Anton Vonk-Noordegraaf

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension
    Gerrina Ruiter
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Rheumatology (Oxford) 53:285-92. 2014
  2. doi request reprint Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology
    Anton Vonk-Noordegraaf
    Department of Pneumology, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    J Am Coll Cardiol 62:D22-33. 2013
  3. pmc Management strategy after diagnosis of Abernethy malformation: a case report
    Caroline Dm Witjes
    Department of Hepatobiliary and Transplantation Surgery, Erasmus Medical Center, University Medical Center Rotterdam, P, O, Box 2040, Rotterdam, The Netherlands
    J Med Case Rep 6:167. 2012
  4. doi request reprint Describing right ventricular function
    Anton Vonk-Noordegraaf
    Dept of Pulmonology, Institute for Cardiovascular Research VU University Medical Center, VU University, Amsterdam, The Netherlands
    Eur Respir J 41:1419-23. 2013
  5. ncbi request reprint Cardiac magnetic resonance imaging: what can it add to our knowledge of the right ventricle in pulmonary arterial hypertension?
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, VU University Medical Center, Amsterdam, Netherlands
    Am J Cardiol 110:25S-31S. 2012
  6. doi request reprint The role of the right ventricle in pulmonary arterial hypertension
    A Vonk Noordegraaf
    VU University Medical Center, Amsterdam, The Netherlands
    Eur Respir Rev 20:243-53. 2011
  7. ncbi request reprint Interventricular septal configuration at mr imaging and pulmonary arterial pressure in pulmonary hypertension
    Roald J Roeleveld
    Departments of Pulmonology and Physics and Medical Technology, VU University Medical Center Institute of Cardiovascular Research ICaR VU, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 234:710-7. 2005
  8. ncbi request reprint ['Palm reading' as a diagnostic aid]
    A Vonk Noordegraaf
    afd Longziekten, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:53-6. 2004
  9. ncbi request reprint Interventricular mechanical asynchrony due to right ventricular pressure overload in pulmonary hypertension plays an important role in impaired left ventricular filling
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Chest 128:628S-630S. 2005
  10. ncbi request reprint [Sinusitis as a major cause of fever in intubated patients]
    A Vonk Noordegraaf
    afd Longziekten, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 145:1713-6. 2001

Detail Information

Publications80

  1. ncbi request reprint Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension
    Gerrina Ruiter
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Rheumatology (Oxford) 53:285-92. 2014
    ..ID is more prevalent in SSc-PH than in SSc-nonPH patients and is associated with exercise impairment in both SSc-PH and SSc-nonPH. In addition, ID SSc-PH patients have a significantly worse survival compared with non-ID patients. ..
  2. doi request reprint Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology
    Anton Vonk-Noordegraaf
    Department of Pneumology, VU University Medical Center, Amsterdam, The Netherlands Electronic address
    J Am Coll Cardiol 62:D22-33. 2013
    ....
  3. pmc Management strategy after diagnosis of Abernethy malformation: a case report
    Caroline Dm Witjes
    Department of Hepatobiliary and Transplantation Surgery, Erasmus Medical Center, University Medical Center Rotterdam, P, O, Box 2040, Rotterdam, The Netherlands
    J Med Case Rep 6:167. 2012
    ..abstract:..
  4. doi request reprint Describing right ventricular function
    Anton Vonk-Noordegraaf
    Dept of Pulmonology, Institute for Cardiovascular Research VU University Medical Center, VU University, Amsterdam, The Netherlands
    Eur Respir J 41:1419-23. 2013
    ..How to estimate wall stress and how to describe diastolic ventricular properties are also discussed...
  5. ncbi request reprint Cardiac magnetic resonance imaging: what can it add to our knowledge of the right ventricle in pulmonary arterial hypertension?
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, VU University Medical Center, Amsterdam, Netherlands
    Am J Cardiol 110:25S-31S. 2012
    ..Should such standards be developed, it seems likely that CMRI will become an important method for the noninvasive assessment and monitoring of patients with PAH...
