Paul van der Valk

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
    Daphne Y S Vogel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechhorststraat 7, BT Amsterdam, 1081, The Netherlands
    J Neuroinflammation 10:35. 2013
  2. pmc Receptor conversion in distant breast cancer metastases
    Laurien D C Hoefnagel
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    Breast Cancer Res 12:R75. 2010
  3. doi request reprint Preactive lesions in multiple sclerosis
    Paul van der Valk
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Curr Opin Neurol 22:207-13. 2009
  4. pmc Comparative genomic hybridisation divides retinoblastomas into a high and a low level chromosomal instability group
    J E van der Wal
    Department of Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Pathol 56:26-30. 2003
  5. pmc Russell bodies in a skin biopsy: a case report
    Joanne Verheij
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Med Case Reports 3:108. 2009
  6. pmc Gene expression in the rat brain: high similarity but unique differences between frontomedial-, temporal- and occipital cortex
    Christine Stansberg
    Dr E Martens Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Norway
    BMC Neurosci 12:15. 2011
  7. doi request reprint Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    Maarten E Witte
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:231-43. 2013
  8. ncbi request reprint Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis
    Catharina M P Vos
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurobiol Dis 20:953-60. 2005
  9. doi request reprint Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 134:555-70. 2011
  10. doi request reprint Homogeneity of active demyelinating lesions in established multiple sclerosis
    Esther C W Breij
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Ann Neurol 63:16-25. 2008

Collaborators

Detail Information

Publications46

  1. pmc Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
    Daphne Y S Vogel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechhorststraat 7, BT Amsterdam, 1081, The Netherlands
    J Neuroinflammation 10:35. 2013
    ..Stimulation of monocyte-derived macrophages in vitro with interferon-γ and lipopolysaccharide results in classically activated (CA/M1) macrophages, and activation with interleukin 4 induces alternatively activated (AA/M2) macrophages...
  2. pmc Receptor conversion in distant breast cancer metastases
    Laurien D C Hoefnagel
    Department of Pathology, University Medical Center Utrecht, The Netherlands
    Breast Cancer Res 12:R75. 2010
    ....
  3. doi request reprint Preactive lesions in multiple sclerosis
    Paul van der Valk
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Curr Opin Neurol 22:207-13. 2009
    ..This review highlights the accumulating evidence for early pathological changes we term 'preactive lesions', characterized by clusters of activated microglia in otherwise normal-appearing white matter...
  4. pmc Comparative genomic hybridisation divides retinoblastomas into a high and a low level chromosomal instability group
    J E van der Wal
    Department of Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Pathol 56:26-30. 2003
    ..Six cases were hereditary and seven cases were sporadic...
  5. pmc Russell bodies in a skin biopsy: a case report
    Joanne Verheij
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Med Case Reports 3:108. 2009
    ..The differential diagnosis of these eosinophilic structures include microorganisms such as histoplasmosis or cryptococcosis, fungi, Michaelis-Gutmann bodies, deposits of amyloid or immunoglobulins, colloid bodies or elastic bodies...
  6. pmc Gene expression in the rat brain: high similarity but unique differences between frontomedial-, temporal- and occipital cortex
    Christine Stansberg
    Dr E Martens Research Group for Biological Psychiatry, Department of Clinical Medicine, University of Bergen, Norway
    BMC Neurosci 12:15. 2011
    ..However, global gene expression seems to be almost identical across the cerebral cortex and only a few genes have so far been reported to show regional enrichment in specific cortical areas...
  7. doi request reprint Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex
    Maarten E Witte
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Neuropathol 125:231-43. 2013
    ..Taken together, our data indicate that reduced neuronal PGC-1α expression in MS cortex partly underlies mitochondrial dysfunction in MS grey matter and thereby contributes to neurodegeneration in MS cortex...
  8. ncbi request reprint Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis
    Catharina M P Vos
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurobiol Dis 20:953-60. 2005
    ..This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI...
