Rein Willemze

Summary

Country: The Netherlands

Publications

  1. ncbi WHO-EORTC classification for cutaneous lymphomas
    Rein Willemze
    Department of Dermatology, B1 Q 93, Leiden University Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 105:3768-85. 2005
  2. ncbi Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review
    Tony Petrella
    Centre de Pathologie, Department of Pathology, Centre Hospitalo Universitaire, Dijon, France
    Am J Clin Pathol 123:662-75. 2005
  3. pmc Epidermal transit of replication-arrested, undifferentiated keratinocytes in UV-exposed XPC mice: an alternative to in situ apoptosis
    Gerdine J Stout
    Department of Dermatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:18980-5. 2005
  4. ncbi Primary cutaneous B-cell lymphoma: classification and treatment
    Rein Willemze
    Leiden University Medical Center, Department of Dermatology, Leiden, The Netherlands
    Curr Opin Oncol 18:425-31. 2006
  5. pmc CD56-positive haematological neoplasms of the skin: a multicentre study of the Cutaneous Lymphoma Project Group of the European Organisation for Research and Treatment of Cancer
    Chalid Assaf
    Department of Dermatology, Charite, Berlin, Germany
    J Clin Pathol 60:981-9. 2007
  6. ncbi Thirty years of progress in cutaneous lymphoma research
    R Willemze
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    G Ital Dermatol Venereol 147:515-21. 2012
  7. ncbi Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC
    Rein Willemze
    Department of Dermatology, Leiden University Medical Center, Leiden, Netherlands
    J Cutan Pathol 33:18-26. 2006
  8. ncbi Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases
    Rein Willemze
    Department of Dermatology, Leiden University Medical Center, The Netherlands
    Blood 111:838-45. 2008
  9. doi An in vitro three-dimensional model of primary human cutaneous squamous cell carcinoma
    Suzan Commandeur
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Dermatol 18:849-56. 2009
  10. doi Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome
    Remco van Doorn
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 113:127-36. 2009

Detail Information

Publications84

  1. ncbi WHO-EORTC classification for cutaneous lymphomas
    Rein Willemze
    Department of Dermatology, B1 Q 93, Leiden University Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 105:3768-85. 2005
    ....
  2. ncbi Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review
    Tony Petrella
    Centre de Pathologie, Department of Pathology, Centre Hospitalo Universitaire, Dijon, France
    Am J Clin Pathol 123:662-75. 2005
    ..The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided...
  3. pmc Epidermal transit of replication-arrested, undifferentiated keratinocytes in UV-exposed XPC mice: an alternative to in situ apoptosis
    Gerdine J Stout
    Department of Dermatology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 102:18980-5. 2005
    ..This expulsion apparently constitutes an alternative route, different from in situ apoptosis, to eliminate DNA-damaged arrested cells from the epidermis...
  4. ncbi Primary cutaneous B-cell lymphoma: classification and treatment
    Rein Willemze
    Leiden University Medical Center, Department of Dermatology, Leiden, The Netherlands
    Curr Opin Oncol 18:425-31. 2006
    ....
  5. pmc CD56-positive haematological neoplasms of the skin: a multicentre study of the Cutaneous Lymphoma Project Group of the European Organisation for Research and Treatment of Cancer
    Chalid Assaf
    Department of Dermatology, Charite, Berlin, Germany
    J Clin Pathol 60:981-9. 2007
    ..However, prognostic subsets within the CD56+ group have been difficult to identify due to the lack of uniform clinicopathological and immunophenotypical criteria...
  6. ncbi Thirty years of progress in cutaneous lymphoma research
    R Willemze
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    G Ital Dermatol Venereol 147:515-21. 2012
    ..In this review the importance of a multidisciplinary approach and continued international collaboration not only in clinical trials and guideline development, but also in basic research is emphasized...
  7. ncbi Classification of cutaneous T-cell lymphoma: from Alibert to WHO-EORTC
    Rein Willemze
    Department of Dermatology, Leiden University Medical Center, Leiden, Netherlands
    J Cutan Pathol 33:18-26. 2006
    ..The aim of this review is to contribute to a better communication between dermatologist and pathologist and in this way to a better diagnosis and classification of CTCLs...
  8. ncbi Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases
    Rein Willemze
    Department of Dermatology, Leiden University Medical Center, The Netherlands
    Blood 111:838-45. 2008
    ..SPTL-ABs without associated HPS have an excellent prognosis, and multiagent chemotherapy as first choice of treatment should be questioned...
