Research Topics
Genomes and Genes
| Marjo S van der KnaapSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
MLC1 is associated with the dystrophin-glycoprotein complex at astrocytic endfeetIlja Boor
Department of Pediatrics Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Acta Neuropathol 114:403-10. 2007..We demonstrated a direct protein interaction between MLC1 and Kir4.1. From these results we conclude that MLC1 is associated with the DGC at astrocytic endfeet...
Hyaluronan accumulation and arrested oligodendrocyte progenitor maturation in vanishing white matter diseaseMarianna Bugiani
Department of Child Neurology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Brain 136:209-22. 2013....- Megalencephalic leukoencephalopathy with subcortical cysts: chronic white matter oedema due to a defect in brain ion and water homoeostasisMarjo S van der Knaap
Department of Pediatrics Child Neurology, VU University Medical Centre, Amsterdam, Netherlands Electronic address
Lancet Neurol 11:973-85. 2012..An understanding of the mechanisms of white matter oedema in MLC is emerging. Further insight into the specific function of MLC1 is necessary to find treatment targets... - Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutationsMarjan E Steenweg
VU University Medical Centre, De Boelelaan 1117, Amsterdam, The Netherlands
Brain 135:1387-94. 2012.... - MRI as diagnostic tool in early-onset peroxisomal disordersM S van der Knaap
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Neurology 78:1304-8. 2012..Brain MRI showed typical abnormalities as observed in the neonatal adrenoleukodystrophy variant of infantile peroxisomal disorders. Our aim was to evaluate the accuracy of this MRI diagnosis with further peroxisomal testing... - Cerebellar leukoencephalopathy: most likely histiocytosis-relatedM S van der Knaap
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Neurology 71:1361-7. 2008..We discovered similar MRI abnormalities in 13 patients and wondered whether they could have the same syndrome... - Megalencephalic leukoencephalopathy with cysts without MLC1 defectMarjo S van der Knaap
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Ann Neurol 67:834-7. 2010..They lacked motor decline. Five had normal intelligence; 3 displayed cognitive deficiency. In conclusion, 2 phenotypes can be distinguished among the non-MLC1 mutated MLC patients: a classical and a benign phenotype... 
Alexander disease: ventricular garlands and abnormalities of the medulla and spinal cordM S van der Knaap
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Neurology 66:494-8. 2006..The disease is caused by mutation of the GFAP gene. Clinical and MRI phenotypic variation have been increasingly recognized...- Neonatal porencephaly and adult stroke related to mutations in collagen IV A1Marjo S van der Knaap
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Ann Neurol 59:504-11. 2006..The objective of this study was to describe leukoencephalopathy, lacunar infarcts, microbleeds and macrobleeds in the context of a collagen IV A1 mutation... - Hypomyelination with atrophy of the basal ganglia and cerebellum: follow-up and pathologyM S van der Knaap
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Neurology 69:166-71. 2007..Only a few patients have been described. We report on 11 additional patients and new MRI findings and provide histopathologic confirmation of the MRI interpretation... - Unusual variants of Alexander's diseaseMarjo S van der Knaap
Department of Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Ann Neurol 57:327-38. 2005..In conclusion, DNA diagnostics is warranted in patients who display MRI features suggestive of Alexander's disease, even if they do not meet the full set of previously established MRI criteria... - Vanishing white matter diseaseMarjo S van der Knaap
Department of Pediatrics and Child Neurology, VU University Medical Center, Amsterdam, Netherlands
Lancet Neurol 5:413-23. 2006..Recently, undue activation of the unfolded-protein response has emerged as important in the pathophysiology of VWM, but the selective vulnerability of glia for defects in eIF2B is poorly understood... - A new leukoencephalopathy with brainstem and spinal cord involvement and high lactateMarjo S van der Knaap
Department of Child Neurology, Free University Medical Center, Amsterdam, The Netherlands
Ann Neurol 53:252-8. 2003..The uniform, highly characteristic magnetic resonance imaging pattern and the similarities in clinical and magnetic resonance spectroscopy findings provide evidence for a new disease entity. Autosomal recessive inheritance is likely... - Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matterMarjo S van der Knaap
Department of Child Neurology, Free University Medical Center, Amsterdam, The Netherlands
Ann Neurol 51:264-70. 2002..A defect in eIF2B may explain the sensitivity to stress factors in vanishing white matter patients... - Arg113His mutation in eIF2Bepsilon as cause of leukoencephalopathy in adultsM S van der Knaap
Department of Child Neurology, Free University Medical Center, Amsterdam, The Netherlands
Neurology 62:1598-600. 2004.... 
