Victor W M van Hinsbergh

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead
    Victor W M van Hinsbergh
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    Cardiovasc Res 78:203-12. 2008
  2. ncbi request reprint Pericellular proteases in angiogenesis and vasculogenesis
    Victor W M van Hinsbergh
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:716-28. 2006
  3. pmc Endothelium--role in regulation of coagulation and inflammation
    Victor W M van Hinsbergh
    Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Semin Immunopathol 34:93-106. 2012
  4. doi request reprint S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 221:48-54. 2012
  5. doi request reprint Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)
    Jessica A Sipkens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Mol Cell Biochem 358:229-39. 2011
  6. doi request reprint Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer
    Astrid A M van der Veldt
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 131:E484-93. 2012
  7. pmc Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 6:e23448. 2011
  8. doi request reprint Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Physiol Biochem 28:53-62. 2011
  9. ncbi request reprint Nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction
    Cora M L Beckers
    Department for Physiology, VU University Medical Center, Institute for Cardiovascular Research, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Cardiovasc Res 79:679-88. 2008
  10. pmc Single and combined effects of alphavbeta3- and alpha5beta1-integrins on capillary tube formation in a human fibrinous matrix
    Nancy Laurens
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Centre Amsterdam, Amsterdam, The Netherlands
    Angiogenesis 12:275-85. 2009

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Endothelial sprouting and angiogenesis: matrix metalloproteinases in the lead
    Victor W M van Hinsbergh
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    Cardiovasc Res 78:203-12. 2008
    ..Better understanding of the various activities of proteases may be helpful in developing more specific inhibitors that could result in tailor-made modification of proteolytic activities in disease...
  2. ncbi request reprint Pericellular proteases in angiogenesis and vasculogenesis
    Victor W M van Hinsbergh
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:716-28. 2006
    ..Understanding the complexity of protease activities in angiogenesis contributes to recognizing new targets for stimulation or inhibition of neovascularization in disease...
  3. pmc Endothelium--role in regulation of coagulation and inflammation
    Victor W M van Hinsbergh
    Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Semin Immunopathol 34:93-106. 2012
    ..Fibrin and products of platelets and inflammatory cells modulate the angiogenic response of endothelial cells and contribute to tissue repair...
  4. doi request reprint S-Adenosylhomocysteine induces apoptosis and phosphatidylserine exposure in endothelial cells independent of homocysteine
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Atherosclerosis 221:48-54. 2012
    ....
  5. doi request reprint Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox)
    Jessica A Sipkens
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Mol Cell Biochem 358:229-39. 2011
    ....
  6. doi request reprint Sunitinib-induced changes in circulating endothelial cell-related proteins in patients with metastatic renal cell cancer
    Astrid A M van der Veldt
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 131:E484-93. 2012
    ..In conclusion, sunitinib-induced changes in Ang-2, sTie-2, sVCAM-1 and VEGF are related to the administration schedule, while reduction in Ang-2 is also associated with decrease in tumor burden...
  7. pmc Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 6:e23448. 2011
    ....
  8. doi request reprint Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Physiol Biochem 28:53-62. 2011
    ..In the present study the mechanism(s) involved in Hcy-induced PS exposure were analyzed...
  9. ncbi request reprint Nuclear targeting of beta-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction
    Cora M L Beckers
    Department for Physiology, VU University Medical Center, Institute for Cardiovascular Research, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Cardiovasc Res 79:679-88. 2008
    ..The aim of this study was, therefore, to investigate the fate of beta-catenin and the related catenin p120catenin (p120ctn), during disruption of the endothelial barrier function in human umbilical vein endothelial cells (ECs)...
  10. pmc Single and combined effects of alphavbeta3- and alpha5beta1-integrins on capillary tube formation in a human fibrinous matrix
    Nancy Laurens
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Centre Amsterdam, Amsterdam, The Netherlands
    Angiogenesis 12:275-85. 2009
    ..These data show that blocking of tube formation in a fibrinous exudate requires the simultaneous inhibition of alphavbeta3- and alpha5beta1-integrins. This may bear impact on attempts to influence angiogenesis in a fibrinous environment...
