Wiesje M van der Flier

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Study protocol: EXERcise and cognition in sedentary adults with early-ONset dementia (EXERCISE-ON)
    Astrid M Hooghiemstra
    Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands
    BMC Neurol 12:75. 2012
  2. doi request reprint Clinical aspects of microbleeds in Alzheimer's disease
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Sci 322:56-8. 2012
  3. doi request reprint Microbleeds in vascular dementia: clinical aspects
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Exp Gerontol 47:853-7. 2012
  4. doi request reprint Microbleeds do not affect rate of cognitive decline in Alzheimer disease
    Annelies E van der Vlies
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:763-9. 2012
  5. ncbi request reprint Shifting paradigms in dementia: toward stratification of diagnosis and treatment using MRI
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann N Y Acad Sci 1097:215-24. 2007
  6. ncbi request reprint The effect of APOE genotype on clinical phenotype in Alzheimer disease
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 67:526-7. 2006
  7. ncbi request reprint Apolipoprotein E genotype influences presence and severity of delusions and aggressive behavior in Alzheimer disease
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 23:42-6. 2007
  8. pmc Use of laboratory and imaging investigations in dementia
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:v45-52. 2005
  9. pmc Epidemiology and risk factors of dementia
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:v2-7. 2005
  10. pmc Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study
    W M van der Flier
    Department of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:1497-500. 2005

Detail Information

Publications100

  1. pmc Study protocol: EXERcise and cognition in sedentary adults with early-ONset dementia (EXERCISE-ON)
    Astrid M Hooghiemstra
    Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands
    BMC Neurol 12:75. 2012
    ..The main aim of the EXERCISE-ON study is to assess whether exercise slows down the progressive course of the symptoms of dementia...
  2. doi request reprint Clinical aspects of microbleeds in Alzheimer's disease
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Sci 322:56-8. 2012
    ....
  3. doi request reprint Microbleeds in vascular dementia: clinical aspects
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Exp Gerontol 47:853-7. 2012
    ..New definitions and diagnostic criteria for vascular dementia and vascular cognitive impairment are needed and should take into account microbleeds...
  4. doi request reprint Microbleeds do not affect rate of cognitive decline in Alzheimer disease
    Annelies E van der Vlies
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:763-9. 2012
    ..To investigate the relationship between brain microbleeds (MBs) and the rate of cognitive decline in Alzheimer disease (AD)...
  5. ncbi request reprint Shifting paradigms in dementia: toward stratification of diagnosis and treatment using MRI
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann N Y Acad Sci 1097:215-24. 2007
    ..For the future, we see an important role for MRI in identifying those different compartments, regardless of clinical classification. Treatment could be directed by (and evaluated through) MRI patterns, rather than a diagnostic label...
  6. ncbi request reprint The effect of APOE genotype on clinical phenotype in Alzheimer disease
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 67:526-7. 2006
    ..2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-epsilon4 allele...
  7. ncbi request reprint Apolipoprotein E genotype influences presence and severity of delusions and aggressive behavior in Alzheimer disease
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 23:42-6. 2007
    ..We investigated differences in the prevalence and severity of 10 neuropsychiatric and behavioral symptoms according to apolipoprotein E (APOE) genotype and dementia severity in Alzheimer disease (AD)...
  8. pmc Use of laboratory and imaging investigations in dementia
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:v45-52. 2005
  9. pmc Epidemiology and risk factors of dementia
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:v2-7. 2005
  10. pmc Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study
    W M van der Flier
    Department of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:1497-500. 2005
    ..To assess the associations of medial temporal lobe atrophy (MTA) and white matter hyperintensities (WMH) with cognitive function in a large group of independently functioning elderly people...
  11. ncbi request reprint Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
    ..We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease...
  12. ncbi request reprint Interaction of medial temporal lobe atrophy and white matter hyperintensities in AD
    W M van der Flier
    Department of Neurology, Leiden University Medical Center, The Netherlands
    Neurology 62:1862-4. 2004
    ..Moreover, there was an interaction between MTL and WMH (p = 0.045). These results suggest that vascular and Alzheimer-type pathology act in synergy in the clinical syndrome of AD...
