Erik Thunnissen

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Molecular sputum analysis for the diagnosis of lung cancer
    A J Hubers
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Br J Cancer 109:530-7. 2013
  2. ncbi Prognostic and predictive biomarkers in lung cancer. A review
    Erik Thunnissen
    Departments of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Virchows Arch 464:347-58. 2014
  3. pmc A new brace treatment similar for adolescent scoliosis and kyphosis based on restoration of thoracolumbar lordosis. Radiological and subjective clinical results after at least one year of treatment
    Piet Jm van Loon
    Department Orthopaedic Surgery, Gelre Ziekenhuizen Apeldoorn, Albert Schweitzerlaan 31, 7300, DS, Apeldoorn, The Netherlands
    Scoliosis 7:19. 2012
  4. doi Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study
    Erik Thunnissen
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Mod Pathol 25:1574-83. 2012
  5. doi Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma
    Erik Thunnissen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Virchows Arch 461:629-38. 2012
  6. pmc EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations
    Erik Thunnissen
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Virchows Arch 461:245-57. 2012
  7. doi The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group
    Erik Thunnissen
    Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Lung Cancer 76:1-18. 2012
  8. doi Smoking history and lung carcinoma: KRAS mutation is an early hit in lung adenocarcinoma development
    F B Thunnissen
    Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands
    Lung Cancer 75:156-60. 2012
  9. doi EGFR and KRAS quality assurance schemes in pathology: generating normative data for molecular predictive marker analysis in targeted therapy
    Erik Thunnissen
    Department of Pathology, Vrije Universteit Medical Centre, Amsterdam, The Netherlands
    J Clin Pathol 64:884-92. 2011
  10. ncbi EU-USA pathology panel for uniform diagnosis in randomised controlled trials for HRCT screening in lung cancer
    F B Thunnissen
    Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Eur Respir J 28:1186-9. 2006