  9. doi An in vitro three-dimensional model of primary human cutaneous squamous cell carcinoma
    Suzan Commandeur
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Dermatol 18:849-56. 2009
    ..This model may provide a platform to develop refined preventive and curative treatments and thereby gain understanding of SCC pathogenesis...
  10. doi Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome
    Remco van Doorn
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 113:127-36. 2009
    ..Furthermore, our analysis uncovered genomic differences between MF and Sz, which suggest that the molecular pathogenesis and therefore therapeutic requirements of these cutaneous T-cell lymphomas may be distinct...
  11. doi Primary cutaneous anaplastic large cell lymphoma shows a distinct miRNA expression profile and reveals differences from tumor-stage mycosis fungoides
    Marchina F Benner
    Department of Dermatology, LUMC, Leiden, The Netherlands
    Exp Dermatol 21:632-4. 2012
    ..This study, the first describing the miRNA expression profile of C-ALCL, reveals differences with tumor-stage MF, suggesting a different contribution to the pathogenesis of these lymphomas...
  12. doi A meta-analysis of gene expression data identifies a molecular signature characteristic for tumor-stage mycosis fungoides
    Marloes S van Kester
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 132:2050-9. 2012
    ..Loss of expression of the NF-κB inhibitor, NFKBIZ, may partly explain the enhanced activity of NF-κB, which is a hallmark of MF and other CTCLs...
  13. ncbi Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities
    Remco Dijkman
    Department of Dermatology, Leiden University Medical Center, The Netherlands
    Blood 109:1720-7. 2007
    ..We noted high expression of various plasmacytoid dendritic-cell (pDC)-related genes, pointing to the cell of origin of this malignancy...
  14. doi Increased risk of squamous-cell carcinoma in simultaneous pancreas kidney transplant recipients compared with kidney transplant recipients
    Hermina C Wisgerhof
    Department of Dermatology, B1 Q, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    J Invest Dermatol 129:2886-94. 2009
    ..Adjustment for induction and rejection therapy or HLA mismatching did not change the hazard ratio significantly. SPKTRs have an increased risk of SCC compared with KTRs, despite partial confounding by the immunosuppressive regimen...
  15. doi Increased risk of cancer other than melanoma in CDKN2A founder mutation (p16-Leiden)-positive melanoma families
    Femke A De Snoo
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Clin Cancer Res 14:7151-7. 2008
    ..We report the largest study to date analyzing the risk of cancers other than melanoma in melanoma families positive for the same CDKN2A mutation...
  16. ncbi Aberrant DNA methylation in cutaneous malignancies
    Remco van Doorn
    Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 AL Leiden, The Netherlands
    Semin Oncol 32:479-87. 2005
    ....
  17. doi Cutaneous anaplastic large cell lymphoma and peripheral T-cell lymphoma NOS show distinct chromosomal alterations and differential expression of chemokine receptors and apoptosis regulators
    Marloes S van Kester
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 130:563-75. 2010
    ..Furthermore, C-ALCL and PTL-NOS showed aberrant expression of distinct genes implicated in apoptosis and proliferation, such as IRF4/MUM1 and PRKCQ, which may account for differences in clinical aggressiveness...
  18. pmc Molecular profiling of cutaneous squamous cell carcinomas and actinic keratoses from organ transplant recipients
    Liesbeth Hameetman
    Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300, RC Leiden, The Netherlands
    BMC Cancer 13:58. 2013
    ..The aim of this genome-wide study was to identify pathways and genomic alterations that are consistently involved in the formation of SCCs and their precursor lesions, actinic keratoses (AKs)...
  19. doi The risk of cancer is not increased in patients with multiple kidney transplantations
    Hermina C Wisgerhof
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Transpl Immunol 27:189-94. 2012
    ..The aim of this study was to investigate whether the number of transplantations, as a marker of the graft rejection status of the patient, is associated with an increased risk of malignancies...
  20. ncbi Distinct types of primary cutaneous large B-cell lymphoma identified by gene expression profiling
    Juliette J Hoefnagel
    Department of Dermatology, B1 Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 105:3671-8. 2005
    ..The results of this study suggest that different pathogenetic mechanisms are involved in the development of PCFCCLs and PCLBCLs-leg and provide molecular support for the subdivision used in the EORTC classification...
