E F Wouters

Summary

Country: The Netherlands

Publications

  1. pmc Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease
    Mehmet Küçükaycan
    Nutrition and Toxicology Research Institute Maastricht, Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Respir Res 3:29. 2002
  2. ncbi Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD
    Karin H Groenewegen
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:459-67. 2003
  3. pmc Chronic obstructive pulmonary disease. 5: systemic effects of COPD
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Thorax 57:1067-70. 2002
  4. ncbi Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 160:1220-6. 1999
  5. ncbi Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema
    M P Engelen
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 161:98-103. 2000
  6. ncbi Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives
    H R Gosker
    Departments of Pulmonology and Physiology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 71:1033-47. 2000
  7. ncbi Acute effects of nebulized salbutamol on resting energy expenditure in patients with chronic obstructive pulmonary disease and in healthy subjects
    E C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Respiration 65:375-80. 1998
  8. ncbi Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1488-92. 2000
  9. ncbi Characterization of nonresponse to high caloric oral nutritional therapy in depleted patients with chronic obstructive pulmonary disease
    E C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 161:745-52. 2000
  10. ncbi Exercise-induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology and Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1697-704. 2000

Collaborators

Detail Information

Publications65

  1. pmc Tumor necrosis factor-alpha +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease
    Mehmet Küçükaycan
    Nutrition and Toxicology Research Institute Maastricht, Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Respir Res 3:29. 2002
    ..In the present study the putative involvement of TNF-alpha gene polymorphisms in pathogenesis of COPD was studied by analysis of four TNF-alpha gene polymorphisms in a Caucasian COPD population...
  2. ncbi Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD
    Karin H Groenewegen
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Chest 124:459-67. 2003
    ..As yet, little information is available about the long-term outcome of patients who have been hospitalized with acute exacerbations, although high mortality rates have been reported...
  3. pmc Chronic obstructive pulmonary disease. 5: systemic effects of COPD
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Thorax 57:1067-70. 2002
    ..The role of body cell mass wasting, muscle wasting, and changes in muscle metabolism in the pathogenesis of chronic obstructive pulmonary disease is reviewed...
  4. ncbi Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 160:1220-6. 1999
    ..Schols AMWJ, Creutzberg EC, Buurman WA, Campfield LA, Saris WHM, Wouters EFM. Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease...
  5. ncbi Altered glutamate metabolism is associated with reduced muscle glutathione levels in patients with emphysema
    M P Engelen
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 161:98-103. 2000
    ..61; p < 0.001), but not with Gln. This study illustrates that reduced Glu levels in skeletal muscle of patients with emphysema are possibly related to an enhanced glycolytic activity and associated with decreased GSH levels...
  6. ncbi Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart failure: underlying mechanisms and therapy perspectives
    H R Gosker
    Departments of Pulmonology and Physiology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 71:1033-47. 2000
    ....
  7. ncbi Acute effects of nebulized salbutamol on resting energy expenditure in patients with chronic obstructive pulmonary disease and in healthy subjects
    E C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Respiration 65:375-80. 1998
    ..The metabolic effects of salbutamol were however not sufficient to explain totally the elevated REE seen in these patients...
  8. ncbi Enhanced levels of whole-body protein turnover in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology and Surgery, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1488-92. 2000
    ..The present study reveals elevated levels for protein turnover in patients with COPD, and indicates that infusion of the Leu tracer gives a reflection of Leu metabolism but not of whole-body protein metabolism in these patients...
  9. ncbi Characterization of nonresponse to high caloric oral nutritional therapy in depleted patients with chronic obstructive pulmonary disease
    E C Creutzberg
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 161:745-52. 2000
    ..Further research is needed to investigate whether these factors contribute to eventual disturbances in intermediary metabolism as reflected by the increased glucose concentration and ECW/ICW ratio...
  10. ncbi Exercise-induced lactate increase in relation to muscle substrates in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology and Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1697-704. 2000
    ..However, factors other than physical inactivity, such as Pa(O(2)) or DL(CO), play a role in the different La responses during exercise in subjects with different subtypes of COPD...
