria Research and Training Center, Department of Hematology, University of Bamako, Bamako, Mali
PLoS ONE 2:e1045. 2007
..After a peak 14 days following the second vaccination, antibody levels decreased to baseline levels one year later at the time of the third vaccination that induced little or no increase in antibody levels...
- Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease
Mahamadou A Thera
Bandiagara Malaria Project, Malaria Research and Training Center, University of Bamako, Mali
J Infect Dis 192:1823-9. 2005
..CONCLUSIONS. In this setting of low antifolate resistance, TS was highly effective in preventing falciparum malaria infection and disease and did not appear to select for SP-resistant parasites...
- Plasmodium falciparum clearance with artemisinin-based combination therapy (ACT) in patients with glucose-6-phosphate dehydrogenase deficiency in Mali
Abdoulaye K Kone
Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, P, O, Box 1805 Bamako, Mali
Malar J 9:332. 2010
..The impact of G6PD deficiency on parasite clearance with ACT treatment was compared between G6PD-deficient patients and G6PD-normal group...
A randomized trial of artesunate-sulfamethoxypyrazine-pyrimethamine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in MaliIssaka Sagara
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Bamako, Bamako, Mali
Am J Trop Med Hyg 75:630-6. 2006
..0%, respectively (P = 0.08). No serious adverse events occurred. Artesunate-sulfamethoxypyrazine-pyrimethamine is well-tolerated and effective against P. falciparum malaria. It showed an additional benefit of preventing new infections...
- Use of a pLDH-based dipstick in the diagnostic and therapeutic follow-up of malaria patients in Mali
Amed Ouattara
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
Malar J 10:345. 2011
..In this context, Rapid Diagnostic Tests (RDTs) may improve case management particularly in remote areas...
- Season, fever prevalence and pyrogenic threshold for malaria disease definition in an endemic area of Mali
Alassane Dicko
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy and Odonto Stomatology, University of Bamako, Bamako, Mali
Trop Med Int Health 10:550-6. 2005
..Modelling malaria parasitaemia as function of fever has been proposed as best alternative to estimate the attributable fraction of malaria fever and the sensitivity and specificity of different case definitions of malaria disease...
- Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications
Amed Ouattara
Malaria Research and Training Center, University of Sciences, Techniques and Technology, Bamako, Mali
J Infect Dis 207:511-9. 2013
..These results indicate that a multivalent AMA1 vaccine with broad efficacy could include only a limited set of key alleles of this extremely polymorphic antigen...
- High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children
Ogobara K Doumbo
Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Mali
Am J Trop Med Hyg 81:987-93. 2009
..28). Thus rosetting may contribute to the pathogenesis of all severe malaria syndromes in African children, and interventions to disrupt rosetting could be potential adjunctive therapies for all forms of severe malaria in Africa...
- Acceptability and efficacy of intra-rectal quinine alkaloids as a pre-transfer treatment of non-per os malaria in peripheral health care facilities in Mopti, Mali
Mahamadou A Thera
Malaria Research and Training Centre, Department of Epidemiology of Parasitic Diseases DEAP Faculty of Medicine, Pharmacy and Odonto Stomatologie, University of Bamako, Bamako, Mali
Malar J 6:68. 2007
..The acceptability and efficacy of a new kit with a new formulation of quinine alkaloids designed for the intra-rectal administration in the treatment of non-per os malaria was assessed in the peripheral health care system of Mopti, Mali...
- No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali
Amelia W Maiga
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Bamako, Mali
Am J Trop Med Hyg 87:23-8. 2012
..Artesunate was highly efficacious, with no evidence of delayed parasite clearance. We provide baseline surveillance data for the emergence or dissemination of P. falciparum resistance in sub-Saharan Africa...
- Candidate polymorphisms and severe malaria in a Malian population
Ousmane Toure
Malaria Research and Training Centre, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali
PLoS ONE 7:e43987. 2012
..It also demonstrates the need for establishing the region-specific repertoire of functional variation in important genes, including the glucose-6-phosphatase deficiency gene, before embarking on focused genotyping...
- Impact of preseason treatment on incidence of falciparum malaria and parasite density at a site for testing malaria vaccines in Bandiagara, Mali
Drissa Coulibaly
Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Mali, Bamako, Mali, West Africa
Am J Trop Med Hyg 67:604-10. 2002
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