Micha M M Wilhelmus

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Exp Gerontol 48:109-14. 2013
  2. doi request reprint Tissue transglutaminase: a novel therapeutic target in cerebral amyloid angiopathy
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurodegener Dis 10:317-9. 2012
  3. doi request reprint Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, The Netherlands
    Brain Pathol 21:130-9. 2011
  4. doi request reprint Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, The Netherlands
    J Pathol 226:132-42. 2012
  5. doi request reprint Novel role of transglutaminase 1 in corpora amylacea formation?
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands
    Neurobiol Aging 32:845-56. 2011
  6. doi request reprint Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Brain Pathol 19:612-22. 2009
  7. doi request reprint Tissue transglutaminase: a novel pharmacological target in preventing toxic protein aggregation in neurodegenerative diseases
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences VU University Medical Center, Institute for Clinical and Experimental Neurosciences ICEN, Amsterdam, The Netherlands
    Eur J Pharmacol 585:464-72. 2008
  8. pmc Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Am J Pathol 179:2152-6. 2011
  9. doi request reprint Tissue transglutaminase colocalizes with extracellular matrix proteins in cerebral amyloid angiopathy
    Mieke de Jager
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:1159-69. 2013
  10. doi request reprint Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease
    Robin Verhaar
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 45:839-50. 2012

Collaborators

Detail Information

Publications21

  1. doi request reprint Extracellular matrix modulator lysyl oxidase colocalizes with amyloid-beta pathology in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis--Dutch type
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Exp Gerontol 48:109-14. 2013
    ....
  2. doi request reprint Tissue transglutaminase: a novel therapeutic target in cerebral amyloid angiopathy
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurodegener Dis 10:317-9. 2012
    ..Therefore, inhibition of tTG activity might be a promising novel therapeutic target to counteract CAA...
  3. doi request reprint Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, The Netherlands
    Brain Pathol 21:130-9. 2011
    ..Moreover, as also α-synuclein aggregates were observed in tTG granule positive neurons, these results provide a clue to the cellular site of interaction between α-synuclein and tTG...
  4. doi request reprint Transglutaminase 1 and its regulator tazarotene-induced gene 3 localize to neuronal tau inclusions in tauopathies
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, The Netherlands
    J Pathol 226:132-42. 2012
    ..We conclude that TG1-catalysed cross-linking, regulated by TIG3, might play an important role in the formation of neuronal tau inclusions in PSP, FTDP-17T, and PiD brain...
  5. doi request reprint Novel role of transglutaminase 1 in corpora amylacea formation?
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, VU University Medical Center, Neuroscience Campus Amsterdam, The Netherlands
    Neurobiol Aging 32:845-56. 2011
    ..We propose that TG1-catalyzed cross-linking and consequent polymerization of cytoskeletal and cytoskeleton-associated proteins may underlie CA formation...
  6. doi request reprint Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Brain Pathol 19:612-22. 2009
    ..We conclude that these TGs demonstrate cross-linking activity in AD lesions, which suggests that both TG1 and TG2 are likely involved in the protein aggregation processes underlying the formation of SPs, CAA and/or NFTs in AD brain...
  7. doi request reprint Tissue transglutaminase: a novel pharmacological target in preventing toxic protein aggregation in neurodegenerative diseases
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences VU University Medical Center, Institute for Clinical and Experimental Neurosciences ICEN, Amsterdam, The Netherlands
    Eur J Pharmacol 585:464-72. 2008
    ....
  8. pmc Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Am J Pathol 179:2152-6. 2011
    ..Our data suggest that alterations in lipoprotein homeostasis/signaling in melanized neurons of the SN are an early event during PD pathogenesis...
  9. doi request reprint Tissue transglutaminase colocalizes with extracellular matrix proteins in cerebral amyloid angiopathy
    Mieke de Jager
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:1159-69. 2013
    ....
  10. doi request reprint Increase in endoplasmic reticulum-associated tissue transglutaminase and enzymatic activation in a cellular model of Parkinson's disease
    Robin Verhaar
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 45:839-50. 2012
    ....
  11. doi request reprint Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Free Radic Biol Med 50:469-76. 2011
    ....
  12. doi request reprint Blockade of enzyme activity inhibits tissue transglutaminase-mediated transamidation of α-synuclein in a cellular model of Parkinson's disease
    Robin Verhaar
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurochem Int 58:785-93. 2011
    ..Moreover, our cell model appears an excellent readout to identify candidate inhibitors of intracellular tTG...
  13. doi request reprint Involvement and interplay of Parkin, PINK1, and DJ1 in neurodegenerative and neuroinflammatory disorders
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 53:983-92. 2012
    ....
  14. doi request reprint Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions
    Maarten E Witte
    Department of Pathology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 36:445-52. 2009
    ..Our data indicate that parkin is upregulated in AD and MS brain tissue and might represent a defense mechanism to counteract stress-induced damage in AD and MS pathogenesis...
  15. doi request reprint Tissue transglutaminase cross-links beclin 1 and regulates autophagy in MPP⁺-treated human SH-SY5Y cells
    Robin Verhaar
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurochem Int 62:486-91. 2013
    ..Our data provide first evidence for a role of tTG-mediated regulation of beclin 1 and autophagy in MPP(+)-treated human SH-SY5Y cells...
  16. pmc Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Center, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 171:1989-99. 2007
    ..Although perivascular cells may adapt their A beta internalization capacity to the levels of A beta present, saturated LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells...
  17. pmc Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, 830 LKN, Nijmegen, 6500 HB, Netherlands
    Mol Neurobiol 35:203-16. 2007
    ....
  18. ncbi request reprint Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain Res 1089:67-78. 2006
    ..In conclusion, sHsps may regulate Abeta aggregation and serve as antagonists of the biological action of Abeta, but the extent of their interaction depends on the type of sHsp and Abeta peptide...
  19. ncbi request reprint Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, Nijmegen, The Netherlands
    Acta Neuropathol 111:139-49. 2006
    ..We conclude that HspB8 might play an important role in regulating Abeta aggregation and, therefore, the development of classic SPs in AD and CAA in HCHWA-D...
  20. ncbi request reprint Apolipoprotein E genotype regulates amyloid-beta cytotoxicity
    Micha M M Wilhelmus
    Department of Neurology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    J Neurosci 25:3621-7. 2005
    ....
  21. ncbi request reprint Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    Brain Pathol 12:456-62. 2002
    ....