  11. ncbi Different effects of corticosteroid-induced muscle wasting compared with undernutrition on rat diaphragm energy metabolism
    E Koerts-de Lang
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Eur J Appl Physiol 82:493-8. 2000
    ..25 mg/kg per day i.m.) causes a decrease in muscle energy status together with a mismatch between glycolysis and oxidative metabolism...
  12. ncbi Analysis of body water compartments in relation to tissue depletion in clinically stable patients with chronic obstructive pulmonary disease
    E M Baarends
    Department of Pulmonology, University of Limburg, Maastricht, Netherlands
    Am J Clin Nutr 65:88-94. 1997
    ..66 +/- 0.12, P < 0.05); this was most pronounced in women. In conclusion, it was found that COPD patients with extreme FFM wasting are characterized by an increased ECW-ICW ratio despite a relatively spared fat mass...
  13. ncbi Factors contributing to alterations in skeletal muscle and plasma amino acid profiles in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology, Surgery, and Clinical Chemistry, Maastricht University, Maastricht, The Netherlands
    Am J Clin Nutr 72:1480-7. 2000
    ....
  14. ncbi Dual-energy X-ray absorptiometry in the clinical evaluation of body composition and bone mineral density in patients with chronic obstructive pulmonary disease
    M P Engelen
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Am J Clin Nutr 68:1298-303. 1998
    ..Depletion of fat-free mass (FFM) occurs in a considerable number of patients with chronic obstructive pulmonary disease (COPD)...
  15. ncbi Quality of life and depressive symptoms in patients suffering from sarcoidosis
    M Drent
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Sarcoidosis Vasc Diffuse Lung Dis 15:59-66. 1998
    ..Data on patients with sarcoidosis, however, are lacking. The aim of this study was to investigate the quality of life (QOL) and the influence of QOL factors on depressive symptoms in these patients...
  16. pmc The effects of treatment with chemotherapy on energy metabolism and inflammatory mediators in small-cell lung carcinoma
    A J Staal van den Brekel
    Department of Pulmonology, University Hospital, Maastricht, The Netherlands
    Br J Cancer 76:1630-5. 1997
    ..No correlation, however, existed between the decrease in REE and the decrease in the acute-phase proteins. In conclusion, chemotherapeutic treatment attenuates the tumour-related metabolic derangements and acute-phase response...
  17. ncbi beta-Adrenoceptor-mediated thermogenesis and lipolysis in patients with chronic obstructive pulmonary disease
    S L Schiffelers
    Department of Human Biology, Maastricht University, PO Box 616, NL 6200 MD Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 280:E357-64. 2001
    ..05). In conclusion, beta-adrenoceptor-mediated lipolysis and thermogenesis are impaired in COPD patients. This may play a role in the development or maintenance of their relatively increased fat mass...
  18. ncbi Analysis of respiratory impedance characteristics in chronic bronchitis
    G J Wesseling
    Department of Pulmonary Diseases, University Hospital, Maastricht, The Netherlands
    Respiration 59:81-8. 1992
    ....
  19. ncbi NF-kappaB activation in sarcoidosis
    M Drent
    Dept of Pulmonology, University Hospital Maastricht, The Netherlands
    Sarcoidosis Vasc Diffuse Lung Dis 18:50-6. 2001
    ..We hypothesized that NF-kappaB activation might be involved in the pathological process of sarcoidosis...
  20. ncbi Disturbances in leptin metabolism are related to energy imbalance during acute exacerbations of chronic obstructive pulmonary disease
    E C Creutzberg
    Department of Pulmonology, Heart and Lung Function Laboratory, University Hospital Maastricht, Maastricht, The Netherlands
    Am J Respir Crit Care Med 162:1239-45. 2000
    ..Evidence was found that the elevated leptin concentrations were in turn under control of the systemic inflammatory response, and, presumably, the high-dose systemic glucocorticosteroid treatment...
  21. ncbi Association of man-made mineral fibre exposure and sarcoidlike granulomas
    M Drent
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Respir Med 94:815-20. 2000
    ..These findings indicate that in susceptible people MMMF exposure might be related to a chronic granulomatous disease similar to chronic beryllium disease...
