Esther J Kok
Affiliation: Wageningen University
Country: The Netherlands
- Plants with stacked genetically modified events: to assess or not to assess?Esther J Kok
RIKILT Wageningen UR, Akkermaalsbos 2, 6708 WB, Wageningen, The Netherlands Electronic address
Trends Biotechnol 32:70-3. 2014..This paper advocates rethinking the current food/feed safety assessment of stacked GM events in Europe based on an analysis of different aspects that currently form the rationale for the safety assessment of stacked GM events. ..
- Comparative safety assessment for biotech cropsEsther J Kok
RIKILT Institute for Food Safety, Bornsesteeg 45, PO Box 230, 6700 AE Wageningen, The Netherlands
Trends Biotechnol 21:439-44. 2003
- Comparative safety assessment of plant-derived foodsE J Kok
RIKILT Institute of Food Safety, Bornsesteeg 45, PO Box 230, 6700 AE Wageningen, The Netherlands
Regul Toxicol Pharmacol 50:98-113. 2008..We propose to develop a general screening frame for all newly developed plant varieties to select varieties that cannot, on the basis of scientific criteria, be considered as safe as plant varieties that are already on the market...
- Assessment of representational difference analysis (RDA) to construct informative cDNA microarrays for gene expression analysis of species with limited transcriptome information, using red and green tomatoes as a modelEsther J Kok
RIKILT Institute for Food Safety, Bornsesteeg 45, 6700 AE Wageningen, The Netherlands
J Plant Physiol 164:337-49. 2007..Further, known and putative ripening-related cDNAs were identified in hybridisation experiments on the basis of RNA populations as isolated from the green and red stage of ripening...
- Exploitation of molecular profiling techniques for GM food safety assessmentHarry A Kuiper
RIKILT, Institute of Food Safety, PO Box 230, 6700 AE, Wageningen, The Netherlands
Curr Opin Biotechnol 14:238-43. 2003....
- The identification and interpretation of differences in the transcriptomes of organically and conventionally grown potato tubersJeroen P van Dijk
RIKILT Institute of Food Safety Wageningen UR, Wageningen, The Netherlands
J Agric Food Chem 60:2090-101. 2012..This study confirmed that gene expression profiling in combination with pathway analysis can identify and characterize differences between plants grown under different environmental conditions...
- Comparison and transfer testing of multiplex ligation detection methods for GM plantsGabriella Ujhelyi
RIKILT Institute of Food Safety WUR, Akkermaalsbos 2, 6708 WB Wageningen, The Netherlands
BMC Biotechnol 12:4. 2012..Sensitivity and the specificity of the padlock probes (PLPs) with the ligation protocol with the best performance were also tested and the selected method was initially validated in a laboratory exchange study...
- Optimised padlock probe ligation and microarray detection of multiple (non-authorised) GMOs in a single reactionTheo W Prins
RIKILT Institute of Food Safety WUR, Bornsesteeg 45, 6708 PD Wageningen, The Netherlands
BMC Genomics 9:584. 2008..As a result of this increase GMO laboratories currently need to apply many different methods to establish to potential presence of NAGs in raw materials and complex derived products...
- Detecting authorized and unauthorized genetically modified organisms containing vip3A by real-time PCR and next-generation sequencingChanjuan Liang
RIKILT Wageningen UR, P O Box 230, 6700 AE, Wageningen, The Netherlands
Anal Bioanal Chem 406:2603-11. 2014..Both approaches outperformed Sanger sequencing, underlining the potential for next-generation sequencing in UGMO identification...
- Development of a multiplex DNA-based traceability tool for crop plant materialsMarleen M Voorhuijzen
RIKILT Institute of Food Safety, Wageningen UR, Wageningen, The Netherlands
Anal Bioanal Chem 402:693-701. 2012..PPLMD has been shown to be a useful tool for the detection of fraudulent/intentional admixtures in premium foods and is ready for the monitoring of correct labelling of premium foods worldwide...