  6. doi request reprint The role of the right ventricle in pulmonary arterial hypertension
    A Vonk Noordegraaf
    VU University Medical Center, Amsterdam, The Netherlands
    Eur Respir Rev 20:243-53. 2011
    ....
  7. ncbi request reprint Interventricular septal configuration at mr imaging and pulmonary arterial pressure in pulmonary hypertension
    Roald J Roeleveld
    Departments of Pulmonology and Physics and Medical Technology, VU University Medical Center Institute of Cardiovascular Research ICaR VU, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 234:710-7. 2005
    ..To investigate whether a relationship exists between septum shape and systolic pulmonary arterial pressure (PAP) in patients with pulmonary hypertension...
  8. ncbi request reprint ['Palm reading' as a diagnostic aid]
    A Vonk Noordegraaf
    afd Longziekten, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 148:53-6. 2004
    ..These cases show that inspection of the hand may give a clue to the diagnosis...
  9. ncbi request reprint Interventricular mechanical asynchrony due to right ventricular pressure overload in pulmonary hypertension plays an important role in impaired left ventricular filling
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Chest 128:628S-630S. 2005
  10. ncbi request reprint [Sinusitis as a major cause of fever in intubated patients]
    A Vonk Noordegraaf
    afd Longziekten, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 145:1713-6. 2001
    ..A maxillary sinus lavage and culture, followed by treatment with specific antibiotics should be an integral part of the diagnosis and treatment in these patients. Surgery is indicated in the event of persistent sepsis...
  11. doi request reprint Right ventricular function in scleroderma-related pulmonary hypertension
    A Vonk Noordegraaf
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Rheumatology (Oxford) 47:v42-3. 2008
    ..More pathological, imaging and haemodynamic studies are needed for a better understanding for relatively more important vulnerability of the RV in SSc-PAH...
  12. ncbi request reprint Early changes of cardiac structure and function in COPD patients with mild hypoxemia
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Chest 127:1898-903. 2005
    ..Although functional abnormalities of the right ventricle (RV) have been well described in COPD patients with severe hypoxemia, little is known about these changes in patients with normoxia and mild hypoxemia...
  13. ncbi request reprint Noninvasive assessment and monitoring of the pulmonary circulation
    A Vonk-Noordegraaf
    Dept of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Eur Respir J 25:758-66. 2005
    ..Further improvement and evaluation of the clinical value of these techniques are therefore obligatory before they can be used in clinical practice...
  14. ncbi request reprint Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients
    C Tji Joong Gan
    VU University Medical Center, De Boelelaan 1117 PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:11-7. 2007
    ..In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity...
  15. doi request reprint Systolic pulmonary artery pressure and heart rate are main determinants of oxygen consumption in the right ventricular myocardium of patients with idiopathic pulmonary arterial hypertension
    Yeun Ying Wong
    Department of Pulmonology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Eur J Heart Fail 13:1290-5. 2011
    ..We hypothesize that systolic pulmonary artery pressure (PAP) and heart rate (HR) are the major determinants of RV MVO(2) in IPAH...
  16. ncbi request reprint Supine-exercise-induced oxygen supply to the right myocardium is attenuated in patients with severe idiopathic pulmonary arterial hypertension
    Yeun Ying Wong
    Department of Pulmonology, Institute of Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Heart 97:2069-74. 2011
    ..MBF and O(2) extraction from myocardial capillaries (O(2) extraction fraction (OEF)) influence myocardial O(2) supply...
  17. doi request reprint Right ventricular failure in idiopathic pulmonary arterial hypertension is associated with inefficient myocardial oxygen utilization
    Yeun Ying Wong
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circ Heart Fail 4:700-6. 2011
    ..We related RV mechanical efficiency to clinical and hemodynamic parameters of RV function in patients with IPAH and associated it with glucose metabolism...
  18. ncbi request reprint Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur Heart J 28:1250-7. 2007
    ..This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH)...
  19. doi request reprint Acute effects of sildenafil on exercise pulmonary hemodynamics and capacity in patients with COPD
    Sebastiaan Holverda
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Pulm Pharmacol Ther 21:558-64. 2008
    ....