  22. ncbi Nutritional abnormalities and supplementation in chronic obstructive pulmonary disease
    A M Schols
    Department of Pulmonology, University Hospital Maastricht, Maastricht, Netherlands
    Clin Chest Med 21:753-62. 2000
    ..Nutritional or pharmacologic modulation of the catabolic response may further enhance the response in the near future...
  23. doi Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling
    N A Pansters
    Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    J Appl Physiol (1985) 114:1329-39. 2013
    ....
  24. ncbi Effects of exercise on amino acid metabolism in patients with chronic obstructive pulmonary disease
    M P Engelen
    Departments of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Am J Respir Crit Care Med 163:859-64. 2001
    ..01 and 21%, p < 0.01, respectively), suggesting enhanced nitrogen efflux. This study shows that exercise alters amino acid (intermediary) metabolism in patients with COPD and independent of the presence of FFM wasting...
  25. ncbi Dose effects of inhaled ipratropium bromide on the impedance of the respiratory system in normal subjects
    G J Wesseling
    Department of Pulmonary Diseases, State University Limburg, Maastricht, The Netherlands
    Int J Clin Pharmacol Ther Toxicol 28:33-8. 1990
    ..Furthermore, inhaled ipratropium bromide, especially in the higher dose, led to an increase in the imaginary part of impedance suggesting a decrease in the capacitance of pulmonary structures in normal subjects...
  26. ncbi Relationship between enzymatic markers of pulmonary cell damage and cellular profile: a study in bronchoalveolar lavage fluid
    N A Cobben
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Exp Lung Res 25:99-111. 1999
    ..In conclusion, determination of enzyme activity appears to be useful in monitoring pulmonary inflammation...
  27. ncbi Acute effects of different nutritional supplements on symptoms and functional capacity in patients with chronic obstructive pulmonary disease
    M A Vermeeren
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Am J Clin Nutr 73:295-301. 2001
    ..Use of nutritional supplements in depleted patients with chronic obstructive pulmonary disease (COPD) requires optimization between positive effects on outcome and potential acute adverse effects on metabolism and exercise performance...
  28. ncbi Diagnostic yield of computed tomography and densitometric measurements of the lung in thoracoscopically-defined idiopathic spontaneous pneumothorax
    A F van Belle
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Respir Med 95:292-6. 2001
    ..Furthermore CT lung densitometry revealed no parenchymal abnormalities or signs of air trapping in patients with spontaneous pneumothorax...
  29. ncbi Asymptomatic brain metastases (BM) in small cell lung cancer (SCLC): MR-imaging is useful at initial diagnosis
    M M Hochstenbag
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    J Neurooncol 48:243-8. 2000
    ..In this study we evaluated the usefulness of MR-imaging in the detection of asymptomatic brain metastases (BM) at the initial diagnosis in patients with small cell lung cancer (SCLC) and studied the follow-up of these patients. PATIENTS and..
  30. ncbi Computer program supporting the diagnostic accuracy of cellular BALF analysis: a new release
    M Drent
    Department of Pulmonology, University Hospital, Maastricht, The Netherlands
    Respir Med 95:781-6. 2001
    ....
  31. ncbi Intratracheal instillation of lipopolysaccharide in mice induces apoptosis in bronchial epithelial cells: no role for tumor necrosis factor-alpha and infiltrating neutrophils
    J H Vernooy
    Department of Pulmonology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Am J Respir Cell Mol Biol 24:569-76. 2001
    ....
  32. ncbi Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB
    R C Langen
    Department of Pulmonology, Maastricht University, Maastricht, The Netherlands
    FASEB J 15:1169-80. 2001
    ..These results demonstrate that inflammatory cytokines may contribute to muscle wasting through the inhibition of myogenic differentiation via a NF-kappaB-dependent pathway...
  33. ncbi Leptin as local inflammatory marker in COPD
    R Broekhuizen
    Department of Respiratory Medicine, Nutrition and Toxicology Research Institute Maastricht, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Respir Med 99:70-4. 2005
    ....
  34. ncbi A dynamic population model of disease progression in COPD
    M Hoogendoorn
    Institute for Medical Technology Assessment iMTA, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Respir J 26:223-33. 2005
    ....
