Y Smulders

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..A gallium scintigraphy provided further support for this diagnosis. No treatment was initiated and the patient recovered slowly afterwards...

..Polycystic ovary syndrome (PCOS) and obesity are associated with diabetes and cardiovascular disease, but it is unclear to what extent PCOS contributes independently of obesity...

..We investigated the association of clamp-derived insulin sensitivity with indices of insulin sensitivity derived from fasting blood in prepubertal children and adults, with and without incorporation of FFAs...

..This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile...

..Treatment with a pulmonary vasodilator has never been studied systematically. We evaluated the effect of epoprostenol on right ventricular diameter and function in patients with acute pulmonary embolism and right ventricular dilatation...

..In this paper, we will explain that searching for 'new causes' of CVD is still highly relevant, and that improvement of risk prediction is often assessed using inappropriate statistical methodology...

..In addition, an independent review committee who would judge whether a guideline shows signs of interference by pharmaceutical companies may be considered...

..In contrast to plasma, RBC folate can appear in different biochemical isoforms. So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC folate vitamer distribution...

..In this article, we explain that searching for 'new causes' of CVD is still highly relevant, and that improvement of risk prediction is often assessed using inappropriate statistical methodology...

..For individual patient care, these apparently opposing trends in the role and financial appreciation of QALYs have complex repercussions...

..This is the first time that virtually all features of the methylfolate trap hypothesis have been demonstrated in a human with vitamin B12 deficiency...

..In the mean time, it seems reasonable to reserve high-dose statin therapy for patients who are at a very high cardiovascular risk, for example those with a history of recurrent cardiovascular events...

..It is unknown how often patients do this, and what effect it has on measured blood pressure readings...

..To determine whether having no medical history is a favourable or unfavourable predictor of the relative risk of post-admission mortality for elderly patients acutely admitted to hospital...

..Hence, in all forms of etiological studies addressing recurrent disease risk, index event bias is a source of potential underestimation of causal associations...

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..Angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, and (non-dihydropyridine) calcium antagonists have therapeutic potential. Digoxin may be contraindicated...

..To prevent large scale undertreatment of patients at high cardiovascular risk, the commonly used risk threshold for initiating primary preventative treatment should be lowered...

..We propose that epidemiological evidence should be used for benchmarking average care provided by doctors working alone or in group practices, but not for benchmarking care provided to individual patients...

..The underlying mechanisms are undefined. AngII may increase glucose uptake through a direct effect on muscle cell insulin signaling or through increasing insulin delivery to muscle cells through effects on the microvasculature...

..The aim of this study is to assess effects of the multistep intervention on plasma ADMA concentrations in the ATIC Study...

..Hyper- and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle)...

..Calcium antagonists are the cornerstone of RP pharmacotherapy...

..Fundoscopy is sometimes indicated in patients with severe hypertension to assess damage to the eye and to decide whether the patient must be hospitalised...

..These beneficial effects on blood pressure and cardiovascular events make chlorthalidone a tenable choice for the treatment of hypertension...

..Birth weight is associated with salt sensitivity of blood pressure, and this may play a role in the maintenance of elevated blood pressure in individuals with a low birth weight...

..The literature about reptile-associated salmonellosis is briefly reviewed...

..While numerous studies have analyzed the role of homocysteine (Hcy) in the vasculature, only a few studies investigated the role of Hcy in the heart. Therefore we have analyzed the effects of Hcy on isolated cardiomyocytes...

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..To compare steroids and their associations in men with type 1 diabetes and healthy control subjects...

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..We describe a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method for determination of cytosine and 5-methylcytosine in DNA...

..The objective of this study was to examine whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance, both cross-sectionally and longitudinally...

..We aimed to identify the effects of HIV, ART, and lipodystrophy (LD) on carotid artery intima-media thickness (C-IMT), a surrogate measure of atherosclerosis, and arterial stiffness, a marker of cardiovascular risk...

..As cardiovascular researchers, we should try to develop a more integrative view on folate metabolism, rather than focusing merely on hyperhomocysteinemia...

..044). In conclusion, reduction in skin capillary density is associated with a rise in blood pressure during sunitinib therapy and, by itself, might be useful as a predictive marker of clinical outcome...

..In conclusion, folic acid treatment lowered plasma homocysteine concentration and increased whole-body remethylation and transmethylation flux in healthy subjects...

..We investigated subclinical atherosclerosis and arterial stiffness in patients with AS compared with controls, and identified CV and AS related risk factors for atherosclerotic disease...

..In particular, accumulation of non-methyltetrahydrofolates due to altered partitioning of folate metabolism at the level of methylenetetrahydrofolate is of interest...

..To systematically review the literature pertaining to the reversal of type 2 diabetes mellitus (DM2) after Roux-en-Y gastric bypass and adjustable gastric banding...

..The objective of this study was to assess the interobserver agreement between on-call radiology residents and radiology specialists in the evaluation of pulmonary embolism (PE) using computed tomographic pulmonary angiography (CTPA)...

..FDG-probe guided surgery can potentially increase the sensitivity of diagnostic resections...

..5%), and that the clinical usefulness of the total area under the diagnostic 3-h OGTT is superior to all other glycemic parameters for detecting early postpartum diabetes...

..The effects of different breath-holding positions during electrocardiographic (ECG) recording on the QRS complex are unknown...

..We prospectively assessed the incidence of CVD in patients with RA compared with patients with type 2 diabetes mellitus (DM) and the general population...

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..In this study, we investigated whether PKC theta activation impairs insulin-mediated vasoreactivity and insulin signaling in muscle resistance arteries...

..CONCLUSIONS: Carriers for the ABCC6 R1141X mutation, which is frequent and confers a high risk of premature coronary artery disease, do not commonly have skin or eye abnormalities consistent with a mild PXE phenotype...

..Given the association between CVD and PXE, we hypothesized that heterozygosity of this ABCC6 mutation could also confer an increased risk for CVD...