  20. ncbi request reprint Effect of pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension on stroke volume response to exercise
    Sulaiman Surie
    Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Electronic address
    Am J Cardiol 114:136-40. 2014
    ..In conclusion, in CTEPH, exercise is limited by an impaired stroke volume response. PEA induces a restoration of SVI response to exercise that appears, however, incomplete and not evident in all patients. ..
  21. pmc Pulmonary endarterectomy normalizes interventricular dyssynchrony and right ventricular systolic wall stress
    Gert Jan Mauritz
    Department of Pulmonary Diseases, University of Amsterdam, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 14:5. 2012
    ..We studied the role of right ventricular (RV) wall stress in the recovery of interventricular dyssynchrony, after pulmonary endarterectomy (PEA) in chronic thromboembolic pulmonary hypertension (CTEPH)...
  22. ncbi request reprint Stroke volume response during exercise measured by acetylene uptake and MRI
    Herman Groepenhoff
    Institute for Cardiovascular Research and Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Physiol Meas 28:1-11. 2007
    ....
  23. ncbi request reprint Right coronary artery flow impairment in patients with pulmonary hypertension
    Serge A van Wolferen
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Noord Holland, The Netherlands
    Eur Heart J 29:120-7. 2008
    ..This study investigates whether increased right ventricular (RV) pressure in pulmonary hypertension (PH) impairs right coronary artery (RCA) flow and RV perfusion...
  24. ncbi request reprint Ventilatory and cardiocirculatory exercise profiles in COPD: the role of pulmonary hypertension
    Bart G Boerrigter
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Chest 142:1166-74. 2012
    ..The impact of PH on exercise tolerance is largely unknown. We evaluated and compared the circulatory and ventilatory profiles during exercise in patients with COPD without PH, with moderate PH, and with severe PH...
  25. pmc Rapid quantification of myocardial fibrosis: a new macro-based automated analysis
    Awal M Hadi
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol (Dordr) 34:343-54. 2011
    ..Current quantification methods are time-consuming and laborious. We describe a semi-automated quantification technique for myocardial fibrosis and validated this using traditional methods...
  26. ncbi request reprint Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension
    C Tji Joong Gan
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:1906-12. 2007
    ....
  27. pmc Non-invasive stroke volume assessment in patients with pulmonary arterial hypertension: left-sided data mandatory
    Gert Jan Mauritz
    Department of Pulmonary Diseases, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 10:51. 2008
    ..Derivation of stroke volume (SV) from the pulmonary flow curves is considered as a standard in this respect. Our aim was to investigate the accuracy of pulmonary artery (PA) flow for measuring SV...
  28. doi request reprint Progressive changes in right ventricular geometric shortening and long-term survival in pulmonary arterial hypertension
    Gert Jan Mauritz
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Chest 141:935-43. 2012
    ..The aim of this study was to investigate time courses of RV geometric changes during the progression of RV failure...
  29. ncbi request reprint Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension
    Frances S de Man
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Circ Heart Fail 5:97-105. 2012
    ..We therefore investigated whether chronic low-dose treatment with bisoprolol (a cardioselective β-blocker) has beneficial effects on cardiac function in experimental PH...
  30. ncbi request reprint Right ventricular oscillatory power is a constant fraction of total power irrespective of pulmonary artery pressure
    Nabil Saouti
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 182:1315-20. 2010
    ..Because mean power provides for net blood flow, the ratio of oscillatory to total power (oscillatory power fraction) preferably should be small. It is unknown whether this is the case in pulmonary arterial hypertension (PAH)...
  31. doi request reprint Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy
    Marielle C van de Veerdonk
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 58:2511-9. 2011
    ....
  32. ncbi request reprint Quantification of right ventricular afterload in patients with and without pulmonary hypertension
    Jan Willem Lankhaar
    Dept of Pulmonary Diseases, VU Univ Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 291:H1731-7. 2006
    ..Furthermore, the data suggest that the RC time and the elastic properties of the large pulmonary arteries remain unchanged in PH...
  33. doi request reprint Addition of prostanoids in pulmonary hypertension deteriorating on oral therapy
    Wouter Jacobs
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Heart Lung Transplant 28:280-4. 2009
    ..The aim of our study was to describe the efficacy of addition of intravenous or subscutaneous prostanoids in idiopathic pulmonary arterial hypertension (PAH) patients deteriorating on bosentan or on bosentan-sildenafil...