  11. doi request reprint Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase
    Paul A J Krijnen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 49:781-90. 2010
    ..In this study, we show a regulatory role for a novel signaling route, Rho-ROCK-flippase signaling, in maintaining asymmetrical membrane phospholipid distribution in cardiomyocytes...
  12. pmc Homocysteine-induced apoptosis in endothelial cells coincides with nuclear NOX2 and peri-nuclear NOX4 activity
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cell Biochem Biophys 67:341-52. 2013
    ..The data presented in this article reveal accumulation of nuclear NOX2 and peri-nuclear NOX4 accumulation as potential source of ROS production in Hcy-induced apoptosis in endothelial cells. ..
  13. pmc Perivascular adipose tissue control of insulin-induced vasoreactivity in muscle is impaired in db/db mice
    Rick I Meijer
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes 62:590-8. 2013
    ..PVAT from obese mice inhibits insulin-induced vasodilation, which can be restored by inhibition of JNK...
  14. doi request reprint Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome
    Jurjan Aman
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
    Crit Care Med 39:89-97. 2011
    ..We hypothesized that plasma protein levels predict increased vascular permeability and acute respiratory distress syndrome...
  15. doi request reprint Effective treatment of edema and endothelial barrier dysfunction with imatinib
    Jurjan Aman
    Department of Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Circulation 126:2728-38. 2012
    ..Here, we explored the effect of imatinib on endothelial barrier dysfunction and edema formation...
  16. doi request reprint Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue
    Etto C Eringa
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Vascul Pharmacol 56:204-9. 2012
    ..An altered profile of adipokine and cytokine production by PVAT of resistance arteries may also contribute to or modulate hypertension, but a causal role in hypertension has still to be established...
  17. doi request reprint The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Shock 33:263-8. 2010
    ..However, this shedding may not prevent a direct role of Angs in pulmonary vascular permeability...
  18. ncbi request reprint Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation
    Marten A Engelse
    Department for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Angiogenesis 11:153-67. 2008
    ..Overexpression of CDC42GAP in hMVEC attenuated endothelial tubule formation, while its suppression by siRNA slightly enhanced this process. Thus, CDC42GAP was identified as a counter-regulatory mediator for tubule formation...
  19. doi request reprint Driving Rho GTPase activity in endothelial cells regulates barrier integrity
    Cora M L Beckers
    Department for Physiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Thromb Haemost 103:40-55. 2010
    ..The challenge and promise lies in unfolding this complex regulation, as this will provide leads for new therapeutic opportunities...
  20. ncbi request reprint TAFI and pancreatic carboxypeptidase B modulate in vitro capillary tube formation by human microvascular endothelial cells
    Ana H C Guimarães
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 27:2157-62. 2007
    ..Here we examined the involvement of thrombin activatable fibrinolysis inhibitor (TAFI) and pancreatic carboxypeptidase B (CPB) in an in vitro capillary tube formation system, which is largely plasminogen-dependent...
  21. pmc Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrity
    Robert Szulcek
    Department for Physiology, VU University Medical Center, Institute for Cardiovascular Research, Van der Boechorststraat 7, Amsterdam 1108 BH, The Netherlands
    Cardiovasc Res 99:471-82. 2013
    ..Here, we aimed to elucidate whether the opening and closure of the endothelial barrier are associated with distinct localized RhoA activities at the subcellular level...
  22. ncbi request reprint Increased numbers of small circulating endothelial cells in renal cell cancer patients treated with sunitinib
    Laura Vroling
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Angiogenesis 12:69-79. 2009
    ..The increase in CECs is likely caused by sunitinib targeting of immature tumor vessels...
  23. ncbi request reprint Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cells
    Casper G Schalkwijk
    Department of Clinical Chemistry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    FEBS Lett 580:1565-70. 2006
    ..This argpyrimidine modification of Hsp27 may contribute to changes in endothelial cell function associated to diabetes...
  24. doi request reprint Endothelial dysfunction in (pre)diabetes: characteristics, causative mechanisms and pathogenic role in type 2 diabetes
    Etto C Eringa
    Departments of Physiology, VU University Medical Center, Amsterdam, The Netherlands
    Rev Endocr Metab Disord 14:39-48. 2013
    ..Finally, we will discuss the therapeutic potential of endothelial dysfunction in T2D...
