Martijn B Katan

Summary

Affiliation: Wageningen University
Country: The Netherlands

Publications

  1. ncbi Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels
    Martijn B Katan
    Division of Human Nutrition and Epidemiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Mayo Clin Proc 78:965-78. 2003
  2. ncbi Commentary: Mendelian Randomization, 18 years on
    Martijn B Katan
    Wageningen Centre for Food Sciences and Division of Human Nutrition and Epidemiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Int J Epidemiol 33:10-1. 2004
  3. ncbi The response of lipoproteins to dietary fat and cholesterol in lean and obese persons
    Martijn B Katan
    Centre for Food Sciences, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, The Netherlands
    Curr Atheroscler Rep 7:460-5. 2005
  4. ncbi n-3 fatty acids in human fat tissue aspirates are stable for up to 6 y
    M B Katan
    Nutrition and Health Program, Wageningen Centre for Food Sciences, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Eur J Clin Nutr 57:816-8. 2003
  5. ncbi Public health. Toward evidence-based health claims for foods
    Martijn B Katan
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    Science 299:206-7. 2003
  6. ncbi Promises and problems of functional foods
    Martijn B Katan
    Wageningen Centre for Food Sciences, Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands
    Crit Rev Food Sci Nutr 44:369-77. 2004
  7. ncbi Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes
    Anouk Geelen
    Wageningen Centre for Food Sciences WCFS and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Br J Nutr 93:787-90. 2005
  8. ncbi Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans
    Anouk Geelen
    Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 81:416-20. 2005
  9. ncbi A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses
    Alida Melse-Boonstra
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Am J Clin Nutr 84:1128-33. 2006
  10. pmc Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans
    Margreet R Olthof
    Wageningen Centre for Food Sciences, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    PLoS Med 2:e135. 2005

Detail Information

Publications63

  1. ncbi Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels
    Martijn B Katan
    Division of Human Nutrition and Epidemiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Mayo Clin Proc 78:965-78. 2003
    ..However, present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease...
  2. ncbi Commentary: Mendelian Randomization, 18 years on
    Martijn B Katan
    Wageningen Centre for Food Sciences and Division of Human Nutrition and Epidemiology, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Int J Epidemiol 33:10-1. 2004
  3. ncbi The response of lipoproteins to dietary fat and cholesterol in lean and obese persons
    Martijn B Katan
    Centre for Food Sciences, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, The Netherlands
    Curr Atheroscler Rep 7:460-5. 2005
    ..The most effective way for obese people to normalize their blood lipids is to lose weight, which is, unfortunately, hard to do in our society...
  4. ncbi n-3 fatty acids in human fat tissue aspirates are stable for up to 6 y
    M B Katan
    Nutrition and Health Program, Wageningen Centre for Food Sciences, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Eur J Clin Nutr 57:816-8. 2003
    ..The content of n-3 (omega-3) polyunsaturated fatty acids in fat tissue is a valid indicator of their long-term consumption. We studied the stability of n-3 fatty acids in human subcutaneous fat microbiopsies after 6 and 11 y of storage...
  5. ncbi Public health. Toward evidence-based health claims for foods
    Martijn B Katan
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    Science 299:206-7. 2003
  6. ncbi Promises and problems of functional foods
    Martijn B Katan
    Wageningen Centre for Food Sciences, Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands
    Crit Rev Food Sci Nutr 44:369-77. 2004
    ..We offer a plea for regulations that will permit all health claims that are supported by the totality of scientific evidence, and ban all claims that suggest an unproven benefit...
  7. ncbi Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes
    Anouk Geelen
    Wageningen Centre for Food Sciences WCFS and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Br J Nutr 93:787-90. 2005
    ..However, we cannot exclude effects of n-3 fatty acids on clinical relevant endpoints that are not easily detected by prior changes in the ECG...
  8. ncbi Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans
    Anouk Geelen
    Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 81:416-20. 2005
    ..A large body of evidence suggests that n-3 fatty acids from fish prevent fatal heart disease. They may be an effective and safe alternative to drug treatment for reducing the risk of arrhythmia and sudden cardiac death...
