Research Topics
Species | Renske Dm SteenbergenSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
Quantitative reverse transcription-polymerase chain reaction measurement of HASH1 (ASCL1), a marker for small cell lung carcinomas with neuroendocrine featuresBart A Westerman
Molecular Biology Laboratory, Department of Clinical Chemistry, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
Clin Cancer Res 8:1082-6. 2002..Here we describe a highly sensitive reverse transcription-PCR method for quantifying HASH1 mRNA in clinical samples, using real-time fluorescence resonance energy transfer technology (LightCycler)...
Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrapeSuzanne Snellenberg
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
BMC Cancer 12:551. 2012..e. CADM1, MAL and hsa-miR-124-2) as well as a reference gene β-actin. Based on our experience, we discuss the optimization of the parameters that provide a practical approach towards multiplex qMSP design...- The functional role of Notch signaling in HPV-mediated transformation is dose-dependent and linked to AP-1 alterationsFlorianne E Henken
Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
Cell Oncol (Dordr) 35:77-84. 2012..We examined whether the dual findings in literature may be explained by gene dosage effects and determined the relation with AP-1, a downstream target of Notch... - HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasiaMariska Bierkens
Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
BMC Cancer 12:36. 2012..The current study aimed to investigate whether CIN2/3 with different hrHPV types vary with respect to their chromosomal profiles, both in terms of the number of aberrations and chromosomal loci affected... - PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitroFlorianne E Henken
Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Mol Cancer 10:71. 2011..In this study we experimentally assessed the role of the PI3-kinase pathway and its regulator PIK3CA, which is frequently altered in cervical cancer, in HPV-induced transformation... - Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk populationSusanna H Hutajulu
Faculty of Medicine Dr Sardjito Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia
Mol Cancer 10:48. 2011..This study determined methylation status of multiple TSGs and evaluated whether it may improve early detection... - Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancerSaskia M Wilting
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Mol Cancer 9:167. 2010..Since DNA methylation-based silencing of hsa-miR-124 occurs in various human cancers, we studied the frequency and functional effects of hsa-miR-124 methylation in cervical carcinogenesis... - hTERT promoter activity and CpG methylation in HPV-induced carcinogenesisJillian de Wilde
Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
BMC Cancer 10:271. 2010..In the present study we examined hTERT promoter activity and its relation to DNA methylation as one of the potential mechanisms underlying deregulated hTERT transcription in hrHPV-transformed cells... - TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasiaRenske D M Steenbergen
Department of Pathology, Unit of Molecular Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
J Natl Cancer Inst 96:294-305. 2004..We assessed the role of the gene encoding the adhesion molecule tumor suppressor in lung cancer 1 (TSLC1) in this progression... - HPV-mediated transformation of the anogenital tractRenske D M Steenbergen
Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
J Clin Virol 32:S25-33. 2005.... - Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neckSaskia M Wilting
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
BMC Med Genomics 2:32. 2009..The existence of hrHPV-specific alterations in SCCs of different anatomical origin, suggests that these alterations are crucial for hrHPV-mediated carcinogenesis... 
Comprehensive analysis of human papillomavirus prevalence and the potential role of low-risk types in verrucous carcinomaMarta del Pino
Unit of Molecular Pathology, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Mod Pathol 25:1354-63. 2012..Testing for LR-HPV, particularly HPV 6 and 11, may help in the differential diagnosis of lesions suspicious of verrucous carcinoma as those testing positive for LR-HPV most likely represent giant condylomas...- Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytesLinda Struijk
Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands
J Gen Virol 89:2303-14. 2008..Infections with HPV8 and HPV20 may therefore augment the carcinogenic effect of UV radiation and potentially contribute to oncogenic transformation of the skin... - Integrated genomic and transcriptional profiling identifies chromosomal loci with altered gene expression in cervical cancerSaskia M Wilting
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Genes Chromosomes Cancer 47:890-905. 2008..In conclusion, integrated chromosomal and transcriptional profiling identified chromosomal hotspots at 1q, 3q, 11q, and 20q with altered gene expression within large commonly altered chromosomal regions in cervical cancer... - Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesisJillian de Wilde
Department of Pathology, Unit of Molecular Pathology, VU University Medical Center, Amsterdam, The Netherlands
Cell Oncol 30:77-87. 2008..Here, we aimed to obtain further insight in expression alterations of AP-1 family members during HPV-mediated transformation and their relationship to potential regulatory (Notch1, Net) and target (CADM1) genes... - Down-regulation of GATA-3 expression during human papillomavirus-mediated immortalization and cervical carcinogenesisRenske D M Steenbergen
Department of Pathology, Unit of Molecular Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Am J Pathol 160:1945-51. 2002..Whether GATA-3 down-regulation is etiologically involved in HPV-mediated immortalization and cervical carcinogenesis remains to be examined... - Telomerase activity in high-grade cervical lesions is associated with allelic imbalance at 6Q14-22Mark van Duin
Department of Pathology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Int J Cancer 105:577-82. 2003..These data suggest that 6q14-22 may contain 1 or more genes involved in telomerase deregulation and immortalization during cervical carcinogenesis... - Assessment of TGF-beta1-mediated growth inhibition of HPV-16- and HPV-18-transfected foreskin keratinocytes during and following immortalizationIngo Nindl
Department of Pathology, Section of Molecular Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Arch Dermatol Res 295:297-304. 2003..Therefore, alternative events are likely to underlie unresponsiveness to TGF- beta1 in late-passage FK16A and FK18B cells... - Elevated hTERT mRNA levels: A potential determinant of bronchial squamous cell carcinoma (in situ)Peter J F Snijders
Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Int J Cancer 109:412-7. 2004..03). These data indicate that elevated hTERT mRNA is associated with an increased relative risk of prevalent and incident bronchial squamous cell carcinoma (in situ)... - Clonal selection for transcriptionally active viral oncogenes during progression to cancerBrian A Van Tine
Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1918 University Blvd, McCallum Bldg, Rm. 510, Birmingham, AL 35294-0005, USA
J Virol 78:11172-86. 2004..This phenomenon may be critical in clonal selection during carcinogenesis. Examination of HPV-associated cancers supports this hypothesis... - Oncolytic adenovirus expressing a p53 variant resistant to degradation by HPV E6 protein exhibits potent and selective replication in cervical cancerDaniëlle A M Heideman
Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Mol Ther 12:1083-90. 2005..This favorable efficacy and safety profile was confirmed in organotypic raft cultures. Our findings suggest that AdCB016-mp53(268N) is a promising new agent for treatment of HPV-associated human cancers... - HPV-mediated cervical carcinogenesis: concepts and clinical implicationsPeter J F Snijders
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
J Pathol 208:152-64. 2006..The potential implications of hrHPV testing and some other biomarkers deduced from this model for cervical screening and the clinical management of CIN disease are also discussed... - A role for EZH2 in silencing of IFN-gamma inducible MHC2TA transcription in uveal melanomaTjadine M Holling
Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
J Immunol 179:5317-25. 2007..Our data therefore reveal that EZH2 contributes to silencing of IFN-gamma-inducible transcription of MHC2TA in uveal melanoma cells... - Gene expression profiling to identify markers associated with deregulated hTERT in HPV-transformed keratinocytes and cervical cancerJillian de Wilde
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Int J Cancer 122:877-88. 2008..In summary, we identified 32 candidate biomarkers for deregulated hTERT mRNA expression, which may enable the identification of cervical premalignant lesions that are at highest risk to progress to invasive cancer...