  13. ncbi request reprint Neuropsychological correlates of MRI measures in the continuum of cognitive decline at old age
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, VU Medical Center, Leiden, The Netherlands
    Dement Geriatr Cogn Disord 20:82-8. 2005
    ..To investigate the independent associations between medial temporal lobe atrophy and white matter hyperintensities (WMH) and cognitive functions in the elderly...
  14. ncbi request reprint Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes
    Wiesje M van der Flier
    Department of Neurology, J3R 43 Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Neurol 251:671-5. 2004
    ..These preliminary results suggest that memory complaints may reflect minimal brain deficits associated with impending dementia, depression or a combination of both disorders...
  15. doi request reprint MRI biomarkers of vascular damage and atrophy predicting mortality in a memory clinic population
    Wouter J P Henneman
    Department of Radiology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 40:492-8. 2009
    ..MRI biomarkers play an important role in the diagnostic work-up of dementia, but their prognostic value is less well-understood. We investigated if simple MRI rating scales predict mortality in a memory clinic population...
  16. doi request reprint Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 135:2115-25. 2012
    ..As such, increased amyloid burden, together with metabolic dysfunction, in the parietal lobe of younger patients with Alzheimer's disease may contribute to the distinct cognitive profile in these patients...
  17. ncbi request reprint CSF biomarker levels in early and late onset Alzheimer's disease
    Femke H Bouwman
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 30:1895-901. 2009
    ..To compare CSF levels of beta-amyloid 1-42 (Abeta(1-42)), total tau (tau) and tau phosphorylated at threonine 181 (ptau-181) between AD patients and controls according to age...
  18. doi request reprint Impact of molecular imaging on the diagnostic process in a memory clinic
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:414-21. 2013
    ..We evaluated the impact of these tracers on the diagnostic process in a memory clinic population...
  19. doi request reprint Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 80:359-65. 2013
    ..To examine the relationships between apolipoprotein E (APOE) ε4 dose and in vivo distributions of both fibrillary amyloid burden and glucose metabolism in the same Alzheimer disease dementia patients, selected for abnormal amyloid imaging...
  20. doi request reprint Injury markers but not amyloid markers are associated with rapid progression from mild cognitive impairment to dementia in Alzheimer's disease
    Ineke A van Rossum
    Department of Neurology Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 29:319-27. 2012
    ..Our findings implicate a different role for biomarkers in diagnosis and prognosis of MCI-AD. While amyloid markers can be used to identify MCI-AD, injury markers may predict rapid progression to dementia...
  21. doi request reprint Early onset Alzheimer's disease is associated with a distinct neuropsychological profile
    Lieke L Smits
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 30:101-8. 2012
    ..In conclusion, early onset AD presents with a different cognitive profile and the disease course seems different. Relative sparing of memory function in early stages stresses the need to adequately test other cognitive domains...
  22. doi request reprint Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: a longitudinal study
    Jasper D Sluimer
    Alzheimer Centre and Department of Diagnostic Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 31:758-64. 2010
    ..To assess associations between cerebrospinal fluid (CSF) biomarker levels and MRI-based whole-brain atrophy rate in mild cognitive impairment (MCI) and Alzheimer's disease (AD)...
  23. doi request reprint Cognitive correlates of cerebrospinal fluid biomarkers in frontotemporal dementia
    Esther L G E Koedam
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:269-75. 2013
    ..In this study we investigated the relationships between cerebrospinal fluid (CSF) biomarkers (tau and amyloid-β1-42 [Aβ1-42]) and cognition or behavior in patients with frontotemporal dementia (the behavioral variant, bvFTD)...
