Y Smulders

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Determinants of mild gestational hyperglycemia and gestational diabetes mellitus in a large dutch multiethnic cohort
    Rob N M Weijers
    Department of Clinical Chemistry and Haematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Diabetes Care 25:72-7. 2002
  2. ncbi request reprint Clinical practice guideline for cardiovascular risk management in the Netherlands
    Y M Smulders
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Neth J Med 66:169-74. 2008
  3. ncbi request reprint [Clinical reasoning and decision-making in practice. A man with swelling of both corners of the jaw]
    Y Smulders
    VU Medisch Centrum, afd Inwendige Geneeskunde, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 152:1097-104. 2008
  4. doi request reprint Obese but not normal-weight women with polycystic ovary syndrome are characterized by metabolic and microvascular insulin resistance
    Iris J G Ketel
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, De Boelelaan 1118, Room 0Z106, 1081 HV Amsterdam, The Netherlands
    J Clin Endocrinol Metab 93:3365-72. 2008
  5. doi request reprint Incorporation of the fasting free fatty acid concentration into quantitative insulin sensitivity check index improves its association with insulin sensitivity in adults, but not in children
    Richard G Ijzerman
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 160:59-64. 2009
  6. pmc 18F-fluorodeoxyglucose positron emission tomography in elderly patients with an elevated erythrocyte sedimentation rate of unknown origin
    Karel Jan D F Lensen
    Department of Internal Medicine and the Institute for Cardiovascular Research ICaR VU, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e58917. 2013
  7. doi request reprint A two-step manuscript submission process can reduce publication bias
    Yvo M Smulders
    Department of Internal Medicine, VU University Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    J Clin Epidemiol 66:946-7. 2013
  8. pmc Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis
    Alexander Semmler
    University Zurich, Department of Neurology, Switzerland
    Nutr J 9:31. 2010
  9. pmc No effect of epoprostenol on right ventricular diameter in patients with acute pulmonary embolism: a randomized controlled trial
    Albertus J Kooter
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 10:18. 2010
  10. ncbi request reprint Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status
    Yvo M Smulders
    Department of Internal Medicine and Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
    J Nutr Biochem 18:693-9. 2007

