Jan E Kammenga

Summary

Affiliation: Wageningen University
Country: The Netherlands

Publications

  1. Kammenga J, Doroszuk A, Riksen J, Hazendonk E, Spiridon L, Petrescu A, et al. A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3. PLoS Genet. 2007;3:e34 pubmed
    ..These findings provide a novel step toward the molecular understanding of the temperature-size rule, which has puzzled biologists for decades. ..
  2. Snoek L, Orbidans H, Stastna J, Aartse A, Rodriguez M, Riksen J, et al. Widespread genomic incompatibilities in Caenorhabditis elegans. G3 (Bethesda). 2014;4:1813-23 pubmed publisher
    ..Taken together, these results indicate that numerous BDM incompatibilities that could contribute to reproductive isolation can be detected and mapped within C. elegans. ..
  3. Kamkina P, Snoek L, Grossmann J, Volkers R, Sterken M, Daube M, et al. Natural Genetic Variation Differentially Affects the Proteome and Transcriptome in Caenorhabditis elegans. Mol Cell Proteomics. 2016;15:1670-80 pubmed publisher
    ..Our findings indicate that in C. elegans only a fraction of the changes in protein abundance can be explained by the changes in mRNA abundance. These findings corroborate with the observations made across species. ..
  4. Sterken M, van Bemmelen van der Plaat L, Riksen J, Rodriguez M, Schmid T, Hajnal A, et al. Ras/MAPK Modifier Loci Revealed by eQTL in Caenorhabditis elegans. G3 (Bethesda). 2017;7:3185-3193 pubmed publisher
    ..elegans These loci harbor putative polymorphic modifier genes that would not have been detected using mutant screens in single genetic backgrounds. ..
  5. Snoek B, Volkers R, Nijveen H, Petersen C, Dirksen P, Sterken M, et al. A multi-parent recombinant inbred line population of C. elegans allows identification of novel QTLs for complex life history traits. BMC Biol. 2019;17:24 pubmed publisher
    ..The use of multi-parent RIL populations can further enhance our understanding of local adaptation and life history trade-offs. ..
  6. Volkers R, Snoek L, Hubar C, Coopman R, Chen W, Yang W, et al. Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis elegans populations. BMC Biol. 2013;11:93 pubmed publisher
    ..elegans, which covers only a diminutive part of the myriad of genotype-phenotype relations that are present in the wild. ..
  7. Sterken M, Snoek L, Kammenga J, Andersen E. The laboratory domestication of Caenorhabditis elegans. Trends Genet. 2015;31:224-31 pubmed publisher
    ..We highlight strategies to reduce the influence of laboratory-derived alleles and to harness the full power of C. elegans. ..
  8. Nakad R, Snoek L, Yang W, Ellendt S, Schneider F, Mohr T, et al. Contrasting invertebrate immune defense behaviors caused by a single gene, the Caenorhabditis elegans neuropeptide receptor gene npr-1. BMC Genomics. 2016;17:280 pubmed publisher
  9. Hesp K, Smant G, Kammenga J. Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related disease. Exp Gerontol. 2015;72:1-7 pubmed publisher
    ..In this review we investigate the mechanisms by which FOXO proteins influence the development of age-related disease pathways in both species. ..

More Information

Publications11

  1. Snoek B, Sterken M, Bevers R, Volkers R, Van t Hof A, Brenchley R, et al. Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans. BMC Genomics. 2017;18:500 pubmed publisher
  2. van Sluijs L, Pijlman G, Kammenga J. Why do Individuals Differ in Viral Susceptibility? A Story Told by Model Organisms. Viruses. 2017;9: pubmed publisher
    ..Insights in causal polymorphisms and mechanisms underlying individual differences in viral susceptibility in model organisms likely provide a better understanding in humans. ..