Jerry M Wells

Summary

Affiliation: Wageningen University
Country: The Netherlands

Publications

  1. doi request reprint The role of innate signaling in the homeostasis of tolerance and immunity in the intestine
    Jerry M Wells
    Host Microbe Interactomics Group, University of Wageningen, Animal Sciences Department, Wageningen, The Netherlands
    Int J Med Microbiol 300:41-8. 2010
  2. doi request reprint Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
    Jurgen Karczewski
    Host Microbe Interactomics Group, Univ of Wageningen, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 298:G851-9. 2010
  3. pmc Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization
    Marjolein Meijerink
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 5:e10632. 2010
  4. pmc Epithelial crosstalk at the microbiota-mucosal interface
    Jerry M Wells
    Host Microbe Interactomics Group, Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 108:4607-14. 2011
  5. pmc Immunomodulatory mechanisms of lactobacilli
    Jerry M Wells
    Host Microbe Interactomics, University of Wageningen, Animal Sciences Department, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Microb Cell Fact 10:S17. 2011
  6. pmc Immunomodulatory effects of Streptococcus suis capsule type on human dendritic cell responses, phagocytosis and intracellular survival
    Marjolein Meijerink
    Host Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 7:e35849. 2012
  7. doi request reprint Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1
    Oriana Rossi
    Host Microbe Interactomics Group, ASG, University of Wageningen, Wageningen, The Netherlands
    BMC Res Notes 6:431. 2013
  8. pmc Impact of 4 Lactobacillus plantarum capsular polysaccharide clusters on surface glycan composition and host cell signaling
    Daniela M Remus
    TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
    Microb Cell Fact 11:149. 2012
  9. pmc In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A
    Marcela de Azevedo
    INRA, UMR1319 MICALIS, Commensals and Probiotics Host Interactions Laboratory, Jouy en Josas, France
    BMC Microbiol 12:299. 2012
  10. pmc AI-2 does not function as a quorum sensing molecule in Campylobacter jejuni during exponential growth in vitro
    Kathryn Holmes
    School of Molecular Medical Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Clifton Boulevard, University Park, Nottingham NG7 2RD, UK
    BMC Microbiol 9:214. 2009

