S Kersten

Summary

Affiliation: Wageningen University
Country: The Netherlands

Publications

  1. ncbi request reprint The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    FASEB J 15:1971-8. 2001
  2. ncbi request reprint The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Hepatol 46:869-77. 2007
  3. ncbi request reprint Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation
    Rinke Stienstra
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    Endocrinology 148:2753-63. 2007
  4. ncbi request reprint PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation
    Nadine Wieneke
    Universitat Potsdam, Institut für Ernährungswissenschaft, Biochemie der Ernährung, Arthur Scheunert Allee 114 116, D 14558, Nuthetal, Germany
    FEBS Lett 581:5617-26. 2007
  5. ncbi request reprint Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c
    Sander Kersten
    Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, The Netherlands
    Proc Nutr Soc 61:371-4. 2002
  6. pmc Mechanisms of nutritional and hormonal regulation of lipogenesis
    S Kersten
    Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    EMBO Rep 2:282-6. 2001
  7. ncbi request reprint Peroxisome proliferator activated receptors and obesity
    Sander Kersten
    Nutrition, Metabolism and Genomics Group, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    Eur J Pharmacol 440:223-34. 2002
  8. pmc Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors
    S Mandard
    Nutrition, Metabolism and Genomics Group and Nutrigenomics Consortium, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Cell Mol Life Sci 64:1145-57. 2007
  9. pmc Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Clin Invest 103:1489-98. 1999
  10. ncbi request reprint Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Switzerland
    J Biol Chem 275:28488-93. 2000

