Research Topics
| Ingeborg A BrouwerSummaryAffiliation: Wageningen University Country: The Netherlands Publications
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Detail Information
Publications
Effect of fish oil on ventricular tachyarrhythmia and death in patients with implantable cardioverter defibrillators: the Study on Omega-3 Fatty Acids and Ventricular Arrhythmia (SOFA) randomized trialIngeborg A Brouwer
Wageningen Centre for Food Sciences, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
JAMA 295:2613-9. 2006..Very-long-chain n-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish are thought to reduce risk of sudden death, possibly by reducing susceptibility to cardiac arrhythmia...- n-3 Fatty acids, cardiac arrhythmia and fatal coronary heart diseaseIngeborg A Brouwer
Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Prog Lipid Res 45:357-67. 2006.... - Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation. The Rotterdam StudyIngeborg A Brouwer
Wageningen Centre for Food Sciences, Wageningen, The Netherlands
Am Heart J 151:857-62. 2006..The objective of this study was to examine whether high intakes of fish and its very long-chain n-3 fatty acids eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) are associated with risk of incident atrial fibrillation... - Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysisIngeborg A Brouwer
Wageningen Centre for Food Sciences, Wageningen, The Netherlands
J Nutr 134:919-22. 2004..70; 95% CI 1.12-2.58). This meta-analysis shows that consumption of ALA might reduce heart disease mortality. However, the association between high intake of ALA and prostate cancer is of concern and warrants further study... 
Intake of very long chain n-3 fatty acids from fish and the incidence of heart failure: the Rotterdam StudyS Coosje Dijkstra
Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
Eur J Heart Fail 11:922-8. 2009..We examined EPA plus DHA and fish intake in relation to incident heart failure in the population-based Rotterdam Study...- Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexesAnouk Geelen
Wageningen Centre for Food Sciences WCFS and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Br J Nutr 93:787-90. 2005..However, we cannot exclude effects of n-3 fatty acids on clinical relevant endpoints that are not easily detected by prior changes in the ECG... - Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humansAnouk Geelen
Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, Netherlands
Am J Clin Nutr 81:416-20. 2005..A large body of evidence suggests that n-3 fatty acids from fish prevent fatal heart disease. They may be an effective and safe alternative to drug treatment for reducing the risk of arrhythmia and sudden cardiac death... - Intake of fish and marine n-3 fatty acids in relation to coronary calcification: the Rotterdam StudyRenate C Heine-Bröring
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Am J Clin Nutr 91:1317-23. 2010..Epidemiologic and experimental data suggest a cardioprotective effect of n-3 (omega-3) fatty acids from fish [eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA)]... 
Effect of fish oil on ventricular tachyarrhythmia in three studies in patients with implantable cardioverter defibrillatorsIngeborg A Brouwer
TI Food and Nutrition, Wageningen, The Netherlands
Eur Heart J 30:820-6. 2009....- Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjectsAnouk Geelen
Wageningen Centre for Food Sciences, Wageningen, The Netherlands
Am Heart J 146:E4. 2003..Effects of n-3 fatty acids on these risk indicators of arrhythmia have not been widely studied. We investigated the effect of supplemental intake of n-3 fatty acids on HRV and BRS in apparently healthy subjects aged 50 to 70 years... - Differences in fatty acid composition between cerebral brain lobes in juvenile pigs after fish oil feedingCarla Dullemeijer
Top Institute Food and Nutrition, Wageningen, The Netherlands
Br J Nutr 100:794-800. 2008..The functional consequences of these differences are a challenging focus for future investigation... - Antiarrhythmic effects of n-3 fatty acids: evidence from human studiesAnouk Geelen
Wageningen Centre for Food Sciences and Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Curr Opin Lipidol 15:25-30. 2004..In this paper, the authors discuss the results of human studies with regard to the hypothesis that n-3 fatty acids reduce the risk of fatal coronary heart disease through antiarrhythmic effects... - Lactotripeptides show no effect on human blood pressure: results from a double-blind randomized controlled trialMarielle F Engberink