  34. pmc Prognostic relevance of changes in exercise test variables in pulmonary arterial hypertension
    Herman Groepenhoff
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e72013. 2013
    ..The aim of this study was to determine changes in exercise variables in PAH patients and to relate these changes to survival...
  35. doi request reprint Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling
    J Tim Marcus
    Department of Physics and Medical Technology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 51:750-7. 2008
    ..The purpose of this study was to explore in pulmonary arterial hypertension (PAH) whether the cause of interventricular asynchrony lies in onset of shortening or duration of shortening...
  36. ncbi request reprint Cardiac function and position more than 5 years after pneumonectomy
    Sietske A Smulders
    Department of Pulmonary Diseases, Catharina Hospital, Eindhoven, The Netherlands
    Ann Thorac Surg 83:1986-92. 2007
    ..We investigated long-term effects of pneumonectomy on right ventricular (RV) and left ventricular (LV) function and whether this function is influenced by the side of pneumonectomy or the migration of the heart to its new position...
  37. doi request reprint Pulmonary vascular resistance and compliance stay inversely related during treatment of pulmonary hypertension
    Jan Willem Lankhaar
    Department of Physics and Medical Technology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur Heart J 29:1688-95. 2008
    ..We aimed at testing the hypothesis that R and C are coupled during treatment of PH and that substantial changes in both R and C would result in more haemodynamic improvement than changes in R alone...
  38. doi request reprint Cardiac phase-dependent time normalization reduces load dependence of time-varying elastance
    Taco Kind
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 296:H342-9. 2009
    ..4 mmHg (P < 0.001), and VAF: 97.4 +/- 0.5 vs. 81.8 +/- 15.5% (P < 0.001)]. In conclusion, phase-dependent time normalization reduces cardiac load dependency of timing and increases accuracy in estimating time-varying elastance...
  39. doi request reprint Exercise testing to estimate survival in pulmonary hypertension
    Herman Groepenhoff
    Institute for Cardiovascular Research and Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Med Sci Sports Exerc 40:1725-32. 2008
    ..The aims of our study were to compare prognostic values of different exercise parameters in PH and to assess whether CPET adds prognostic value to the information from the 6MWD...
  40. doi request reprint Progressive dilatation of the main pulmonary artery is a characteristic of pulmonary arterial hypertension and is not related to changes in pressure
    Bart Boerrigter
    VU University Medical Center, Amsterdam, The Netherlands
    Chest 138:1395-401. 2010
    ..The aim of this study was to evaluate PA size during follow-up in treated patients with PAH and whether it reflects pulmonary vascular hemodynamics...
  41. doi request reprint Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes
    Yeun Ying Wong
    Dept of Physiology, Vrije Univ Medical Center, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 298:H1190-7. 2010
    ..024), respectively]. We conclude that efficiency decreases with increasing cardiomyocyte hypertrophy. Thus, the reduced efficiency of diseased whole hearts can be at least partly explained by reduced efficiency at the cardiomyocyte level...
  42. doi request reprint Exercise stroke volume and heart rate response differ in right and left heart failure
    Herman Groepenhoff
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, PO Box 7057, Amsterdam 1007 MB, The Netherlands
    Eur J Heart Fail 12:716-20. 2010
    ..Therefore, we tested the hypothesis that SV and HR responses during exercise are different between PAH and LHF patients...
  43. ncbi request reprint Effects of epoprostenol on right ventricular hypertrophy and dilatation in pulmonary hypertension
    Roald J Roeleveld
    Department of Pulmonology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Chest 125:572-9. 2004
    ..To gain more knowledge of changes in main pulmonary artery flow and right ventricular mass and volumes in patients with pulmonary hypertension during epoprostenol therapy...
  44. ncbi request reprint Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart
    M Louis Handoko
    Department of Physiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H1752-9. 2009
    ..Taken together, we demonstrate that, in experimental PH, RV pacing improves RV function and diminishes adverse diastolic interaction. These findings provide a strong rationale for further in vivo explorations...