  21. doi Fine-mapping chromosomal loss at 9p21: correlation with prognosis in primary cutaneous diffuse large B-cell lymphoma, leg type
    Nancy J Senff
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 129:1149-55. 2009
    ..In most patients the deletion involves a large area of at least several kilobase pairs instead of a small minimal common region...
  22. doi miRNA expression profiling of mycosis fungoides
    Marloes S van Kester
    Department of Dermatology, LUMC, Leiden, The Netherlands
    Mol Oncol 5:273-80. 2011
    ..Taken together this report is the first describing the miRNA signature of tumor stage MF...
  23. ncbi Expression of B-cell transcription factors in primary cutaneous B-cell lymphoma
    Juliette J Hoefnagel
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Mod Pathol 19:1270-6. 2006
    ....
  24. ncbi Primary cutaneous follicle center lymphoma and primary cutaneous large B-cell lymphoma, leg type, are both targeted by aberrant somatic hypermutation but demonstrate differential expression of AID
    Remco Dijkman
    Department of Dermatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Blood 107:4926-9. 2006
    ..Our results suggest that (aberrant) SHM may contribute to the pathogenesis of PCLBCL, leg type, and PCFCL and is not restricted to diffuse large B-cell lymphomas with an aggressive clinical behavior...
  25. ncbi Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73
    Remco van Doorn
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 23:3886-96. 2005
    ..To analyze the occurrence of promoter hypermethylation in primary cutaneous T-cell lymphoma (CTCL) on a genome-wide scale, focusing on epigenetic alterations with pathogenetic significance...
  26. ncbi Reclassification of 300 primary cutaneous B-Cell lymphomas according to the new WHO-EORTC classification for cutaneous lymphomas: comparison with previous classifications and identification of prognostic markers
    Nancy J Senff
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 25:1581-7. 2007
    ..This study aimed to assess the clinical significance of the new classification compared with previous classification schemes (EORTC 1997; WHO 2001) and to define prognostic factors within the newly defined categories...
  27. doi Functional characterization of cancer-associated fibroblasts of human cutaneous squamous cell carcinoma
    Suzan Commandeur
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Dermatol 20:737-42. 2011
    ..These distinct features of CAFs point out a specific role in cutaneous SCC development...
  28. ncbi Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis
    Remco van Doorn
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 64:5578-86. 2004
    ..Detection of EphA4 and Twist may be used in the molecular diagnosis of Sz and related cutaneous T-cell lymphomas. Furthermore, the membrane-bound EphA4 receptor may serve as a target for directed therapeutic intervention...
  29. doi Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors
    Hermina C Wisgerhof
    Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands
    Transplantation 89:1231-8. 2010
    ..The aim of this study was to estimate the cumulative incidence of subsequent squamous- and basal-cell carcinomas (BCCs) and to analyze potential risk factors...
  30. doi No acceleration of UV-induced skin carcinogenesis from evenly spread dietary intake of cyclosporine in contrast to oral bolus dosages
    Pieter Voskamp
    1 Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands 2 Department of Surgery, University of Regensburg, Regensburg, Germany 3 Address correspondence to Dr Frank R de Gruijl, Department of Dermatology, Leiden University Medical Center LUMC, postal zone S2P, P O Box 9600, 2300 RC Leiden, The Netherlands
    Transplantation 96:871-6. 2013
    ..Therefore, we set out to compare three experimental protocols using mice, with the aim to emulate most closely the increased skin cancer risk in organ transplant recipients...
  31. doi IgM expression on paraffin sections distinguishes primary cutaneous large B-cell lymphoma, leg type from primary cutaneous follicle center lymphoma
    Lianne Koens
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Surg Pathol 34:1043-8. 2010
    ..Finally, the expression of IgM (and IgD) in this type of lymphoma might imply defective class switch recombination...
  32. ncbi More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine
    Ymke G L de Graaf
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Dermatol 17:349-55. 2008
    ..011). UV-induced UDS in humans is dominated by repair of cyclobutane pyrimidine dimers, and these DNA lesions can lead to 'UV-signature' mutations in the P53 gene, giving rise to p53 patches...
  33. ncbi Results of radiotherapy in 153 primary cutaneous B-Cell lymphomas classified according to the WHO-EORTC classification
    Nancy J Senff
    Department of Dermatology, B1 Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arch Dermatol 143:1520-6. 2007
    ....
