Michael Muller

Summary

Affiliation: Wageningen University
Country: The Netherlands

Publications

  1. ncbi request reprint Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine
    Nicole de Wit
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 303:G589-99. 2012
  2. pmc Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis
    Duccio Cavalieri
    Department of Pharmacology, University of Firenze, Firenze, Italy
    BMC Genomics 10:596. 2009
  3. ncbi request reprint Nutrigenomics: goals and strategies
    Michael Muller
    Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Nat Rev Genet 4:315-22. 2003
  4. pmc PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
    Heleen M de Vogel-van den Bosch
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, NL 6700EV, Wageningen, The Netherlands
    BMC Genomics 9:231. 2008
  5. doi request reprint Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart
    Anastasia Georgiadi
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    Physiol Genomics 44:352-61. 2012
  6. pmc Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice
    Caroline Duval
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Diabetes 59:3181-91. 2010
  7. doi request reprint Postprandial dietary lipid-specific effects on human peripheral blood mononuclear cell gene expression profiles
    Mark Bouwens
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Clin Nutr 91:208-17. 2010
  8. doi request reprint Resistant starch induces catabolic but suppresses immune and cell division pathways and changes the microbiome in the proximal colon of male pigs
    Daniëlle Haenen
    Nutrition Metabolism and Genomics Group, Division of Human Nutrition, 5Adaptation Physiology Group, 6Animal Nutrition Group, 7Laboratory of Microbiology, and 8Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands
    J Nutr 143:1889-98. 2013
  9. pmc Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response
    Mark Bouwens
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    BMC Genomics 9:262. 2008
  10. ncbi request reprint Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
    Anastasia Georgiadi
    Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Circ Res 106:1712-21. 2010

Detail Information

Publications59

  1. ncbi request reprint Saturated fat stimulates obesity and hepatic steatosis and affects gut microbiota composition by an enhanced overflow of dietary fat to the distal intestine
    Nicole de Wit
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 303:G589-99. 2012
    ..We speculate that both are directly or indirectly contributive to the saturated fat-induced development of obesity and hepatic steatosis...
  2. pmc Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis
    Duccio Cavalieri
    Department of Pharmacology, University of Firenze, Firenze, Italy
    BMC Genomics 10:596. 2009
    ..To further investigate the function of PPARalpha, we have applied a cross-species meta-analysis approach to integrate sixteen microarray datasets studying high fat diet and PPARalpha signal perturbations in different organisms...
  3. ncbi request reprint Nutrigenomics: goals and strategies
    Michael Muller
    Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Nat Rev Genet 4:315-22. 2003
    ..Ultimately, nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases...
  4. pmc PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
    Heleen M de Vogel-van den Bosch
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, NL 6700EV, Wageningen, The Netherlands
    BMC Genomics 9:231. 2008
    ..To this end we used triacylglycerols composed of identical fatty acids in combination with gene expression profiling in wild-type and PPARalpha-null mice. Treatment with the synthetic PPARalpha agonist WY14643 served as reference...
  5. doi request reprint Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart
    Anastasia Georgiadi
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    Physiol Genomics 44:352-61. 2012
    ..6) Deletion and activation of PPARα had a major effect on expression of numerous genes involved in metabolism and immunity. Our analysis demonstrates the marked impact of dietary fatty acids on gene regulation in the heart via PPARα...
  6. pmc Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice
    Caroline Duval
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Diabetes 59:3181-91. 2010
    ..Here, we aimed to investigate the interaction between adipose tissue and liver in NAFLD and identify potential early plasma markers that predict nonalcoholic steatohepatitis (NASH)...
  7. doi request reprint Postprandial dietary lipid-specific effects on human peripheral blood mononuclear cell gene expression profiles
    Mark Bouwens
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Clin Nutr 91:208-17. 2010
    ..The mechanisms of action of PUFAs are still not completely understood, but it is known that PUFAs can influence the expression of a broad set of genes...
