Genomes and Genes


Ad Peijnenburg


Affiliation: Wageningen University
Country: The Netherlands


  1. Shao J, Stout I, Volger O, Hendriksen P, Van Loveren H, Peijnenburg A. Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants. Arch Toxicol. 2016;90:1685-94 pubmed publisher
    ..Despite this difference, the present study indicated that some compounds may exert their immunotoxic effects through inhibition of CXCL12-mediated chemotaxis. ..
  2. Janssen A, Betzel B, Stoopen G, Berends F, Janssen I, Peijnenburg A, et al. The impact of PPARα activation on whole genome gene expression in human precision cut liver slices. BMC Genomics. 2015;16:760 pubmed publisher
  3. Ruiz Aracama A, Peijnenburg A, Kleinjans J, Jennen D, van Delft J, Hellfrisch C, et al. An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. BMC Genomics. 2011;12:251 pubmed publisher
    ..The effects of TCDD on HepG2 cells reported herein are in agreement with previous studies and serve to validate the procedures used in the present work. ..
  4. Szalowska E, Pronk T, Peijnenburg A. Cyclosporin A induced toxicity in mouse liver slices is only slightly aggravated by Fxr-deficiency and co-occurs with upregulation of pro-inflammatory genes and downregulation of genes involved in mitochondrial functions. BMC Genomics. 2015;16:822 pubmed publisher
    ..Therefore, FXR can exert its hepatoprotective functions by controlling inflammation and mitochondrial functions, possibly involving an FXR-PPAR delta cross-talk. ..
  5. Parra Pessoa I, Lopes Neto J, Silva de Almeida T, Felipe Farias D, Vieira L, Lima de Medeiros J, et al. Polyphenol Composition, Antioxidant Activity and Cytotoxicity of Seeds from Two Underexploited Wild Licania Species: L. rigida and L. tomentosa. Molecules. 2016;21: pubmed publisher
    ..Both plant species showed a promising phenolic profile with potent antioxidant capacity and deserve attention to be sustainably explored. ..