Detail Information

Publications25

  1. pmc Molecular sputum analysis for the diagnosis of lung cancer
    A J Hubers
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Br J Cancer 109:530-7. 2013
    ..The sputum shows a promising potential for routine diagnostic and possibly screening purposes. ..
  2. ncbi Prognostic and predictive biomarkers in lung cancer. A review
    Erik Thunnissen
    Departments of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Virchows Arch 464:347-58. 2014
    ..Mutation analysis as a basis for treatment choice can have an impressive clinical impact with dramatic responses. However, as yet the impact of these approaches to overall survival is less striking...
  3. pmc A new brace treatment similar for adolescent scoliosis and kyphosis based on restoration of thoracolumbar lordosis. Radiological and subjective clinical results after at least one year of treatment
    Piet Jm van Loon
    Department Orthopaedic Surgery, Gelre Ziekenhuizen Apeldoorn, Albert Schweitzerlaan 31, 7300, DS, Apeldoorn, The Netherlands
    Scoliosis 7:19. 2012
    ..abstract:..
  4. doi Reproducibility of histopathological subtypes and invasion in pulmonary adenocarcinoma. An international interobserver study
    Erik Thunnissen
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Mod Pathol 25:1574-83. 2012
    ..However, more precise definitions and better education on interpretation of existing terminology are required to improve recognition of purely in-situ disease, this being an area of increasing importance...
  5. doi Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma
    Erik Thunnissen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Virchows Arch 461:629-38. 2012
    ..In the diagnostic work-up of non-small cell lung carcinoma the limited reproducibility on small biopsies is optimized with immunohistochemical analysis, resulting in reliable delineation for predictive analysis...
  6. pmc EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations
    Erik Thunnissen
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Virchows Arch 461:245-57. 2012
    ....
  7. doi The challenge of NSCLC diagnosis and predictive analysis on small samples. Practical approach of a working group
    Erik Thunnissen
    Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Lung Cancer 76:1-18. 2012
    ....
  8. doi Smoking history and lung carcinoma: KRAS mutation is an early hit in lung adenocarcinoma development
    F B Thunnissen
    Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands
    Lung Cancer 75:156-60. 2012
    ..The aim of this study was to compare KRAS mutation analysis with smoking status at the time of diagnosis...
  9. doi EGFR and KRAS quality assurance schemes in pathology: generating normative data for molecular predictive marker analysis in targeted therapy
    Erik Thunnissen
    Department of Pathology, Vrije Universteit Medical Centre, Amsterdam, The Netherlands
    J Clin Pathol 64:884-92. 2011
    ....
  10. ncbi EU-USA pathology panel for uniform diagnosis in randomised controlled trials for HRCT screening in lung cancer
    F B Thunnissen
    Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Eur Respir J 28:1186-9. 2006
    ....
  11. doi Acetylcholine receptor pathway and lung cancer
    Frederik B Thunnissen
    Department of Pathology, VU Medical Center Amsterdam, Amsterdam, The Netherlands
    J Thorac Oncol 4:943-6. 2009
    ..Continuation of smoking after lung cancer has been diagnosed should be discouraged because smoking may not only support tumor growth but also interferes with treatment...
  12. ncbi [EGFR-mutation in non-small cell lung carcinoma. Treatment with tyrosine kinase inhibitors possible]
    Erik Thunnissen
    VU Medisch Centrum, afd Pathologie, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A2554. 2011
    ....
  13. doi KRAS mutations in advanced nonsquamous non-small-cell lung cancer patients treated with first-line platinum-based chemotherapy have no predictive value
    Wouter W Mellema
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 8:1190-5. 2013
    ..The role of KRAS mutation as a predictor of response to chemotherapy for patients with metastatic NSCLC is poorly understood...
  14. doi EGFR mutation analysis in sputum of lung cancer patients: a multitechnique study
    A Jasmijn Hubers
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Lung Cancer 82:38-43. 2013
    ..The aim of the present study was to determine whether EGFR mutation analysis is attainable on sputum samples, employing different assays in a multicenter study...
  15. doi In compressed lung tissue microscopic sections of adenocarcinoma in situ may mimic papillary adenocarcinoma
    Erik Thunnissen
    From the Departments of Pathology Drs Thunnissen and Beliën, Radiology Dr Lely, and Surgery Dr Hartemink, VU University Medical Center, Amsterdam, the Netherlands the Department of Pathology, Aberdeen Royal Infirmary, Aberdeen University Medical School, Aberdeen, Scotland Dr Kerr the Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea Dr Chung the Department of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania Dr Flieder the Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan Dr Noguchi the Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan Dr Yatabe the Department of Pathology, University Health Network Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada Drs Hwang and Tsao and the Department of Pathology, Symbiant Medical Center Alkmaar, Alkmaar, the Netherlands Dr Meijer Jorna
    Arch Pathol Lab Med 137:1792-7. 2013
    ..Surgical removal and pathologic handling of lung tissue has a compressive effect upon its architecture. The effect of surgical atelectasis on morphology has not been examined in depth, especially with respect to lung adenocarcinomas...
  16. doi A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer
    Joline S W Lind
    Departments of Pulmonary Diseases, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Clin Cancer Res 16:3078-87. 2010
    ....
  17. doi Development of [(11)C]erlotinib positron emission tomography for in vivo evaluation of EGF receptor mutational status
    Idris Bahce
    Departments of Pulmonary Diseases, VU University Medical Center, Amsterdam, Netherlands
    Clin Cancer Res 19:183-93. 2013
    ....
  18. doi Prolonged sampling of spontaneous sputum improves sensitivity of hypermethylation analysis for lung cancer
    A Jasmijn Hubers
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Pathol 65:541-5. 2012
    ..The aim of this methodological study was to determine whether the hypermethylation detection rate of RASSF1A, adenomatous polyposis coli (APC) and cytoglobin (CYGB) is influenced by the duration of sputum collection...
  19. doi DNA copy number aberrations in endobronchial lesions: a validated predictor for cancer
    Robert A A van Boerdonk
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Thorax 69:451-7. 2014
    ..This classifier could assist in selecting subjects with endobronchial lesions who might benefit from more aggressive therapeutic intervention or surveillance. ..
  20. pmc Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography
    Virginie Frings
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 8:e63705. 2013
    ..The aim of this study was to investigate the effect of pemetrexed-induced TS-inhibition on ¹⁸F-FLT uptake 4 hours after pemetrexed administration in metastatic NSCLC patients...
  21. pmc EGFR and KRAS mutations in lung carcinomas in the Dutch population: increased EGFR mutation frequency in malignant pleural effusion of lung adenocarcinoma
    Alexander J J Smits
    Department of Pathology, St Antonius Hospital, Nieuwegein, The Netherlands
    Cell Oncol (Dordr) 35:189-96. 2012
    ..The aim of the present study was to determine the frequency of EGFR and KRAS mutations in NSCLC in the West European Dutch population in primary carcinomas and different metastatic locations...
  22. doi KRAS and BRAF mutation analysis in routine molecular diagnostics: comparison of three testing methods on formalin-fixed, paraffin-embedded tumor-derived DNA
    Daniëlle A M Heideman
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Mol Diagn 14:247-55. 2012
    ..HRM-SNaPshot is an attractive method for mutation analysis in pathology, given its good performance rate on FFPE-derived DNA, high analytical sensitivity, and prescreening approach...
  23. doi Methylation analysis in spontaneous sputum for lung cancer diagnosis
    A Jasmijn Hubers
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Lung Cancer 84:127-33. 2014
    ..The aim of this study is to examine DNA hypermethylation in sputum compared to sputum cytology for the diagnosis of lung cancer. A novel risk analysis is introduced, using the distinction between diagnostic and risk markers...
  24. doi Complete pathological response is predictive for clinical outcome after tri-modality therapy for carcinomas of the superior pulmonary sulcus
    Johannes L Blaauwgeers
    Department of Pathology, Onze Lieve Vrouwe Gasthuis, Oosterpark 9, 1090, hm, Amsterdam, The Netherlands
    Virchows Arch 462:547-56. 2013
    ..A modification of the pathological staging system after radiotherapy, incorporating the percentage of vital tumour cells, is proposed...
  25. pmc Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo
    F H Guo
    Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, OH 44195, USA
    Proc Natl Acad Sci U S A 92:7809-13. 1995
    ..Based upon these findings, we propose that respiratory epithelial cells are key inflammatory cells in the airway, functioning in host defense and potentially playing a role in airway inflammation...