Renske Dm Steenbergen

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features
    Bart A Westerman
    Molecular Biology Laboratory, Department of Clinical Chemistry, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Clin Cancer Res 8:1082-6. 2002
  2. pmc Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape
    Suzanne Snellenberg
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Cancer 12:551. 2012
  3. pmc The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations
    Florianne E Henken
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol (Dordr) 35:77-84. 2012
  4. pmc HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia
    Mariska Bierkens
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    BMC Cancer 12:36. 2012
  5. pmc PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro
    Florianne E Henken
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Cancer 10:71. 2011
  6. pmc Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population
    Susanna H Hutajulu
    Faculty of Medicine Dr Sardjito Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia
    Mol Cancer 10:48. 2011
  7. pmc Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Cancer 9:167. 2010
  8. pmc hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis
    Jillian de Wilde
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    BMC Cancer 10:271. 2010
  9. ncbi request reprint HPV-mediated transformation of the anogenital tract
    Renske D M Steenbergen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Virol 32:S25-33. 2005
  10. pmc Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Genomics 2:32. 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine features
    Bart A Westerman
    Molecular Biology Laboratory, Department of Clinical Chemistry, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Clin Cancer Res 8:1082-6. 2002
    ..Here we describe a highly sensitive reverse transcription-PCR method for quantifying HASH1 mRNA in clinical samples, using real-time fluorescence resonance energy transfer technology (LightCycler)...
  2. pmc Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape
    Suzanne Snellenberg
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Cancer 12:551. 2012
    ..e. CADM1, MAL and hsa-miR-124-2) as well as a reference gene β-actin. Based on our experience, we discuss the optimization of the parameters that provide a practical approach towards multiplex qMSP design...
  3. pmc The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterations
    Florianne E Henken
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol (Dordr) 35:77-84. 2012
    ..We examined whether the dual findings in literature may be explained by gene dosage effects and determined the relation with AP-1, a downstream target of Notch...
  4. pmc HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia
    Mariska Bierkens
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    BMC Cancer 12:36. 2012
    ..The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected...
  5. pmc PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro
    Florianne E Henken
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Cancer 10:71. 2011
    ..In this study we experimentally assessed the role of the PI3-kinase pathway and its regulator PIK3CA, which is frequently altered in cervical cancer, in HPV-induced transformation...
  6. pmc Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population
    Susanna H Hutajulu
    Faculty of Medicine Dr Sardjito Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia
    Mol Cancer 10:48. 2011
    ..This study determined methylation status of multiple TSGs and evaluated whether it may improve early detection...
  7. pmc Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Mol Cancer 9:167. 2010
    ..Since DNA methylation-based silencing of hsa-miR-124 occurs in various human cancers, we studied the frequency and functional effects of hsa-miR-124 methylation in cervical carcinogenesis...
  8. pmc hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis
    Jillian de Wilde
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    BMC Cancer 10:271. 2010
    ..In the present study we examined hTERT promoter activity and its relation to DNA methylation as one of the potential mechanisms underlying deregulated hTERT transcription in hrHPV-transformed cells...
  9. ncbi request reprint HPV-mediated transformation of the anogenital tract
    Renske D M Steenbergen
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Virol 32:S25-33. 2005
    ....
  10. pmc Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med Genomics 2:32. 2009
    ..The existence of hrHPV-specific alterations in SCCs of different anatomical origin, suggests that these alterations are crucial for hrHPV-mediated carcinogenesis...
  11. ncbi request reprint TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia
    Renske D M Steenbergen
    Department of Pathology, Unit of Molecular Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Natl Cancer Inst 96:294-305. 2004
    ..We assessed the role of the gene encoding the adhesion molecule tumor suppressor in lung cancer 1 (TSLC1) in this progression...
  12. doi request reprint Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis
    Renske Dm Steenbergen
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 231:53-62. 2013
    ..Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  13. doi request reprint Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinoma
    Marta del Pino
    Unit of Molecular Pathology, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Mod Pathol 25:1354-63. 2012
    ..Testing for LR-HPV, particularly HPV 6 and 11, may help in the differential diagnosis of lesions suspicious of verrucous carcinoma as those testing positive for LR-HPV most likely represent giant condylomas...