  8. doi request reprint Resistant starch induces catabolic but suppresses immune and cell division pathways and changes the microbiome in the proximal colon of male pigs
    Daniëlle Haenen
    Nutrition Metabolism and Genomics Group, Division of Human Nutrition, 5Adaptation Physiology Group, 6Animal Nutrition Group, 7Laboratory of Microbiology, and 8Laboratory of Biochemistry, Wageningen University, Wageningen, The Netherlands
    J Nutr 143:1889-98. 2013
    ..Overall, this study provides novel insights on effects of RS in proximal colon and contributes to our understanding of a healthy diet. ..
  9. pmc Activation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells reveals an individual gene expression profile response
    Mark Bouwens
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    BMC Genomics 9:262. 2008
    ..However, the extent of the role of PPARalpha in human PBMCs remains unclear. In this study, we therefore performed gene expression profiling of PBMCs incubated with the specific PPARalpha ligand WY14,643...
  10. ncbi request reprint Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
    Anastasia Georgiadi
    Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Circ Res 106:1712-21. 2010
    ..Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart...
  11. ncbi request reprint Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue
    Rinke Stienstra
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 283:22620-7. 2008
    ..The alternatively activated macrophages might play a role in peroxisome proliferator-activated receptor gamma-dependent expansion and remodeling of adipose tissue...
  12. pmc Responses to high-fat challenges varying in fat type in subjects with different metabolic risk phenotypes: a randomized trial
    Susan J van Dijk
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 7:e41388. 2012
    ..The aim of this study was to compare the responses to high-fat challenges varying in fat type in subjects with different metabolic risk phenotypes...
  13. doi request reprint Comparative transcriptomic and metabolomic analysis of fenofibrate and fish oil treatments in mice
    Yingchang Lu
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Physiol Genomics 43:1307-18. 2011
    ....
  14. ncbi request reprint Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, P O Box 8129, 6700 EV, Wageningen, The Netherlands
    Endocrinology 147:1508-16. 2006
    ..It is concluded that 1) PPARalpha and PPARalpha-signaling are activated in liver by chronic high-fat feeding; and 2) PPARgamma may compensate for PPARalpha in PPARalpha null mice on HFD...
  15. pmc Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting
    Heleen M van den Bosch
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen, University, Wageningen, The Netherlands
    BMC Genomics 8:267. 2007
    ..We therefore investigated the effects of fasting on expression of these genes using Affymetrix GeneChip MOE430A arrays and quantitative RT-PCR...
  16. doi request reprint Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells
    Mark Bouwens
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6703 HD Wageningen, Netherlands
    Am J Clin Nutr 90:415-24. 2009
    ..Polyunsaturated fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). However, the mechanisms of action of polyunsaturated fatty acids on immune cells are still largely unknown...
  17. ncbi request reprint Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation
    Rinke Stienstra
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    Endocrinology 148:2753-63. 2007
    ....
  18. ncbi request reprint The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Biol Chem 281:934-44. 2006
    ..Our data indicate that disturbances in FIAF signaling might be involved in dyslipidemia...
  19. pmc Maternal Western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring
    Mona Mischke
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 8:e78623. 2013
    ..Remarkably, the observed biological responses of the offspring reveal pronounced sex-specificity. ..
  20. doi request reprint Overexpression of angiopoietin-like protein 4 protects against atherosclerosis development
    Anastasia Georgiadi
    Nutrition, Metabolism, and Genomics Group, Wageningen University, Wageningen, The Netherlands
    Arterioscler Thromb Vasc Biol 33:1529-37. 2013
    ..Here we characterized the regulation of Angptl4 expression in macrophages and examined the impact of Angptl4 on atherosclerosis development...
  21. ncbi request reprint Stress- (and diet-) related regulation of hepatic nuclear receptors and its relevance for ABC-transporter functions
    Rinke Stienstra
    Division of Human Nutrition, Nutrition, Metabolism and Genomics Group, Wageningen University, Wageningen, The Netherlands
    Drug Metab Rev 36:391-406. 2004
    ....