  24. doi request reprint Progression to dementia in memory clinic patients without dementia: a latent profile analysis
    Sebastian Kohler
    From the Alzheimer Center Limburg S K, R H, P J V, P A, F R J V, I R, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht and Alzheimer Center and Department of Neurology N S, Y A L P, W M v d F, P S, P J V, Department of Medical Psychology T K, Neuroscience Campus Amsterdam, and Department Epidemiology and Biostatistics W M v d F, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 81:1342-9. 2013
    ..To identify the existence of discrete cognitive subtypes among memory clinic patients without dementia and test their prognostic values...
  25. ncbi request reprint Predictors of progression from mild cognitive impairment to dementia in the placebo-arm of a clinical trial population
    Niels D Prins
    Alzheimer Centre and Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 36:79-85. 2013
    ..We conclude that global cognitive function, episodic memory performance, and MTA on MRI independently predict progression to dementia in patients with MCI...
  26. doi request reprint Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  27. ncbi request reprint Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions
    Rik Ossenkoppele
    From the Department of Radiology and Nuclear Medicine R O, S C J V, H V, A V, R A v S, S M A, M D Z, R B, A D W, F B, A A L, B N M v B, Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam R O, W M v d F, S A S, S M A, M D Z, P S, and Department of Epidemiology and Biostatistics W M v d F, S A S, J T, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 82:1768-75. 2014
    ..To assess how amyloid deposition, glucose hypometabolism, and cerebral atrophy affect neuropsychological performance in patients with Alzheimer disease (AD) dementia, patients with mild cognitive impairment (MCI), and controls over time...
  28. ncbi request reprint Preclinical AD predicts decline in memory and executive functions in subjective complaints
    Argonde C van Harten
    From the Alzheimer Center A C v H, L L S, P J V, T K, P S, W M v d F, Department of Neurology A C v H, L L S, P S, W M v d F, Neuroscience Campus Amsterdam A C v H, L L S, C E T, P J V, P S, W M v d F, Department of Clinical Chemistry C E T, M A B, Department of Medical Psychology T K, and Department of Epidemiology Biostatistics W M v d F, VU University Medical Center, Amsterdam and the Department of Psychiatry and Neuropsychology Alzheimer Center Limburg P J V, School for Mental Health and Neurosciences, Maastricht University Medical Center, Maastricht, The Netherlands
    Neurology 81:1409-16. 2013
    ....
  29. doi request reprint Discriminatory and predictive capabilities of enzyme-linked immunosorbent assay and multiplex platforms in a longitudinal Alzheimer's disease study
    Wesley Jongbloed
    Department of Clinical Chemistry, Neurological laboratory, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:276-83. 2013
    ....
  30. doi request reprint Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study
    Alie Schuitemaker
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:128-36. 2013
    ..The purpose of this study was to assess whether increased (R)-[(11)C]PK11195 binding is present in AD and mild cognitive impairment (MCI), currently also known as "prodromal AD."..
  31. pmc No evidence for additional blood-brain barrier P-glycoprotein dysfunction in Alzheimer's disease patients with microbleeds
    Daniëlle M E van Assema
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 32:1468-71. 2012
    ..No differences were found in binding potential and nonspecific volume of distribution of (R)-[(11)C]verapamil between patient groups. These results provide no evidence for additional Pgp dysfunction in AD patients with MBs...
  32. doi request reprint EEG functional connectivity and ApoE genotype in Alzheimer's disease and controls
    Gerdien Kramer
    Department of Neurology, Alzheimer Centre, VU University Medical Center, PO Box 7057, De Boelelaan 1118, 1007 MB Amsterdam, Noord Holland, The Netherlands
    Clin Neurophysiol 119:2727-32. 2008
    ....
  33. doi request reprint Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease
    Cees Mulder
    Department of Clinical Chemistry, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Clin Chem 56:248-53. 2010
    ..We have used these markers and evaluated their performance...
  34. ncbi request reprint Behavioural and psychological symptoms are not related to white matter hyperintensities and medial temporal lobe atrophy in Alzheimer's disease
    Salka S Staekenborg
    Alzheimer Centre and Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Int J Geriatr Psychiatry 23:387-92. 2008
    ..On MRI, medial temporal lobe atrophy (MTA) is presumed to reflect Alzheimer- type pathology. White matter hyperintensities (WMH) are considered markers of vascular pathology...