  34. doi Novel and highly recurrent chromosomal alterations in Sézary syndrome
    Maarten H Vermeer
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Res 68:2689-98. 2008
    ..Prominent among deregulated genes are those encoding cMYC, cMYC-regulating proteins, mediators of MYC-induced apoptosis, and IL-2 signaling pathway components...
  35. doi Incidence of cancer in kidney-transplant recipients: a long-term cohort study in a single center
    Hermina C Wisgerhof
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Cancer Epidemiol 35:105-11. 2011
    ..The increased incidence of non-cutaneous malignancies after kidney transplantation is associated with a high mortality. Prevention of cancer after kidney transplantation should be a major focus of future research...
  36. doi Low-dose palliative radiotherapy for cutaneous B- and T-cell lymphomas
    Karen J Neelis
    Department of Clinical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Radiat Oncol Biol Phys 74:154-8. 2009
    ..To determine the efficacy of low-dose palliative radiotherapy for both low-grade malignant cutaneous B-cell lymphomas (CBCLs) and cutaneous T-cell lymphomas (mycosis fungoides)...
  37. ncbi Peripheral T-cell lymphomas unspecified presenting in the skin: analysis of prognostic factors in a group of 82 patients
    Marcel W Bekkenk
    Department of Dermatology, B1 Q 93, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 102:2213-9. 2003
    ..The only exception was a group of primary cutaneous small- or medium-sized pleomorphic CTCLs with a CD3+CD4+CD8- phenotype and presenting with localized skin lesions...
  38. ncbi Array-based comparative genomic hybridization analysis reveals recurrent chromosomal alterations and prognostic parameters in primary cutaneous large B-cell lymphoma
    Remco Dijkman
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Oncol 24:296-305. 2006
    ..To evaluate the clinical relevance of genomic aberrations in primary cutaneous large B-cell lymphoma (PCLBCL)...
  39. doi Kidney transplant recipients with cutaneous squamous cell carcinoma have an increased risk of internal malignancy
    Hermina C Wisgerhof
    Department of Dermatology, B1 Q, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 132:2176-83. 2012
    ..KTRs with cutaneous SCCs have an increased risk to develop IMs, and this information can be used to identify KTRs who are at an increased risk for IMs...
  40. doi Autocrine IL-21 stimulation is involved in the maintenance of constitutive STAT3 activation in Sézary syndrome
    Leslie van der Fits
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 132:440-7. 2012
    ....
  41. doi Prognostic factors in transformed mycosis fungoides: a retrospective analysis of 100 cases
    Marchina F Benner
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 119:1643-9. 2012
    ..001). This prognostic index may be helpful in predicting prognosis and selecting the most appropriate treatment in patients with transformed MF...
  42. doi Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas
    Pieter Voskamp
    Department of Dermatology, Leiden University Medical Center, The Netherlands
    Cancer Prev Res (Phila) 6:129-38. 2013
    ..Moreover, the lack of any accelerative effect on tumor development suggests that immunosuppressive medication is not the sole cause of the dramatic increase in skin cancer risk in organ transplant recipients...
  43. doi MicroRNA-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sézary syndrome
    Leslie van der Fits
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 131:762-8. 2011
    ..Silencing of miR-21 in Sézary cells results in increased apoptosis, suggesting a functional role for miR-21 in the leukomogenic process. Consequently, miR-21 might represent a therapeutic target for the treatment of SS...
  44. ncbi The influence of painful sunburns and lifetime sun exposure on the risk of actinic keratoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer
    Cornelis Kennedy
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 120:1087-93. 2003
    ..Neither painful sunburns nor lifetime sun exposure were associated with an increased risk of seborrheic warts...
  45. ncbi Photodynamic therapy does not prevent cutaneous squamous-cell carcinoma in organ-transplant recipients: results of a randomized-controlled trial
    Ymke G L de Graaf
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 126:569-74. 2006
    ..No long-term adverse events were noted. In conclusion, PDT does not appear to prevent the occurrence of new squamous-cell carcinomas in organ-transplant recipients, but to some degree, reduces the increase of keratotic skin lesions...
  46. doi Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families
    Femke A De Snoo
    Departments of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 16:1135-41. 2008
    ..The strongest evidence for an atypical nevus susceptibility gene was mapped to chromosome band 7q21.3 (two-point LOD score=2.751), a region containing candidate gene CDK6...
  47. doi Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells
    Marloes S van Kester
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 128:1691-5. 2008
    ..These data strengthen the notion that activation of Stat3 plays an essential part in the malignant transformation of Sz and provide further rationale for the therapeutical targeting of Stat3 in Sz...
