Research Topics
| A E VoskuylSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Publications
Membrane diffusion- and capillary blood volume measurements are not useful as screening tools for pulmonary arterial hypertension in systemic sclerosis: a case control studyMaria J Overbeek
Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
Respir Res 9:68. 2008..The use of the partitioned diffusion to detect PAH in SSc is not well established yet. This study evaluates whether Dm and Vc could be candidates for further study of the use for screening for PAH in SSc...
Platelet-derived growth factor receptor-β and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive diseaseMaria J Overbeek
Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
Arthritis Res Ther 13:R61. 2011..Immunoreactivity patterns of phosphorylated PDGFR-β (pPDGFR-β) and the ligand PDGF-B were evaluated to provide more insight into the patterns of PDGFR-b activation...
Deficiency of functional mannose-binding lectin is not associated with infections in patients with systemic lupus erythematosusIrene E M Bultink
Department of Rheumatology, VU University Medical Center, Postbox 7057, Amsterdam 1007 MB, The Netherlands
Arthritis Res Ther 8:R183. 2006..In conclusion, SLE patients frequently suffer from infections, but deficiency of functional MBL does not confer additional risk...
Disease-modifying antirheumatic drugs are associated with a reduced risk for cardiovascular disease in patients with rheumatoid arthritis: a case control studyVokko P van Halm
Department of Rheumatology, VU University Medical Center, Boelelaan 1117, Amsterdam, 1085 HV, The Netherlands
Arthritis Res Ther 8:R151. 2006..We hypothesize that DMARD use, in particular MTX use, results in powerful suppression of inflammation, thereby reducing the development of atherosclerosis and subsequently clinically overt CVD...
Remission and radiographic progression in rheumatoid arthritisA E Voskuyl
VU University Medical Center, Amsterdam, The Netherlands
Clin Exp Rheumatol 24:S-37-40. 2006..Until these techniques are validated and assessed for predictive value, we would advocate that radiographic progression be added to existing criteria for clinical remission, in order to define remission in RA more comprehensively...
Diagnostic strategy for the assessment of rheumatoid vasculitisA E Voskuyl
Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Ann Rheum Dis 62:407-13. 2003....
The heart and cardiovascular manifestations in rheumatoid arthritisA E Voskuyl
Department of Rheumatology, 4 A 42, VU University Medical Center, POB 9057, 1007 MB Amsterdam, The Netherlands
Rheumatology (Oxford) 45:iv4-7. 2006..This overview discusses the epidemiological aspects of these cardiovascular diseases and their relevance for diagnosis and treatment of RA...
Changes in lipid profile during infliximab and corticosteroid treatment in rheumatoid arthritisM J L Peters
Department of Rheumatology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Ann Rheum Dis 66:958-61. 2007..To evaluate the effects of infliximab and corticosteroid treatment on the lipid profile in patients with active rheumatoid arthritis (RA)...
Tight control and intensified COBRA combination treatment in early rheumatoid arthritis: 90% remission in a pilot trialL H D van Tuyl
Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
Ann Rheum Dis 67:1574-7. 2008..To investigate the efficacy and feasibility of an intensive combination treatment in early rheumatoid arthritis (RA) combined with monitoring both disease activity and cartilage degradation...
Beneficial effect of 1-year etanercept treatment on the lipid profile in responding patients with rheumatoid arthritis: the ETRA studyA Jamnitski
Jan van Breemen Institute, Amsterdam, The Netherlands
Ann Rheum Dis 69:1929-33. 2010..Available evidence is derived from short-term studies, and it is not clear whether TNFα inhibitors have a similar effect on the lipid profile in responders and non-responders to the treatment...
Discordant perspectives of rheumatologists and patients on COBRA combination therapy in rheumatoid arthritisL H D van Tuyl
Department of Clinical Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
Rheumatology (Oxford) 47:1571-6. 2008..The present qualitative study was carried out to further explore the reservation of Dutch rheumatologists towards prescribing COBRA therapy and include patients' view on (components of) COBRA therapy...
The metabolic syndrome is amplified in hypothyroid rheumatoid arthritis patients: a cross-sectional studyH G Raterman
VU University Medical Centre, Departments of Internal Medicine and Rheumatology, 1007 MB Amsterdam, The Netherlands
Ann Rheum Dis 69:39-42. 2010..This study compared first, MetS (features) and second, the Framingham 10-year CVD risk in RA patients with hypothyroidism compared with euthyroid RA patients...
Expression of a pathogen-response program in peripheral blood cells defines a subgroup of rheumatoid arthritis patientsT C T M van der Pouw Kraan
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Genes Immun 9:16-22. 2008..We conclude that activation of a host-pathogen response defines a subgroup of RA patients characterized by increased autoreactivity against citrullinated proteins...