  22. pmc Structural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice
    Wilma T Steegenga
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    BMC Med Genomics 5:38. 2012
    ..To what extent aging-related changes in the intestinal system contribute to the functional decline associated with aging is still under debate...
  23. doi request reprint Phenotyping the effect of diet on non-alcoholic fatty liver disease
    Nicole J W de Wit
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Hepatol 57:1370-3. 2012
    ....
  24. ncbi request reprint A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine
    Heleen M de Vogel-van den Bosch
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Physiol Gastrointest Liver Physiol 294:G1171-80. 2008
    ..This study highlights the induction of adaptive changes in small intestinal cholesterol metabolism during exposure to dietary fat...
  25. doi request reprint Consumption of a high monounsaturated fat diet reduces oxidative phosphorylation gene expression in peripheral blood mononuclear cells of abdominally overweight men and women
    Susan J van Dijk
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Nutr 142:1219-25. 2012
    ..We hypothesize that replacement of SFA with MUFA may improve health, thereby reducing metabolic stress and OXPHOS activity in PBMC. The MED diet may have additional antiatherogenic effects by lowering proinflammatory plasma proteins...
  26. doi request reprint Plasma mannose-binding lectin is stimulated by PPARα in humans
    Maryam Rakhshandehroo
    The Netherlands Nutrigenomics Center, Top Institute Food and Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Physiol Endocrinol Metab 302:E595-602. 2012
    ....
  27. ncbi request reprint Exploration of PPAR functions by microarray technology--a paradigm for nutrigenomics
    Meike Bünger
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, NL 6700 EV Wageningen, The Netherlands
    Biochim Biophys Acta 1771:1046-64. 2007
    ..In this review we summarize and discuss the application of transcriptomics to study PPAR function, and discuss some of the challenges inherent to the application of transcriptomics to nutrigenomics research...
  28. pmc Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects
    Susan J van Dijk
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 5:e14422. 2010
    ....
  29. pmc Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis
    David L M van der Meer
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, NL 6703 HD Wageningen, The Netherlands
    Nucleic Acids Res 38:2839-50. 2010
    ..Overall, our analysis leads to important new insights into the mechanisms and impact of transcriptional regulation by PPARalpha in human liver and highlight the importance of cross-talk with other transcription factors...
  30. ncbi request reprint The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 279:34411-20. 2004
    ..Together, these data suggest that FIAF, similar to other adipocytokines such as adiponectin, may partially exert its function via a truncated form...
  31. pmc Dietary protein affects gene expression and prevents lipid accumulation in the liver in mice
    Jessica Schwarz
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 7:e47303. 2012
    ..The aim of our study was to detect mechanisms by which a HP diet affects hepatic lipid accumulation...
  32. pmc Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study
    Yingchang Lu
    Division of Human Nutrition, Wageningen University and Research Center, Wageningen, The Netherlands
    PLoS ONE 7:e41681. 2012
    ..Therefore, the aim of this study was to investigate the relation between these ratios as well as genotypes of FADS1 rs174547 and CHD incidence...
  33. pmc Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle
    Milène Catoire
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    PLoS ONE 7:e51066. 2012
    ..The study points to a major influence of exercise beyond the contracting muscle...
  34. doi request reprint Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism
    Bart L T Vaes
    Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, The Netherlands
    Bone 46:514-23. 2010
    ....
  35. ncbi request reprint Genome-wide analysis of PPARalpha activation in murine small intestine
    Meike Bünger
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Physiol Genomics 30:192-204. 2007
    ..We show that PPARalpha is an important transcriptional regulator in small intestine, which may be of importance for the development of novel foods and therapies for obesity and inflammatory bowel diseases...