eIF2B-related disorders: antenatal onset and involvement of multiple organsMarjo S van der Knaap
Department of Child Neurology, Free University Medical Center, Amsterdam, The Netherlands
Am J Hum Genet 73:1199-207. 2003....- Glia-specific activation of all pathways of the unfolded protein response in vanishing white matter diseaseBarbara Van Kollenburg
Department of Pediatrics/Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 65:707-15. 2006..The selective involvement of these cells suggests that inappropriate UPR activation may play a key role in the pathophysiology of VWM... - Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation is associated with cell-type-dependent splicing of mtAspRS mRNALaura van Berge
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Biochem J 441:955-62. 2012..The combined result of these two effects may explain the selective vulnerability of specific white matter tracts in LBSL patients... - MLC1: a novel protein in distal astroglial processesP K Ilja Boor
Department of Pediatrics Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 64:412-9. 2005..Elucidation of the function of MLC1 will contribute to a better understanding of not only the pathophysiology of the disease, but also the role of astrocytes in normal neural tissue... - Childhood white matter disorders: quantitative MR imaging and spectroscopyJ Patrick van der Voorn
Department of Child Neurology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
Radiology 241:510-7. 2006.... - Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1P K Ilja Boor
Department of Pediatrics Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Hum Mutat 27:505-12. 2006..Therefore, we suggest extended mutation analysis for the MLC1 gene, if no mutations are found during standard analysis... - The unfolded protein response in vanishing white matter diseaseJ Patrick van der Voorn
Department of Pediatrics Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 64:770-5. 2005..We demonstrate activation of the UPR in glia of patients with VWM. Our findings may point to a possible explanation for the dysmorphic glia, the increased numbers of oligodendrocytes, and the apoptotic loss of oligodendrocytes in VWM... - Unraveling pathology in juvenile Alexander disease: serial quantitative MR imaging and spectroscopy of white matterJ Patrick van der Voorn
Department of Child Neurology, VU University Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
Neuroradiology 51:669-75. 2009.... - Quantification of sugar phosphate intermediates of the pentose phosphate pathway by LC-MS/MS: application to two new inherited defects of metabolismMirjam M C Wamelink
Metabolic Unit of the Department of Clinical Chemistry, VU University Medical Centre, Amsterdam, The Netherlands
J Chromatogr B Analyt Technol Biomed Life Sci 823:18-25. 2005.... - Regulation of protein synthesis in lymphoblasts from vanishing white matter patientsBarbara Van Kollenburg
Dept. of Pediatrics/Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Neurobiol Dis 21:496-504. 2006..These findings could form part of the explanation for the episodes of rapid and severe deterioration in VWM patients that are precipitated by febrile infections... - Leucoencephalopathy with brainstem and spinal cord involvement and high lactate: quantitative magnetic resonance imagingMarianne E Steenweg
Department of Child Neurology, VU University Medical Centre, 1081 HV Amsterdam, The Netherlands
Brain 134:3333-41. 2011..We hypothesize that it is loss of water rather than structural restoration that causes the change in T(2) signal intensity, which would be in better agreement with the slow clinical deterioration... - Long-term follow-up and treatment in nine boys with X-linked creatine transporter defectJiddeke M van de Kamp
Department of Clinical Genetics, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
J Inherit Metab Dis 35:141-9. 2012..After an initial improvement in locomotor and personal-social IQ subscales, no lasting clinical improvement was recorded. Additionally, we noticed an age-related decline in IQ subscales in boys affected with the CRTR defect... - Magnetic resonance imaging pattern recognition in hypomyelinating disordersMarjan E Steenweg
Department of Child Neurology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
Brain 133:2971-82. 2010.... - New syndrome characterized by hypomyelination with atrophy of the basal ganglia and cerebellumMarjo S van der Knaap
Department of Child Neurology, Free University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
AJNR Am J Neuroradiol 23:1466-74. 2002..The acronym H-ABC is offered to indicate patients sharing these clinical and MR imaging features... - Restricted diffusion in vanishing white matterHannemieke D W van der Lei