Lipids and inflammation: serial measurements of the lipid profile of blood donors who later developed rheumatoid arthritisV P van Halm
Departments of Internal Medicine and Rheumatology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Ann Rheum Dis 66:184-8. 2007..It was recently shown that active early rheumatoid arthritis is associated with dyslipidaemia, which may partially explain the enhanced cardiovascular risk. However, it is unknown when this dyslipidaemia starts...
Patients non-responding to etanercept obtain lower etanercept concentrations compared with responding patientsA Jamnitski
Jan van Breemen Research Institute Reade, Amsterdam, The Netherlands
Ann Rheum Dis 71:88-91. 2012..To investigate the relationship between serum etanercept levels and clinical response...
Evaluation of bone mineral density, bone metabolism, osteoprotegerin and receptor activator of the NFkappaB ligand serum levels during treatment with infliximab in patients with rheumatoid arthritisM Vis
Department of Rheumatology, VU University Medical Centre, Amsterdam, The Netherlands
Ann Rheum Dis 65:1495-9. 2006....
Molecular subtypes of systemic sclerosis in association with anti-centromere antibodies and digital ulcersC L Bos
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Genes Immun 10:210-8. 2009..In conclusion, patients with SSc can be classified on the basis of differential expression of immune defense genes. Differences in the activity of the type I IFN response program stratify patients into two clinically relevant subgroups...
Subclinical renal dysfunction is independently associated with cardiovascular events in rheumatoid arthritis: the CARRÉ StudyA M van Sijl
Department of Rheumatology, Jan van Breemen Research Institute Reade, Amsterdam, The Netherlands
Ann Rheum Dis 71:341-4. 2012..Renal dysfunction is associated with CV morbidity and mortality in the general population, but data on this association in RA are lacking...
Increased cellularity and expression of adhesion molecules in muscle biopsy specimens from patients with rheumatoid arthritis with clinical suspicion of vasculitis, but negative routine histologyP C Verschueren
Leiden University Medical Centre, The Netherlands
Ann Rheum Dis 59:598-606. 2000..This study aimed at determining the immunohistological features in patients with clinical suspicion of rheumatoid vasculitis, but without a transmural infiltrate or fibrinoid necrosis of the vessel wall on routine histology...
Is the Alifax Test-1TH useful to determine the Disease Activity Score (DAS28) in rheumatoid arthritis patients?M Levitus
Department of Clinical Chemistry, VU University Medical Center, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands
Clin Rheumatol 28:469-74. 2009..7%) and the DAS28 (10.6%). These results suggest that it may be useful to determine the ESR by the Alifax Test-1TH, with a DAS28 misclassification in less than 11% of the patients...
Bone mineral density in patients with rheumatoid arthritis: relation between disease severity and low bone mineral densityM C Lodder
Department of Rheumatology, Room 4A42, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
Ann Rheum Dis 63:1576-80. 2004..To examine variables associated with bone mineral density (BMD) in patients with rheumatoid arthritis (RA)...
Rheumatoid arthritis is associated with a high prevalence of hypothyroidism that amplifies its cardiovascular riskH G Raterman
Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
Ann Rheum Dis 67:229-32. 2008..Our objective was to determine first, the prevalence of hypothyroid disorders in RA patients, and second, the risk of CVD in RA patients with hypothyroid abnormalities...
Pulmonary arterial hypertension in limited cutaneous systemic sclerosis: a distinctive vasculopathyM J Overbeek
Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
Eur Respir J 34:371-9. 2009..This might explain its different clinical behaviour from IPAH. Small vessel intimal fibrosis may provide clues to elucidation of differences in pathogenetic mechanisms between the groups...
Receptor for advanced glycation end products (RAGE) polymorphisms are associated with systemic lupus erythematosus and disease severity in lupus nephritisH A Martens
Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
Lupus 21:959-68. 2012..In addition, we investigated whether these polymorphisms in SLE are associated with serum levels of soluble RAGE (sRAGE), renal involvement (lupus nephritis (LN)) and its outcome...
Rheumatoid arthritis versus diabetes as a risk factor for cardiovascular disease: a cross-sectional study, the CARRE InvestigationV P van Halm
Department of Rheumatology, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
Ann Rheum Dis 68:1395-400. 2009..A study was undertaken to investigate the associations between RA and type 2 diabetes (DM2), a well-established cardiovascular risk factor, on the one hand, and cardiovascular disease (CVD) on the other...
Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritisM A Kropholler
Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
Eur J Nucl Med Mol Imaging 36:624-31. 2009..This study evaluated methods for the quantification of (R)-[(11)C]PK11195 binding in the knee joints of RA patients...