Collaborators

Detail Information

Publications30

  1. doi request reprint The role of innate signaling in the homeostasis of tolerance and immunity in the intestine
    Jerry M Wells
    Host Microbe Interactomics Group, University of Wageningen, Animal Sciences Department, Wageningen, The Netherlands
    Int J Med Microbiol 300:41-8. 2010
    ..The intestinal epithelium appears to have uniquely evolved to maintain mucosal tolerance and immunity, and future efforts to further understand the molecular mechanisms of intestinal homeostasis may have a major impact on human health...
  2. doi request reprint Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier
    Jurgen Karczewski
    Host Microbe Interactomics Group, Univ of Wageningen, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 298:G851-9. 2010
    ..Our results identifying commensal bacterial stimulation of TLR2 in the gut epithelium as a regulator of epithelial integrity have important implications for understanding probiotic mechanisms and the control of intestinal homeostasis...
  3. pmc Identification of genetic loci in Lactobacillus plantarum that modulate the immune response of dendritic cells using comparative genome hybridization
    Marjolein Meijerink
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 5:e10632. 2010
    ..However, the precise molecular mechanisms and the strain-dependent factors involved are poorly understood...
  4. pmc Epithelial crosstalk at the microbiota-mucosal interface
    Jerry M Wells
    Host Microbe Interactomics Group, Animal Sciences, Wageningen University, 6700 AH Wageningen, The Netherlands
    Proc Natl Acad Sci U S A 108:4607-14. 2011
    ..These immune mechanisms depend heavily on IEC recognition of microbes and are consistent with several studies in knockout mice that demonstrate TLR signaling in the epithelium has a profoundly beneficial role in maintaining homeostasis...
  5. pmc Immunomodulatory mechanisms of lactobacilli
    Jerry M Wells
    Host Microbe Interactomics, University of Wageningen, Animal Sciences Department, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Microb Cell Fact 10:S17. 2011
    ....
  6. pmc Immunomodulatory effects of Streptococcus suis capsule type on human dendritic cell responses, phagocytosis and intracellular survival
    Marjolein Meijerink
    Host Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 7:e35849. 2012
    ..Furthermore, we showed that 24 h after phagocytosis, significant numbers of viable intracellular S. suis were still present intracellularly. This may contribute to the dissemination of S. suis in the body...
  7. doi request reprint Vectorial secretion of interleukin-8 mediates autocrine signalling in intestinal epithelial cells via apically located CXCR1
    Oriana Rossi
    Host Microbe Interactomics Group, ASG, University of Wageningen, Wageningen, The Netherlands
    BMC Res Notes 6:431. 2013
    ..e. apical versus basolateral) depending on the location of the TLR stimulus...
  8. pmc Impact of 4 Lactobacillus plantarum capsular polysaccharide clusters on surface glycan composition and host cell signaling
    Daniela M Remus
    TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
    Microb Cell Fact 11:149. 2012
    ..Therefore, improved knowledge on these molecules is potentially of great importance to understand the strain-specific and proposed beneficial modes of probiotic action...
  9. pmc In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A
    Marcela de Azevedo
    INRA, UMR1319 MICALIS, Commensals and Probiotics Host Interactions Laboratory, Jouy en Josas, France
    BMC Microbiol 12:299. 2012
    ..In order to avoid the limitations of LL-InlA+ and LL-FnBPA+, a new L. lactis strain was engineered to produce a previously described mutated form of InlA (LL-mInlA+) allowing the binding of mInlA on murine E-cadherin...
  10. pmc AI-2 does not function as a quorum sensing molecule in Campylobacter jejuni during exponential growth in vitro
    Kathryn Holmes
    School of Molecular Medical Sciences, Centre for Biomolecular Sciences, The University of Nottingham, Clifton Boulevard, University Park, Nottingham NG7 2RD, UK
    BMC Microbiol 9:214. 2009
    ..The aim of this study was to determine whether AI-2 acted as a diffusible quorum sensing signal controlling C. jejuni gene expression when it is produced at high levels during mid exponential growth phase...
  11. doi request reprint Mucosal vaccination and therapy with genetically modified lactic acid bacteria
    Jerry Wells
    Host Microbe Interactomics, University of Wageningen, Animal Sciences Department, 6700 AH, Wageningen, The Netherlands
    Annu Rev Food Sci Technol 2:423-45. 2011
    ..lactis that secretes Il-10 should pave the way for new LAB delivery applications in the future...
  12. doi request reprint Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
    Jerry M Wells
    Host Microbe Interactomics, University of Wageningen, Animal Sciences Department, P O Box 338, 6700 AH, Wageningen, The Netherlands
    Nat Rev Microbiol 6:349-62. 2008
    ....
  13. pmc The impact of Lactobacillus plantarum WCFS1 teichoic acid D-alanylation on the generation of effector and regulatory T-cells in healthy mice
    Maaike J Smelt
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 8:e63099. 2013
    ..With this study we provide insight in host-microbe interactions, by demonstrating the involvement of D-alanylation of TAs on the bacterial membrane in intestinal and systemic immunomodulation in healthy mice...
  14. pmc Probiotics can generate FoxP3 T-cell responses in the small intestine and simultaneously inducing CD4 and CD8 T cell activation in the large intestine
    Maaike J Smelt
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 8:e68952. 2013
    ..Our data also indicate that selection of specific probiotic strain activities on the basis of responses in healthy mice may be a promising strategy to specifically stimulate or suppress immunity in specific parts of the intestine. ..
  15. pmc Impact of Lactobacillus plantarum sortase on target protein sorting, gastrointestinal persistence, and host immune response modulation
    Daniela M Remus
    TI Food and Nutrition, Wageningen, The Netherlands
    J Bacteriol 195:502-9. 2013
    ....
  16. pmc Lactobacillus plantarum possesses the capability for wall teichoic acid backbone alditol switching