  14. doi request reprint Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes
    Linda Struijk
    Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
    J Gen Virol 89:2303-14. 2008
    ..Infections with HPV8 and HPV20 may therefore augment the carcinogenic effect of UV radiation and potentially contribute to oncogenic transformation of the skin...
  15. pmc Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancer
    Saskia M Wilting
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Genes Chromosomes Cancer 47:890-905. 2008
    ..In conclusion, integrated chromosomal and transcriptional profiling identified chromosomal hotspots at 1q, 3q, 11q, and 20q with altered gene expression within large commonly altered chromosomal regions in cervical cancer...
  16. ncbi request reprint Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesis
    Jillian de Wilde
    Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Cell Oncol 30:77-87. 2008
    ..Here, we aimed to obtain further insight in expression alterations of AP-1 family members during HPV-mediated transformation and their relationship to potential regulatory (Notch1, Net) and target (CADM1) genes...
  17. pmc Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesis
    Renske D M Steenbergen
    Department of Pathology, Unit of Molecular Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 160:1945-51. 2002
    ..Whether GATA-3 down-regulation is etiologically involved in HPV-mediated immortalization and cervical carcinogenesis remains to be examined...
  18. ncbi request reprint Telomerase activity in high-grade cervical lesions is associated with allelic imbalance at 6Q14-22
    Mark van Duin
    Department of Pathology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Cancer 105:577-82. 2003
    ..These data suggest that 6q14-22 may contain 1 or more genes involved in telomerase deregulation and immortalization during cervical carcinogenesis...
  19. ncbi request reprint Assessment of TGF-beta1-mediated growth inhibition of HPV-16- and HPV-18-transfected foreskin keratinocytes during and following immortalization
    Ingo Nindl
    Department of Pathology, Section of Molecular Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Arch Dermatol Res 295:297-304. 2003
    ..Therefore, alternative events are likely to underlie unresponsiveness to TGF- beta1 in late-passage FK16A and FK18B cells...
  20. ncbi request reprint Elevated hTERT mRNA levels: A potential determinant of bronchial squamous cell carcinoma (in situ)
    Peter J F Snijders
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Int J Cancer 109:412-7. 2004
    ..03). These data indicate that elevated hTERT mRNA is associated with an increased relative risk of prevalent and incident bronchial squamous cell carcinoma (in situ)...
  21. pmc Clonal selection for transcriptionally active viral oncogenes during progression to cancer
    Brian A Van Tine
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1918 University Blvd, McCallum Bldg, Rm 510, Birmingham, AL 35294 0005, USA
    J Virol 78:11172-86. 2004
    ..This phenomenon may be critical in clonal selection during carcinogenesis. Examination of HPV-associated cancers supports this hypothesis...
  22. ncbi request reprint Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancer
    Daniëlle A M Heideman
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Ther 12:1083-90. 2005
    ..This favorable efficacy and safety profile was confirmed in organotypic raft cultures. Our findings suggest that AdCB016-mp53(268N) is a promising new agent for treatment of HPV-associated human cancers...
  23. ncbi request reprint HPV-mediated cervical carcinogenesis: concepts and clinical implications
    Peter J F Snijders
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Pathol 208:152-64. 2006
    ..The potential implications of hrHPV testing and some other biomarkers deduced from this model for cervical screening and the clinical management of CIN disease are also discussed...
  24. ncbi request reprint A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanoma
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 179:5317-25. 2007
    ..Our data therefore reveal that EZH2 contributes to silencing of IFN-gamma-inducible transcription of MHC2TA in uveal melanoma cells...
  25. ncbi request reprint Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancer
    Jillian de Wilde
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Cancer 122:877-88. 2008
    ..In summary, we identified 32 candidate biomarkers for deregulated hTERT mRNA expression, which may enable the identification of cervical premalignant lesions that are at highest risk to progress to invasive cancer...