Relationship between serum trough infliximab levels, pretreatment C reactive protein levels, and clinical response to infliximab treatment in patients with rheumatoid arthritisG J Wolbink
Jan van Breemen Institute, Amsterdam, The Netherlands
Ann Rheum Dis 64:704-7. 2005..To investigate the relationship between serum trough infliximab levels and clinical response to infliximab treatment in patients with rheumatoid arthritis (RA)...
Imaging and serum analysis of immune complex formation of radiolabelled infliximab and anti-infliximab in responders and non-responders to therapy for rheumatoid arthritisC J van der Laken
Department of Rheumatology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Ann Rheum Dis 66:253-6. 2007..One of the postulated hypotheses of not responding is the fast clearance of infliximab due to the development of infliximab-anti-infliximab complexes...
Prevalence of and risk factors for the metabolic syndrome in women with systemic lupus erythematosusI E M Bultink
Department of Rheumatology, VU University Medical Center, Slotervaart Hospital and Jan van Breemen Institute, Amsterdam, The Netherlands
Clin Exp Rheumatol 26:32-8. 2008..To examine the prevalence of the metabolic syndrome and the relationship between metabolic syndrome score (MetS score) and disease characteristics and cardiovascular events (CVEs) in women with SLE...
Raised plasma levels of asymmetric dimethylarginine are associated with cardiovascular events, disease activity, and organ damage in patients with systemic lupus erythematosusI E M Bultink
Department of Rheumatology, VU University Medical Centre, Postbus 7057, 1007 MB, Amsterdam, The Netherlands
Ann Rheum Dis 64:1362-5. 2005..Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide inhibitor and a new independent risk factor for endothelial dysfunction and cardiovascular disease...
Nailfold capillary density is associated with the presence and severity of pulmonary arterial hypertension in systemic sclerosisH M A Hofstee
Department of Internal Medicine, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
Ann Rheum Dis 68:191-5. 2009....
Diagnostic strategies for the histological examination of muscle biopsy specimens for the assessment of vasculitis in rheumatoid arthritisA H Zwinderman
Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
Stat Med 19:3433-47. 2000..FN appeared to cluster in the RV biopsies, and a first-order Markov model satisfactorily described the (auto)correlation between adjacent tissue sections in RV biopsies...
Dutch guidelines for diagnosis and therapy of proliferative lupus nephritisA van Tellingen
Department of Nephrology, VU University Medical Centre, Amsterdam, The Netherlands
Neth J Med 70:199-207. 2012....
Influence of HLA polymorphism on persistent remission in rheumatoid arthritisE T H Molenaar
Department of Rheumatology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
Ann Rheum Dis 61:351-3. 2002..Persistent remission of RA was not associated with any particular HLA subtypes, indicating that HLA typing is not useful for predicting persistent clinical remission...
The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter studyB de Laat
Department of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands
J Thromb Haemost 7:1767-73. 2009..Anti-beta2-glycoprotein I (beta 2GPI) antibodies play a central role in the disease process of APS...
Symmetrical, painful ulceration of the lower limbs in a vascular surgery ward: a diagnostic challenge. Pyoderma gangrenosum associated with IgG-kappa paraproteinaemiaS Simsek
Department of Endocrinology Diabetes Centre, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Neth J Med 62:168-71. 2004....
[Persistent fever in a patient with Salmonella typhimurium gonarthritis]A Becker
afd Inwendige Geneeskunde, VU Medisch Centrum, De Boelelaan 1117, 1081 HV Amsterdam
Ned Tijdschr Geneeskd 149:33-6. 2005..In patients with impaired cell-mediated immunity, an extra-intestinal manifestation of Salmonella should be taken into consideration particularly if there appears to be no clinical focus. This may be detected by FDG-PET...
2-Deoxy-2-[F-18]fluoro-D-glucose joint uptake on positron emission tomography images: rheumatoid arthritis versus osteoarthritisE H Elzinga
Department of Rheumatology, VU University Medical Centre, Amsterdam, The Netherlands
Mol Imaging Biol 9:357-60. 2007..This study compares FDG uptake in joints of RA and OA patients and FDG-uptake with clinical signs of inflammation...
Complement activation in patients with rheumatoid arthritis mediated in part by C-reactive proteinE T Molenaar
Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Arthritis Rheum 44:997-1002. 2001..CONCLUSION: Part of the activation of complement in RA is mediated by CRP and is correlated with disease activity. We suggest that this activation is involved in the pathogenesis of RA...