  45. ncbi request reprint Pulmonary arterial hypertension associated with a congenital heart defect: advanced medium-term medical treatment stabilizes clinical condition
    Mariëlle Duffels
    Academic Medical Center Department of Cardiology, Amsterdam, The Netherlands
    Congenit Heart Dis 2:242-9. 2007
    ..In this study, we describe medium-term follow-up of adult patients with PAH associated with CHD, treated in a single center with different types of advanced medication...
  46. doi request reprint Right ventricular oxygen supply parameters are decreased in human and experimental pulmonary hypertension
    Gerrina Ruiter
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    J Heart Lung Transplant 32:231-40. 2013
    ..Because autopsy tissue only reflects end-stage disease, rat models with stable and progressive pulmonary hypertension (PH) were studied as well...
  47. ncbi request reprint Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension
    C Tji Joong Gan
    Dept of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 290:H1528-33. 2006
    ..In PAH patients, ventricular interaction mediated by the interventricular septum impairs left ventricular filling, contributing to decreased stroke volume...
  48. ncbi request reprint Cardiopulmonary exercise test characteristics in patients with chronic obstructive pulmonary disease and associated pulmonary hypertension
    Sebastiaan Holverda
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Respiration 76:160-7. 2008
    ..It remains unclear whether exercise parameters can be used to discriminate between COPD patients with associated PH (COPD-PH) and COPD patients without associated PH (COPD-nonPH)...
  49. ncbi request reprint Pulmonary vascular responses to hypoxia and hyperoxia in healthy volunteers and COPD patients measured by electrical impedance tomography
    Henk J Smit
    Department of Pulmonary Medicine, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Chest 123:1803-9. 2003
    ..Electrical impedance tomography (EIT) is a noninvasive imaging technique using impedance to visualize and measure blood volume changes...
  50. doi request reprint Prolonged right ventricular post-systolic isovolumic period in pulmonary arterial hypertension is not a reflection of diastolic dysfunction
    Gert Jan Mauritz
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Heart 97:473-8. 2011
    ..This concept recently has been questioned, since it was shown that RV contraction continues after pulmonary valve closure causing a post-systolic contraction period...
  51. ncbi request reprint Severely reduced diffusion capacity in idiopathic pulmonary arterial hypertension: patient characteristics and treatment responses
    Pia Trip
    Institute for Cardiovascular Research, VU University Medical Center, Amsterdam
    Eur Respir J 42:1575-85. 2013
    ..We confirm the decreased survival in this patient group and now show that this poor outcome is related to age, sex and the presence of coronary disease...
  52. pmc Membrane diffusion- and capillary blood volume measurements are not useful as screening tools for pulmonary arterial hypertension in systemic sclerosis: a case control study
    Maria J Overbeek
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Respir Res 9:68. 2008
    ..The use of the partitioned diffusion to detect PAH in SSc is not well established yet. This study evaluates whether Dm and Vc could be candidates for further study of the use for screening for PAH in SSc...
  53. pmc Right ventricular ejection fraction is better reflected by transverse rather than longitudinal wall motion in pulmonary hypertension
    Taco Kind
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Cardiovasc Magn Reson 12:35. 2010
    ..Therefore, the aim of this study was to evaluate regional RV transverse wall motion in PH, and its relation to global RV pump function, quantified as RV ejection fraction (RVEF)...
  54. ncbi request reprint Contractile dysfunction of left ventricular cardiomyocytes in patients with pulmonary arterial hypertension
    Emmy Manders
    Department of Pulmonology, Vrije Universiteit VU University Medical Center, Amsterdam, The Netherlands Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands
    J Am Coll Cardiol 64:28-37. 2014
    ..LV dysfunction in pulmonary arterial hypertension (PAH) is characterized by a reduced LV ejection fraction and impaired diastolic function...
  55. ncbi request reprint Correction of phase offset errors in main pulmonary artery flow quantification
    Jan Willem Lankhaar
    Department of Physics and Medical Technology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    J Magn Reson Imaging 22:73-9. 2005
    ....
