Nelleke Tolboom

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:1464-70. 2009
  2. doi Longitudinal amyloid imaging using 11C-PiB: methodologic considerations
    Bart N M van Berckel
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:1570-6. 2013
  3. doi Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:191-7. 2009
  4. pmc Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:1629-38. 2009
  5. doi Dementia mimicking Alzheimer's disease Owing to a tau mutation: CSF and PET findings
    Nelleke Tolboom
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 24:303-7. 2010
  6. doi Simplified parametric methods for [11C]PIB studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 42:76-86. 2008
  7. doi Peripheral metabolism of [(18)F]FDDNP and cerebral uptake of its labelled metabolites
    Gert Luurtsema
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Nucl Med Biol 35:869-74. 2008
  8. pmc Evaluation of tracer kinetic models for analysis of [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Mol Imaging Biol 11:322-33. 2009
  9. doi Simplified parametric methods for [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Neuroimage 49:433-41. 2010
  10. ncbi Amyloid and its association with default network integrity in Alzheimer's disease
    Sofie M Adriaanse
    Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 35:779-91. 2014

Collaborators

Detail Information

Publications15

  1. doi Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:1464-70. 2009
    ....
  2. doi Longitudinal amyloid imaging using 11C-PiB: methodologic considerations
    Bart N M van Berckel
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:1570-6. 2013
    ..Several methods are in use for analyzing (11)C-Pittsburgh compound-B ((11)C-PiB) data. The objective of this study was to identify the method of choice for measuring longitudinal changes in specific (11)C-PiB binding...
  3. doi Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Nucl Med 50:191-7. 2009
    ..The purpose of this study was to directly compare these tracers in patients with AD, patients with mild cognitive impairment (MCI), and healthy controls...
  4. pmc Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease
    Nelleke Tolboom
    Departments of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:1629-38. 2009
    ....
  5. doi Dementia mimicking Alzheimer's disease Owing to a tau mutation: CSF and PET findings
    Nelleke Tolboom
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Alzheimer Dis Assoc Disord 24:303-7. 2010
    ..This, in combination with elevated levels of CSF t-tau and p-tau, has potential value in differential diagnosis of frontotemporal dementia from AD...
  6. doi Simplified parametric methods for [11C]PIB studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 42:76-86. 2008
    ..RPM2 and MRTM2 also provided best accuracy and precision in the simulation studies and are therefore the methods of choice for parametric analysis of clinical [11C]PIB studies...
  7. doi Peripheral metabolism of [(18)F]FDDNP and cerebral uptake of its labelled metabolites
    Gert Luurtsema
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Nucl Med Biol 35:869-74. 2008
    ..These labelled metabolites were reproduced in vitro using human hepatocytes. PET studies in rats showed that these polar metabolites can penetrate the blood-brain barrier and result in uniform brain uptake...
  8. pmc Evaluation of tracer kinetic models for analysis of [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Mol Imaging Biol 11:322-33. 2009
    ..Different pharmacokinetic methods for [18F]FDDNP studies were evaluated using both simulations and clinical data...
  9. doi Simplified parametric methods for [18F]FDDNP studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Neuroimage 49:433-41. 2010
    ..Furthermore, in simulations, RPM2 and MRTM2 provided the most accurate and precise BP(ND) estimates. RPM2 and MRTM2 are the methods of choice for parametric analysis of [(18)F]FDDNP studies...
  10. ncbi Amyloid and its association with default network integrity in Alzheimer's disease
    Sofie M Adriaanse
    Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 35:779-91. 2014
    ..Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779-791, 2014. © 2012 Wiley Periodicals, Inc. ..
  11. ncbi The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease
    Sofie M Adriaanse
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 41:1190-8. 2014
    ..The present multimodal neuroimaging study examined whether amyloid pathology and glucose metabolism are related to cortical volume loss over time in Alzheimer's disease (AD) patients and healthy elderly controls...
  12. ncbi [Amyloid-plaque imaging of the brain using PET]
    Rik Ossenkoppele
    VU Medisch Centrum, Afd Nucleaire Geneeskunde and PET Research, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A2981. 2011
    ..In the future, amyloid imaging could also be useful for selecting patients for clinical trials and in evaluating the effects of disease modifying agents tailored at lowering Aβ burden...
  13. doi Molecular imaging in the diagnosis of Alzheimer's disease: visual assessment of [11C]PIB and [18F]FDDNP PET images
    Nelleke Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 81:882-4. 2010
    ..To evaluate visual assessment of [(11)C]PIB and [(18)F]FDDNP PET images as potential supportive diagnostic markers for Alzheimer's disease (AD)...
  14. doi Resting-state fMRI changes in Alzheimer's disease and mild cognitive impairment
    Maja A A Binnewijzend
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 33:2018-28. 2012
    ..Correlation with cognitive dysfunction demonstrated the clinical relevance of FC changes within the DMN. In conclusion, clinically relevant decreased FC within the DMN was observed in AD...
  15. doi Blood-brain barrier P-glycoprotein function in Alzheimer's disease
    Daniëlle M E van Assema
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 135:181-9. 2012
    ....