Departments of Pediatrics Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Arch Neurol 69:723-7. 2012..To investigate the occurrence of restricted diffusion in vanishing white matter, the affected structures,the time of occurrence in the disease course, and the histopathologic correlate... - Defective translation initiation causes vanishing of cerebral white matterGert C Scheper
Department of Pediatrics, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
Trends Mol Med 12:159-66. 2006..Here, we discuss the mechanisms that might be responsible for the selective involvement of the brain white matter in VWM. At present, VWM research is in need of an animal model to study disease mechanisms and therapeutic interventions... - Histopathologic correlates of radial stripes on MR images in lysosomal storage disordersJ Patrick van der Voorn
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
AJNR Am J Neuroradiol 26:442-6. 2005..CONCLUSION: Results of our postmortem study showed that radial stripes of white matter on MR images represented relative myelin sparing in some lysosomal storage disorders, but they may also represent lipid storage... - Vanishing white matter disease: a review with focus on its geneticsJan C Pronk
Department of Human Genetics, VU University Medical Center, Amsterdam, The Netherlands
Ment Retard Dev Disabil Res Rev 12:123-8. 2006..The pathophysiology of the disease is still poorly understood... - Defective glial maturation in vanishing white matter diseaseMarianna Bugiani
Department of Pediatrics Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 70:69-82. 2011..We also demonstrated a significant increase in numbers of premyelinating oligodendrocyte progenitors in VWM, which may explain the coexistence of oligodendrocytosis and myelin paucity in the patients' white matter... - Leukoencephalopathy with vanishing white matter: a reviewMarianna Bugiani
Departments of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands
J Neuropathol Exp Neurol 69:987-96. 2010..In view of the fact that VWM genes are housekeeping genes, it is surprising that the disease is primarily a leukoencephalopathy. The pathophysiology of selective glial vulnerability in VWM remains poorly understood... - Megalencephalic leucoencephalopathy with cysts: defect in chloride currents and cell volume regulationMargreet C Ridder
Department of Child Neurology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
Brain 134:3342-54. 2011.... - Novel infantile-onset leukoencephalopathy with high lactate level and slow improvementMarjan E Steenweg
Departments of Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Arch Neurol 69:718-22. 2012..To describe a novel pattern of magnetic resonance imaging (MRI) abnormalities as well as the associated clinical and laboratory findings... - Evaluation of pentitol metabolism in mammalian tissues provides new insight into disorders of human sugar metabolismJojanneke H J Huck
Department of Child Neurology, VU University Medical Centre, Amsterdam, The Netherlands
Mol Genet Metab 82:231-7. 2004..3 to 6.1 pmol NADH/min/microl erythrocytes observed using sorbitol and xylitol. Our results indicate that ribitol and arabitol are metabolic end products in humans... - Progress in understanding 2-hydroxyglutaric aciduriasMartijn Kranendijk
Metabolic Unit Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
J Inherit Metab Dis 35:571-87. 2012.... - Translation matters: protein synthesis defects in inherited diseaseGert C Scheper
Department of Child Neurology Center for Neurogenomics and Cognitive Research, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands
Nat Rev Genet 8:711-23. 2007..Given the numerous proteins involved in mRNA translation, it is likely that further inherited diseases will turn out to be caused by mutations in genes that are involved in this complex process... - Ribose-5-phosphate isomerase deficiency: new inborn error in the pentose phosphate pathway associated with a slowly progressive leukoencephalopathyJojanneke H J Huck
Department of Child Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Am J Hum Genet 74:745-51. 2004..RPI is the second known inborn error in the reversible phase of the PPP, confirming that defects in pentose and polyol metabolism constitute a new area of inborn metabolic disorders... - Detection of low-level somatic and germline mosaicism by denaturing high-performance liquid chromatography in a EURO-MRX family with SLC6A8 deficiencyOfir T Betsalel
Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Neurogenetics 9:183-90. 2008..This study indicates DHPLC as an important tool in the detection of low-level mosaicism, as does it illustrate the importance of considering somatic and germline mosaicism in the case of apparent de novo mutation... - Leukoencephalopathy with vanishing white matter: from magnetic resonance imaging pattern to five genesPeter A J Leegwater
Department of Child Neurology, Free University Medical Center, Amsterdam, The Netherlands
