Yvette van Kooyk

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology, Faculty of Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 55:143-5. 2013
  2. ncbi request reprint DC-SIGN: escape mechanism for pathogens
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology Vrije Universiteit Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Nat Rev Immunol 3:697-709. 2003
  3. ncbi request reprint Pathogens use carbohydrates to escape immunity induced by dendritic cells
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Curr Opin Immunol 16:488-93. 2004
  4. doi request reprint Protein-glycan interactions in the control of innate and adaptive immune responses
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Van de Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Nat Immunol 9:593-601. 2008
  5. doi request reprint C-type lectins on dendritic cells: key modulators for the induction of immune responses
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Biochem Soc Trans 36:1478-81. 2008
  6. ncbi request reprint DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Postbus 7057, 1007MB Amsterdam, The Netherlands
    Mol Immunol 45:2359-69. 2008
  7. ncbi request reprint The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma
    Eirikur Saeland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Immunol Immunother 56:1225-36. 2007
  8. doi request reprint MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells
    Eirikur Saeland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 46:2309-16. 2009
  9. doi request reprint Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation
    Satwinder Kaur Singh
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Mol Immunol 47:164-74. 2009
  10. ncbi request reprint Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens
    Ellis Van Liempt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    J Biol Chem 279:33161-7. 2004

Collaborators

Detail Information

Publications78

  1. doi request reprint Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology, Faculty of Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 55:143-5. 2013
    ..Here, we discuss the capacity of glycan-based vaccines to enhance antigen-specific CD4(+) and CD8(+) T cell responses in human skin and mouse model systems...
  2. ncbi request reprint DC-SIGN: escape mechanism for pathogens
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology Vrije Universiteit Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Nat Rev Immunol 3:697-709. 2003
    ..This implies that adaptation of pathogens to target DC-SIGN might support pathogen survival...
  3. ncbi request reprint Pathogens use carbohydrates to escape immunity induced by dendritic cells
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Curr Opin Immunol 16:488-93. 2004
    ..Several pathogens specifically target CLRs to subvert this communication to escape immune surveillance, either by inducing tolerance or skewing the protective immune responses...
  4. doi request reprint Protein-glycan interactions in the control of innate and adaptive immune responses
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Van de Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Nat Immunol 9:593-601. 2008
    ..Similarly important is the effect of glycan-containing 'information' in the development of autoimmune diseases and cancer. In this review, we provide an overview of these new directions and their impact in the field of glycoimmunology...
  5. doi request reprint C-type lectins on dendritic cells: key modulators for the induction of immune responses
    Yvette van Kooyk
    Department of Molecular Cell Biology and Immunology VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Biochem Soc Trans 36:1478-81. 2008
    ....
  6. ncbi request reprint DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Postbus 7057, 1007MB Amsterdam, The Netherlands
    Mol Immunol 45:2359-69. 2008
    ..The identification of Le(Y) as the carbohydrate ligand of DC-SIGN in endothelial cells opens new possibilities for the manipulation of DC migration...
  7. ncbi request reprint The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma
    Eirikur Saeland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Immunol Immunother 56:1225-36. 2007
    ..The detection of MGL positive cells in situ at the tumor site together with the modified glycosylation status of MUC1 to target MGL on DC suggests that MGL positive antigen presenting cells may play a role in tumor progression...
  8. doi request reprint MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells
    Eirikur Saeland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 46:2309-16. 2009
    ..We hypothesize that repetitive units of Lewis X, within the mucin domain, play an important role in inhibiting transmission of HIV-1 from mother to child...
  9. doi request reprint Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation
    Satwinder Kaur Singh
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Mol Immunol 47:164-74. 2009
    ..Furthermore, our data demonstrate that DC-SIGN transgenic mice are valuable tool for optimisation and efficiency testing of DC vaccination strategies that are designed to target in particular the human DC-SIGN receptor...
  10. ncbi request reprint Molecular basis of the differences in binding properties of the highly related C-type lectins DC-SIGN and L-SIGN to Lewis X trisaccharide and Schistosoma mansoni egg antigens
    Ellis Van Liempt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    J Biol Chem 279:33161-7. 2004
    ....
  11. ncbi request reprint Glycan modification of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells
    Corlien A Aarnoudse
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Int J Cancer 122:839-46. 2008
    ....
  12. doi request reprint Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses
    Satwinder Kaur Singh
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 128:1371-83. 2011
    ..Our data strongly suggest that tumour-associated GalNAc modification of antigen targets MGL on DCs and greatly enhances both MHC class II and class I presentation in a TLR independent manner...
  13. ncbi request reprint Identification of the mycobacterial carbohydrate structure that binds the C-type lectins DC-SIGN, L-SIGN and SIGNR1
    Estella A Koppel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunobiology 209:117-27. 2004
    ..Moreover, the identification of SIGNR1 as a receptor for ManLAM will enable in vivo studies to investigate the role of DC-SIGN in M. tuberculosis pathogenesis...
  14. ncbi request reprint Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils
    Klaas P J M van Gisbergen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    FEBS Lett 579:6159-68. 2005
    ..This indicates that glycosylation-driven binding of both Mac-1 and CEACAM1 to DC-SIGN is essential for interactions of neutrophils with DCs and enables neutrophils to modulate T cell responses through interactions with DCs...
  15. doi request reprint Schistosoma mansoni worm glycolipids induce an inflammatory phenotype in human dendritic cells by cooperation of TLR4 and DC-SIGN
    Caroline M W van Stijn
    VU University Medical Center, Van den Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 47:1544-52. 2010
    ..This mechanism of TLR4 activation by worm glycolipids may contribute to eliciting Th1 immune responses in schistosome infection...
  16. ncbi request reprint Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation
    Ellis Van Liempt
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 44:2605-15. 2007
    ..The internalization of SEA by multiple C-type lectins may be important to regulate the response of the iDCs to TLR-induced signals...
  17. doi request reprint Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties
    Satwinder Kaur Singh
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 46:1240-9. 2009
    ..Strikingly, MGL2 interacted strongly to adenocarcinoma cells, suggesting a potential role in tumor immunity...
  18. doi request reprint TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program
    Sonia Chamorro
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands
    J Immunol 183:2984-94. 2009
    ..Therefore, both DX-DC and 1,25(OH)(2)D(3)-DC display the strongest tolerogenic and anti-inflammatory features and might be most suitable tools for the treatment of autoimmune diseases...
  19. doi request reprint Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae
    Estella A Koppel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Mol Immunol 45:2881-7. 2008
    ..pneumoniae...
  20. ncbi request reprint Dendritic cells recognize tumor-specific glycosylation of carcinoembryonic antigen on colorectal cancer cells through dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin
    Klaas P J M van Gisbergen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands
    Cancer Res 65:5935-44. 2005
    ..Similar to pathogens that target DC-SIGN to escape immunosurveillance, tumor cells may interact with DC-SIGN to suppress dendritic cell functions...
  21. ncbi request reprint Two way communication between neutrophils and dendritic cells
    Irene S Ludwig
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, PO Box 7057, 1081 BT Amsterdam, The Netherlands
    Curr Opin Pharmacol 6:408-13. 2006
    ..Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses...
  22. pmc Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction
    Fedde Groot
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Virol 79:3009-15. 2005
    ..DC-mediated capture of a bLF-resistant HIV-1 variant that was selected during long-term culturing in T cells could still be blocked by bLF. This underscores the usefulness of bLF as a microbicide drug to prevent HIV-1 transmission...
  23. ncbi request reprint Viral piracy: HIV-1 targets dendritic cells for transmission
    Annemarie N Lekkerkerker
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Curr HIV Res 4:169-76. 2006
    ..This review discusses the different processes that govern viral piracy of DCs by HIV-1, emphasizing the intracellular routing of the virus from capture on the cell surface to egress in the infectious synapse...
  24. ncbi request reprint Potency of HIV-1 envelope glycoprotein gp120 antibodies to inhibit the interaction of DC-SIGN with HIV-1 gp120
    Annemarie N Lekkerkerker
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, Amsterdam, The Netherlands
    Virology 329:465-76. 2004
    ..Furthermore, we demonstrate that DC-SIGN binding to gp120 enhanced CD4 binding, suggesting that DC-SIGN induces conformational changes in gp120, which may provide new targets for neutralizing antibodies...
  25. ncbi request reprint MGL-mediated internalization and antigen presentation by dendritic cells: a role for tyrosine-5
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 37:2075-81. 2007
    ..In conclusion, MGL contributes to the antigen processing and presentation capacities of DC and may provide a suitable target for the initiation of anti-tumor immune responses...
  26. ncbi request reprint The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x
    Irma van Die
    Department of Molecular Cell Biology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Glycobiology 13:471-8. 2003
    ....
  27. pmc Mycobacteria target DC-SIGN to suppress dendritic cell function
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    J Exp Med 197:7-17. 2003
    ..Moreover, we demonstrate that DC-SIGN has a broader pathogen recognition profile than previously shown, suggesting that DC-SIGN may represent a molecular target for clinical intervention in infections other than HIV-1...
  28. pmc Measles virus targets DC-SIGN to enhance dendritic cell infection
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, V U University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Virol 80:3477-86. 2006
    ..Moreover, MV might not only target DC-SIGN to infect DCs but may also use DC-SIGN for viral transmission and immune suppression...
  29. ncbi request reprint Cutting edge: carbohydrate profiling identifies new pathogens that interact with dendritic cell-specific ICAM-3-grabbing nonintegrin on dendritic cells
    Ben J Appelmelk
    Department of Medical Microbiology, Vrije Universiteit Medical Center, Van der Boechorstraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 170:1635-9. 2003
    ..This analysis expands our knowledge on the carbohydrate and pathogen-specificity of DC-SIGN and identifies this lectin to be central in pathogen-DC interactions...
  30. pmc Dynamic populations of dendritic cell-specific ICAM-3 grabbing nonintegrin-positive immature dendritic cells and liver/lymph node-specific ICAM-3 grabbing nonintegrin-positive endothelial cells in the outer zones of the paracortex of human lymph nodes
    Anneke Engering
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 164:1587-95. 2004
    ..During both cellular and humoral immune responses changes in the amount of DC-SIGN+ immature and mature DCs and L-SIGN+ endothelial cells were observed, indicating that the influx or proliferation of these cells is dynamically regulated...
  31. ncbi request reprint Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Int Immunol 17:661-9. 2005
    ..Our results indicate an endogenous function for DC-expressed MGL in the clearance and tolerance to self-gangliosides, and in the pattern recognition of tumor antigens and foreign glycoproteins derived from helminth parasites...
  32. pmc Helicobacter pylori modulates the T helper cell 1/T helper cell 2 balance through phase-variable interaction between lipopolysaccharide and DC-SIGN
    Mathijs P Bergman
    Department of Medical Microbiology and Infection Control, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
    J Exp Med 200:979-90. 2004
    ..Our data indicate a role for LPS phase variation and Le antigen expression by H. pylori in suppressing immune responses through DC-SIGN...
  33. doi request reprint MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion
    Sandra J van Vliet
    VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    J Leukoc Biol 94:315-23. 2013
    ..Together, our results demonstrate that MGL activation of the ERK-p90RSK-CREB axis converges with TLR2-induced pathways, thereby fine-tuning the DC maturation phenotype. ..
  34. doi request reprint Notch controls generation and function of human effector CD8+ T cells
    Loes M Kuijk
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Blood 121:2638-46. 2013
    ..These data indicate that Notch signaling controls human CD8(+) T cell priming and also influences effector T cell functions. This may provide important information for designing new immunotherapies for treatment of cancer...
  35. doi request reprint Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients
    Eirikur Saeland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 131:117-28. 2012
    ....
  36. ncbi request reprint One-step biotinylation procedure for carbohydrates to study carbohydrate-protein interactions
    Christian H Grün
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, 1081 BT Amsterdam, The Netherlands
    Anal Biochem 354:54-63. 2006
    ..In addition, the biotinylated glycans will be great tools for investigating functional lectin receptors in situ...
  37. pmc Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation
    Irene S Ludwig
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Virol 78:8322-32. 2004
    ....
  38. pmc Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS Pathog 5:e1000625. 2009
    ..Together, our results indicate that N. gonorrhoeae LOS variation allows for selective manipulation of dendritic cell function, thereby shifting subsequent immune responses in favor of bacterial survival...
  39. pmc Interaction of polysialic acid with CCL21 regulates the migratory capacity of human dendritic cells
    Marieke Bax
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e6987. 2009
    ..Together our results indicate that prolonged TLR4 engagement is required for the generation of polySia-expressing DCs that facilitate CCL21 capture and subsequent CCL21-directed migration...
  40. ncbi request reprint Subset of DC-SIGN(+) dendritic cells in human blood transmits HIV-1 to T lymphocytes
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Amsterdam, The Netherlands
    Blood 100:1780-6. 2002
    ..Therefore DC-SIGN(+) blood DCs can be the first target for HIV-1 upon transmission via blood; they can capture minute amounts of HIV-1 through DC-SIGN and transfer HIV-1 to infect target T cells in trans...
  41. doi request reprint Glycodendrimers prevent HIV transmission via DC-SIGN on dendritic cells
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Int Immunol 25:221-33. 2013
    ..Thus, Le(X) glycodendrimers could be incorporated into topic prophylactic approaches for the prevention of HIV-1 transmission...
  42. doi request reprint Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans
    Dinja Oosterhoff
    Department of Medical Oncology, VU University Medical Center, Amsterdam 1081 HV, The Netherlands
    J Immunol 190:3338-45. 2013
    ..These data warrant further exploration of PGN and Poly I:C, alone or in combination, as DC-targeted adjuvants for intradermal cancer vaccines...
  43. doi request reprint Multivalent glycopeptide dendrimers for the targeted delivery of antigens to dendritic cells
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, Faculty of Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 53:387-97. 2013
    ..This report provides the basis for the design of efficient targeting of peptide antigens for the immunotherapy of cancer, autoimmunity and infectious diseases...
  44. ncbi request reprint C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007
    ..Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens...
  45. doi request reprint Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN
    Marein A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gen Virol 89:2398-409. 2008
    ..These data strongly suggest that DC-SIGN is a potential target to prevent HSV infection and virus dissemination. Further studies will show whether these interactions are involved in HSV-induced immune suppression...
  46. ncbi request reprint The C-type lectin macrophage galactose-type lectin impedes migration of immature APCs
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Immunol 181:3148-55. 2008
    ..Thus, MGL(+) DCs are hampered in their migratory responses and only upon maturation, when MGL expression is abolished; these DCs will be released from their MGL-mediated restraints...
  47. ncbi request reprint Molecular mechanisms that set the stage for DC-T cell engagement
    Klaas P J M van Gisbergen
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Van der Boechorstraat 7, 1081 BT Amsterdam, The Netherlands
    Immunol Lett 97:199-208. 2005
    ....
  48. doi request reprint Design of neo-glycoconjugates that target the mannose receptor and enhance TLR-independent cross-presentation and Th1 polarization
    Satwinder Kaur Singh
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 41:916-25. 2011
    ....
  49. ncbi request reprint A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance
    Yvette van Kooyk
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Trends Mol Med 9:153-9. 2003
    ..A better understanding of DC-SIGN-pathogen interactions and their effects on DC function should help to combat infections...
  50. ncbi request reprint Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, Amsterdam, The Netherlands
    APMIS 111:698-714. 2003
    ..Thus, a better understanding of DC-SIGN-pathogen interactions and their effects on DC function is necessary to combat infections...
  51. ncbi request reprint Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, van de Boechorstraat 7, 1081BT Amsterdam, The Netherlands
    Nat Med 13:367-71. 2007
    ..Thus Langerin is a natural barrier to HIV-1 infection, and strategies to combat infection must enhance, preserve or, at the very least, not interfere with Langerin expression and function...
  52. ncbi request reprint DC-SIGN specifically recognizes Streptococcus pneumoniae serotypes 3 and 14
    Estella A Koppel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Immunobiology 210:203-10. 2005
    ..The immunological consequences of the serotype-specific capacity to interact with DC-SIGN should be further explored and might result in new insights in the development of new and more potent vaccines...
  53. pmc Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN
    Klaas P J M van Gisbergen
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, 1081 BT Amsterdam, Netherlands
    J Exp Med 201:1281-92. 2005
    ..Our data demonstrate that DC-SIGN and Mac-1 define a molecular pathway to establish cellular adhesion between DCs and neutrophils, thereby providing a novel cellular link between innate and adaptive immunity...
  54. ncbi request reprint Carbohydrate specificities of the murine DC-SIGN homologue mSIGNR1
    Estella A Koppel
    Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Immunobiology 210:195-201. 2005
    ..The differential recognition of Lewis antigens suggests differences between mSIGNR1 and DC-SIGN in the recognition of cellular ligands and pathogens that express Lewis epitopes...
  55. pmc Ligand binding and signaling of dendritic cell immunoreceptor (DCIR) is modulated by the glycosylation of the carbohydrate recognition domain
    Karien Bloem
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e66266. 2013
    ..These results show that glycan binding to DCIR is influenced by the glycosylation of the CRD region in DCIR and that interaction with its ligands result in signaling via its ITIM motif...
  56. ncbi request reprint Recognition of tumor glycans by antigen-presenting cells
    Corlien A Aarnoudse
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, PO Box 7057, 1081 BT Amsterdam, The Netherlands
    Curr Opin Immunol 18:105-11. 2006
    ..In addition, in vivo studies in mice recently demonstrated the potency of targeting antigens to C-type lectins on antigen-presenting cells for anti-tumor vaccination strategies...
  57. ncbi request reprint Immune escape through C-type lectins on dendritic cells
    Anneke Engering
    Dept of Molecular Cell Biology, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Trends Immunol 23:480-5. 2002
    ..More insight into ligand specificity, intracellular targeting and signalling will reveal the pathways by which pathogens modulate immunity through C-type lectins...
  58. doi request reprint Sweet preferences of MGL: carbohydrate specificity and function
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Immunol 29:83-90. 2008
    ..We discuss here the functional similarities and differences between MGL orthologs and compare MGL to its closest homolog, the liver-specific asialoglycoprotein receptor (ASGP-R)...
  59. ncbi request reprint Self- and nonself-recognition by C-type lectins on dendritic cells
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center Amsterdam, 1081 BT Amsterdam, Netherlands
    Annu Rev Immunol 22:33-54. 2004
    ..Here we discuss the concept that cross talk between TLRs and CLRs, differentially expressed by subsets of DCs, accounts for the different pathways to peripheral tolerance, such as deletion and suppression, and immune activation...
  60. ncbi request reprint Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunobiology 211:577-85. 2006
    ..Our results demonstrate that depending on the local microenvironment, DC can adopt different C-type lectin profiles, which could have major influences on cell-cell interactions, antigen uptake and presentation...
  61. ncbi request reprint Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands
    Blood 100:2908-16. 2002
    ..Thus, mSIGNR1, a murine homologue of DC-SIGN, is important in the defense against pathogens and this study will facilitate further investigations into the in vivo function of DC-SIGN and its homologues...
  62. ncbi request reprint Binding of human papilloma virus L1 virus-like particles to dendritic cells is mediated through heparan sulfates and induces immune activation
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Immunobiology 212:679-91. 2007
    ..Our results support an important role for syndecan-3 as a HPV receptor on DCs, which could be important for both vaccine development and understanding HPV pathogenesis...
  63. doi request reprint Highly glycosylated tumour antigens: interactions with the immune system
    Eirikur Saeland
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Post Box 7057, 1007 MB Amsterdam, The Netherlands
    Biochem Soc Trans 39:388-92. 2011
    ..The potential to use recombinant CLR as diagnostic tools will also be discussed...
  64. ncbi request reprint Innate signaling and regulation of Dendritic cell immunity
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Curr Opin Immunol 19:435-40. 2007
    ..Notably, members within one family of PRRs can trigger opposite signalling features, indicating that the ultimate outcome of pathogen-induced immune responses depends on the pathogen signature and the collective PRRs involved...
  65. ncbi request reprint Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 7:1200-8. 2006
    ..Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases...
  66. doi request reprint Identification of pathogen receptors on dendritic cells to understand their function and to identify new drug targets
    Lot de Witte
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Methods Mol Biol 531:267-85. 2009
    ....
  67. ncbi request reprint Vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) provide co-stimulation in positive selection along with survival of selected thymocytes
    Lutz C Paessens
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Immunol 45:42-8. 2008
    ..This suggests that not only the cortical epithelium may use the co-stimulatory molecule ICAM-1 to mediate positive selection, but also cortical hAPCs may contribute to positive selection of thymocytes by using the co-stimulator VCAM-1...
  68. ncbi request reprint DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, The Netherlands
    J Leukoc Biol 71:921-31. 2002
    ..Here we discuss the carbohydrate/protein recognition profile and other features of DC-SIGN that contribute to the potency of DC to control immunity...
  69. ncbi request reprint The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells
    Anneke Engering
    Department of Molecular Cell Biology, Vrye Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Immunol 168:2118-26. 2002
    ..These data point to a novel function of the adhesion receptor DC-SIGN as an efficient DC-specific Ag receptor that can be used as a target to induce viral and antitumor immunity...
  70. ncbi request reprint Specific ICAM-3 grabbing nonintegrin-related 1 (SIGNR1) expressed by marginal zone macrophages is essential for defense against pulmonary Streptococcus pneumoniae infection
    Estella A Koppel
    Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Eur J Immunol 35:2962-9. 2005
    ..pneumoniae for antigen presentation to and activation of marginal zone B cells, resulting in an anti-phosphorylcholine IgM response...
  71. ncbi request reprint Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease
    Anje A te Velde
    Laboratory of Experimental Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 33:143-51. 2003
    ..The characteristics of these in-situ-differentiated DC markedly differ from the in-vitro-generated DC that simultaneously express DC-SIGN, CD83 and cytokines...
  72. pmc Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner
    Marieke Bax
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, PO Box 7057, 1007MB Amsterdam, Netherlands
    Infect Immun 79:2681-9. 2011
    ..Thus, our data demonstrate for the first time that depending on the sialylated composition of Campylobacter jejuni LOS, specific Th differentiation programs are initiated, possibly through targeting of distinct DC-expressed siglecs...
  73. ncbi request reprint Mucosal-targeted AIDS vaccines: the next generation?
    Annemarie N Lekkerkerker
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Trends Microbiol 12:447-50. 2004
  74. doi request reprint Endogenous ligands for C-type lectin receptors: the true regulators of immune homeostasis
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunol Rev 230:22-37. 2009
    ..Special attention is given to the signaling events initiated upon recognition of the self ligand and the regulation of glycosylation as a switch modulating CLR recognition, and therefore, immune homeostasis...
  75. doi request reprint Dendritic cells and C-type lectin receptors: coupling innate to adaptive immune responses
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunol Cell Biol 86:580-7. 2008
    ....
  76. ncbi request reprint A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions
    Yvette van Kooyk
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center Amsterdam, Amsterdam, The Netherlands
    Immunol Rev 186:47-56. 2002
    ....
  77. ncbi request reprint Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation
    Estella A Koppel
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Cell Microbiol 7:157-65. 2005
    ..Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans...
  78. ncbi request reprint Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins
    Marieke Bax
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 179:8216-24. 2007
    ..Interestingly, the binding of the LacNAc-specific lectins galectin-3 and -8 increased during maturation and up-regulation of sialic acid expression by mDC correlated with an increased binding of siglec-1, -2, and -7...