  56. doi request reprint Accurate assessment of load-independent right ventricular systolic function in patients with pulmonary hypertension
    Pia Trip
    Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Heart Lung Transplant 32:50-5. 2013
    ..The objective of this study was to determine whether, in PAH patients, E(es) can be estimated from mean pulmonary artery pressure (mPAP) and end-systolic volume (ESV) only...
  57. doi request reprint Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension
    Frances S de Man
    VU University Medical Center, Department of Pulmonology, De Boelelaan 1117, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 186:780-9. 2012
    ..To compensate, neurohormonal systems such as the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system are up-regulated, but this may have long-term negative effects on the progression of iPAH...
  58. ncbi request reprint Estimation of three- and four-element windkessel parameters using subspace model identification
    Taco Kind
    Department of Pulmonology, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
    IEEE Trans Biomed Eng 57:1531-8. 2010
    ..However, application to a four-element windkessel model was less accurate because of low identifiability of L. Therefore, based on the simulation results, the use of the four-element windkessel model is questionable...
  59. doi request reprint Early onset of retrograde flow in the main pulmonary artery is a characteristic of pulmonary arterial hypertension
    Frank Helderman
    Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
    J Magn Reson Imaging 33:1362-8. 2011
    ..To evaluate if early onset of retrograde flow in the main pulmonary artery is a characteristic of pulmonary arterial hypertension (PAH)...
  60. ncbi request reprint Assessment of the pulmonary volume pulse in idiopathic pulmonary arterial hypertension by means of electrical impedance tomography
    Henk J Smit
    Department of Pulmonary Diseases, VU Medical Center, Amsterdam, The Netherlands
    Respiration 73:597-602. 2006
    ..Electrical impedance tomography (EIT) is a non-invasive imaging technique which can be used to measure the blood volume changes in the pulmonary vascular bed during the cardiac cycle...
  61. ncbi request reprint A comparison of noninvasive MRI-based methods of estimating pulmonary artery pressure in pulmonary hypertension
    Roald J Roeleveld
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    J Magn Reson Imaging 22:67-72. 2005
    ..To assess the accuracy of several noninvasive MRI-based estimators of pulmonary artery pressure by comparing them with invasive pressure measurement...
  62. doi request reprint Rapid quantification of myocardial fibrosis: A new macro-based automated analysis
    Awal M Hadi
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Anal Cell Pathol (Amst) 33:257-69. 2010
    ..Current quantification methods are time-consuming and laborious. We describe a semi-automated quantification technique for myocardial fibrosis and validated this using traditional methods...
  63. doi request reprint Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction
    Emmy Manders
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 303:L1070-8. 2012
    ..Together, these findings indicate that diaphragm weakness in PH is at least partly caused by sarcomeric dysfunction, which appears to be specific for the diaphragm...
  64. pmc Platelet-derived growth factor receptor-β and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis-associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno-occlusive disease
    Maria J Overbeek
    Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Arthritis Res Ther 13:R61. 2011
    ..Immunoreactivity patterns of phosphorylated PDGFR-β (pPDGFR-β) and the ligand PDGF-B were evaluated to provide more insight into the patterns of PDGFR-b activation...
  65. doi request reprint Usefulness of serial N-terminal pro-B-type natriuretic peptide measurements for determining prognosis in patients with pulmonary arterial hypertension
    Gert Jan Mauritz
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 108:1645-50. 2011
    ..In conclusion, a serum NT-pro-BNP level ≥1,256 pg/ml at time of diagnosis identifies poor outcome in patients with PAH. In addition, a decrease in NT-pro-BNP of >15%/year is associated with survival in PAH...
  66. doi request reprint Right ventricular energetics in patients with hypertrophic cardiomyopathy and the effect of alcohol septal ablation
    S A J Timmer
    Department of Cardiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Card Fail 17:827-31. 2011
    ..The aim was to study right-to-left ventricular oxidative metabolism in HCM and the effects of alcohol septal ablation (ASA)...