  35. doi request reprint Alzheimer's disease patients not carrying the apolipoprotein E ε4 allele show more severe slowing of oscillatory brain activity
    Hanneke De Waal
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2158-63. 2013
    ..In conclusion, the most pronounced effect of genotype was seen in AD patients, and APOE ε4 noncarriers showed slower activity, especially in parieto-occipital regions...
  36. ncbi request reprint Increase in cerebrospinal fluid F2-isoprostanes is related to cognitive decline in APOE ε4 carriers
    Flora H Duits
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 36:563-70. 2013
    ..Our results reiterate the importance of oxidative stress in neurodegeneration, especially in APOE ε4 carrying patients. Future studies should focus on the possibility of increased vulnerability to oxidative damage in APOE ε4 carriers. ..
  37. doi request reprint Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaints
    Argonde C van Harten
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:481-7. 2013
    ....
  38. doi request reprint On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...
  39. pmc Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands
    BMC Neurosci 13:85. 2012
    ....
  40. doi request reprint Progression of mild cognitive impairment to dementia: contribution of cerebrovascular disease compared with medial temporal lobe atrophy
    Salka S Staekenborg
    Department of Neurology, Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 40:1269-74. 2009
    ....
  41. ncbi request reprint Transcranial Doppler blood flow assessment in patients with mild heart failure: correlates with neuroimaging and cognitive performance
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital and the Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands
    Congest Heart Fail 14:61-5. 2008
    ....
  42. doi request reprint CSF biomarkers in Alzheimer's disease and controls: associations with APOE genotype are modified by age
    Maartje I Kester
    Alzheimer Center and Department of Neurology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Alzheimers Dis 16:601-7. 2009
    ..This suggests that cognitively healthy APOE epsilon4 carriers are more prone to develop AD pathology with aging. For AD patients, this provides support for the existence of subtypes within the disease...
  43. ncbi request reprint Diagnostic impact of CSF biomarkers in a local hospital memory clinic
    Maartje I Kester
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 29:491-7. 2010
    ..We examined the impact of these biomarkers in the diagnostic process in a non-academic memory clinic...
  44. doi request reprint Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:191-7. 2009
    ..The purpose of this study was to directly compare these tracers in patients with AD, patients with mild cognitive impairment (MCI), and healthy controls...
  45. doi request reprint Different patterns of gray matter atrophy in early- and late-onset Alzheimer's disease
    Christiane Möller
    Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2014-22. 2013
    ..Our results suggest that patterns of atrophy might vary in the spectrum of AD...
  46. pmc Injury markers predict time to dementia in subjects with MCI and amyloid pathology
    Ineke A van Rossum
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:1809-16. 2012
    ..However, little is known about the rate of decline in those subjects. In this cohort study, we aimed to assess the conversion rate to dementia and identify prognostic markers in subjects with MCI and evidence of amyloid pathology...
  47. ncbi request reprint MRI measures and progression of cognitive decline in nondemented elderly attending a memory clinic
    Wiesje M van der Flier
    Department of Neurology and Alzheimer Center, VU Medical Center, The Netherlands
    Int J Geriatr Psychiatry 20:1060-6. 2005
    ..To investigate whether MRI-based volumes of whole brain, medial temporal lobe and white matter hyperintensities (WMH) predict progression of cognitive decline in a sample of nondemented elderly...
  48. doi request reprint Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease
    Salka S Staekenborg
    Department of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 81:547-51. 2010
    ....
  49. doi request reprint BACE1 activity in cerebrospinal fluid and its relation to markers of AD pathology
    Sandra D Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 20:253-60. 2010
    ..38, r=0.63, and r=0.65; all p< 0.05), but not with Abeta(42). These data suggest that increased BACE1 activity in CSF relates to AD pathology in the brain...
