Ad Peijnenburg

Summary

Affiliation: Wageningen University
Country: The Netherlands

Publications

  1. ncbi request reprint Induction of the cholesterol biosynthesis pathway in differentiated Caco-2 cells by the potato glycoalkaloid alpha-chaconine
    Tafadzwa Mandimika
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, P O Box 230, 6700 AE Wageningen, The Netherlands
    Food Chem Toxicol 45:1918-27. 2007
  2. pmc Feasibility of a liver transcriptomics approach to assess bovine treatment with the prohormone dehydroepiandrosterone (DHEA)
    Jeroen C W Rijk
    RIKILT Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE Wageningen, The Netherlands
    BMC Vet Res 6:44. 2010
  3. pmc Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells
    Danyel Jennen
    Department of Toxicogenomics, Maastricht University, The Netherlands
    BMC Syst Biol 5:139. 2011
  4. pmc Allermatch, a webtool for the prediction of potential allergenicity according to current FAO/WHO Codex alimentarius guidelines
    Mark W E J Fiers
    BMC Bioinformatics 5:133. 2004
  5. doi request reprint AhR-agonistic, anti-androgenic, and anti-estrogenic potencies of 2-isopropylthioxanthone (ITX) as determined by in vitro bioassays and gene expression profiling
    Ad Peijnenburg
    RIKILT Institute of Food Safety, Wageningen UR, Wageningen, The Netherlands
    Toxicol In Vitro 24:1619-28. 2010
  6. doi request reprint Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights
    Madhumohan R Katika
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Toxicol Appl Pharmacol 264:51-64. 2012
  7. doi request reprint Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells
    Madhumohan R Katika
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Toxicol Lett 212:126-36. 2012
  8. doi request reprint Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO)
    Sandra W M van Kol
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Toxicology 296:37-47. 2012
  9. ncbi request reprint Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach
    Marjoke Heneweer
    RIKILT Institute of Food Safety, Wageningen UR, 6700 AE Wageningen, The Netherlands
    Toxicol Sci 99:303-14. 2007
  10. doi request reprint Bioassay directed identification of natural aryl hydrocarbon-receptor agonists in marmalade
    Karin van Ede
    RIKILT Institute of Food Safety, Wageningen UR, P O Box 230, 6700 AE Wageningen, The Netherlands
    Anal Chim Acta 617:238-45. 2008

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Induction of the cholesterol biosynthesis pathway in differentiated Caco-2 cells by the potato glycoalkaloid alpha-chaconine
    Tafadzwa Mandimika
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, P O Box 230, 6700 AE Wageningen, The Netherlands
    Food Chem Toxicol 45:1918-27. 2007
    ..This study is useful in understanding the mechanism(s) of alpha-chaconine toxicity, which may be extended to other potato glycoalkaloids more generally...
  2. pmc Feasibility of a liver transcriptomics approach to assess bovine treatment with the prohormone dehydroepiandrosterone (DHEA)
    Jeroen C W Rijk
    RIKILT Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE Wageningen, The Netherlands
    BMC Vet Res 6:44. 2010
    ....
  3. pmc Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells
    Danyel Jennen
    Department of Toxicogenomics, Maastricht University, The Netherlands
    BMC Syst Biol 5:139. 2011
    ....
  4. pmc Allermatch, a webtool for the prediction of potential allergenicity according to current FAO/WHO Codex alimentarius guidelines
    Mark W E J Fiers
    BMC Bioinformatics 5:133. 2004
    ..org is a webtool for the efficient and standardized prediction of potential allergenicity of proteins and peptides according to the current recommendations of the FAO/WHO Expert Consultation, as outlined in the Codex alimentarius...
  5. doi request reprint AhR-agonistic, anti-androgenic, and anti-estrogenic potencies of 2-isopropylthioxanthone (ITX) as determined by in vitro bioassays and gene expression profiling
    Ad Peijnenburg
    RIKILT Institute of Food Safety, Wageningen UR, Wageningen, The Netherlands
    Toxicol In Vitro 24:1619-28. 2010
    ..The observed in vitro effects warrant further in vivo studies for confirmation and hazard characterization...
  6. doi request reprint Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights
    Madhumohan R Katika
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Toxicol Appl Pharmacol 264:51-64. 2012
    ..Comparison of the Jurkat microarray data with those obtained with PBMCs showed that most of the processes affected by DON in the Jurkat cell line were also affected in the PBMCs...
  7. doi request reprint Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells
    Madhumohan R Katika
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Toxicol Lett 212:126-36. 2012
    ..Finally, comparative microarray data analysis showed that many of the processes observed in vitro also occur in vivo in thymuses of TBTO-treated mice...
  8. doi request reprint Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO)
    Sandra W M van Kol
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Toxicology 296:37-47. 2012
    ..Induction of the T cell activation response was corroborated by demonstrating that TBTO exposure resulted in translocation of NFAT to the nucleus, which is an essential event for T cell activation...
  9. ncbi request reprint Estrogenic effects in the immature rat uterus after dietary exposure to ethinylestradiol and zearalenone using a systems biology approach
    Marjoke Heneweer
    RIKILT Institute of Food Safety, Wageningen UR, 6700 AE Wageningen, The Netherlands
    Toxicol Sci 99:303-14. 2007
    ..This observation may explain the observed differences at the histological level...
  10. doi request reprint Bioassay directed identification of natural aryl hydrocarbon-receptor agonists in marmalade
    Karin van Ede
    RIKILT Institute of Food Safety, Wageningen UR, P O Box 230, 6700 AE Wageningen, The Netherlands
    Anal Chim Acta 617:238-45. 2008
    ..The approach and method developed resulted in the successful identification of the bioactive component. However, potential pitfalls of the procedure will be discussed...
  11. doi request reprint Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis
    Madhumohan R Katika
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    Toxicol Appl Pharmacol 254:311-22. 2011
    ..We propose that the induction of ER stress leading to a T cell activation response is a major factor in the higher sensitivity of immune cells above other types of cells for TBTO...
  12. pmc An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Ainhoa Ruiz-Aracama
    RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
    BMC Genomics 12:251. 2011
    ..The human liver cell line HepG2, and the well-known hepatotoxic and non-genotoxic carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), were used as the in vitro model system and model toxicant, respectively...