C E Teunissen

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi The inflammatory marker GDF-15 is not independently associated with late-life depression
    C E Teunissen
    Dept of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, The Netherlands Electronic address
    J Psychosom Res 83:46-9. 2016
  2. pmc Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies
    Charlotte E Teunissen
    Department of Clinical Chemistry, Neurological Laboratory and Biobank, VU University Medical Center, FdG, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Mult Scler Int 2011:246412. 2011
  3. doi Biobanking of CSF: international standardization to optimize biomarker development
    Charlotte E Teunissen
    Neurochemistry Laboratory and Biobank, Dept of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, The Netherlands Electronic address
    Clin Biochem 47:288-92. 2014
  4. pmc The effectiveness of aerobic training, cognitive behavioural therapy, and energy conservation management in treating MS-related fatigue: the design of the TREFAMS-ACE programme
    Heleen Beckerman
    Department of Rehabilitation Medicine, VU University Medical Center, PO Box 7057, Amsterdam, MB 1007, The Netherlands
    Trials 14:250. 2013
  5. doi Increased plasma 8,12-iso-iPF2alpha- VI levels in relapsing multiple sclerosis patients are not predictive of disease progression
    C E Teunissen
    Department of Clinical Chemistry, VU University Medical Center, The Netherlands
    Mult Scler 18:1092-8. 2012
  6. doi Neurofilaments as biomarkers in multiple sclerosis
    Charlotte E Teunissen
    Department of Clinical Chemistry, VU University Medical Center, The Netherlands
    Mult Scler 18:552-6. 2012
  7. pmc Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types
    Elly J F Vereyken
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuroinflammation 8:58. 2011
  8. doi Identification of biomarkers for diagnosis and progression of MS by MALDI-TOF mass spectrometry
    C E Teunissen
    NUBIN, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 17:838-50. 2011
  9. doi Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases
    C E Teunissen
    Neurological laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Neurol 18:865-71. 2011
  10. doi Biomarker research in multiple sclerosis: addressing axonal damage and heterogeneity
    Charlotte E Teunissen
    VU University Medical Center, Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, NeuroUnit Biomarkers for Inflammation and Neurodegneration Amsterdam, FdG, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Biomark Med 1:111-9. 2007

Detail Information

Publications39

  1. doi The inflammatory marker GDF-15 is not independently associated with late-life depression
    C E Teunissen
    Dept of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, The Netherlands Electronic address
    J Psychosom Res 83:46-9. 2016
    ..Growth differentiation factor-15 (GDF-15) is an inflammatory molecule that reacts to cell stress. Since major depression is associated with inflammation, we examined whether GDF-15 levels are elevated in patients with late-life depression...
  2. pmc Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies
    Charlotte E Teunissen
    Department of Clinical Chemistry, Neurological Laboratory and Biobank, VU University Medical Center, FdG, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Mult Scler Int 2011:246412. 2011
    ..Importantly, the biobanking protocols are applicable for CSF biobanks for research targeting any neurological disease...
  3. doi Biobanking of CSF: international standardization to optimize biomarker development
    Charlotte E Teunissen
    Neurochemistry Laboratory and Biobank, Dept of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, The Netherlands Electronic address
    Clin Biochem 47:288-92. 2014
    ..The streamlining of biobanking procedures, including quality control, and the selection of optimal control groups for investigating biomarkers are important improvements to perform high quality biomarker studies. ..
  4. pmc The effectiveness of aerobic training, cognitive behavioural therapy, and energy conservation management in treating MS-related fatigue: the design of the TREFAMS-ACE programme
    Heleen Beckerman
    Department of Rehabilitation Medicine, VU University Medical Center, PO Box 7057, Amsterdam, MB 1007, The Netherlands
    Trials 14:250. 2013
    ....
  5. doi Increased plasma 8,12-iso-iPF2alpha- VI levels in relapsing multiple sclerosis patients are not predictive of disease progression
    C E Teunissen
    Department of Clinical Chemistry, VU University Medical Center, The Netherlands
    Mult Scler 18:1092-8. 2012
    ..Oxidative stress plays an important role in multiple sclerosis (MS). Isoprostanes are biomarkers for oxidative stress and have been related to neurological disease progression...
  6. doi Neurofilaments as biomarkers in multiple sclerosis
    Charlotte E Teunissen
    Department of Clinical Chemistry, VU University Medical Center, The Netherlands
    Mult Scler 18:552-6. 2012
    ..Future studies should be aimed at the optimisation, standardisation and interlaboratory implementation of the assays and address the predictive value of these biomarkers...
  7. pmc Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell types
    Elly J F Vereyken
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuroinflammation 8:58. 2011
    ..The aim of this study was therefore to determine the characteristics of these phenotypically different macrophages in the context of the CNS in an in vitro setting...
  8. doi Identification of biomarkers for diagnosis and progression of MS by MALDI-TOF mass spectrometry
    C E Teunissen
    NUBIN, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 17:838-50. 2011
    ..Proteomics tools are optimal for the unbiased simultaneous detection of large series of peptides and proteins...