Collaborators

Detail Information

Publications31

  1. ncbi request reprint The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    FASEB J 15:1971-8. 2001
    ..It is concluded that in addition to oxidation of fatty acids, PPARalpha also regulates metabolism of amino acids in liver, indicating that PPARalpha is a key controller of intermediary metabolism during fasting...
  2. ncbi request reprint The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Hepatol 46:869-77. 2007
    ..The objective of this study was to further characterize the role of PPARalpha in inflammatory gene regulation in liver...
  3. ncbi request reprint Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation
    Rinke Stienstra
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    Endocrinology 148:2753-63. 2007
    ....
  4. ncbi request reprint PPARalpha-dependent induction of the energy homeostasis-regulating nuclear receptor NR1i3 (CAR) in rat hepatocytes: potential role in starvation adaptation
    Nadine Wieneke
    Universitat Potsdam, Institut für Ernährungswissenschaft, Biochemie der Ernährung, Arthur Scheunert Allee 114 116, D 14558, Nuthetal, Germany
    FEBS Lett 581:5617-26. 2007
    ..Since free fatty acids are natural ligands for PPARalpha, a fasting-induced increase in free fatty acids might induce CAR. In accordance with this hypothesis, CAR induction by fasting was abrogated in PPARalpha-deficient mice...
  5. ncbi request reprint Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c
    Sander Kersten
    Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, The Netherlands
    Proc Nutr Soc 61:371-4. 2002
    ..These data indicate that fatty acids induce or inhibit the mRNA expression of a variety of different genes by acting both as agonists and as antagonists for nuclear hormone receptors...
  6. pmc Mechanisms of nutritional and hormonal regulation of lipogenesis
    S Kersten
    Nutrition, Metabolism and Genomics Group, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    EMBO Rep 2:282-6. 2001
    ..Both transcription factors are attractive targets for pharmaceutical intervention of disorders such as hypertriglyceridemia and obesity...
  7. ncbi request reprint Peroxisome proliferator activated receptors and obesity
    Sander Kersten
    Nutrition, Metabolism and Genomics Group, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    Eur J Pharmacol 440:223-34. 2002
    ..In this article, the diverse pieces of evidence that have linked PPARs with obesity are reviewed. Furthermore, the association between PPARs and type 2 diabetes is discussed...
  8. pmc Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors
    S Mandard
    Nutrition, Metabolism and Genomics Group and Nutrigenomics Consortium, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Cell Mol Life Sci 64:1145-57. 2007
    ..Overall, we conclude that mouse Gys-2 is a novel PPAR target gene and that transactivation by PPARs and HNF4alpha is mediated by two distinct response elements...
  9. pmc Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Clin Invest 103:1489-98. 1999
    ..By modulating gene expression, PPARalpha stimulates hepatic fatty acid oxidation to supply substrates that can be metabolized by other tissues...
  10. ncbi request reprint Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Switzerland
    J Biol Chem 275:28488-93. 2000
    ..Its plasma abundance is increased by fasting and decreased by chronic high fat feeding. The data suggest that FIAF represents a novel endocrine signal involved in the regulation of metabolism, especially under fasting conditions...
  11. ncbi request reprint Peroxisome proliferator-activated receptor alpha target genes
    S Mandard
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 Wageningen, The Netherlands
    Cell Mol Life Sci 61:393-416. 2004
    ....
  12. ncbi request reprint Roles of PPARs in health and disease
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, Switzerland
    Nature 405:421-4. 2000
    ..Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases...
  13. ncbi request reprint Regulation of lipid metabolism via angiopoietin-like proteins
    S Kersten
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV, Wageningen, The Netherlands
    Biochem Soc Trans 33:1059-62. 2005
    ..This review summarizes contemporary data on ANGPTLs with emphasis on the connection with energy metabolism...
  14. ncbi request reprint The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Biol Chem 281:934-44. 2006
    ..Our data indicate that disturbances in FIAF signaling might be involved in dyslipidemia...
  15. pmc PPARalpha governs glycerol metabolism
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Clin Invest 114:94-103. 2004
    ..Overall, these data indicate that PPARalpha directly governs glycerol metabolism in liver, whereas PPARgamma regulates glycerol metabolism in adipose tissue...
  16. ncbi request reprint The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment
    Stéphane Mandard
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 279:34411-20. 2004
    ..Together, these data suggest that FIAF, similar to other adipocytokines such as adiponectin, may partially exert its function via a truncated form...
  17. doi request reprint Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue
    Rinke Stienstra
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 283:22620-7. 2008
    ..The alternatively activated macrophages might play a role in peroxisome proliferator-activated receptor gamma-dependent expansion and remodeling of adipose tissue...
  18. pmc Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis
    David L M van der Meer
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, NL 6703 HD Wageningen, The Netherlands
    Nucleic Acids Res 38:2839-50. 2010
    ..Overall, our analysis leads to important new insights into the mechanisms and impact of transcriptional regulation by PPARalpha in human liver and highlight the importance of cross-talk with other transcription factors...
  19. ncbi request reprint Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, P O Box 8129, 6700 EV, Wageningen, The Netherlands
    Endocrinology 147:1508-16. 2006
    ..It is concluded that 1) PPARalpha and PPARalpha-signaling are activated in liver by chronic high-fat feeding; and 2) PPARgamma may compensate for PPARalpha in PPARalpha null mice on HFD...
  20. ncbi request reprint Exploration of PPAR functions by microarray technology--a paradigm for nutrigenomics
    Meike Bünger
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, NL 6700 EV Wageningen, The Netherlands
    Biochim Biophys Acta 1771:1046-64. 2007
    ..In this review we summarize and discuss the application of transcriptomics to study PPAR function, and discuss some of the challenges inherent to the application of transcriptomics to nutrigenomics research...
  21. ncbi request reprint Genome-wide analysis of PPARalpha activation in murine small intestine
    Meike Bünger
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Physiol Genomics 30:192-204. 2007
    ..We show that PPARalpha is an important transcriptional regulator in small intestine, which may be of importance for the development of novel foods and therapies for obesity and inflammatory bowel diseases...
  22. pmc In vivo activation of PPAR target genes by RXR homodimers
    Annemieke IJpenberg
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    EMBO J 23:2083-91. 2004
    ..These observations have important pharmacological implications for the development of new rexinoid-based treatments...
  23. ncbi request reprint Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain
    Claude Knauf
    Unit Mixte de Recherche, 5018, Centre National de la Recherche Scientifique University Paul Sabatier, IFR 31, Bt L1 Rue J Poulhès, 31403 Toulouse, France
    Endocrinology 147:4067-78. 2006
    ..By contrast, activation of PPARalpha in the brain stimulates peripheral glucose use. This suggests that the alteration in adipocyte glucose metabolism in the knockout mice may result from the absence of PPARalpha in the brain...
  24. doi request reprint The glucocorticoid receptor controls hepatic dyslipidemia through Hes1
    Ulrike Lemke
    Emmy Noether and Marie Curie Research Group Molecular Metabolic Control, DKFZ ZMBH Alliance, German Cancer Research Center Heidelberg, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cell Metab 8:212-23. 2008
    ..As glucocorticoid action is increased during starvation, myotonic dystrophy, and Cushing's syndrome, the inhibition of Hes1 through the GR might explain the fatty liver phenotype in these subjects...
  25. pmc The G0/G1 switch gene 2 is a novel PPAR target gene
    Fokko Zandbergen
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 EV, Wageningen, The Netherlands
    Biochem J 392:313-24. 2005
    ..Together, these data indicate that G0S2 is a novel target gene of PPARs that may be involved in adipocyte differentiation...
  26. pmc Effect of synthetic dietary triglycerides: a novel research paradigm for nutrigenomics
    Linda M Sanderson
    Nutrigenomics Consortium, Top Institute TI Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 3:e1681. 2008
    ..However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo...
  27. doi request reprint The PPARgamma ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARgamma in the subcutaneous adipose tissue
    Annemiek M C P Joosen
    Department of Molecular Genetics, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 99:487-93. 2008
    ..These results suggest that in healthy, non-obese males the PPARgamma ligand RSG influences TAG metabolism, independent of its PPARgamma transcriptional activity in the subcutaneous adipose tissue...
  28. ncbi request reprint Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake
    Laeticia Lichtenstein
    Nutrigenomics Consortium, TI Food and Nutrition, Wageningen, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2420-7. 2007
    ..Here we take advantage of the fasting-dependent phenotype of Angptl4-transgenic (Angptl4-Tg) mice to better characterize the metabolic function of Angptl4...
  29. ncbi request reprint Sulfonylureas and glinides exhibit peroxisome proliferator-activated receptor gamma activity: a combined virtual screening and biological assay approach
    Marco Scarsi
    Biozentrum, University of Basel, Klingelbergstr 50 70, CH 4056 Basel, Switzerland
    Mol Pharmacol 71:398-406. 2007
    ..In addition, we provide a unified concept of the PPARgamma binding ability of seemingly disparate compound classes...
  30. ncbi request reprint Nutrigenomics: goals and strategies
    Michael Muller
    Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Nat Rev Genet 4:315-22. 2003
    ..Ultimately, nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases...
  31. ncbi request reprint Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha
    Raphael Genolet
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 280:24143-52. 2005
    ..Overall, these data indicate a species-specific regulation by PPARalpha of GRHPR, a key gene of the glyoxylate cycle...