Wageningen University, Division of Human Nutrition, P O Box 8129, 6700 EV Wageningen, The Netherlands
Hypertension 51:399-405. 2008..In conclusion, the present study does not support the hypothesis of a blood pressure lowering effect of the lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline... - Bioavailability of food folates is 80% of that of folic acidRenate M Winkels
Wageningen Centre for Food Sciences, Wageningen, Netherlands
Am J Clin Nutr 85:465-73. 2007..The bioavailability of natural food folates is lower than that of synthetic folic acid, but no agreement exists as to the extent of the difference... - Alpha-linolenic acid: is it essential to cardiovascular health?Johanna M Geleijnse
Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Curr Atheroscler Rep 12:359-67. 2010..Findings from long-term trials of ALA supplementation are awaited to answer the question whether food-based or higher doses of ALA could be important for cardiovascular health in cardiac patients and the general population... - Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response studyFloor V A van Oort
Wageningen Centre for Food Sciences, Wageningen, Netherlands
Am J Clin Nutr 77:1318-23. 2003..CONCLUSION: In older adults, daily supplementation with folic acid effectively lowers plasma homocysteine concentrations, and a daily dose of approximately 400 micro g is the minimum dose required for adequate homocysteine reduction... - n 3 fatty acid proportions in plasma and cognitive performance in older adultsCarla Dullemeijer
Wageningen Centre for Food Sciences, Wageningen, Netherlands
Am J Clin Nutr 86:1479-85. 2007..However, limited data exist on the association between n-3 PUFAs and performance in specific cognitive domains... - Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteersIngeborg A Brouwer
Wageningen Centre for Food Sciences, Wageningen, The Netherlands
Am J Cardiol 89:629-31. 2002 - Erythrocyte folate and plasma DHA in the FACIT studyCarla Dullemeijer
Lancet 370:216. 2007 - (N-3) fatty acids do not affect electrocardiographic characteristics of healthy men and womenAnouk Geelen
Wageningen Centre for Food Sciences WCFS, The Netherlands
J Nutr 132:3051-4. 2002..These results do not support the hypothesis that (n-3) fatty acids prevent arrhythmia through electrophysiologic effects on heart cell membranes. However, an effect on the ECG in more susceptible populations can not be excluded... - Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trialsDariush Mozaffarian
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Circulation 112:1945-52. 2005..The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans... - Risks and benefits of omega 3 fats: health benefits of omega 3 fats are in doubtJohanna M Geleijnse
BMJ 332:915; discussion 915-6. 2006 - Effects of n-3 fatty acids on arrhythmic events and mortality in the SOFA implantable cardioverter defibrillator trialIngeborg A Brouwer
Am J Clin Nutr 84:1554; author reply 1554-5. 2006 - Identification of potential serum biomarkers of inflammation and lipid modulation that are altered by fish oil supplementation in healthy volunteersBaukje de Roos
Department of Vascular Health, Rowett Research Institute, Aberdeen, UK
Proteomics 8:1965-74. 2008..These proteins are potential diagnostic biomarkers to assess the mechanisms whereby fish oil protects against CHD in humans... - Gender and body size affect the response of erythrocyte folate to folic acid treatmentRenate M Winkels
Top Institute Food and Nutrition, 6709PA Wageningen, The Netherlands
J Nutr 138:1456-61. 2008..This could be an indication that the RDA for folate should be higher for men than for women, or that the RDA should be expressed per kilogram of lean body mass... - Acute administration of fish oil inhibits triggered activity in isolated myocytes from rabbits and patients with heart failureHester M den Ruijter
Department of Experimental Cardiology, Center for Heart Failure Research, Academic Medical Center, Room K2 113, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Circulation 117:536-44. 2008..We hypothesized that superfusion with omega3-polyunsaturated fatty acids (omega3-PUFAs) from fish inhibits triggered activity in heart failure... - Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trialRenate M Winkels
Top Institute of Food and Nutrition, Wageningen, Netherlands
Am J Clin Nutr 88:348-55. 2008..Cofortification of flour with folic acid and vitamin B-12 could simultaneously improve folate and vitamin B-12 status...