  9. doi Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases
    C E Teunissen
    Neurological laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Neurol 18:865-71. 2011
    ..The aim of this study was to measure the serum levels of brain-type fatty acid-binding protein (FABP) and heart-type FABP in patients with dementia-involving diseases...
  10. doi Biomarker research in multiple sclerosis: addressing axonal damage and heterogeneity
    Charlotte E Teunissen
    VU University Medical Center, Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, NeuroUnit Biomarkers for Inflammation and Neurodegneration Amsterdam, FdG, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Biomark Med 1:111-9. 2007
    ..Such networks enhance the opportunities to obtain sufficient samples for in-depth studies on biomarkers in precious material, such as cerebrospinal fluid...
  11. pmc A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking
    C E Teunissen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 73:1914-22. 2009
    ..We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease...
  12. doi Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosis
    C E Teunissen
    Molecular Cell Biology and Immunology, VU University Medical Center, FdG, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 72:1322-9. 2009
    ..Next, we wanted to know the additional value of measurement of NAA compared to other candidate markers for axonal damage, such as neurofilament subunits and tau protein...
  13. doi Serum homocysteine levels in relation to clinical progression in multiple sclerosis
    C E Teunissen
    Molecular Cell Biology and Immunology, VU University Medical Centre, FdG, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 79:1349-53. 2008
    ..Homocysteine levels may be elevated in patients with multiple sclerosis (MS) but large studies are lacking and the relation with disease progression remains to be determined...
  14. ncbi 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis
    C E Teunissen
    Department of Molecular Cell Biology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurosci Res 85:1499-505. 2007
    ..The data indicate that changes in serum oxysterols occur early in EAE and can be formed by macrophages. These early changes indicate an important role for oxysterols in the development of EAE...
  15. ncbi Growth-associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosis
    C E Teunissen
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 32:318-31. 2006
    ..The increased levels of GAP-43 in remyelinated or nondemyelinated white matter close to MS lesions may reflect regenerative attempts by damaged axons...
  16. ncbi Homocysteine in relation to cognitive performance in pathological and non-pathological conditions
    Charlotte E Teunissen
    Department of Molecular Cell Biology and Immunology, Amsterdam, and VUmc Medical Center Amsterdam, Amsterdam, The Netherlands
    Clin Chem Lab Med 43:1089-95. 2005
    ..The relationship between homocysteine and cognitive function in non-pathological and pathological situations indicates that changes in its levels may play a role in cognitive functioning in a broad spectrum of conditions...
  17. ncbi Biological markers in CSF and blood for axonal degeneration in multiple sclerosis
    Charlotte E Teunissen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands
    Lancet Neurol 4:32-41. 2005
    ..These concepts may be helpful for biomarker research in various neurodegenerative diseases...
  18. ncbi Biomarkers for Alzheimer's disease. Which way to go?
    Charlotte E Teunissen
    NeuroUnit Biomarkers for Inflammation and Neurodegeneration, Department of Molecular Cell Biology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurobiol Aging 25:695-6. 2004
  19. doi Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosis
    M H J Vogt
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1110-5. 2009
    ..Here, myelin particles were used to detect anti-myelin antibodies in the CSF of MS patients. Subsequently, their relation with MRI parameters was evaluated...
  20. doi Cerebrospinal fluid anti-whole myelin antibodies are not correlated to magnetic resonance imaging activity in multiple sclerosis
    P Tewarie
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuroimmunol 251:103-6. 2012
    ..The role of antimyelin antibodies as biomarker in multiple sclerosis is subject of debate. Here antimyelin antibody reactivity against native myelin is studied in CSF and serum...
  21. doi Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
    N S M Schoonenboom
    Departments of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Neurology 78:47-54. 2012
    ..To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) levels in CSF behave in a large cohort of patients with different types of dementia...
  22. doi Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis
    C Van de Kraats
    Department of Neurology, MS Center Amsterdam, VU University Medical Center, The Netherlands
    Mult Scler 20:412-7. 2014
    ..However, how changes in sterol levels relate to the pathological processes in MS is not clear...
  23. ncbi Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patients
    C E Teunissen
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, FdG, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Neurosci Lett 347:159-62. 2003
    ..The decreased levels of brain specific and peripheral sterols indicate a role for cholesterol homeostasis in relation to the pathology of multiple sclerosis, at least in the primary progressive clinical subtype...
  24. doi Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: a pathogenetically based approach
    Karin D van Dijk
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Neurobiol Dis 39:229-41. 2010
    ..Furthermore, identified candidate biomarkers will have to be thoroughly validated before they can be implemented as diagnostic aids...