  9. ncbi A dual-isotope-labeling method of studying the bioavailability of hexaglutamyl folic acid relative to that of monoglutamyl folic acid in humans by using multiple orally administered low doses
    Alida Melse-Boonstra
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Am J Clin Nutr 84:1128-33. 2006
    ..Previous studies comparing the bioavailabilities of polyglutamyl and monoglutamyl folic acid had inconsistent results...
  10. pmc Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans
    Margreet R Olthof
    Wageningen Centre for Food Sciences, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    PLoS Med 2:e135. 2005
    ..We therefore investigated the effect of betaine, of its precursor choline in the form of phosphatidylcholine, and of the classical homocysteine-lowering vitamin folic acid on blood lipid concentrations in healthy humans...
  11. ncbi A high-protein diet increases postprandial but not fasting plasma total homocysteine concentrations: a dietary controlled, crossover trial in healthy volunteers
    Petra Verhoef
    Nutrition and Health Programme, Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Am J Clin Nutr 82:553-8. 2005
    ..A high protein intake and hence a high intake of methionine--the sole dietary precursor of homocysteine--may raise plasma tHcy concentrations...
  12. ncbi Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a randomized crossover trial in humans
    Petra Verhoef
    Wageningen Centre for Food Sciences, Nutrition and Health Programme, Wageningen, Netherlands
    Am J Clin Nutr 80:674-9. 2004
    ..The increase in tHcy induced by methionine, the sole dietary precursor of homocysteine, might be modulated by other amino acids present in dietary proteins...
  13. ncbi Choline supplemented as phosphatidylcholine decreases fasting and postmethionine-loading plasma homocysteine concentrations in healthy men
    Margreet R Olthof
    Wageningen Centre for Food Sciences and the Division of Human Nutrition, Wageningen University, Wageningen, Netherlands Quality of Life, Zeist, Netherlands
    Am J Clin Nutr 82:111-7. 2005
    ..Choline is the precursor for betaine, but the effects of choline supplementation on plasma total homocysteine (tHcy) concentrations in healthy humans are unknown...
  14. ncbi Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects
    Anouk Geelen
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Am Heart J 146:E4. 2003
    ..Effects of n-3 fatty acids on these risk indicators of arrhythmia have not been widely studied. We investigated the effect of supplemental intake of n-3 fatty acids on HRV and BRS in apparently healthy subjects aged 50 to 70 years...
  15. ncbi Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial
    Jane Durga
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, Netherlands
    Lancet 369:208-16. 2007
    ....
  16. ncbi Betaine supplementation lowers plasma homocysteine in healthy men and women
    Gery R Steenge
    Wageningen Centre for Food Sciences, Nutrition and Health Programme, Wageningen, The Netherlands
    J Nutr 133:1291-5. 2003
    ..It is not known whether this potential of betaine to "stabilize" circulating homocysteine concentrations lowers the risk of cardiovascular disease...
  17. pmc Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillators
    Ingeborg A Brouwer
    TI Food and Nutrition, Wageningen, The Netherlands
    Eur Heart J 30:820-6. 2009
    ....
  18. doi Differences in fatty acid composition between cerebral brain lobes in juvenile pigs after fish oil feeding
    Carla Dullemeijer
    Top Institute Food and Nutrition, Wageningen, The Netherlands
    Br J Nutr 100:794-800. 2008
    ..The functional consequences of these differences are a challenging focus for future investigation...
  19. doi Effect of low doses of n-3 fatty acids on cardiovascular diseases in 4,837 post-myocardial infarction patients: design and baseline characteristics of the Alpha Omega Trial
    Johanna M Geleijnse
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am Heart J 159:539-546.e2. 2010
    ..There is a need for food-based trials to establish the efficacy of low doses of n-3 fatty acids in CVD prevention...
  20. ncbi Bioavailability of heptaglutamyl relative to monoglutamyl folic acid in healthy adults
    Alida Melse-Boonstra
    Wageningen Centre for Food Sciences, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 79:424-9. 2004
    ..The bioavailability of dietary folate has been estimated to be approximately 50% of that of synthetic folic acid. Folate in the diet is linked to a polyglutamate chain that may restrict folate absorption...