- Substantial equivalence--an appropriate paradigm for the safety assessment of genetically modified foods?Harry A Kuiper
RIKILT, Wageningen University and Research Center, P O Box 230, 6700 AE Wageningen, The Netherlands
Toxicology 181:427-31. 2002..e. at the genome level, during gene expression and protein translation, and at the level of cellular metabolism...
- New EU legislation for risk assessment of GM food: no scientific justification for mandatory animal feeding trialsHarry A Kuiper
Formerly RIKILT Wageningen UR, Wageningen, The Netherlands
Plant Biotechnol J 11:781-4. 2013....
- Transcriptome analysis of potato tubers--effects of different agricultural practicesJeroen P van Dijk
RIKILT Institute of Food Safety, Bornsesteeg 45, P O Box 230, 6700 AE Wageningen, The Netherlands
J Agric Food Chem 57:1612-23. 2009..Transcriptomics results were confirmed by quantitative PCR. Furthermore, the bandwidth of natural variation of gene expression was explored to facilitate biological and/or toxicological evaluation in future assessments...
- DNA methods: critical review of innovative approachesEsther J Kok
State Institute for Quality Control of Agricultural Products RIKILT, Department of Food Safety and Health, Wageningen, The Netherlands
J AOAC Int 85:797-800. 2002..This report discusses the current state-of-the-art as well as future developments in GMO detection...
- Increased efficacy for in-house validation of real-time PCR GMO detection methodsI M J Scholtens
RIKILT Institute of Food Safety, Wageningen University and Research Centre, P O Box 230, 6700 AE Wageningen, The Netherlands
Anal Bioanal Chem 396:2213-27. 2010..The resulting data are discussed in the light of agreed European criteria for qualified GMO detection methods...
- Timely awareness and prevention of emerging chemical and biochemical risks in foods: proposal for a strategy based on experience with recent casesG A Kleter
RIKILT Institute of Food Safety, Wageningen University and Research Center, P O Box 230, NL 6700 AE Wageningen, The Netherlands
Food Chem Toxicol 47:992-1008. 2009..Cooperation with the private sector and foreign authorities may be required to achieve these goals. While food and feed safety are viewed from the European perspective, the outcomes also apply to other regions...
- Gene expression profiling for food safety assessment: examples in potato and maizeJeroen P van Dijk
RIKILT Institute of Food Safety, PO Box 230, 6700 AE Wageningen, The Netherlands
Regul Toxicol Pharmacol 58:S21-5. 2010..New techniques as next generation sequencing may overcome issues on throughput time and cost, standard operation procedures and array design for individual crops...
- A high-throughput method for GMO multi-detection using a microfluidic dynamic arrayFábio Cristiano Angonesi Brod
RIKILT Wageningen UR, P O Box 230, 6700 AE, Wageningen, The Netherlands
Anal Bioanal Chem 406:1397-410. 2014..06 % were successfully detected. The approach proposed in this work presents the Fluidigm system as a suitable and promising platform for GMO multi-detection. ..
- Assessment of the food safety issues related to genetically modified foodsH A Kuiper
National Institute for Quality Control of Agricultural Products RIKILT, Wageningen University and Research Centre, PO Box 230, NL 6700 AE Wageningen, The Netherlands
Plant J 27:503-28. 2001..It is concluded, among others that, that application of the principle of substantial equivalence has proven adequate, and that no alternative adequate safety assessment strategies are available...
- The application of DNA microarrays in gene expression analysisN L Van Hal
RIKILT State Institute for Quality Control of Agricultural Products, Gene Expression and Detection Centre, PO Box 230, 6700 AE, Wageningen, The Netherlands
J Biotechnol 78:271-80. 2000..Furthermore, it is discussed how DNA microarrays can be applied in the working fields of: safety, functionality and health of food and gene discovery and pathway engineering in plants...
- Traceability of genetically modified organismsHenk J M Aarts
Expert Rev Mol Diagn 2:69-76. 2002..New tools will be necessary to keep up with these developments. One of the most promising techniques is microarray analysis. This technique enables the screening for a large number of different GMOs within a single experiment...
- Nutritional and safety assessments of foods and feeds nutritionally improved through biotechnologyBruce Chassy
University of Illinois, Urbana, USA
Food Nutr Bull 26:436-42. 2005