  25. doi Endogeneous peptide profiling of cerebrospinal fluid by MALDI-TOF mass spectrometry: Optimization of magnetic bead-based peptide capture and analysis of preanalytical variables
    Connie R Jimenez
    OncoProteomics Laboratory, Department of Medical Oncology, VU Medical Center, Amsterdam, The Netherlands
    Proteomics Clin Appl 1:1385-92. 2007
    ..01%). These peptides may be used for quality control in a MALDI-TOF-MS screening strategy to select high quality samples for in-depth proteomics analysis in disease studies...
  26. pmc N-acetylaspartic acid in cerebrospinal fluid of multiple sclerosis patients determined by gas-chromatography-mass spectrometry
    Bas Jasperse
    Dept of Neurology, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    J Neurol 254:631-7. 2007
    ..To our knowledge there are no studies available that evaluated NAA in cerebrospinal fluid (CSF) as a possible marker for disease severity...
  27. ncbi CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer's disease and controls
    Yolande A L Pijnenburg
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands, and Chelsea and Westminster, Brompton and Charing Cross Hospitals, London, UK
    Dement Geriatr Cogn Disord 23:225-30. 2007
    ....
  28. ncbi In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytology
    Babs O Fabriek
    Department of Molecular Cell Biology and Immunology, VU Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroimmunol 161:190-4. 2005
    ..This novel approach allows investigation of the first draining site of the brain for in vivo analysis of the immune regulation of MS...
  29. doi Gray matter network differences between behavioral variant frontotemporal dementia and Alzheimer's disease
    E G B Vijverberg
    Alzheimer Centre and Department of Neurology, Amsterdam Neuroscience, VU University Medical Centre, Amsterdam, The Netherlands Department of Neurology, Haga Ziekenhuis, The Hague, The Netherlands Electronic address
    Neurobiol Aging 50:77-86. 2017
    ..GM showed disease-specific alterations, when comparing bvFTD with AD patients, and these alterations were associated with cognitive deficits...
  30. doi An in vitro model for de- and remyelination using lysophosphatidyl choline in rodent whole brain spheroid cultures
    E J F Vereyken
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Glia 57:1326-40. 2009
    ..This model for demyelination with potential for remyelination offers possibilities for testing novel therapies and studying mechanisms of remyelination...
  31. ncbi Macrophages and neurodegeneration
    Jerome J A Hendriks
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Brain Res Brain Res Rev 48:185-95. 2005
    ..Interference with the process of infiltration and migration of monocytes across the blood-brain barrier is one of the possibilities to reduce the damage by activated macrophages...
  32. doi Application of serum natalizumab levels during plasma exchange in MS patients with progressive multifocal leukoencephalopathy
    A Vennegoor
    VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 21:481-4. 2015
    ..Measuring serum natalizumab concentrations before and during PLEX is helpful to determine the optimum number of PLEX treatments in individual MS patients with PML. ..
  33. ncbi Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis
    Babs O Fabriek
    Department of Molecular Cell Biology and Immunology, VU Medical Center, The Netherlands
    J Neuroimmunol 187:179-86. 2007
    ..Collectively, our results provide evidence for proteolytic shedding of CD163 in MS and suggest a possible link to cytokine production...
  34. doi Concomitant AD pathology affects clinical manifestation and survival in dementia with Lewy bodies
    A W Lemstra
    Alzheimer Center and Department of Neurology, VU University Medical Center and Neuroscience Campus, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 88:113-118. 2017
    ....
  35. doi Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease
    M Del Campo
    Neurochemistry Laboratory of the Clinical Chemistry department, VU University Medical Center, 1081HV, Amsterdam, The Netherlands Alzheimer Center, VU University Medical Center, 1081HV, Amsterdam, The Netherlands Electronic address
    Neurosci Lett 589:47-51. 2015
    ..Thus, the formation and accumulation high of molecular weight BRI2 forms observed in AD may impair IDE functioning and consequently lead to impaired Aβ clearance and to the accumulation of Aβ. ..
  36. ncbi Myelin flow cytometry assay detects enhanced levels of antibodies to human whole myelin in a subpopulation of multiple sclerosis patients
    Esther C W Breij
    Department of Molecular Cell Biology and Immunology, VU Medical Center Amsterdam, FdG, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroimmunol 176:106-14. 2006
    ..Anti-myelin IgG levels were not correlated with clinical parameters of disease. In the same population, serum antibody responses to recombinant myelin oligodendrocyte glycoprotein were comparable in MS patients and HD...
  37. ncbi Evaluation of 3-nitrotyrosine as a marker for 3-nitropropionic acid-induced oxidative stress in Lewis and Wistar rats and strain-specific whole brain spheroid cultures
    Charlotte E Teunissen
    European Graduate School of Neuroscience EURON, Universiteit Maastricht, Department of Psychiatry and Neuropsychology, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Brain Res 931:5-20. 2002
    ..Finally, the similarities between the 3-NP spheroid model and the vivo model indicate that the spheroid cultures provide a good alternative for chronic exposure of animals to neurotoxins...
  38. ncbi Use of proteomic approaches to identify disease biomarkers
    Charlotte E Teunissen
    Lancet Neurol 6:1036-7. 2007