  21. ncbi n-3 Fatty acids, cardiac arrhythmia and fatal coronary heart disease
    Ingeborg A Brouwer
    Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Prog Lipid Res 45:357-67. 2006
    ....
  22. ncbi Antiarrhythmic effects of n-3 fatty acids: evidence from human studies
    Anouk Geelen
    Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Curr Opin Lipidol 15:25-30. 2004
    ..In this paper, the authors discuss the results of human studies with regard to the hypothesis that n-3 fatty acids reduce the risk of fatal coronary heart disease through antiarrhythmic effects...
  23. ncbi Coffee oil consumption increases plasma levels of 7alpha-hydroxy-4-cholesten-3-one in humans
    Mark V Boekschoten
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Nutr 135:785-9. 2005
    ..Therefore, this study does not support the hypothesis that cafestol decreases bile acid synthesis in humans...
  24. ncbi Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trial
    Ingeborg A Brouwer
    Wageningen Centre for Food Sciences, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    JAMA 295:2613-9. 2006
    ..Very-long-chain n-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish are thought to reduce risk of sudden death, possibly by reducing susceptibility to cardiac arrhythmia...
  25. ncbi Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study
    Floor V A van Oort
    Wageningen Centre for Food Sciences, Wageningen, Netherlands
    Am J Clin Nutr 77:1318-23. 2003
    ..The minimum dose of folic acid required for maximal reduction of homocysteine concentrations is not yet known reliably...
  26. ncbi Within-subject variability of flow-mediated vasodilation of the brachial artery in healthy men and women: implications for experimental studies
    Nicole M De Roos
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    Ultrasound Med Biol 29:401-6. 2003
    ..This includes biologic and reading variation. Repeated measurements and repeated readings of recorded measurements are recommended to reduce variability...
  27. ncbi Replacement of dietary saturated fat with trans fat reduces serum paraoxonase activity in healthy men and women
    Nicole M De Roos
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    Metabolism 51:1534-7. 2002
    ..Whether the changes in serum paraoxonase activity caused the changes in endothelial function needs to be further investigated...
  28. doi The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol
    Saskia T J van Cruchten
    Department of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Nutr Biochem 21:757-63. 2010
    ..The effects on EpRE can also explain the induction of GSH which seems to be involved in the reported beneficial effects of cafestol, for example, when administered with aflatoxin B1 or other toxic or carcinogenic compounds...
  29. ncbi Bioavailability of food folates is 80% of that of folic acid
    Renate M Winkels
    Wageningen Centre for Food Sciences, Wageningen, Netherlands
    Am J Clin Nutr 85:465-73. 2007
    ..The bioavailability of natural food folates is lower than that of synthetic folic acid, but no agreement exists as to the extent of the difference...
  30. pmc Salmonella induces prominent gene expression in the rat colon
    Wendy Rodenburg
    TI Food and Nutrition, PO Box 557, 6700 AN, Wageningen, The Netherlands
    BMC Microbiol 7:84. 2007
    ..Colonic mucosal samples were isolated at day 2 post-infection...
  31. ncbi Dietary fructooligosaccharides affect intestinal barrier function in healthy men
    Sandra J M Ten Bruggencate
    Nutrition and Health Program, Wageningen Center for Food Sciences, Wageningen, The Netherlands
    J Nutr 136:70-4. 2006
    ..The FOS-induced increase in mucin excretion in our human study suggests mucosal irritation in humans, but the overall effects are more moderate than those in rats...
  32. ncbi High stability of markers of cardiovascular risk in blood samples
    Erik J Giltay
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    Clin Chem 49:652-5. 2003
  33. ncbi Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans
    Margreet R Olthof
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    J Nutr 133:1806-14. 2003
    ..Metabolites of dietary phenols have lower antioxidant activity than their parent compounds; therefore, the contribution of dietary phenols to antioxidant activity in vivo might be lower than expected from in vitro tests...
  34. ncbi Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis
    Ingeborg A Brouwer
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    J Nutr 134:919-22. 2004
    ..70; 95% CI 1.12-2.58). This meta-analysis shows that consumption of ALA might reduce heart disease mortality. However, the association between high intake of ALA and prostate cancer is of concern and warrants further study...
  35. ncbi Olive oil phenols are absorbed in humans
    Maud N Vissers
    Division of Human Nutrition and Epidemiology, Wageningen University, Wageningen, The Netherlands
    J Nutr 132:409-17. 2002
    ..Thus, humans absorb a large part of ingested olive oil phenols and absorbed olive oil phenols are extensively modified in the body...
  36. ncbi Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers
    Ingeborg A Brouwer
    Wageningen Centre for Food Sciences, Wageningen, The Netherlands
    Am J Cardiol 89:629-31. 2002
  37. ncbi Contribution of caffeine to the homocysteine-raising effect of coffee: a randomized controlled trial in humans
    Petra Verhoef
    Wageningen Centre for Food Sciences, Nutrition and Health Programme, Wageningen, Netherlands
    Am J Clin Nutr 76:1244-8. 2002
    ..Consumption of unfiltered or filtered coffee raises total homocysteine concentrations in healthy volunteers. The responsible compound, however, is unknown...
  38. ncbi Diet, nutrition and the prevention of hypertension and cardiovascular diseases
    K Srinath Reddy
    Department of Cardiology, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India
    Public Health Nutr 7:167-86. 2004
    ..This requires coordinated action at the level of governments, international organizations, civil society and responsible sections of the food industry...
  39. ncbi Alternatives to low-fat diets
    Martijn B Katan
    Am J Clin Nutr 83:989-90. 2006
  40. ncbi Regulation of trans fats: the gap, the Polder, and McDonald's French fries
    Martijn B Katan
    Vrije Universiteit, Faculty of Earth and Life Sciences, Institute of Health Sciences, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Atheroscler Suppl 7:63-6. 2006
    ..The question whether these ruminant TFA have the same effect on coronary heart disease risk as industrial TFA has not been settled...
  41. ncbi The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors
    Marie Louise Ricketts
    Department of Molecular and Cellular Biology, Baylor College of Medicine, BCM 130, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 21:1603-16. 2007
    ..In conclusion, cafestol acts as an agonist ligand for both FXR and PXR, and this may contribute to its impact on cholesterol homeostasis...
  42. ncbi Dietary n-3 fatty acids promote arrhythmias during acute regional myocardial ischemia in isolated pig hearts
    Ruben Coronel
    Department of Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 73:386-94. 2007
    ..The underlying electrophysiologic mechanisms are poorly understood. We studied the arrhythmias and the electrophysiologic changes during regional ischemia in hearts from pigs fed a diet rich in fish oil...
  43. ncbi Effects of n-3 fatty acids on arrhythmic events and mortality in the SOFA implantable cardioverter defibrillator trial
    Ingeborg A Brouwer
    Am J Clin Nutr 84:1554; author reply 1554-5. 2006
  44. ncbi Within-person variation in serum lipids: implications for clinical trials
    Mark A Pereira
    University of Minnesota, School of Public Health, Division of Epidemiology, Minneapolis, MN 55454, USA
    Int J Epidemiol 33:534-41. 2004
    ..Materials and Methods The authors studied within-person variation in serum total and high density lipoprotein (HDL) cholesterol in 458 participants of 27 dietary intervention studies in Wageningen, The Netherlands, from 1976 to 1995...
  45. ncbi Trans fatty acids and cardiovascular disease
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 354:1601-13. 2006
  46. ncbi Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    J Lipid Res 46:1474-83. 2005
    ..The limited incorporation of dietary ALA into the hepatic phospholipid pool contributes to the low hepatic conversion of ALA into EPA. A low conversion of ALA-derived EPA into DPA might be an additional obstacle for DHA synthesis...
  47. ncbi (N-3) fatty acids do not affect electrocardiographic characteristics of healthy men and women
    Anouk Geelen
    Wageningen Centre for Food Sciences WCFS, The Netherlands
    J Nutr 132:3051-4. 2002
    ..These results do not support the hypothesis that (n-3) fatty acids prevent arrhythmia through electrophysiologic effects on heart cell membranes. However, an effect on the ECG in more susceptible populations can not be excluded...
  48. ncbi Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial
    Renate M Winkels
    Top Institute of Food and Nutrition, Wageningen, Netherlands
    Am J Clin Nutr 88:348-55. 2008
    ..Cofortification of flour with folic acid and vitamin B-12 could simultaneously improve folate and vitamin B-12 status...
  49. ncbi Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women
    Erik J Giltay
    Psychiatric Center GGZ Delfland, Delft, The Netherlands
    J Endocrinol 182:399-408. 2004
    ..Short term administration of raloxifene in elderly men did not affect AA or DHA. The synthesis of AA and DHA from precursors may be enhanced through an estrogen receptor-dependent pathway...
  50. ncbi CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol or cafestol interventions in humans
    Maaike K Hofman
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    J Nutr 134:2200-4. 2004
    ..In conclusion, the CYP7A1 polymorphism has a small but significant effect on the increase in plasma HDL cholesterol and plasma total cholesterol after an increased intake of dietary cholesterol and cafestol, respectively...
  51. ncbi Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:1945-52. 2005
    ..The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans...
  52. ncbi A healthy lifestyle lowers homocysteine, but should we care?
    Petra Verhoef
    Am J Clin Nutr 79:713-4. 2004
  53. ncbi Gender and body size affect the response of erythrocyte folate to folic acid treatment
    Renate M Winkels
    Top Institute Food and Nutrition, 6709PA Wageningen, The Netherlands
    J Nutr 138:1456-61. 2008
    ..This could be an indication that the RDA for folate should be higher for men than for women, or that the RDA should be expressed per kilogram of lean body mass...
  54. ncbi Effects of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins: a meta-analysis of 60 controlled trials
    Ronald P Mensink
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 77:1146-55. 2003
    ..Fats, however, also affect HDL cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is LDL cholesterol...
  55. ncbi Flavonol and flavone intakes in US health professionals
    Laura Sampson
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Am Diet Assoc 102:1414-20. 2002
    ..To determine flavonoid content of US foods, mean individual intakes, major food sources, and associations with other nutrients...
  56. ncbi Conversion of alpha-linolenic acid in humans is influenced by the absolute amounts of alpha-linolenic acid and linoleic acid in the diet and not by their ratio
    Petra L L Goyens
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 84:44-53. 2006
    ..Human in vivo data on dietary determinants of alpha-linolenic acid (ALA; 18:3n-3) metabolism are scarce...
  57. pmc Health claims for functional foods
    Martijn B Katan
    BMJ 328:180-1. 2004
  58. ncbi Caffeine and arrhythmia
    Martijn B Katan
    Am J Clin Nutr 81:539-40. 2005
  59. ncbi Low HDL cholesterol levels
    Martijn B Katan
    N Engl J Med 354:417-9; author reply 417-9. 2006
  60. ncbi Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects
    Erik J Giltay
    Psychiatric Center GGZ Delfland, Delft, Netherlands
    Am J Clin Nutr 80:1167-74. 2004
    ..During pregnancy there is a high demand for docosahexaenoic acid (DHA), which is needed for formation of the fetal brain. Women who do not consume marine foods must synthesize DHA from fatty acid precursors in vegetable foods...
  61. ncbi Green vegetables, red meat and colon cancer: chlorophyll prevents the cytotoxic and hyperproliferative effects of haem in rat colon
    Johan de Vogel
    Nutrition and Health Programme, Wageningen Centre for Food Sciences and NIZO Food Research, PO Box 20, 6710 BA Ede, The Netherlands
    Carcinogenesis 26:387-93. 2005
    ..We conclude that green vegetables may decrease colon cancer risk because chlorophyll prevents the detrimental, cytotoxic and hyperproliferative colonic effects of dietary haem...
  62. ncbi Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer
    Clement A Adebamowo
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Cancer 114:628-33. 2005
    ..76 (0.57, 1.00; p-value for test of trend=0.03). While we found no overall association between intake of flavonols and risk of breast cancer, there was an inverse association with intake of beans or lentils that merits further evaluation...
  63. ncbi The elimination of trans fats from spreads: how science helped to turn an industry around
    Onno Korver
    Faculty of Earth and Life Sciences, Institute of Health Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Nutr Rev 64:275-9. 2006
    ..Over the next 14 years, manufacturers worldwide followed suit. This experience illustrates that food companies need to know about the health effects of their products and how to apply that knowledge...