  25. pmc Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients
    Paul A J Krijnen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Basic Res Cardiol 107:233. 2012
    ..Our data suggest that the loss of DPP4 activity affects the anti-thrombogenic nature of the endothelium...
  26. ncbi request reprint Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix
    Yvette van Hensbergen
    Department of Medical Oncology, Amsterdam, VU University Medical Center, The Netherlands
    Thromb Haemost 90:921-9. 2003
    ..The identification of this novel effect of bestatin is important in the light of the proposed use of bestatin as anti-angiogenic and/or anti-tumor agent...
  27. doi request reprint Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity
    Wineke Bakker
    Laboratory of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Cell Tissue Res 335:165-89. 2009
    ..Hence, an initial dysfunction of endothelial cells underlies metabolic and vascular alterations that contribute to the development of type 2 diabetes...
  28. ncbi request reprint Degeneration and atherosclerosis inducing increased deposition of type IIA secretory phospholipase A2, C-reactive protein and complement in aortic valves cause neutrophilic granulocyte influx
    Koba Kupreishvili
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Heart Valve Dis 20:29-36. 2011
    ..The study aim was to monitor the deposition of CRP, its activator sPLA2-IIA and its effector complement, and the subsequent influx of neutrophilic granulocytes in degenerative and atherosclerotic aortic valves...
  29. ncbi request reprint Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension
    Koen T B Mouchaers
    Department of Pulmonary Diseases, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H200-7. 2009
    ..These data indicate that the combination of Bosentan and Sildenafil may beneficially contribute to RV adaptation in PAH, not only by reducing PVR but also by acting on the mitochondria in the heart...
  30. doi request reprint The influence of hypoxia and fibrinogen variants on the expansion and differentiation of adipose tissue-derived mesenchymal stem cells
    Ester M Weijers
    Department of Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    Tissue Eng Part A 17:2675-85. 2011
    ..These data emphasize the importance of oxygen concentrations during stem cell growth and differentiation...
  31. doi request reprint C1-esterase inhibitor protects against early vein graft remodeling under arterial blood pressure
    Paul A J Krijnen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Atherosclerosis 220:86-92. 2012
    ..Inflammation, including complement activation, is assumed to play a pivotal role herein. Here, we analyzed the effects of C1-esterase inhibitor (C1inh) on early vein graft remodeling...
  32. ncbi request reprint Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genes
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    J Cell Physiol 206:203-10. 2006
    ....
  33. doi request reprint The basement membrane of intramyocardial capillaries is thickened in patients with acute myocardial infarction
    Mark P V Begieneman
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Vasc Res 47:54-60. 2010
    ..Recently, we found that intramyocardial capillaries may also play a role in AMI induction. We have now evaluated intramyocardial capillaries using ultrastructural analysis in AMI patients...
  34. ncbi request reprint VEGFR2 expressing circulating (progenitor) cell populations in volunteers and cancer patients
    Laura Vroling
    Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 98:440-50. 2007
    ..Quantification of such cell populations in the blood of tumor patients may be valuable to monitor the efficacy of anti-angiogenic treatment...
  35. pmc Perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease
    Rick I Meijer
    Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands
    Curr Diab Rep 11:211-7. 2011
    ..Furthermore, we will discuss mechanisms controlling the quantity and adipokines secretion by PAT...
  36. ncbi request reprint Targets for pharmacological intervention of endothelial hyperpermeability and barrier function
    Geerten P van Nieuw Amerongen
    Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, 1081BT Amsterdam, The Netherlands
    Vascul Pharmacol 39:257-72. 2002
    ..This review discusses strategies for targeting signaling molecules in therapies for diseases involving altered endothelial permeability...
  37. ncbi request reprint N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities with atherosclerotic blood vessels
    Alexi Baidoshvili
    Department of Cardiac Surgery, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Atherosclerosis 174:287-92. 2004
    ..Our data support the hypothesis that the process of degeneration of aortic valves resembles that of atherosclerosis in blood vessels. They suggest that CML also plays a role in the process of atherosclerosis in aortic valves...
