Research Topics
Genomes and Genes
| Victor W M van HinsberghSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Pericellular proteases in angiogenesis and vasculogenesisVictor W M van Hinsbergh
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Arterioscler Thromb Vasc Biol 26:716-28. 2006..Understanding the complexity of protease activities in angiogenesis contributes to recognizing new targets for stimulation or inhibition of neovascularization in disease...- Endothelial sprouting and angiogenesis: matrix metalloproteinases in the leadVictor W M van Hinsbergh
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
Cardiovasc Res 78:203-12. 2008..Better understanding of the various activities of proteases may be helpful in developing more specific inhibitors that could result in tailor-made modification of proteolytic activities in disease... 
Endothelium--role in regulation of coagulation and inflammationVictor W M van Hinsbergh
Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Semin Immunopathol 34:93-106. 2012..Fibrin and products of platelets and inflammatory cells modulate the angiogenic response of endothelial cells and contribute to tissue repair...
S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteineJessica A Sipkens
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
Atherosclerosis 221:48-54. 2012....- Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)Jessica A Sipkens
Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
Mol Cell Biochem 358:229-39. 2011.... - Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancerAstrid A M van der Veldt
Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
Int J Cancer 131:E484-93. 2012..In conclusion, sunitinib-induced changes in Ang-2, sTie-2, sVCAM-1 and VEGF are related to the administration schedule, while reduction in Ang-2 is also associated with decrease in tumor burden... - Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cellsMelanie van der Heijden
Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
PLoS ONE 6:e23448. 2011.... - Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activityJessica A Sipkens
Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
Cell Physiol Biochem 28:53-62. 2011..In the present study the mechanism(s) involved in Hcy-induced PS exposure were analyzed... - Nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunctionCora M L Beckers
Department for Physiology, VU University Medical Center, Institute for Cardiovascular Research, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Cardiovasc Res 79:679-88. 2008..The aim of this study was, therefore, to investigate the fate of beta-catenin and the related catenin p120catenin (p120ctn), during disruption of the endothelial barrier function in human umbilical vein endothelial cells (ECs)... - Single and combined effects of alphavbeta3- and alpha5beta1-integrins on capillary tube formation in a human fibrinous matrixNancy Laurens
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Centre Amsterdam, Amsterdam, The Netherlands
Angiogenesis 12:275-85. 2009..These data show that blocking of tube formation in a fibrinous exudate requires the simultaneous inhibition of alphavbeta3- and alpha5beta1-integrins. This may bear impact on attempts to influence angiogenesis in a fibrinous environment... - Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippasePaul A J Krijnen
Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
J Mol Cell Cardiol 49:781-90. 2010..In this study, we show a regulatory role for a novel signaling route, Rho-ROCK-flippase signaling, in maintaining asymmetrical membrane phospholipid distribution in cardiomyocytes... - Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndromeJurjan Aman
Department of Physiology, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
Crit Care Med 39:89-97. 2011..We hypothesized that plasma protein levels predict increased vascular permeability and acute respiratory distress syndrome... - Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissueEtto C Eringa
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Vascul Pharmacol 56:204-9. 2012..An altered profile of adipokine and cytokine production by PVAT of resistance arteries may also contribute to or modulate hypertension, but a causal role in hypertension has still to be established... - TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cellsAna H C Guimarães
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Arterioscler Thromb Vasc Biol 27:2157-62. 2007..Here we examined the involvement of thrombin activatable fibrinolysis inhibitor (TAFI) and pancreatic carboxypeptidase B (CPB) in an in vitro capillary tube formation system, which is largely plasminogen-dependent... - The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patientsMelanie van der Heijden
Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Shock 33:263-8. 2010..However, this shedding may not prevent a direct role of Angs in pulmonary vascular permeability... - Driving Rho GTPase activity in endothelial cells regulates barrier integrityCora M L Beckers
Department for Physiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