  48. pmc MicroRNA Profiling of Primary Cutaneous Large B-Cell Lymphomas
    Lianne Koens
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e82471. 2013
    ..In conclusion, PCFCL and PCLBCL-LT differ in their microRNA profiles. In contrast to their gene expression profile, they only show slight resemblance with the microRNA profiles found in GCB- and ABC-type nodal DLBCL. ..
  49. doi Results of bone marrow examination in 275 patients with histological features that suggest an indolent type of cutaneous B-cell lymphoma
    Nancy J Senff
    Department of Dermatology, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 142:52-6. 2008
    ..001). These results indicate that bone marrow investigation is essential for staging patients with a FCL first presenting in the skin. Bone marrow examination appears to have limited value in patients with MZL presenting in the skin...
  50. doi European Organization for Research and Treatment of Cancer and International Society for Cutaneous Lymphoma consensus recommendations for the management of cutaneous B-cell lymphomas
    Nancy J Senff
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 112:1600-9. 2008
    ..They may therefore contribute to uniform staging and treatment and form the basis for future clinical trials in patients with a CBCL...
  51. doi Replacement of animal-derived collagen matrix by human fibroblast-derived dermal matrix for human skin equivalent products
    Abdoelwaheb El Ghalbzouri
    Department of Dermatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Biomaterials 30:71-8. 2009
    ..This study, therefore, demonstrates the role of the dermal microenvironment on epidermal regeneration and lifespan in vitro...
  52. doi Applicability and prognostic value of the new TNM classification system in 135 patients with primary cutaneous anaplastic large cell lymphoma
    Marchina F Benner
    Department of Dermatology, B1 Q, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arch Dermatol 145:1399-404. 2009
    ....
  53. doi Efficacy of a hypofractionated schedule in electron beam radiotherapy for epithelial skin cancer: Analysis of 434 cases
    Marjan van Hezewijk
    Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands
    Radiother Oncol 95:245-9. 2010
    ..Efficacy of radiotherapy for epithelial skin cancer was evaluated and treatment outcomes of two electron beam fractionation schedules were compared...
  54. ncbi The CXCR3 targeting chemokine CXCL11 has potent antitumor activity in vivo involving attraction of CD8+ T lymphocytes but not inhibition of angiogenesis
    Paul J Hensbergen
    Department of Dermatology, Leiden University Medical Center, 7333 AL Leiden, The Netherlands
    J Immunother 28:343-51. 2005
    ..These experiments show, for the first time, antitumor activity of CXCL11 in vivo, which warrants exploration for its potential role in anticancer immunotherapy...
  55. ncbi From sporadic atypical nevi to familial melanoma: risk analysis for melanoma in sporadic atypical nevus patients
    Femke A De Snoo
    Department of Human Genetics, Leiden University Medical Center, The Netherlands
    J Am Acad Dermatol 56:748-52. 2007
    ..Atypical nevi (AN), present in either a familial or a sporadic setting, are strong indicators of increased melanoma risk...
  56. doi Programmed death-1 expression in cutaneous B-cell lymphoma
    Fatma Cetinözman
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Cutan Pathol 41:14-21. 2014
    ..In this study we determined the expression and distribution of PD-1 on neoplastic B cells and reactive T cells in skin sections from primary CBCLs...
  57. doi Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma
    Fatma Cetinözman
    Department of Dermatology, Leiden University Medical Center, RC Leiden, The Netherlands
    Am J Surg Pathol 36:109-16. 2012
    ....
  58. ncbi Primary cutaneous CD30-positive lymphoproliferative disorders
    Rein Willemze
    Department of Dermatology, B1 Q 93 Leiden University, Medical Center Post Office Box 9600, 2300 RC Leiden, The Netherlands
    Hematol Oncol Clin North Am 17:1319-32, vii-viii. 2003
    ..Most patients within this spectrum of disease have an excellent prognosis. Multi-agent chemotherapy should be reserved for patients who have extracutaneous disease...
  59. ncbi Follicular mycosis fungoides, a distinct disease entity with or without associated follicular mucinosis: a clinicopathologic and follow-up study of 51 patients
    Remco van Doorn
    Department of Dermatology, B1 Q 93, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arch Dermatol 138:191-8. 2002
    ..Based on these results and those of other studies, we suggest the term follicular MF for cases with or without associated follicular mucinosis...