J Child Neurol 18:639-45. 2003..This gene encodes one of the five subunits of the translation factor eIF2B. Patients without mutations in the EIF2B5 gene were found to be mutated in one of the other genes that encode eIF2B subunits: EIF2B1 to EIF2B4... - Analysis of CLCN2 as candidate gene for megalencephalic leukoencephalopathy with subcortical cystsGert C Scheper
Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands
Genet Test Mol Biomarkers 14:255-7. 2010..Further, in electrophysiological experiments, one of the observed amino acid changes was shown to have no effect on the ClC-2-mediated currents. In conclusion, we found no evidence suggesting that the CLCN2 gene is involved in MLC... - Pathogenic mutations causing LBSL affect mitochondrial aspartyl-tRNA synthetase in diverse waysLaura van Berge
Department of Child Neurology, VU University Medical Center, De Boelalaan 1117, 1081 HV Amsterdam, The Netherlands
Biochem J 450:345-50. 2013..Most mutations have a clear impact on at least one of the properties of mtAspRS studied, probably resulting in a small contribution of the missense variants to the mitochondrial aspartylation activity in the cell... - Novel hypomyelinating leukoencephalopathy affecting early myelinating structuresMarjan E Steenweg
Department of Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Arch Neurol 69:125-8. 2012..To describe 4 children with a novel hypomyelinating leukoencephalopathy, defined by a distinct pattern of magnetic resonance imaging (MRI) abnormalities... - IDH2 mutations in patients with D-2-hydroxyglutaric aciduriaMartijn Kranendijk
Metabolic Unit, Department of Clinical Chemistry, VU University Medical Center, 1081 HV Amsterdam, Netherlands
Science 330:336. 2010..These findings provide additional impetus for investigating the role of D-2-HG in the pathophysiology of metabolic disease and cancer... - Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevationGert C Scheper
Department of Pediatrics and Child Neurology, Vrije University Medical Center, 1081 HV Amsterdam, The Netherlands
Nat Genet 39:534-9. 2007..Enzyme activities of mutant proteins were decreased. We were surprised to find that activities of mitochondrial complexes from fibroblasts and lymphoblasts derived from affected individuals were normal, as determined by different assays... - L-2-Hydroxyglutaric aciduria: pattern of MR imaging abnormalities in 56 patientsMarjan E Steenweg
Dept of Child Neurology, VU Univ Medical Ctr, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Radiology 251:856-65. 2009..To describe the pattern of magnetic resonance (MR) imaging abnormalities in l-2-hydroxyglutaric aciduria (L2HGA) and to evaluate the correlation between imaging abnormalities and disease duration... - Effectiveness of selective dorsal rhizotomy in 2 patients with progressive spasticity due to neurodegenerative diseaseSebastian Grunt
Department of Rehabilitation Medicine, VU University Medical Center, Amsterdam, The Netherlands
J Child Neurol 23:818-22. 2008..Selective dorsal rhizotomy leads to a disappearance of leg spasticity in patients with a neurodegenerative disease. Other motor signs are not influenced and may increase due to the progressive nature of the underlying disease... - Fright is a provoking factor in vanishing white matter diseaseGerre Vermeulen
Department of Pediatrics/Child Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Ann Neurol 57:560-3. 2005..These episodes typically are provoked by febrile infections or minor head trauma. We report on two patients who experienced an episode of rapid neurological deterioration after a fright... - Enzyme assay for diagnosis of guanidinoacetate methyltransferase deficiencyNanda M Verhoeven
Department of Child Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Clin Chem 50:441-3. 2004 - Characteristics of early MRI in children and adolescents with vanishing white matterHannemieke D van der Lei
Department of Child Neurology, VU University Medical Center, Amsterdam, The Netherlands
Neuropediatrics 43:22-6. 2012..MRI in vanishing white matter typically shows diffuse abnormality of the cerebral white matter, which becomes increasingly rarefied and cystic. We investigated the MRI characteristics preceding this stage... - Pattern of white matter abnormalities at MR imaging: use of polymerase chain reaction testing of Guthrie cards to link pattern with congenital cytomegalovirus infectionMarjo S van der Knaap
Department of Child Neurology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Radiology 230:529-36. 2004..To define a magnetic resonance (MR) imaging pattern suggestive of congenital cytomegalovirus (CMV) infection by using polymerase chain reaction (PCR) testing to detect CMV DNA in neonatal blood on Guthrie cards for validation... - The leukoencephalopathy of infantile GM1 gangliosidosis: oligodendrocytic loss and axonal dysfunctionJ Patrick van der Voorn