  9. doi request reprint Adenosine triphosphate-binding cassette transporters mediate chemokine (C-C motif) ligand 2 secretion from reactive astrocytes: relevance to multiple sclerosis pathogenesis
    Gijs Kooij
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 134:555-70. 2011
    ....
  10. doi request reprint Homogeneity of active demyelinating lesions in established multiple sclerosis
    Esther C W Breij
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Ann Neurol 63:16-25. 2008
    ..The aim of this study was to determine whether lesion heterogeneity also exists in an unselected collection of autopsy material from patients with established MS...
  11. doi request reprint Enhanced number and activity of mitochondria in multiple sclerosis lesions
    Maarten E Witte
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 219:193-204. 2009
    ..Together, these findings support a mechanism whereby enhanced density of mitochondria in MS lesions might contribute to the formation of free radicals and subsequent tissue damage...
  12. ncbi request reprint Roles for HB-EGF and CD9 in multiple sclerosis
    Geert J Schenk
    Department of Anatomy and Neurosciences, Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, The Netherlands Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Glia 61:1890-905. 2013
    ..Together, we demonstrate that these molecules are likely implicated in processes that are highly relevant for MS lesion formation, and therefore, HB-EGF and TSPs are promising therapeutic targets...
  13. doi request reprint Imaging the tip of the iceberg: visualization of cortical lesions in multiple sclerosis
    Alexandra Seewann
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 17:1202-10. 2011
    ..Here, we investigated whether CLs that are visible on conventional MRI differ from MRI-invisible CLs in terms of underlying histopathology and quantitative MRI (qMRI) measures...
  14. doi request reprint Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Free Radic Biol Med 50:469-76. 2011
    ....
  15. ncbi request reprint Extensive hippocampal demyelination in multiple sclerosis
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 66:819-27. 2007
    ..Our results indicate that hippocampal demyelination is frequent and extensive in MS and that anatomical localization, size, and inflammatory activity vary for different lesion types...
  16. doi request reprint Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Free Radic Biol Med 49:1283-9. 2010
    ....
  17. pmc Oligodendrocyte-microglia cross-talk in the central nervous system
    Laura Peferoen
    Pathology Department, VU University Medical Centre, Amsterdam, The Netherlands
    Immunology 141:302-13. 2014
    ..Knowledge of the cross-talk between microglia and oligodendrocytes may continue to uncover novel pathways of immune regulation in the brain that could be further exploited to control neuroinflammation and degeneration...
  18. ncbi request reprint Cellular distribution of glucose and monocarboxylate transporters in human brain white matter and multiple sclerosis lesions
    Philip G Nijland
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 62:1125-41. 2014
    ....
  19. ncbi request reprint Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
    Lars Bö
    Department of Pathology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Arch Neurol 64:76-80. 2007
    ..Histopathologic studies have shown that subpial cortical demyelination is extensive in chronic multiple sclerosis (MS)...
  20. pmc Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology Neuropathology, VU University Medical Center, Van der Boechorststraat 7, 1081, BT, Amsterdam, The Netherlands
    J Neuroinflammation 9:156. 2012
    ..The aim of this study was to gain more insight into the frequency, distribution and cellular architecture of preactive lesions using a large cohort of well-characterized MS brain samples...
  21. doi request reprint Appearance of tissue transglutaminase in astrocytes in multiple sclerosis lesions: a role in cell adhesion and migration?
    Miriam E van Strien
    VU University Medical Center, Neuroscience Campus Amsterdam, Department of Anatomy and Neurosciences Pathology Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
    Brain Pathol 21:44-54. 2011
    ....
  22. pmc Cholinergic imbalance in the multiple sclerosis hippocampus
    Evert Jan Kooi
    Department of Pathology Neuropathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Acta Neuropathol 122:313-22. 2011
    ..Our findings reveal an MS-specific cholinergic imbalance in the hippocampus, which may be instrumental in terms of future treatment options for memory problems in this disease...