  60. ncbi Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development
    Pieter A van der Velden
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Int J Cancer 106:472-9. 2003
    ..We demonstrate in the cell lines that TIMP3 expression is regulated by methylation. These observations were confirmed in primary uveal melanoma and suggests a role for TIMP3 in uveal melanoma development...
  61. ncbi UVB-induced leucocyte trafficking in the epidermis of photosensitive lupus erythematosus patients: normal depletion of Langerhans cells
    Artiena Soe Janssens
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Exp Dermatol 14:138-42. 2005
    ..In the present study, we tested this hypothesis by investigating leucocyte trafficking in the initial phase of cutaneous LE after intense UVB exposure...
  62. ncbi Effect of smoking and sun on the aging skin
    Cornelis Kennedy
    Department of Dermatology, Leiden University Medical Center, The Netherlands
    J Invest Dermatol 120:548-54. 2003
    ..In contrast to elastosis, telangiectasia may not be a good marker of the aging skin, specifically not in women...
  63. doi Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma
    Linda Gao
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    Pigment Cell Melanoma Res 26:542-54. 2013
    ..This study demonstrates that DNA methylation alterations are widespread in melanoma and suggests that epigenetic silencing of MAPK13 contributes to melanoma progression. ..
  64. doi Effects of serially passaged fibroblasts on dermal and epidermal morphogenesis in human skin equivalents
    David Janson
    Department of Dermatology, Leiden University Medical Center, Room T 02 09, Postal Zone S2 P, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Biogerontology 14:131-40. 2013
    ..In conclusion, compared with HSEs generated with early passage fibroblasts, HSEs generated with late passage fibroblasts showed changes in the dermis, but no or minimal changes in the basement membrane and the epidermis...
  65. doi Skin diseases among schoolchildren in Ghana, Gabon, and Rwanda
    Arjan Hogewoning
    Department of Dermatology, University of Ghana Medical School, Korle Bu Teaching Hospital, Accra, Ghana
    Int J Dermatol 52:589-600. 2013
    ..The objective of this study was to determine the prevalences of skin diseases among children in rural and urban schools in three different African countries and to study the influence of socioeconomic level...
  66. ncbi MICA gene polymorphism is not associated with an increased risk for skin cancer
    Cornelius Kennedy
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands
    J Invest Dermatol 118:686-91. 2002
    ..Therefore, we conclude that an association between MICA gene polymorphism and nonmelanoma skin cancer is not likely...
  67. ncbi A novel splice variant of the Fas gene in patients with cutaneous T-cell lymphoma
    Remco van Doorn
    Department of Dermatology, Vrije Universiteit Medical Center, 1081 HV Amsterdam, The Netherlands
    Cancer Res 62:5389-92. 2002
    ....
  68. ncbi Cytotoxic/natural killer cell cutaneous lymphomas. Report of EORTC Cutaneous Lymphoma Task Force Workshop
    Marco Santucci
    Department of Human Pathology and Oncology, University of Florence Medical School, Florence, Italy
    Cancer 97:610-27. 2003
    ....
  69. ncbi WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects
    Gunter Burg
    Department of Dermatology, University Hospital Zurich, Switzerland
    J Cutan Pathol 32:647-74. 2005
    ..These findings always have to be interpreted in the context of the clinical features and biologic behavior...
  70. ncbi Variations in clinical presentation, frequency of hemophagocytosis and clinical behavior of intravascular lymphoma diagnosed in different geographical regions
    Andres J M Ferreri
    Medical Oncology Unit, Department of Oncology, San Raffaele Scientific Institute, Milan, Italy
    Haematologica 92:486-92. 2007
    ..This study explored variations in the clinical manifestations of intravascular lymphoma (IVL) on the bases of the association with hemophagocytosis and the country where the diagnosis was made...
  71. ncbi TCL1 and CLA expression in agranular CD4/CD56 hematodermic neoplasms (blastic NK-cell lymphomas) and leukemia cutis
    Tony Petrella
    Centre de Pathologie, Department of Pathology, centre hospitalo universitaire du Bocage, Dijon, France
    Am J Clin Pathol 122:307-13. 2004
    ..These results suggest that TCL1 and CLA are good markers for CD4/CD56 HN tumor cells and add support for a plasmacytoid dendritic cell origin. The high skin tropism of CD4/CD56 HN might be related to the skin-homing property of CLA...