  67. pmc Modeling the instantaneous pressure-volume relation of the left ventricle: a comparison of six models
    Jan Willem Lankhaar
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Ann Biomed Eng 37:1710-26. 2009
    ..If only the shape of the PV-loops is important, all models perform nearly identically (Hamming distance between 20 and 23%). For realistic simulation of the instantaneous PV-relation a linear model suffices...
  68. ncbi request reprint Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension
    Koen T B Mouchaers
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H200-7. 2009
    ..These data indicate that the combination of Bosentan and Sildenafil may beneficially contribute to RV adaptation in PAH, not only by reducing PVR but also by acting on the mitochondria in the heart...
  69. ncbi request reprint Epoprostenol in pulmonary arterial hypertension
    Wouter Jacobs
    VU University Medical Center, Department of Pulmonology, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Expert Opin Drug Metab Toxicol 5:83-90. 2009
    ..Pulmonary arterial hypertension (PAH) is a devastating disease leading to right heart failure and death in a relatively young patient population. In recent years novel PAH specific therapies have become available...
  70. ncbi request reprint Multiple suspicious lesions detected by autofluorescence bronchoscopy predict malignant development in the bronchial mucosa in high risk patients
    Arifa Pasic
    Department of Pulmonology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Lung Cancer 41:295-301. 2003
    ..This finding is compatible with field carcinogenesis and warrants a more upfront use of AFB in a lung cancer screening to sift the different risk-cohorts in a population mainly at risk for developing metachronous lung cancer...
  71. doi request reprint Neurohormonal axis in patients with pulmonary arterial hypertension: friend or foe?
    Frances S de Man
    Department of Pulmonology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 187:14-9. 2013
    ..These novel insights shed new light on the role of neurohormonal activity in PAH...
  72. doi request reprint Diaphragm muscle fiber weakness in pulmonary hypertension
    Frances S de Man
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 183:1411-8. 2011
    ..Recently it was suggested that patients with pulmonary hypertension (PH) suffer from inspiratory muscle dysfunction. However, the nature of inspiratory muscle weakness in PH remains unclear...
  73. doi request reprint Myocardial oxygen extraction fraction measured using bolus inhalation of 15O-oxygen gas and dynamic PET
    Mark Lubberink
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 52:60-6. 2011
    ..The method of analysis was optimized by investigating potential reuse of myocardial blood flow (MBF), perfusable tissue fraction, and blood and lung spillover factors derived from separate 15O-water and C15O scans...
  74. ncbi request reprint Pulmonary function and exercise testing in adult survivors of congenital diaphragmatic hernia
    Marieke G Peetsold
    Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands
    Pediatr Pulmonol 42:325-31. 2007
    ..Exercise capacity and gas exchange parameters were normal in this group, indicating that patients do not have a physical impairment, as reflected by a normal quality of life of CDH patients...
  75. ncbi request reprint Delayed contrast-enhanced magnetic resonance imaging in pulmonary arterial hypertension
    Gerry P McCann
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 112:e268. 2005
  76. ncbi request reprint A 31-year-old man with hemoptysis at high altitude and abnormal hepatic biochemistry tests
    Harm J Bogaard
    Department of Pulmonary Medicine, VU Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Chest 132:1088-92. 2007
  77. pmc Smallest detectable change in volume differs between mass flow sensor and pneumotachograph
    Herman Groepenhoff
    Department of pulmonology and institute for Cardiovascular Research ICaR Vu VU University Medical Center, Amsterdam, 1007 MB, The Netherlands
    BMC Res Notes 4:23. 2011
    ..abstract:..
  78. ncbi request reprint Bronchoscopic treatment of patients with intraluminal microinvasive radiographically occult lung cancer not eligible for surgical resection: a follow-up study
    Anton Vonk-Noordegraaf
    Department of Pulmonary Medicine, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Lung Cancer 39:49-53. 2003
    ..Sixteen patients are still alive without any tumor recurrence. These data showed that BT is an effective treatment modality for high-risk patients with ROLC, who are not eligible for surgical resection...
  79. ncbi request reprint Left ventricular encasement after pneumonectomy: case report
    Sietske A Smulders
    Department of Pulmonology, Catharina Hospital, Eindhoven, The Netherlands
    J Thorac Cardiovasc Surg 132:e23-4. 2006