  23. ncbi request reprint Sphingosine 1-phosphate receptor 1 and 3 are upregulated in multiple sclerosis lesions
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 58:1465-76. 2010
    ..Results from this study indicate that astrocytes may act as a yet-unknown target within the CNS for the anti-inflammatory effects observed after FTY720P administration in the treatment of MS...
  24. pmc Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier
    Ruben van Doorn
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    J Neuroinflammation 9:133. 2012
    ..Here we demonstrate that the brain endothelial receptor S1P5 largely contributes to the maintenance of brain endothelial barrier function...
  25. ncbi request reprint Heterogeneity of cortical lesions in multiple sclerosis: clinical and pathologic implications
    Evert Jan Kooi
    Department of Pathology Neuropathology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:1369-76. 2012
    ..Here, we assessed the clinical significance of microglia activation in CLs in a large autopsy sample, and we investigated possible interrelationships with other pathologic characteristics...
  26. ncbi request reprint CX3CL1 and CX3CR1 expression in human brain tissue: noninflammatory control versus multiple sclerosis
    Sandra Hulshof
    Research Institute Neurosciences Amsterdam, VU University Medical Center, Department of Pathology, Division of Neuropathology, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 62:899-907. 2003
    ..Our data suggest that CX3CL1 has more general physiological functions, which occur also in the absence of proinflammatory conditions...
  27. ncbi request reprint CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation
    Babs O Fabriek
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    Glia 51:297-305. 2005
    ..Therefore PVM, which occupy a strategic location at the BBB, are equipped to recognize antigen and present it to T cells, supporting a role in the regulation of perivascular inflammation in the human CNS...
  28. doi request reprint Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis
    Evert Jan Kooi
    Departments of Pathology Neuropathology University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 68:1021-8. 2009
    ..In addition, no follicle-like structures were found in the MS samples. Our data suggest that the occurrence of cortical lesions is not related to the presence of meningeal inflammation in a large number of chronic MS patients...
  29. pmc Inflammation in neurodegenerative diseases--an update
    Sandra Amor
    Department of Pathology, VU University Medical Centre, Amsterdam, the Netherlands Neuroimmunology Unit, Blizard Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    Immunology 142:151-66. 2014
    ....
  30. ncbi request reprint Pathology of multiple sclerosis
    Markus Kipp
    Department of Pathology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    CNS Neurol Disord Drug Targets 11:506-17. 2012
    ..Here we review the latest findings from pathological studies of MS tissues and discuss the relevance of these findings for future therapeutic approaches...
  31. doi request reprint Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?
    Maarten E Witte
    Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Mitochondrion 10:411-8. 2010
    ..Here we describe the involvement of mitochondrial (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation...
  32. ncbi request reprint Remyelinated lesions in multiple sclerosis: magnetic resonance image appearance
    Frederik Barkhof
    Dutch MR MS Center, and Department of Radiology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Arch Neurol 60:1073-81. 2003
    ..Various types of pathologic mechanisms in multiple sclerosis (MS) can alter magnetic resonance imaging (MRI) signals, and the appearance of remyelinated lesions on MRI is largely unknown...
  33. doi request reprint Homing properties of adipose-derived stem cells to intracerebral glioma and the effects of adenovirus infection
    Martine Lamfers
    Department of Neurosurgery, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Cancer Lett 274:78-87. 2009
    ..These results indicate that ASCs are an interesting candidate for further development for cell-based therapy of gliomas, however adenoviruses are not appropriate vectors for delivery of transgenes in this context...
  34. pmc Pediatric meningiomas in The Netherlands 1974-2010: a descriptive epidemiological case study
    Nikki B Thuijs
    Neurosurgical Center Amsterdam, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Childs Nerv Syst 28:1009-15. 2012
    ..The purpose of this study was to review the epidemiology and the clinical, radiological, pathological, and follow-up data of all surgically treated pediatric meningiomas during the last 35 years in The Netherlands...