Thromb Haemost 103:40-55. 2010..The challenge and promise lies in unfolding this complex regulation, as this will provide leads for new therapeutic opportunities... - Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formationMarten A Engelse
Department for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Angiogenesis 11:153-67. 2008..Overexpression of CDC42GAP in hMVEC attenuated endothelial tubule formation, while its suppression by siRNA slightly enhanced this process. Thus, CDC42GAP was identified as a counter-regulatory mediator for tubule formation... - Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinibLaura Vroling
Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
Angiogenesis 12:69-79. 2009..The increase in CECs is likely caused by sunitinib targeting of immature tumor vessels... - Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cellsCasper G Schalkwijk
Department of Clinical Chemistry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
FEBS Lett 580:1565-70. 2006..This argpyrimidine modification of Hsp27 may contribute to changes in endothelial cell function associated to diabetes... - Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patientsPaul A J Krijnen
Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
Basic Res Cardiol 107:233. 2012..Our data suggest that the loss of DPP4 activity affects the anti-thrombogenic nature of the endothelium... - Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertensionKoen T B Mouchaers
Department of Pulmonary Diseases, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
Am J Physiol Heart Circ Physiol 297:H200-7. 2009..These data indicate that the combination of Bosentan and Sildenafil may beneficially contribute to RV adaptation in PAH, not only by reducing PVR but also by acting on the mitochondria in the heart... - Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrixYvette van Hensbergen
Department of Medical Oncology, Amsterdam, VU University Medical Center, The Netherlands
Thromb Haemost 90:921-9. 2003..The identification of this novel effect of bestatin is important in the light of the proposed use of bestatin as anti-angiogenic and/or anti-tumor agent... - Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesityWineke Bakker
Laboratory of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
Cell Tissue Res 335:165-89. 2009..Hence, an initial dysfunction of endothelial cells underlies metabolic and vascular alterations that contribute to the development of type 2 diabetes... - Degeneration and atherosclerosis inducing increased deposition of type IIA secretory phospholipase A2, C-reactive protein and complement in aortic valves cause neutrophilic granulocyte influxKoba Kupreishvili
Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
J Heart Valve Dis 20:29-36. 2011..The study aim was to monitor the deposition of CRP, its activator sPLA2-IIA and its effector complement, and the subsequent influx of neutrophilic granulocytes in degenerative and atherosclerotic aortic valves... - The influence of hypoxia and fibrinogen variants on the expansion and differentiation of adipose tissue-derived mesenchymal stem cellsEster M Weijers
Department of Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
Tissue Eng Part A 17:2675-85. 2011..These data emphasize the importance of oxygen concentrations during stem cell growth and differentiation... - C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressurePaul A J Krijnen
Department of Pathology, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Atherosclerosis 220:86-92. 2012..Inflammation, including complement activation, is assumed to play a pivotal role herein. Here, we analyzed the effects of C1-esterase inhibitor (C1inh) on early vein graft remodeling... - Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genesJuan J Garcia-Vallejo
Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
J Cell Physiol 206:203-10. 2006.... - Effective treatment of edema and endothelial barrier dysfunction with imatinibJurjan Aman
Department of Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Circulation 126:2728-38. 2012..Here, we explored the effect of imatinib on endothelial barrier dysfunction and edema formation... - Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular diseaseRick I Meijer
Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands
Curr Diab Rep 11:211-7. 2011..Furthermore, we will discuss mechanisms controlling the quantity and adipokines secretion by PAT... - VEGFR2 expressing circulating (progenitor) cell populations in volunteers and cancer patientsLaura Vroling
Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
Thromb Haemost 98:440-50. 2007..Quantification of such cell populations in the blood of tumor patients may be valuable to monitor the efficacy of anti-angiogenic treatment... - The basement membrane of intramyocardial capillaries is thickened in patients with acute myocardial infarctionMark P V Begieneman
Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
J Vasc Res 47:54-60. 2010..Recently, we found that intramyocardial capillaries may also play a role in AMI induction. We have now evaluated intramyocardial capillaries using ultrastructural analysis in AMI patients... - N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vesselsAlexi Baidoshvili