  35. ncbi Are patients with COPD psychologically distressed?
    E J Wagena
    Pulmonary Rehabilitation Centre, Hornerheide, Horn, The Netherlands
    Eur Respir J 26:242-8. 2005
    ....
  36. ncbi Nutritional support in patients with chronic obstructive pulmonary disease during hospitalization for an acute exacerbation; a randomized controlled feasibility trial
    M A P Vermeeren
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Clin Nutr 23:1184-92. 2004
    ..The aim of the study was to investigate the feasibility and effectiveness of energy- and protein-rich nutritional supplements during hospitalization for an acute exacerbation in nutritionally depleted COPD patients...
  37. ncbi Glutathione and glutamate levels in the diaphragm of patients with chronic obstructive pulmonary disease
    M P K J Engelen
    Dept of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Respir J 23:545-51. 2004
    ..Glutamate and reduced glutathione levels are strongly interrelated in both muscles, independent of fibre type distribution and fibre size...
  38. ncbi Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, Nutrition Toxicology and Environment Research Institute Maastricht, Maastricht, The Netherlands
    Eur Respir J 22:280-5. 2003
    ..Also, in this group of clinically and weight stable chronic obstructive pulmonary disease patients, apoptosis appeared not to be involved in muscle pathology...
  39. pmc Raised CRP levels mark metabolic and functional impairment in advanced COPD
    R Broekhuizen
    Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 61:17-22. 2006
    ..A study was undertaken to investigate the discriminative value of high sensitivity CRP in COPD with respect to markers of local and systemic impairment, disability, and handicap...
  40. pmc Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease
    R Broekhuizen
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Thorax 60:376-82. 2005
    ..The aim of this study was to investigate the effect of PUFA modulation on systemic inflammation, reversal of muscle wasting, and functional status in COPD...
  41. ncbi ROS in the local and systemic pathogenesis of COPD
    R C J Langen
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Free Radic Biol Med 35:226-35. 2003
    ....
  42. ncbi Efficacy of bupropion and nortriptyline for smoking cessation among people at risk for or with chronic obstructive pulmonary disease
    E J Wagena
    Department of General Practice, Maastricht University, The Netherlands
    Arch Intern Med 165:2286-92. 2005
    ..No clinical trial has studied the efficacy of bupropion hydrochloride and nortriptyline hydrochloride for smoking cessation in this patient population, to our knowledge...
  43. ncbi Prevalence of nutritional depletion in a large out-patient population of patients with COPD
    M A P Vermeeren
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 100:1349-55. 2006
    ....
  44. ncbi Chronic obstructive pulmonary disease is associated with the -1055 IL-13 promoter polymorphism
    T C T M van der Pouw Kraan
    Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands
    Genes Immun 3:436-9. 2002
    ..2 and 0.9, respectively). These results could implicate a functional role for the IL-13 promoter polymorphism in the enhanced risk to develop COPD...
  45. pmc Differences in local versus systemic TNFalpha production in COPD: inhibitory effect of hyaluronan on LPS induced blood cell TNFalpha release
    M A Dentener
    Nutrition and Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 61:478-84. 2006
    ....
  46. ncbi The systemic face of airway diseases: the role of C-reactive protein
    E F M Wouters
    Eur Respir J 27:877-9. 2006
  47. ncbi Minimal clinically important differences in COPD: body mass index and muscle strength
    E F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    COPD 2:149-55. 2005
    ..The relationship between these outcome measures and COPD-related management goals is discussed. Minimal clinically important differences (MCID) in the approach of patients suffering from COPD for these measures are discussed...
  48. ncbi COPD: a chronic and overlooked pulmonary disease
    E F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, Maastricht 6202 AZ, Netherlands
    Lancet 370:715-6. 2007
  49. ncbi Exhaled nitric oxide and biomarkers in exhaled breath condensate indicate the presence, severity and control of childhood asthma
    C M H H T Robroeks
    Department of Paediatric Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Clin Exp Allergy 37:1303-11. 2007
    ..Their ability to indicate an asthma diagnosis, and to assess asthma severity and control, is largely unknown...