  35. pmc Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment
    Dannis G van Vuurden
    Department of Pediatric Oncology Hematology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e5953. 2009
    ..This commonly results in Na(+) and Ca(2+)-permeability and thereby in excitotoxic cell death of the surrounding neurons. Here we investigated how the GBM cells themselves survive in a glutamate-rich environment...
  36. doi request reprint Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions
    Maarten E Witte
    Department of Pathology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 36:445-52. 2009
    ..Our data indicate that parkin is upregulated in AD and MS brain tissue and might represent a defense mechanism to counteract stress-induced damage in AD and MS pathogenesis...
  37. ncbi request reprint Retinoblastoma: MR imaging parameters in detection of tumor extent
    Pim de Graaf
    Department of Radiology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Radiology 235:197-207. 2005
    ..To assess diagnostic accuracy of preoperatively performed magnetic resonance (MR) imaging for detection of tumor extent in a large patient population with histopathologically proved retinoblastoma...
  38. pmc Inflammation in neurodegenerative diseases
    Sandra Amor
    Department of Pathology, VU University Medical Centre De Boelelaan, Amsterdam, The Netherlands
    Immunology 129:154-69. 2010
    ....
  39. ncbi request reprint Matrix metalloproteinase-12 is expressed in phagocytotic macrophages in active multiple sclerosis lesions
    Catharina M P Vos
    Department of Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    J Neuroimmunol 138:106-14. 2003
    ..A lower proportion of phagocytes was positive for MMP-12 in chronic active demyelinating lesions and inactive lesions. This suggests a role for MMP-12 during demyelination in MS...
  40. doi request reprint T lymphocytes impair P-glycoprotein function during neuroinflammation
    Gijs Kooij
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Autoimmun 34:416-25. 2010
    ..Loss of vascular P-gp function during neuroinflammation may disturb brain homeostasis and thereby aggravate disease progression via exposure of vulnerable CNS cells to detrimental compounds...
  41. ncbi request reprint Cellular localization and expression patterns of interleukin-10, interleukin-4, and their receptors in multiple sclerosis lesions
    Sandra Hulshof
    Research Institute Neurosciences Amsterdam, VU University Medical Center, Department of Pathology, Division of Neuropathology, Amsterdam, The Netherlands
    Glia 38:24-35. 2002
    ....
  42. ncbi request reprint The pathology of multiple sclerosis is location-dependent: no significant complement activation is detected in purely cortical lesions
    Bianca P Brink
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 64:147-55. 2005
    ..In contrast, in the purely cortical lesions, the extent of complement deposition in general was low. In conclusion, the role of complement in MS pathogenesis seems lesion location-dependent...
  43. ncbi request reprint Differential effects of combined Ad5- delta 24RGD and radiation therapy in in vitro versus in vivo models of malignant glioma
    Martine L M Lamfers
    Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 13:7451-8. 2007
    ..c. glioma xenografts. In the current study, the underlying mechanism of action to this synergy was studied and the effects of combined therapy were assessed in an orthotopic glioma model...
  44. ncbi request reprint Diffuse signal abnormalities in the spinal cord in multiple sclerosis: direct postmortem in situ magnetic resonance imaging correlated with in vitro high-resolution magnetic resonance imaging and histopathology
    Elisabeth Bergers
    Department of Radiology, VU Medical Center, Amsterdam, The Netherlands
    Ann Neurol 51:652-6. 2002
    ....
  45. ncbi request reprint Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme
    Peter Sminia
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Cancer Res Clin Oncol 131:653-61. 2005
    ..The relationship between COX-2 and epidermal growth factor receptor (EGFR) immunoreactivities was evaluated...
  46. ncbi request reprint Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain
    Eleonora Aronica
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Epilepsia 46:849-57. 2005
    ..This study investigated the expression and cellular distribution of BCRP in human control and epileptic brain, including a large number of both neoplastic and nonneoplastic specimens from patients with chronic pharmacoresistant epilepsy...