Influence of glucocorticoids and disease activity on total and high density lipoprotein cholesterol in patients with rheumatoid arthritisM Boers
Department of Clinical Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands
Ann Rheum Dis 62:842-5. 2003..CONCLUSION: In established, but especially in early RA, disease activity is accompanied by atherogenic lipid levels. This dyslipidaemia can be rapidly reversed by aggressive antirheumatic treatment including glucocorticoids...
Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patientsT C T M van der Pouw Kraan
Department of Molecular and Cellular Biology and Immunology, VU Medical Centre, J295, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Ann Rheum Dis 66:1008-14. 2007..Rheumatoid arthritis (RA) is a heterogeneous disease with unknown cause...
Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertensionM J Overbeek
Dept of Pulmonary Diseases, VU University Medical Centre, Vrije University, Amsterdam, The Netherlands
Eur Respir J 31:1160-6. 2008..Right ventricular contractility is lower in systemic sclerosis-associated pulmonary arterial hypertension than in idiopathic pulmonary arterial hypertension...
Axonal neuropathy with prolonged sulphasalazine useM Liedorp
Department of Neurology and the Department of Rheumatology, V U University Medical Centre, Amsterdam, The Netherlands
Clin Exp Rheumatol 26:671-2. 2008..Most reported patients developed symptoms several weeks after onset of treatment. We describe a patient with an axonal polyneuropathy that occurred after two years of treatment with sulphasalazine...
Relapsing splenic vein thrombosis associated with antiphospholipid antibodies in a patient with wegener granulomatosisK S Steen
Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
J Clin Rheumatol 13:92-3. 2007....
Long-term outcome in polymyositis and dermatomyositisI M Bronner
Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Ann Rheum Dis 65:1456-61. 2006..In the long term, myositis has a major effect on perceived disability and quality of life, despite the regained muscle strength...
Randomized comparison of a multidisciplinary team care program with usual care in patients with systemic sclerosisA A Schouffoer
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Care Res (Hoboken) 63:909-17. 2011..To compare the effectiveness of a multidisciplinary team care program with usual outpatient care in patients with systemic sclerosis (SSc; scleroderma)...
Pregnancy, chimerism and lupus nephritis: a multi-centre studyI C L Kremer Hovinga
Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
Lupus 17:541-7. 2008..Our data support the theory that only certain subsets of chimeric cells persist into the maternal circulation after pregnancy...
Increased prevalence of antithyroid antibodies in rheumatoid arthritis (RA) patients with a low prevalence of hormonal alterationsH G Raterman
Autoimmunity 41:337. 2008
Antibodies against human 60 kDa heat shock protein are not associated with cardiovascular disease in patients with rheumatoid arthritisV P van Halm
Department of Rheumatology, VU University Medical Centre, Amsterdam 1007 MB, Netherlands
Ann Rheum Dis 65:590-4. 2006..These findings could be the result of an altered immune response to HSP60 in rheumatoid arthritis...
Adverse events in patients with rheumatoid arthritis treated with infliximab in daily clinical practiceN Neven
Ann Rheum Dis 64:645-6. 2005
Bone mineral density in patients with rheumatoid arthritis treated with infliximabM Vis
Ann Rheum Dis 64:336-7. 2005
[Rheumatic diseases as risk factors for cardiovascular disease]M T Nurmohamed
VU Medisch Centrum, afd. Reumatologie, 4A42, Postbus 7057, 1007 MB Amsterdam
Ned Tijdschr Geneeskd 150:1921-4. 2006..In addition to SLE, RA and AS should be acknowledged as new risk factors for cardiovascular disease...
Infliximab treatment reduces complement activation in patients with rheumatoid arthritisA Familian
Department of Immunopathology, Sanquin Research at the CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
Ann Rheum Dis 64:1003-8. 2005..Tumour necrosis factor (TNF) blocking agents decrease C reactive protein (CRP) levels in rheumatoid arthritis (RA). It has been shown that CRP may contribute to complement activation in RA...
[Diagnosis of pulmonary hypertension: experiences with 187 patients referred to the VU Medical Center]R J Roeleveld
afd. Longziekten, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam
Ned Tijdschr Geneeskd 148:82-8. 2004..The application of a multidisciplinary diagnostic protocol together with a contribution of specialists with specific expertise can help to adjust the initial diagnosis and sometimes even reject it...
Polymyositis: an overdiagnosed entityM F G van der Meulen
Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center, Utrecht, The Netherlands
Neurology 61:316-21. 2003..The authors investigated the applicability of diagnostic features for diagnosing PM and DM...
Early-onset polyarthritis as presenting feature of intestinal infection with Strongyloides stercoralisA W R van Kuijk
Rheumatology (Oxford) 42:1419-20. 2003