  50. doi request reprint Prevalence of cortical superficial siderosis in a memory clinic population
    Hazel I Zonneveld
    From the Alzheimer Center and the Neuroscience Campus Amsterdam, and Departments of Radiology and Nuclear Medicine H I Z, M P W, F B, Neurology J D C G, N D P, P S, W M v d F, Epidemiology and Biostatistics W M v d F, Physics and Medical Technology J P A K, and Internal Medicine M M, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 82:698-704. 2014
    ....
  51. doi request reprint Specific risk factors for microbleeds and white matter hyperintensities in Alzheimer's disease
    Marije R Benedictus
    Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2488-94. 2013
    ..Our results suggest that, unlike WMH, microbleeds in AD are particularly associated with additional amyloid burden, and as such, may relate to cerebral amyloid angiopathy. ..
  52. pmc Single-subject grey matter graphs in Alzheimer's disease
    Betty M Tijms
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e58921. 2013
    ..These findings contribute to a better understanding of structural alterations and cognitive dysfunction in AD...
  53. doi request reprint Cerebral blood flow measured with 3D pseudocontinuous arterial spin-labeling MR imaging in Alzheimer disease and mild cognitive impairment: a marker for disease severity
    Maja A A Binnewijzend
    Department of Radiology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Radiology 267:221-30. 2013
    ..0 t...
  54. doi request reprint Microbleeds relate to altered amyloid-β metabolism in Alzheimer's disease
    Jeroen D C Goos
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:1011.e1-9. 2012
    ..MB distribution related to different amyloid profiles, supporting distinct etiologies. Our results suggest that Aβ42 is retained in cerebrovasculature of AD patients with MBs, while in contrast, VaD patients may possibly drain amyloid...
  55. doi request reprint Serial CSF sampling in Alzheimer's disease: specific versus non-specific markers
    Maartje I Kester
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:1591-8. 2012
    ..Contrary to AD-specific markers, nonspecific CSF biomarkers, most notably isoprostane, showed change over time. These markers could potentially be used to monitor disease progression in AD...
  56. ncbi request reprint Neuroimaging and correlates of cognitive function among patients with heart failure
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 24:418-23. 2007
    ..We purposed to investigate the relationship between cerebral abnormalities detected by magnetic resonance imaging (MRI) and cognitive performance in nondemented outpatients with heart failure (HF)...
  57. doi request reprint Serum amyloid p component as a biomarker in mild cognitive impairment and Alzheimer's disease
    Nicolaas A Verwey
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 26:522-7. 2008
    ..The aim was to investigate if SAP levels in cerebrospinal fluid (CSF) and serum can be used to discriminate controls, AD and mild cognitive impairment (MCI) patients, and to identify incipient AD among MCI patients...
  58. doi request reprint Early-onset dementia is associated with higher mortality
    Esther L G E Koedam
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 26:147-52. 2008
    ..Our objective was to compare the mortality risks of patients with early- and late-onset dementia with non-demented controls of the same age range and to analyse the mortality risks in subtypes of dementia...
  59. doi request reprint EEG abnormalities are associated with different cognitive profiles in Alzheimer's disease
    Lieke L Smits
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 31:1-6. 2011
    ..Our purpose was to investigate associations between different cognitive profiles and their underlying functional brain changes as measured by electroencephalogram (EEG) in Alzheimer's disease (AD)...
  60. ncbi request reprint Additional value of CSF amyloid-beta 40 levels in the differentiation between FTLD and control subjects
    Nicolaas A Verwey
    Department of Neurology, VU University Medical Center, Alzheimer Center Amsterdam, The Netherlands
    J Alzheimers Dis 20:445-52. 2010
    ..Our findings favor the implementation of CSF Abeta40 in differential diagnosis between FTLD, AD, and control subjects...
  61. doi request reprint Alzheimer's disease: connecting findings from graph theoretical studies of brain networks
    Betty M Tijms
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:2023-36. 2013
    ..We highlight confounding factors such as differences in graph construction methods and provide recommendations for future research...
  62. doi request reprint Young Alzheimer patients show distinct regional changes of oscillatory brain dynamics
    Hanneke De Waal
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:1008.e25-31. 2012
    ..This finding supports the hypothesis that early onset AD presents with a distinct endophenotype...
  63. doi request reprint Disruption of functional brain networks in Alzheimer's disease: what can we learn from graph spectral analysis of resting-state magnetoencephalography?
    Willem de Haan
    Department of Clinical Neurophysiology and Magnetoencephalography, VU University Medical Center, Amsterdam, The Netherlands
    Brain Connect 2:45-55. 2012
    ..Our findings imply that GSA is valuable for the purpose of studying altered brain network topology and dynamics in AD...
  64. doi request reprint Patients with Alzheimer disease with multiple microbleeds: relation with cerebrospinal fluid biomarkers and cognition
    Jeroen D C Goos
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 40:3455-60. 2009
    ..A minority of patients has multiple MBs. We aimed to investigate associations of multiple MBs in Alzheimer disease with clinical and MRI characteristics and cerebrospinal fluid biomarkers...
  65. ncbi request reprint Magnetic resonance imaging predictors of cognition in mild cognitive impairment
    Laura A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, Vrije Universiteit Amsterdam, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Arch Neurol 64:1023-8. 2007
    ..To describe magnetic resonance imaging characteristics in a large sample of subjects with mild cognitive impairment (MCI) and to investigate associations between these characteristics and cognition...
  66. doi request reprint Early-versus late-onset Alzheimer's disease: more than age alone
    Esther L G E Koedam
    Department of Neurology, VU University Medical Centre, Alzheimer Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 19:1401-8. 2010
    ..Atypical presentations of AD should be considered in the clinical differential diagnosis of early-onset dementia...
  67. ncbi request reprint The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia
    Antonio J Bastos-Leite
    Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 38:3182-5. 2007
    ..Therefore, our purpose was to investigate the relative contribution of cerebrovascular disease and MTA to cognitive impairment in patients fulfilling diagnostic criteria for VaD...
  68. ncbi request reprint Cognitive impairment in Alzheimer's disease is modified by APOE genotype
    Annelies E van der Vlies
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 24:98-103. 2007
    ..We examined whether impairment in specific cognitive domains in Alzheimer's disease (AD) differed according to APOE genotype and age at onset...
  69. doi request reprint Evaluation of intrathecal serum amyloid P (SAP) and C-reactive protein (CRP) synthesis in Alzheimer's disease with the use of index values
    Sandra D Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 22:1073-9. 2010
    ..Interestingly, the SAP index value was much lower than expected, based on its molecular size. In conclusion, these data suggest that local production of SAP and CRP in the AD brain does not substantially contribute to the CSF levels...
  70. ncbi request reprint Magnetization transfer imaging in normal aging, mild cognitive impairment, and Alzheimer's disease
    Wiesje M van der Flier
    Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Neurol 52:62-7. 2002
    ..Moreover, structural changes also were observed in MCI patients, indicating that widespread brain damage can be demonstrated before patients are clinically demented...
  71. ncbi request reprint Prevalence and clinical significance of epileptiform EEG discharges in a large memory clinic cohort
    Maarten Liedorp
    Alzheimer Center and Departments of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands m liedorp havenziekenhuis nl
    Dement Geriatr Cogn Disord 29:432-7. 2010
    ..Although EEG is not considered as standard in memory clinics, evidence indicates that epileptiform discharges are of value in diagnosing cognitive complaints as epilepsy...
  72. doi request reprint EEG abnormalities in early and late onset Alzheimer's disease: understanding heterogeneity
    Hanneke De Waal
    Alzheimer Center, Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:67-71. 2011
    ..EEG) abnormalities between early and late onset Alzheimer's disease (AD) and to assess the influence of APOE genotype on this association, in order to understand the biological differences in AD according to age at onset..
  73. doi request reprint Episodic memory and the medial temporal lobe: not all it seems. Evidence from the temporal variants of frontotemporal dementia
    C Machiel Pleizier
    Department of Neurology, Diakonessenhuis, PO Box 80250, 3508 TG, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 83:1145-8. 2012
    ..Episodic memory impairment and MTA are also found in semantic dementia (SD) and in right temporal lobe atrophy (RTLA), the temporal variants of frontotemporal dementia, but their relationship is unclear...
  74. doi request reprint Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment
    Maja A A Binnewijzend
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:2018-28. 2012
    ..Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD...
  75. doi request reprint Variability in longitudinal cerebrospinal fluid tau and phosphorylated tau measurements
    Nicolaas A Verwey
    Neurology Department, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Clin Chem Lab Med 46:1300-4. 2008
    ..The influence of assay variation and duration of storage on changes in cerebrospinal fluid (CSF) levels of tau and phosphorylated (P)-tau with time was evaluated in 112 patients with various neurological disorders...
  76. doi request reprint Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, Netherlands
    Eur J Nucl Med Mol Imaging 39:990-1000. 2012
    ..18)F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients with AD or mild cognitive impairment (MCI) and in healthy controls...
  77. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
    ..To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer's disease (AD) and other dementias...
  78. doi request reprint Clinical characteristics of patients with frontotemporal dementia with and without lobar atrophy on MRI
    Esther L G E Koedam
    Alzheimer Centre and Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 24:242-7. 2010
    ..We compared clinical characteristics of bvFTD patients with frontotemporal lobar atrophy on MRI to those lacking the typical pattern at presentation...
  79. ncbi request reprint Profile of cognitive impairment in chronic heart failure
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    J Am Geriatr Soc 55:1764-70. 2007
    ..To determine the frequency and pattern of cognitive dysfunction in outpatients with chronic congestive heart failure (CHF) and to identify the corresponding demographic and clinical correlates...
  80. doi request reprint Tau and p-tau as CSF biomarkers in dementia: a meta-analysis
    Argonde C van Harten
    Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Chem Lab Med 49:353-66. 2011
    ....
  81. doi request reprint Clinical relevance of improved microbleed detection by susceptibility-weighted magnetic resonance imaging
    Jeroen D C Goos
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 42:1894-900. 2011
    ..We sought to determine whether associations of MBs with clinical characteristics, risk factors, white-matter hyperintensities, and lacunes were different on GRE versus SWI in memory clinic patients...
  82. doi request reprint Whole-brain atrophy rate and cognitive decline: longitudinal MR study of memory clinic patients
    Jasper D Sluimer
    Department of Diagnostic Radiology, Alzheimer Centre, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Radiology 248:590-8. 2008
    ....
  83. doi request reprint Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations
    Alida A Gouw
    VU University Medical Centre, Department of Neurology, De Boelelaan 1117, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:126-35. 2011
    ..By reviewing studies that directly correlated postmortem MRI and histopathology, this paper aimed to characterise the pathological substrates of SVD in order to create more understanding as to its heterogeneous clinical manifestation...
  84. ncbi request reprint Neurological signs in relation to type of cerebrovascular disease in vascular dementia
    Salka S Staekenborg
    Department of Neurology and Alzheimer Centre, Vrije University Medical Centre, Amsterdam, The Netherlands
    Stroke 39:317-22. 2008
    ....
  85. doi request reprint Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:1464-70. 2009
    ....
  86. ncbi request reprint Late-onset dementia: structural brain damage and total cerebral blood flow
    Aart Spilt
    Department of Radiology, General Internal Medicine and Neurology, Leiden University Medical Center, Albinusdreef, C2 S, 2333 ZA Leiden, The Netherlands
    Radiology 236:990-5. 2005
    ..To prospectively compare indicators of structural brain damage and total cerebral blood flow in patients with late-onset dementia, subjects of the same age with optimal cognitive function, and young subjects...