  38. ncbi request reprint Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cells
    Casper G Schalkwijk
    Department of Clinical Chemistry, Institute for Cardiovascular Research, Vrije Univeristeit Medical Center, Amsterdam, The Netherlands
    Clin Hemorheol Microcirc 37:179-84. 2007
    ..This study shows that mevastatin has protective effects on endothelial cells by inducing eNOS and by inhibiting lipid peroxidation...
  39. ncbi request reprint Increased levels of N(epsilon)-(carboxymethyl)lysine and N(epsilon)-(carboxyethyl)lysine in type 1 diabetic patients with impaired renal function: correlation with markers of endothelial dysfunction
    Mariska L M Lieuw-A-Fa
    Department of Physiology, and Institute of Cardiovascular Research, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Nephrol Dial Transplant 19:631-6. 2004
    ....
  40. ncbi request reprint Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries
    Wineke Bakker
    Laboratory of Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, Netherlands
    Diabetes 57:706-13. 2008
    ..In this study, we investigated whether PKC theta activation impairs insulin-mediated vasoreactivity and insulin signaling in muscle resistance arteries...
  41. ncbi request reprint Smooth muscle F-actin disassembly and RhoA/Rho-kinase signaling during endotoxin-induced alterations in pulmonary arterial compliance
    Christa Boer
    Laboratory for Physiology, Department of Anesthesiology, VU University Medical Center, Institute for Cardiovascular Research Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 287:L649-55. 2004
    ..They imply the involvement of F-actin rearrangement and RhoA/Rho-kinase signaling in endotoxemia-induced vascular lung injury...
  42. ncbi request reprint Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro
    Geerten P van Nieuw Amerongen
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 23:211-7. 2003
    ..The small GTPase RhoA previously has been implicated in vascular endothelial growth factor (VEGF)-induced signaling pathways, but its role has not been clarified...
  43. pmc Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality
    Melanie van der Heijden
    Department of Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    Intensive Care Med 35:1567-74. 2009
    ....
  44. ncbi request reprint Fructose-mediated non-enzymatic glycation: sweet coupling or bad modification
    Casper G Schalkwijk
    Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
    Diabetes Metab Res Rev 20:369-82. 2004
    ....
  45. ncbi request reprint Argpyrimidine-modified Heat shock protein 27 in human non-small cell lung cancer: a possible mechanism for evasion of apoptosis
    Jeroen W J van Heijst
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Lett 241:309-19. 2006
    ..These findings suggest that a high level of argpyrimidine-modified Hsp27 is a mechanism of cancer cells for evasion of apoptosis...
  46. ncbi request reprint Endothelial hyperpermeability in vascular leakage
    Victor W M van Hinsbergh
    Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Vascul Pharmacol 39:171-2. 2002
  47. ncbi request reprint The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury
    Melanie van der Heijden
    VU University Medical Center, Institute for Cardiovascular Research, Department of Intensive Care, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Expert Opin Ther Targets 13:39-53. 2009
    ..Amongst other factors, the angiopoietin-tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) system is involved...
  48. ncbi request reprint Distinct accumulation patterns of soluble forms of E-selectin, VCAM-1 and ICAM-1 upon infusion of TNFalpha in tumor patients
    Mariska Lieuw-a-Fa
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Thromb Haemost 89:1052-7. 2003
    ..In contrast, sE-selectin reached its peak at day 1 and declined thereafter. In conclusion, sVCAM-1 and sICAM-1 show a different accumulation pattern upon TNalpha infusion as compared to sE-selectin in man...
  49. pmc Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Apoptosis 12:1407-18. 2007
    ..While numerous studies have analyzed the role of homocysteine (Hcy) in the vasculature, only a few studies investigated the role of Hcy in the heart. Therefore we have analyzed the effects of Hcy on isolated cardiomyocytes...
  50. doi request reprint Pla2g2a attenuates colon tumorigenesis in azoxymethane-treated C57BL/6 mice; expression studies reveal Pla2g2a target genes and pathways
    Remond J A Fijneman
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol 31:345-56. 2009
    ..However, it is unclear how Pla2g2a exerts its tumor-suppressive effects and whether its mode of action depends on Apc-germline mutations...