  36. ncbi request reprint Peroxisome proliferator activated receptor ligands for the treatment of insulin resistance
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Curr Opin Investig Drugs 5:1045-50. 2004
    ..Current data linking PPAR and/or PPAR ligands with the treatment of insulin resistance will be critically reviewed, with the focus on important advances over the past year...
  37. pmc TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis
    Yingchang Lu
    Division of Human Nutrition, Wageningen University and Research Center, PO Box 8129, 6700, Ev, Wageningen, The Netherlands
    BMC Med Genet 13:39. 2012
    ..Genetic variations in TGFB1 gene have been studied in relation to coronary heart disease (CHD) risk, but the results were inconsistent...
  38. ncbi request reprint PPARalpha and dyslipidemia
    Caroline Duval
    Nutrition, Metabolism and Genomics Group and Nutrigenomics Consortium, Wageningen University, P O Box 8129, 6700 EV Wageningen, Netherlands
    Biochim Biophys Acta 1771:961-71. 2007
    ....
  39. doi request reprint Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study
    Yingchang Lu
    Division of Human Nutrition, Wageningen University and Research Center, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Atherosclerosis 213:200-5. 2010
    ..Although ample evidence of genetic determination of separate lipoprotein cholesterol levels has been reported, using TC level directly as a phenotype in a relatively large broad-gene based association study has not been reported to date...
  40. pmc PPARalpha governs glycerol metabolism
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Clin Invest 114:94-103. 2004
    ..Overall, these data indicate that PPARalpha directly governs glycerol metabolism in liver, whereas PPARgamma regulates glycerol metabolism in adipose tissue...
  41. ncbi request reprint Dark chocolate consumption improves leukocyte adhesion factors and vascular function in overweight men
    Diederik Esser
    1Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    FASEB J 28:1464-73. 2014
    ..This study provides new insights on how chocolate affects endothelial health by demonstrating that chocolate consumption, besides improving vascular function, also lowers the adherence capacity of leukocytes in the circulation...
  42. pmc Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs
    Wilma T Steegenga
    Division of Human Nutrition, Wageningen University, Bomenweg 2, Wageningen, 6703 HD, The Netherlands
    Age (Dordr) 36:9648. 2014
    ..In conclusion, aging-induced differential methylation often targets developmental genes and occurs mostly without change in gene expression. ..
  43. ncbi request reprint Nutrigenomics: from molecular nutrition to prevention of disease
    Lydia Afman
    Nutrition, Metabolism and Genomics Chair Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    J Am Diet Assoc 106:569-76. 2006
    ..In this review, we provide a brief overview of nutrigenomics from our point of view by describing current strategies, future opportunities, and challenges...
  44. doi request reprint Oit1/Fam3D, a gut-secreted protein displaying nutritional status-dependent regulation
    Nicole J W de Wit
    Netherlands Nutrigenomics Centre, TI Food and Nutrition, Wageningen, The Netherlands
    J Nutr Biochem 23:1425-33. 2012
    ..In conclusion, Oit1 and Fam3D are gut-derived proteins that are expressed and secreted in a nutritional status-dependent manner...
  45. doi request reprint Human nutrigenomics of gene regulation by dietary fatty acids
    Lydia A Afman
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    Prog Lipid Res 51:63-70. 2012
    ..It is important to use and integrate nutrigenomics in all future nutrition studies to build up the necessary framework for evidence-based nutrition in near future...
  46. doi request reprint The potential influence of genetic variants in genes along bile acid and bile metabolic pathway on blood cholesterol levels in the population
    Yingchang Lu
    Division of Human Nutrition, Wageningen University and Research Center, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Atherosclerosis 210:14-27. 2010
    ..In this review, we summarized the current state of knowledge about genetic variations in bile acid and bile metabolic pathway, and assessed their impact on blood cholesterol levels and cholesterol metabolic kinetics in the population...
  47. ncbi request reprint Fasting induces changes in peripheral blood mononuclear cell gene expression profiles related to increases in fatty acid beta-oxidation: functional role of peroxisome proliferator activated receptor alpha in human peripheral blood mononuclear cells
    Mark Bouwens
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Clin Nutr 86:1515-23. 2007
    ..PBMCs express PPARalpha, making these cells interesting to study FA-dependent gene expression...