  72. pmc Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas
    Frank M Raaphorst
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 164:533-42. 2004
    ..We propose that distinct expression profiles of PcG genes results in abnormal formation of HPC-HPH/PRC1 PcG complexes, and that this contributes to lymphomagenesis and different clinical behavior of clinically defined LBCLs...
  73. ncbi Primary cutaneous B-cell lymphomas: a practical approach
    Marie France Demierre
    Department of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA
    Hematol Oncol Clin North Am 17:1333-50. 2003
    ..Several therapeutic options that are aimed at cure, are available. In most instances, chemotherapy should not be the first line of treatment...
  74. ncbi TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the Cutaneous Lymphoma Task Force of the European Organization of Resear
    Youn H Kim
    Department of Dermatology, Stanford Comprehensive Cancer Center, Stanford, CA 94305, USA
    Blood 110:479-84. 2007
    ..Due to the clinical and pathologic heterogeneity of the cutaneous lymphomas, the currently proposed TNM system is meant to be primarily an anatomic documentation of disease extent and not to be used as a prognostic guide...
  75. ncbi Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Ca
    Elise Olsen
    Department of Medicine, Divisions of Dermatology and Oncology, Duke University Medical Center, Durham, NC 27516, USA
    Blood 110:1713-22. 2007
    ..The evidence supporting the revisions is discussed as well as recommendations for evaluation and staging procedures based on these revisions...
  76. ncbi Indolent CD8-positive lymphoid proliferation of the ear: a distinct primary cutaneous T-cell lymphoma?
    Tony Petrella
    Department of Pathology of Dijon s University Hospital and the Centre de Pathologie of Dijon, 2100 Dijon, France
    Am J Surg Pathol 31:1887-92. 2007
    ..The apparent striking propensity for the ear suggests that they might represent a specific entity. Further cases are needed to confirm this hypothesis. It is important for such indolent lesions to be known to avoid over treatment...
  77. ncbi p53-specific serum antibodies are not associated with a history of skin carcinoma in renal transplant recipients and immunocompetent individuals
    Ymke G L de Graaf
    J Dermatol Sci 38:228-30. 2005
  78. ncbi Update on erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas
    Eric C Vonderheid
    MCP Hahnemann University, Philadelphia, Pennsylvannia 19102, USA
    J Am Acad Dermatol 46:95-106. 2002
    ..For staging purposes, it is proposed that these criteria define the B2 blood rating and that the B2 rating be considered equivalent to nodal involvement...
  79. ncbi Total skin electron radiation in the management of mycosis fungoides: Consensus of the European Organization for Research and Treatment of Cancer (EORTC) Cutaneous Lymphoma Project Group
    Glenn W Jones
    Department of Radiation Oncology, Cancer Care Ontario, Hamilton, Canada
    J Am Acad Dermatol 47:364-70. 2002
    ..The aims of this report are to enhance accessibility of this highly efficacious treatment modality to patients with MF and to provide a point of reference for further clinical research...
  80. doi An immunodeficiency disease with RAG mutations and granulomas
    Catharina Schuetz
    Department of Pediatrics and Adolescent Medicine, University Hospital Ulm, Ulm, Germany
    N Engl J Med 358:2030-8. 2008
    ..In each case, both parents were heterozygous carriers of a RAG mutation. The mutations were associated with reduced function of RAG in vitro (3 to 30% of normal activity). The parents and one sibling in the three families were healthy...
  81. ncbi EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate
    Marcel W Bekkenk
    Blood 102:4243. 2003
  82. ncbi Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'
    Andres J M Ferreri
    Department of Radiochemotherapy, San Raffaele H Scientific Institute, Milan, Italy
    Br J Haematol 127:173-83. 2004
    ..ECOG-PS >1, 'cutaneous variant', stage I and chemotherapy use were independently associated with improved survival...
  83. ncbi Chromosomal aberration patterns differ in subtypes of primary cutaneous B cell lymphomas
    Christian Hallermann
    Department of Dermatology, University Hospital Goettingen, Germany
    J Invest Dermatol 122:1495-502. 2004
    ....
  84. ncbi EORTC consensus recommendations for the treatment of mycosis fungoides/Sézary syndrome
    Franz Trautinger
    Division of Special and Environmental Dermatology, Department of Dermatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna A 1090, Austria
    Eur J Cancer 42:1014-30. 2006
    ..Patients with advanced disease should be encouraged to participate in clinical trials and maintenance of quality of life should be paramount...