  87. pmc Accelerating regional atrophy rates in the progression from normal aging to Alzheimer's disease
    Jasper D Sluimer
    Department of Diagnostic Radiology, VU University Medical Centre, Amsterdam, The Netherlands
    Eur Radiol 19:2826-33. 2009
    ..Finally, in nondemented elderly, medial temporal lobe atrophy was most predictive of progression to AD, demonstrating the involvement of this region in the development of AD...
  88. doi request reprint Investigation of resting-state EEG functional connectivity in frontotemporal lobar degeneration
    Yolande A L Pijnenburg
    Alzheimer Center and Department of Neurology, VU Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Neurophysiol 119:1732-8. 2008
    ....
  89. doi request reprint Diagnostic imaging of patients in a memory clinic: comparison of MR imaging and 64-detector row CT
    Mike P Wattjes
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 253:174-83. 2009
    ....
  90. pmc Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory
    Willem de Haan
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    BMC Neurosci 10:101. 2009
    ..All results were normalized for network size and compared with random control networks...
  91. doi request reprint Microglial activation in healthy aging
    Alie Schuitemaker
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Neurobiol Aging 33:1067-72. 2012
    ..This indicates that activated microglia appear in several cortical and subcortical areas during healthy aging, suggesting widespread neuronal loss...
  92. ncbi request reprint Infratentorial abnormalities in vascular dementia
    Antonio J Bastos Leite
    Department of Radiology and Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 37:105-10. 2006
    ..Our purposes were to determine the prevalence of infratentorial abnormalities in VaD, their relation with supratentorial abnormalities, and whether they are relevant to cognition...
  93. doi request reprint CSF α-synuclein does not discriminate dementia with Lewy bodies from Alzheimer's disease
    Fransje E Reesink
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 22:87-95. 2010
    ..05). Ultimately, CSF α-synuclein was not a useful diagnostic biomarker to differentiate DLB and/or PD (α-synucleinopathies) from AD or SC. In DLB patients maybe lower CSF α-synuclein levels are related to worse cognitive performance...
  94. ncbi request reprint Glycemia and levels of cerebrospinal fluid amyloid and tau in patients attending a memory clinic
    Lieza G Exalto
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Geriatr Soc 58:1318-21. 2010
    ..To determine the association between markers of glycemia and cerebrospinal fluid (CSF) amyloid beta 1-42 (Abeta42) and tau levels in patients attending a memory clinic...
  95. ncbi request reprint CSF and MRI markers independently contribute to the diagnosis of Alzheimer's disease
    Niki S M Schoonenboom
    Department of Neurology, Alzheimer Center, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Neurobiol Aging 29:669-75. 2008
    ..Atrophy of the medial temporal lobe (MTA) on magnetic resonance imaging (MRI) reflects neuronal loss in this area...
  96. doi request reprint Molecular imaging in the diagnosis of Alzheimer's disease: visual assessment of [11C]PIB and [18F]FDDNP PET images
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 81:882-4. 2010
    ..To evaluate visual assessment of [(11)C]PIB and [(18)F]FDDNP PET images as potential supportive diagnostic markers for Alzheimer's disease (AD)...
  97. ncbi request reprint Brain magnetic resonance imaging abnormalities in patients with heart failure
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    Eur J Heart Fail 9:1003-9. 2007
    ..Although heart failure (HF) is a common cardiovascular disorder, to date little research has been conducted into possible associations between HF and structural abnormalities of the brain...
  98. doi request reprint Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele
    Wiesje M van der Flier
    Alzheimer Centre, Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    Lancet Neurol 10:280-8. 2011
    ..Other factors are probably involved in determining the pattern of atrophy, but these are currently unknown...
  99. doi request reprint Improving the accuracy and precision of cognitive testing in mild dementia
    Hans Wouters
    Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Int Neuropsychol Soc 18:314-22. 2012
    ..We conclude that extending dementia specific instruments with neuropsychological tests improves measurement precision and accuracy of cognitive impairment in mild dementia...
  100. doi request reprint Blood-brain barrier P-glycoprotein function in Alzheimer's disease
    Daniëlle M E van Assema
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 135:181-9. 2012
    ....