  48. doi request reprint Systems biology of the gut: the interplay of food, microbiota and host at the mucosal interface
    Vítor Martins dos Santos
    Laboratory of Systems and Synthetic Biology, Wageningen University, Dreijenplein 10, 6710 HB Wageningen, The Netherlands
    Curr Opin Biotechnol 21:539-50. 2010
    ..An integrated, modular modelling framework that cross-links top-down and bottom-up approaches for the various levels of biological organization is paramount for the understanding of intestinal function...
  49. pmc The G0/G1 switch gene 2 is a novel PPAR target gene
    Fokko Zandbergen
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 EV, Wageningen, The Netherlands
    Biochem J 392:313-24. 2005
    ..Together, these data indicate that G0S2 is a novel target gene of PPARs that may be involved in adipocyte differentiation...
  50. doi request reprint Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids
    Sander Kersten
    Nutrigenomics Consortium, TI Food and Nutrition, Wageningen, The Netherlands
    Arterioscler Thromb Vasc Biol 29:969-74. 2009
    ..However, very little is known about ANGPTL4 in human. Here we set out to identify physiological determinants of plasma ANGPTL4 levels in humans, focusing on the effect of energy restriction and plasma FFAs...
  51. ncbi request reprint Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
    Yingchang Lu
    Division of Human Nutrition, Wageningen University Research Center, Wageningen, Netherlands
    Am J Clin Nutr 92:258-65. 2010
    ..Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies...
  52. pmc Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ
    Sheril Alex
    Nutrition, Metabolism and Genomics Group, Wageningen University, Wageningen, The Netherlands
    Mol Cell Biol 33:1303-16. 2013
    ..Our data point to activation of PPARs as a novel mechanism of gene regulation by SCFA in the colon, in addition to other mechanisms of action of SCFA...
  53. ncbi request reprint A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine
    Daniëlle Haenen
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Nutr 143:274-83. 2013
    ..Combined, our data provide an enhanced understanding of the interaction between diet, microbiota, and host...
  54. pmc PPARs, Obesity, and Inflammation
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group and Nutrigenomics Consortium, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    PPAR Res 2007:95974. 2007
    ..This review will address the role of PPARs in obesity-induced inflammation specifically in adipose tissue, liver, and the vascular wall...
  55. doi request reprint Vitamin B(12) deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid
    Bart L T Vaes
    Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, The Netherlands
    Calcif Tissue Int 84:413-22. 2009
    ..On the basis of these results, we conclude that B(12) deficiency may lead to decreased bone mass by increased osteoclast formation due to increased MMA and Hcy levels...
  56. pmc Dietary heme alters microbiota and mucosa of mouse colon without functional changes in host-microbe cross-talk
    Noortje IJssennagger
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 7:e49868. 2012
    ..This unaltered host-microbe cross-talk indicates that the changes in microbiota did not play a causal role in the observed hyperproliferation and hyperplasia...
  57. ncbi request reprint Design guidelines for the development of digital nutrigenomics learning material for heterogeneous target groups
    Maria C Busstra
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Adv Physiol Educ 31:67-75. 2007
    ..Each case consists of several activities to promote active learning by the student. Evaluation of the cases in a realistic academic educational setting indicates that the cases were useful...
  58. pmc An Integrated Statistical Approach to Compare Transcriptomics Data Across Experiments: A Case Study on the Identification of Candidate Target Genes of the Transcription Factor PPARα
    Mohammad Ohid Ullah
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    Bioinform Biol Insights 6:145-54. 2012
    ..Taken together, in this study we present a simple, yet efficient strategy to compare differential expression of genes across experiments while controlling for multiple hypothesis testing...
  59. ncbi request reprint The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Hepatol 46:869-77. 2007
    ..The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver...