M B Katan

..However, physicians need to remain alert to high intakes of vitamin B6 as a cause of unexplained neuropathy...

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..Together with our earlier observation that epoxidation of the furan ring occurs in liver, these findings merit further research on the process of accumulation of this coffee ingredient in liver and intestinal tract...

..To determine the amounts of the serum-cholesterol raising diterpenes cafestol and kahweol in coffee made with coffee pads and the Senseo coffee machine as opposed to filtered and unfiltered coffee...

..In view of these controversies, it is unlikely that The Netherlands will mandate folic-acid fortification of staple foods in the near future. Therefore, women who are planning a pregnancy should be urged to take folic-acid supplements...

..We hypothesised that n-3 fatty acids reduce underlying inflammatory processes and consequently CRP concentrations in healthy middle-aged subjects...

..The content of n-3 (omega-3) polyunsaturated fatty acids in fat tissue is a valid indicator of their long-term consumption. We studied the stability of n-3 fatty acids in human subcutaneous fat microbiopsies after 6 and 11 y of storage...

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..However, because one glass of red wine provides fewer available flavonols than one portion of onions or one glass of tea, red wine appears to be a poorer source of flavonols than these other two sources...

..Therefore, knowledge of these genotypes by themselves is of little use in the identification of subjects who may or may not benefit from dietary treatment...

..Studies in other populations and experimental settings are required to confirm or reject this hypothesis...

..However, the effects are small. Therefore, knowledge of the APOE genotype by itself may be of little use in the identification of subjects who respond to diet...

..However, patients with a ventricular arrhythmia who do not receive specific anti-arrhythmic medication should be careful about taking fish oil capsules...

..The advice to limit cholesterol intake by reducing consumption of eggs and other cholesterol-rich foods may therefore still be valid...

..CONCLUSION: Consumption of 18 mg per day of phenols from extra virgin olive oil for 3 weeks did not affect LDL or HDL oxidation or other markers of antioxidant capacity in fasting plasma samples...

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..The available evidence does not suggest that consumption of phenols in the amounts provided by dietary olive oil will protect LDL against oxidative modification to any important extent...

..This increase is probably due to non-specific meal or time effects and not to phenols from olives or olive oil. Furthermore, these findings stress the need for adequate controlled studies to avoid misinterpretations of the data...

..n-3 PUFA may exert their protective effect through reducing the susceptibility for cardiac arrhythmia...

..Feeding CLA also increased liver weight, which may warrant further studies on the safety of CLA...

..CONCLUSION: FMD was not impaired and not different after test meals with saturated or trans fatty acids. Thus, differences in long-term effects of these fats are not caused by differences in acute effects on the vascular wall...

..Functional foods may have beneficial health effects compared with traditional foods in some cases, but current legislation in the Netherlands cannot protect consumers from misleading claims...

..We decided to use plant sterols to investigate this and studied whether the cholesterol-lowering effect of plant sterols differed between subjects with different apolipoprotein E genotyes...

..However, the role of serum HDL-cholesterol appears to be less than we expected...