Department of Cardiac Surgery, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
Atherosclerosis 174:287-92. 2004..Our data support the hypothesis that the process of degeneration of aortic valves resembles that of atherosclerosis in blood vessels. They suggest that CML also plays a role in the process of atherosclerosis in aortic valves... - Targets for pharmacological intervention of endothelial hyperpermeability and barrier functionGeerten P van Nieuw Amerongen
Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, 1081BT Amsterdam, The Netherlands
Vascul Pharmacol 39:257-72. 2002..This review discusses strategies for targeting signaling molecules in therapies for diseases involving altered endothelial permeability... - Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cellsCasper G Schalkwijk
Department of Clinical Chemistry, Institute for Cardiovascular Research, Vrije Univeristeit Medical Center, Amsterdam, The Netherlands
Clin Hemorheol Microcirc 37:179-84. 2007..This study shows that mevastatin has protective effects on endothelial cells by inducing eNOS and by inhibiting lipid peroxidation... - Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosisJeroen W J van Heijst
Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Cancer Lett 241:309-19. 2006..These findings suggest that a high level of argpyrimidine-modified Hsp27 is a mechanism of cancer cells for evasion of apoptosis... - Increased levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine in type 1 diabetic patients with impaired renal function: correlation with markers of endothelial dysfunctionMariska L M Lieuw-A-Fa
Department of Physiology, and Institute of Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
Nephrol Dial Transplant 19:631-6. 2004..This suggests an involvement of these AGEs in the acceleration of cardiovascular complications in patients with renal impairment... - Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortalityMelanie van der Heijden
Department of Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
Intensive Care Med 35:1567-74. 2009.... - Smooth muscle F-actin disassembly and RhoA/Rho-kinase signaling during endotoxin-induced alterations in pulmonary arterial complianceChrista Boer
Laboratory for Physiology, Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
Am J Physiol Lung Cell Mol Physiol 287:L649-55. 2004..They imply the involvement of F-actin rearrangement and RhoA/Rho-kinase signaling in endotoxemia-induced vascular lung injury... - Fructose-mediated non-enzymatic glycation: sweet coupling or bad modificationCasper G Schalkwijk
Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
Diabetes Metab Res Rev 20:369-82. 2004.... - Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitroGeerten P van Nieuw Amerongen
Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Arterioscler Thromb Vasc Biol 23:211-7. 2003..CONCLUSIONS: VEGF-induced cytoskeletal changes in ECs require RhoA and Rho kinase, and activation of RhoA/Rho kinase signaling is involved in the VEGF-induced in vitro EC migration and angiogenesis... - Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteriesWineke Bakker
Laboratory of Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, Netherlands
Diabetes 57:706-13. 2008..In this study, we investigated whether PKC theta activation impairs insulin-mediated vasoreactivity and insulin signaling in muscle resistance arteries... - Endothelial hyperpermeability in vascular leakageVictor W M van Hinsbergh
Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Vascul Pharmacol 39:171-2. 2002 - The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injuryMelanie van der Heijden
VU University Medical Center, Institute for Cardiovascular Research, Department of Intensive Care, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Expert Opin Ther Targets 13:39-53. 2009..Amongst other factors, the angiopoietin-tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) system is involved... - Distinct accumulation patterns of soluble forms of E-selectin, VCAM-1 and ICAM-1 upon infusion of TNFalpha in tumor patientsMariska Lieuw-a-Fa
Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
Thromb Haemost 89:1052-7. 2003..In contrast, sE-selectin reached its peak at day 1 and declined thereafter. In conclusion, sVCAM-1 and sICAM-1 show a different accumulation pattern upon TNalpha infusion as compared to sE-selectin in man... - Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosisJessica A Sipkens
Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
Apoptosis 12:1407-18. 2007..While numerous studies have analyzed the role of homocysteine (Hcy) in the vasculature, only a few studies investigated the role of Hcy in the heart. Therefore we have analyzed the effects of Hcy on isolated cardiomyocytes... - Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathwaysRemond J A Fijneman
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Cell Oncol 31:345-56. 2009..However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends on Apc-germline mutations...