  50. doi COPD: from an organ- to a disease-oriented approach
    E F M Wouters
    COPD 5:73-4. 2008
  51. doi Serum LDH and exercise capacity in COPD
    M A Spruit
    Thorax 63:472. 2008
  52. ncbi The contribution of starvation, deconditioning and ageing to the observed alterations in peripheral skeletal muscle in chronic organ diseases
    F M E Franssen
    Department of Pulmonology, University Hospital Maastricht, The Netherlands
    Clin Nutr 21:1-14. 2002
    ..Unravelling the relative contributions of these external factors to the observed alterations in the various diseases may contribute to targeted intervention strategies to improve muscle function in selected groups of patients...
  53. ncbi Skeletal muscle fibre-type shifting and metabolic profile in patients with chronic obstructive pulmonary disease
    H R Gosker
    Dept of Pulmonology, University of Maastricht, The Netherlands
    Eur Respir J 19:617-25. 2002
    ..Low oxidative capacity is closely related to the proportion of type-I fibres, but an additional reduction of oxidative enzyme activity is present within IIA fibres. Fibre-type abnormalities may be aggravated in emphysema...
  54. pmc Effects of physical activity in mild to moderate COPD: a systematic review
    Niels Chavannes
    Department of General Practice, University of Maastricht, The Netherlands
    Br J Gen Pract 52:574-8. 2002
    ....
  55. pmc Eat well to get well
    E F M Wouters
    Thorax 58:739-40. 2003
  56. ncbi Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD
    H R Gosker
    Dept of Pulmonology, Maastricht University, Maastricht, The Netherlands
    Eur Respir J 22:88-93. 2003
    ..The low uncoupling protein-3 content is independent of the loss of oxidative capacity observed in these patients...
  57. ncbi Introduction: systemic effects in chronic obstructive pulmonary disease
    E F M Wouters
    Eur Respir J Suppl 46:1s. 2003
  58. ncbi The burden of COPD in The Netherlands: results from the Confronting COPD survey
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 97:S51-9. 2003
    ..In addition, smoking cessation intervention at the early stages of the disease could help to reduce the high costs associated with severe COPD in this country...
  59. ncbi Management of severe COPD
    E F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, 6229 HX Maastricht, Netherlands
    Lancet 364:883-95. 2004
    ..Exacerbations become progressively more troublesome as baseline lung function declines, commonly necessitating hospital admission and associated with the development of acute respiratory failure...
  60. ncbi Economic analysis of the Confronting COPD survey: an overview of results
    E F M Wouters
    Department of Pulmonology, University Hospital Maastricht, Maastricht, The Netherlands
    Respir Med 97:S3-14. 2003
    ....
  61. pmc Enhanced levels of hyaluronan in lungs of patients with COPD: relationship with lung function and local inflammation
    M A Dentener
    Toxicology Research Institute Maastricht, Department of Respiratory Medicine, University Hospital Maastricht, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Thorax 60:114-9. 2005
    ..HA levels in induced sputum from patients with COPD were measured and related to local inflammation. The expression of hyaluronan synthase 2 (HAS2) and hyaluronidase 2 (HYAL2) was analysed in lung tissue...
  62. ncbi [The last breath. The decision of whether or not to ventilate patients with severe chronic obstructive pulmonary disease]
    B E E M van den Borne
    Ned Tijdschr Geneeskd 146:1472. 2002
  63. pmc Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial
    E F M Wouters
    Department of Respiratory Medicine, University Hospital Maastricht, The Netherlands
    Thorax 60:480-7. 2005
    ..Combined treatment with ICS and long acting beta2 agonists (LABA) may provide benefit to the stability of COPD, but it is unknown if withdrawal of ICS will result in disease deterioration...
  64. ncbi Associations of depressive symptoms with gender, body mass index and dyspnea in primary care COPD patients
    N H Chavannes
    Department of Pulmonology, University Hospital, Maastricht, The Netherlands
    Fam Pract 22:604-7. 2005
    ..However, scarce data are available in primary care where most patients suffer from mild or moderate disease...
  65. ncbi [Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial]
    E F M Wouters
    Rev Port Pneumol 11:587-9. 2005