    Peter A Bron
    TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA, Wageningen, The Netherlands
    Microb Cell Fact 11:123. 2012
    ..L. plantarum WCFS1 harbors the genetic potential to switch WTA backbone alditol, providing an opportunity to study the impact of WTA backbone modifications in an isogenic background...
  17. doi request reprint Immunomodulatory effects of potential probiotics in a mouse peanut sensitization model
    Marjolein Meijerink
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    FEMS Immunol Med Microbiol 65:488-96. 2012
    ..In case of HMI001 (high IL-10/IL-12 ratio) and LCS (high interferon-γ and IL-12), partial protection was seen in a mouse peanut allergy model. Strikingly, certain strains may worsen the allergic reaction as shown in the case of WCFS1...
  18. doi request reprint Regulation of intestinal homeostasis and immunity with probiotic lactobacilli
    Peter van Baarlen
    Host Microbe Interactomics Group, Wageningen University, De Elst 1, 6708WD Wageningen, The Netherlands
    Trends Immunol 34:208-15. 2013
    ....
  19. pmc Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells
    Saskia van Hemert
    TI Food and Nutrition, Nieuwe Kanaal 9A, 6709PA, Wageningen, The Netherlands
    BMC Microbiol 10:293. 2010
    ..plantarum with the potential to influence the amounts of cytokines interleukin 10 (IL-10) and IL-12 and the ratio of IL-10/IL-12 produced by peripheral blood mononuclear cells (PBMCs)...
  20. doi request reprint ApuA, a multifunctional alpha-glucan-degrading enzyme of Streptococcus suis, mediates adhesion to porcine epithelium and mucus
    Maria Laura Ferrando
    Host Microbe Interactomics, Wageningen University and Research Centre, Marijkeweg 40, 6709 PG Wageningen, The Netherlands
    Microbiology 156:2818-28. 2010
    ..ApuA was shown to promote adhesion to porcine epithelium and mucus in vitro, highlighting a link between carbohydrate utilization and the ability of S. suis to colonize and infect the host...
  21. pmc Carbohydrate availability regulates virulence gene expression in Streptococcus suis
    M Laura Ferrando
    Host Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 9:e89334. 2014
    ..suis virulence mechanisms and has important implications for the design of future control strategies including the development of anti-infective strategies by modulating animal feed composition. ..
  22. pmc L. plantarum, L. salivarius, and L. lactis attenuate Th2 responses and increase Treg frequencies in healthy mice in a strain dependent manner
    Maaike J Smelt
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 7:e47244. 2012
    ..Our data demonstrate that in healthy mice, lactobacilli can balance T cell immunity in favor of a more regulatory status, via both regulatory T cell dependent and independent mechanisms in a strain dependent manner...
  23. doi request reprint Host-recognition of pathogens and commensals in the mammalian intestine
    Oriana Rossi
    Wageningen University and Research Centre, Wageningen, The Netherlands
    Curr Top Microbiol Immunol 358:291-321. 2013
    ..Research on this topic has important implications for the development of novel therapeutic approaches to treat or prevent inflammatory bowel disease (IBD), inflammation-related cancer and other gut-related diseases and disorders...
  24. pmc Intestinally secreted C-type lectin Reg3b attenuates salmonellosis but not listeriosis in mice
    Marleen T J van Ampting
    TI Food and Nutrition, Wageningen, The Netherlands
    Infect Immun 80:1115-20. 2012
    ..Reg3b plays a protective role against intestinal translocation of the gram-negative bacterium S. enteritidis in mice but not against the gram-positive bacterium L. monocytogenes...
  25. doi request reprint Cryopreservation of monocytes or differentiated immature DCs leads to an altered cytokine response to TLR agonists and microbial stimulation
    Marjolein Meijerink
    Top Institute Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA, Wageningen, The Netherlands
    J Immunol Methods 373:136-42. 2011
    ..These findings have implications for the methods used in bacterial-DC immune assays and highlight the importance of comparing different cytokines and stimuli in immune cell cryopreservation protocols...
  26. pmc Control of Competence for DNA Transformation in Streptococcus suis by Genetically Transferable Pherotypes
    Edoardo Zaccaria
    Host Microbe Interactomics, Animal Sciences, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 9:e99394. 2014
    ..Harnessing natural competence is expected to accelerate genetic research on this and other important streptococcal pathogens and to allow high-throughput mutation approaches to be implemented, opening up new avenues for research. ..
  27. doi request reprint Omics approaches to study host-microbiota interactions
    Peter van Baarlen
    Host Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands
    Curr Opin Microbiol 16:270-7. 2013
    ..Network biology approaches can be combined with studies in animal models and cell lines to create iterative cycle of hypotheses and testing, possibly leading to testing in clinical and nutritional intervention studies. ..
  28. ncbi request reprint An anti-HIV microbicide engineered in commensal bacteria: secretion of HIV-1 fusion inhibitors by lactobacilli
    Oliver Pusch
    Center of Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    AIDS 20:1917-22. 2006
    ..To engineer Lactobacillus spp. to secrete HIV-1 fusion inhibitors with potent neutralizing activity against primary HIV-1 isolates...
  29. ncbi request reprint Bioengineering lactic acid bacteria to secrete the HIV-1 virucide cyanovirin
    Oliver Pusch
    Center of Anatomy and Cell Biology, Laboratories of Genome Dynamics, Medical University of Vienna, Vienna, Austria
    J Acquir Immune Defic Syndr 40:512-20. 2005
    ..Our results suggest that recombinant LAB may serve as effective microbicidal compounds and deserve in vivo testing in simian immunodeficiency virus models of mucosal virus transmission...
  30. ncbi request reprint Expression and delivery of heterologous antigens using lactic acid bacteria
    Mark A Reuter
    Institute of Food Research, Norwich Research Park, Colney, United Kingdom
    Methods Mol Med 87:101-14. 2003