Department of Pathology, Vrije Universiteit Medical Center, DeBoelelaan 1117, 1007 MB, Amsterdam, The Netherlands
Acta Neuropathol 107:539-45. 2004..These data suggest that the myelin deficit results from a loss of oligodendrocytes and abnormal axoplasmic transport, perhaps consequent to massive neuronal storage of GM1... - An overview of L-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype studyMarjan E Steenweg
Department of Child Neurology and VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
Hum Mutat 31:380-90. 2010..nl/L2HGDH). Every user can access the database and submit variants/patients. Furthermore, we report on the phenotype, including neurological manifestations and urinary levels of L2HG, and we evaluate the phenotype-genotype relationship... - Independent component analysis to proton spectroscopic imaging data of human brain tumoursJ Pulkkinen
Department of Biomedical NMR, A.I. Virtanen Institute, University of Kuopio, Finland
Eur J Radiol 56:160-4. 2005..To this end, 10 controls and 34 patients with primary brain tumours were studied. The results indicate that ICA may reveal useful information from metabolic profiling for clinical purposes using long echo time MRSI of gliomas... - Do carriers of POLG mutation W748S have disease manifestations?M Rantamaki
Department of Physical Medicine and Rehabilitation, Seinajoki Central Hospital, Seinajoki, Finland
Clin Genet 72:532-7. 2007..In conclusion, W748S heterozygotes showed no clinically manifesting phenotype... - A distinct phenotype of distal myopathy in a large Finnish familyI Mahjneh
Department of Neurology, Oulu University Hospital, Finland
Neurology 61:87-92. 2003..The authors carried out clinical, histopathologic, immunocytochemical, electrophysiologic, and imaging investigations and molecular genetic analysis in seven patients with distal myopathy belonging to a Finnish family... - Pathology of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutationT Tyni
Department of Child Neurology, Children s Hospital, University of Helsinki, Finland
Pediatr Pathol Lab Med 17:427-47. 1997..The uniform pattern of histopathologic changes facilitates the diagnostics in this severe disorder, allowing opportunities for therapy and prenatal diagnosis... - Cerebral amyloid angiopathy in a 95+ cohort: complement activation and apolipoprotein E (ApoE) genotypeM Tanskanen
Department of Pathology, University of Helsinki, Helsinki University Central Hospital, Finland
Neuropathol Appl Neurobiol 31:589-99. 2005..Our results demonstrate a strong association between CAA and ApoE epsilon4 as well as dementia and suggest that the contribution of CAA to dementia is largely independent of ApoE epsilon4... - Peroxiredoxins and antioxidant enzymes in pilocytic astrocytomasK Nordfors
Department of Pathology, Center for Laboratory Medicine, Tampere University Hospital, P O Box 2000, 33521 Tampere, Finland
Clin Neuropathol 26:210-8. 2007..In this study, their biology and clinical significance were examined in pilocytic astrocytomas (PAs)... - Cerebroretinal microangiopathy with calcifications and cystsT Linnankivi
Department of Pediatric Neurology, Hospital for Children and Adolescents, University of Helsinki, Stenbackinkatu 11, FIN 00290 Helsinki, Finland
Neurology 67:1437-43. 2006.... - Ezrin expression in tissue microarray of primary and recurrent gliomasO Tynninen
Department of Pathology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Neuropathol Appl Neurobiol 30:472-7. 2004..05). However, ezrin was not an independent prognostic factor. The results of this study show that ezrin expression is associated with progression of gliomas and correlates with histological cell type and WHO tumour grade... - Evolution of cerebral tumor necrosis factor-alpha production during human ischemic strokeT Sairanen
Department of Clinical Neurosciences, Helsinki University Central Hospital, University of Western Ontario, London, Ontario, Canada
Stroke 32:1750-8. 2001..CONCLUSIONS: The data support the hypothesis that TNF-alpha may be involved both in the acute propagation of inflammatory processes and cell death and possibly in the more delayed reconstitutive processes of human ischemic stroke... - Variant Alzheimer disease with spastic paraparesis: neuropathological phenotypeA Verkkoniemi
Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Finland
J Neuropathol Exp Neurol 60:483-92. 2001.... - High expression of stanniocalcin in differentiated brain neuronsK Z Zhang
Department of Pathology, Haartman Institute, University of Helsinki, Finland
Am J Pathol 153:439-45. 1998..Given that STC has been found to regulate calcium/phosphate metabolism in some mammalian epithelia, we suggest that STC may act as a regulator of calcium homeostasis in terminally differentiated brain neurons...