Melanie van der Heijden

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi request reprint Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients
    M Van Der Heijden
    Department of Physiology, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Thorax 63:903-9. 2008
  2. ncbi request reprint The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury
    Melanie van der Heijden
    VU University Medical Center, Institute for Cardiovascular Research, Department of Intensive Care, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Expert Opin Ther Targets 13:39-53. 2009
  3. doi request reprint Crystalloid or colloid fluid loading and pulmonary permeability, edema, and injury in septic and nonseptic critically ill patients with hypovolemia
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Crit Care Med 37:1275-81. 2009
  4. doi request reprint Extravascular lung water to blood volume ratios as measures of pulmonary capillary permeability in nonseptic critically ill patients
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Crit Care 25:16-22. 2010
  5. doi request reprint The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Shock 33:263-8. 2010
  6. pmc Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality
    Melanie van der Heijden
    Department of Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    Intensive Care Med 35:1567-74. 2009
  7. pmc Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis
    Melanie van der Heijden
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Apoptosis 13:404-12. 2008
  8. pmc Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 6:e23448. 2011
  9. doi request reprint Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome
    Jurjan Aman
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
    Crit Care Med 39:89-97. 2011

Detail Information

Publications9

  1. doi request reprint Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients
    M Van Der Heijden
    Department of Physiology, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Thorax 63:903-9. 2008
    ..It was hypothesised that circulating angiopoietin-2 is associated with pulmonary permeability oedema and severity of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) during septic or non-septic critical illness...
  2. ncbi request reprint The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury
    Melanie van der Heijden
    VU University Medical Center, Institute for Cardiovascular Research, Department of Intensive Care, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Expert Opin Ther Targets 13:39-53. 2009
    ..Amongst other factors, the angiopoietin-tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (Tie2) system is involved...
  3. doi request reprint Crystalloid or colloid fluid loading and pulmonary permeability, edema, and injury in septic and nonseptic critically ill patients with hypovolemia
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Crit Care Med 37:1275-81. 2009
    ..We hypothesized that 1) crystalloid loading results in more edema formation than colloid loading and 2) the differences among the types of fluid decreases at high permeability...
  4. doi request reprint Extravascular lung water to blood volume ratios as measures of pulmonary capillary permeability in nonseptic critically ill patients
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Crit Care 25:16-22. 2010
    ....
  5. doi request reprint The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Shock 33:263-8. 2010
    ..However, this shedding may not prevent a direct role of Angs in pulmonary vascular permeability...
  6. pmc Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality
    Melanie van der Heijden
    Department of Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    Intensive Care Med 35:1567-74. 2009
    ....
  7. pmc Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis
    Melanie van der Heijden
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Apoptosis 13:404-12. 2008
    ..68, P < 0.05). In conclusion, prevention of F-actin rearrangement by Rho-kinase inhibition or by cytochalasinD treatment attenuated I/R-induced endothelial cell apoptosis by maintaining PI3-kinase and Akt activity...
  8. pmc Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells
    Melanie van der Heijden
    Department of Intensive Care, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
    PLoS ONE 6:e23448. 2011
    ....
  9. doi request reprint Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome
    Jurjan Aman
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Centre, Amsterdam, The Netherlands
    Crit Care Med 39:89-97. 2011
    ..We hypothesized that plasma protein levels predict increased vascular permeability and acute respiratory distress syndrome...