Research Topics
| Ilja C W ArtsSummaryAffiliation: Wageningen University Country: The Netherlands Publications
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Detail Information
Publications
The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosidesIlja C W Arts
RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
Br J Nutr 91:841-7. 2004..The poor bioavailability of important dietary quercetin glycosides has implications for their in vivo bioactivities...- Polyphenols and disease risk in epidemiologic studiesIlja C W Arts
RIKILT Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
Am J Clin Nutr 81:317S-325S. 2005..Careful design of prospective studies is important to offset some of the major drawbacks of epidemiologic studies, including residual confounding (by smoking and other dietary factors) and exposure assessment... - SIRT1 stimulation by polyphenols is affected by their stability and metabolismVincent C J de Boer
RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
Mech Ageing Dev 127:618-27. 2006..This study shows that the stimulation of SIRT1 is strongly affected by polyphenol stability and metabolism, therefore extrapolation of in vitro SIRT1 stimulation results to physiological effects should be done with caution... 
Some phenolic compounds increase the nitric oxide level in endothelial cells in vitroMaaike M Appeldoorn
RIKILT Institute of Food Safety, Wageningen, The Netherlands
J Agric Food Chem 57:7693-9. 2009..Use of this assay showed that only a limited number of phenolic compounds might enhance NO level with an increased amount of eNOS enzyme as a possible contributing mechanism...- Plant foods versus compounds in carcinogenesis; observational versus experimental human studiesEllen Kampman
Division of Human Nutrition and Epidemiology, Wageningen University and Research Centre 6700, EV Wageningen, The Netherlands
Int J Vitam Nutr Res 73:70-8. 2003..An integrated approach combining designs, and implementing new techniques to identify biomarkers, may clarify the role of plant foods in carcinogenesis... - Tissue distribution of quercetin in rats and pigsVincent C J de Boer
RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
J Nutr 135:1718-25. 2005..These studies have for the first time identified target tissues of quercetin, which may help to understand its mechanisms of action in vivo... - Lignan contents of Dutch plant foods: a database including lariciresinol, pinoresinol, secoisolariciresinol and matairesinolIvon E J Milder
RIKILT-Institute of Food Safety, Wageningen University and Research Centre, Wageningen, The Netherlands
Br J Nutr 93:393-402. 2005..Thus, available databases largely underestimate the amount of enterolignan precursors in foods... - A validated method for the quantification of enterodiol and enterolactone in plasma using isotope dilution liquid chromatography with tandem mass spectrometryAnneleen Kuijsten
RIKILT, Institute of Food Safety, Wageningen UR, PO Box 230, 6700 AE, Wageningen, The Netherlands
J Chromatogr B Analyt Technol Biomed Life Sci 822:178-84. 2005..The within-run R.S.D. ranges from 3 to 6% and the between-run R.S.D. ranges from 10 to 14% for both enterolignans. This method allows simple, rapid, and sensitive quantification, and is suitable for measuring large numbers of samples... - Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States)Ilja C W Arts
National Institute of Public Health and the Environment RIVM, Department of Chronic Diseases Epidemiology, Bilthoven, The Netherlands
Cancer Causes Control 13:373-82. 2002..We investigated whether a high intake of catechins are associated with cancer incidence among postmenopausal women... - Intake of the plant lignans secoisolariciresinol, matairesinol, lariciresinol, and pinoresinol in Dutch men and womenIvon E J Milder
Centre for Nutrition and Health, National Institute for Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
J Nutr 135:1202-7. 2005..In brief, this study shows that the amount of enterolignan precursors in the diet has previously been largely underestimated... - Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly StudyIvon E J Milder
Centre for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands
Am J Clin Nutr 84:400-5. 2006..Plant lignans are converted to enterolignans that have antioxidant and weak estrogen-like activities, and therefore they may lower cardiovascular disease and cancer risks... - A review of the epidemiological evidence on tea, flavonoids, and lung cancerIlja C W Arts
Department of Epidemiology, Nutrition, Toxicology Research Institute Maastricht, Maastricht University, 6200 MD, Maastricht, The Netherlands
J Nutr 138:1561S-1566S. 2008..More well-designed cohort studies, in particular for catechins, are needed to strengthen the evidence on effects of long-term exposure to physiological doses of dietary flavonoids... - Relation between plasma enterodiol and enterolactone and dietary intake of lignans in a Dutch endoscopy-based populationIvon E J Milder
Centre for Nutrition and Health, National Institute of Public Health and the Environment, 3720 BA Bilthoven, The Netherlands
J Nutr 137:1266-71. 2007..However, even when we included these nondietary factors in the regression models, the explained variance in plasma END and ENL remained low (2 and 13%, respectively)... - Plasma enterolignans are associated with lower colorectal adenoma riskAnneleen Kuijsten
Division of Human Nutrition, Wageningen University, The Netherlands
Cancer Epidemiol Biomarkers Prev 15:1132-6. 2006..09). We observed a substantial reduction in colorectal adenoma risk among subjects with high plasma concentrations of enterolignans, in particular, enterodiol. These findings could be important in the prevention of colorectal adenomas... - Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestineIlja C W Arts
J Nutr 132:2823; author reply 2824. 2002 - Phytoestrogens and risk of lung cancerPeter C H Hollman
JAMA 295:755; author reply 755-6. 2006 - The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseedAnneleen Kuijsten
RIKILT-Institute of Food Safety, Wageningen UR, The Netherlands
J Nutr 135:2812-6. 2005..01), whereas that of crushed compared with ground flaxseed was 43% (P < or = 0.01). Crushing and milling of flaxseed substantially improve the bioavailability of the enterolignans... - Intestinal uptake of quercetin-3-glucoside in rats involves hydrolysis by lactase phlorizin hydrolaseAloys L A Sesink
Department of Pharmacology and Toxicology, Nijmegen Center for Molecular Life Sciences, The Netherlands
J Nutr 133:773-6. 2003..12), 55% (P < 0.01) and 75% (P < 0.01) lower than in controls (1.23 +/- 0.22 micro mol/L). These data suggest that LPH is a major determinant of intestinal absorption of quercetin-3-glucoside in rats... - Breast cancer resistance protein (Bcrp1/Abcg2) limits net intestinal uptake of quercetin in rats by facilitating apical efflux of glucuronidesAloys L A Sesink
Department of Pharmacology and Toxicology 233, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, P.O Box 9101, 6500 HB Nijmegen, The Netherlands
Mol Pharmacol 67:1999-2006. 2005..In conclusion, Bcrp1 limits net intestinal absorption of quercetin by pumping quercetin glucuronides back into the lumen...