Detail Information

Publications56

  1. ncbi request reprint Determinants of mild gestational hyperglycemia and gestational diabetes mellitus in a large dutch multiethnic cohort
    Rob N M Weijers
    Department of Clinical Chemistry and Haematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Diabetes Care 25:72-7. 2002
    ....
  2. ncbi request reprint Clinical practice guideline for cardiovascular risk management in the Netherlands
    Y M Smulders
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Neth J Med 66:169-74. 2008
  3. ncbi request reprint [Clinical reasoning and decision-making in practice. A man with swelling of both corners of the jaw]
    Y Smulders
    VU Medisch Centrum, afd Inwendige Geneeskunde, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 152:1097-104. 2008
    ..A gallium scintigraphy provided further support for this diagnosis. No treatment was initiated and the patient recovered slowly afterwards...
  4. doi request reprint Obese but not normal-weight women with polycystic ovary syndrome are characterized by metabolic and microvascular insulin resistance
    Iris J G Ketel
    Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, De Boelelaan 1118, Room 0Z106, 1081 HV Amsterdam, The Netherlands
    J Clin Endocrinol Metab 93:3365-72. 2008
    ..Polycystic ovary syndrome (PCOS) and obesity are associated with diabetes and cardiovascular disease, but it is unclear to what extent PCOS contributes independently of obesity...
  5. doi request reprint Incorporation of the fasting free fatty acid concentration into quantitative insulin sensitivity check index improves its association with insulin sensitivity in adults, but not in children
    Richard G Ijzerman
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 160:59-64. 2009
    ..We investigated the association of clamp-derived insulin sensitivity with indices of insulin sensitivity derived from fasting blood in prepubertal children and adults, with and without incorporation of FFAs...
  6. pmc 18F-fluorodeoxyglucose positron emission tomography in elderly patients with an elevated erythrocyte sedimentation rate of unknown origin
    Karel Jan D F Lensen
    Department of Internal Medicine and the Institute for Cardiovascular Research ICaR VU, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 8:e58917. 2013
    ..In particular, large-vessel vasculitis appears to be a common finding. A normal PET/CT scan in these patients suggests that it is safe to follow a wait-and-see policy...
  7. doi request reprint A two-step manuscript submission process can reduce publication bias
    Yvo M Smulders
    Department of Internal Medicine, VU University Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    J Clin Epidemiol 66:946-7. 2013
    ..The pros and cons of such an approach are discussed...
  8. pmc Plasma folate levels are associated with the lipoprotein profile: a retrospective database analysis
    Alexander Semmler
    University Zurich, Department of Neurology, Switzerland
    Nutr J 9:31. 2010
    ..This cross-sectional pilot study aimed at analyzing whether blood levels of the two important cofactors of homocysteine metabolism, folate and vitamin B12, coincide with the lipoprotein profile...
  9. pmc No effect of epoprostenol on right ventricular diameter in patients with acute pulmonary embolism: a randomized controlled trial
    Albertus J Kooter
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    BMC Pulm Med 10:18. 2010
    ..Treatment with a pulmonary vasodilator has never been studied systematically. We evaluated the effect of epoprostenol on right ventricular diameter and function in patients with acute pulmonary embolism and right ventricular dilatation...
  10. ncbi request reprint Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status
    Yvo M Smulders
    Department of Internal Medicine and Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
    J Nutr Biochem 18:693-9. 2007
    ..In contrast to plasma, RBC folate can appear in different biochemical isoforms. So far, only the methylenetetrahydrofolate reductase (MTHFR) 677 TT genotype has been identified as a determinant of RBC folate vitamer distribution...
  11. ncbi request reprint [The influence of the pharmaceutical industry on treatment guidelines]
    Y M Smulders
    VU Medisch Centrum, Afd Algemene Inwendige Geneeskunde, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 151:2429-31. 2007
    ..In addition, an independent review committee who would judge whether a guideline shows signs of interference by pharmaceutical companies may be considered...
  12. doi request reprint New cardiovascular risk determinants do exist and are clinically useful
    Yvo M Smulders
    Department of Internal Medicine, VU University Medical Center, PO Box 7057, Amsterdam 1007MB, The Netherlands
    Eur Heart J 29:436-40. 2008
    ..In this paper, we will explain that searching for 'new causes' of CVD is still highly relevant, and that improvement of risk prediction is often assessed using inappropriate statistical methodology...
  13. pmc The homocysteine controversy
    Yvo M Smulders
    Internal Medicine and Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    J Inherit Metab Dis 34:93-9. 2011
    ....
  14. doi request reprint Giant cell arteritis causing aortic dissection and acute hypertension
    Yvo M Smulders
    VU University Medical Center, Division of Internal Medicine, PO Box 7057, Amsterdam 1081HV, Netherlands
    BMJ 337:a426. 2008
  15. ncbi request reprint [Doubts regarding the existence and clinical relevance of 'new' risk determinants of cardiovascular disease are unfounded]
    Y M Smulders
    Afd Algemene Inwendige Geneeskunde, VU Medisch Centrum, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 152:1610-3. 2008
    ..In this article, we explain that searching for 'new causes' of CVD is still highly relevant, and that improvement of risk prediction is often assessed using inappropriate statistical methodology...
  16. ncbi request reprint [The role of epidemiological evidence in providing care for individual patients]
    Yvo M Smulders
    VU Medisch Centrum, afd Inwendige Geneeskunde, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1910. 2010
    ..We propose that epidemiological evidence should be used for benchmarking average care provided by doctors working alone or in group practices, but not for benchmarking care provided to individual patients...
  17. ncbi request reprint [Index event bias: why causal factors appear not to apply to disease recurrence]
    Yvo M Smulders
    VU Medisch Centrum, afd Interne Geneeskunde, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A3458. 2011
    ..Hence, in all forms of etiological studies addressing recurrent disease risk, index event bias is a source of potential underestimation of causal associations...
  18. ncbi request reprint [The cost per year of life gained: trends and internal contradictions]
    Y M Smulders
    VU Medisch Centrum, Afd Algemene Inwendige Geneeskunde, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 150:2467-70. 2006
    ..For individual patient care, these apparently opposing trends in the role and financial appreciation of QALYs have complex repercussions...
  19. ncbi request reprint [Old and new scoring systems for assessing cardiovascular risks: problems with the validity, the precision and the homogenicity of the risk categories]
    Y M Smulders
    afd Inwendige Geneeskunde, VU Medisch Centrum, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 148:2480-4. 2004
    ..To prevent large scale undertreatment of patients at high cardiovascular risk, the commonly used risk threshold for initiating primary preventative treatment should be lowered...
  20. ncbi request reprint [Unexpectedly high mortality rate after acute hospital admission of elderly patients without a medical history]
    Y M Smulders
    Academisch Medisch Centrum Universiteit van Amsterdam, afd Inwendige Geneeskunde, Amsterdam
    Ned Tijdschr Geneeskd 146:1417-9. 2002
    ..To determine whether having no medical history is a favourable or unfavourable predictor of the relative risk of post-admission mortality for elderly patients acutely admitted to hospital...
  21. ncbi request reprint [Diastolic heart failure]
    Y M Smulders
    afd Inwendige Geneeskunde, VU Medisch Centrum, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 147:2467-70. 2003
    ..Angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, and (non-dihydropyridine) calcium antagonists have therapeutic potential. Digoxin may be contraindicated...
  22. ncbi request reprint [Statins: for the time being, do not as a rule prescribe the maximum dose]
    Y M Smulders
    VU Medisch Centrum, Afd Algemene Inwendige Geneeskunde, De Boelelaan 1117, 1081 HV Amsterdam
    Ned Tijdschr Geneeskd 149:1876-8. 2005
    ..In the mean time, it seems reasonable to reserve high-dose statin therapy for patients who are at a very high cardiovascular risk, for example those with a history of recurrent cardiovascular events...
  23. pmc Large deletion causing the TSC2-PKD1 contiguous gene syndrome without infantile polycystic disease
    Y M Smulders
    Department of Nephrology, Academic Medical Centre, Amsterdam, The Netherlands
    J Med Genet 40:E17. 2003
  24. ncbi request reprint Frequency of spontaneous fist clenching during routine blood pressure measurements and its effect on measurement accuracy
    Yvo M Smulders
    Department of Internal Medicine, Academic Medical Centre F4 222, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
    Blood Press Monit 7:145-7. 2002
    ..It is unknown how often patients do this, and what effect it has on measured blood pressure readings...
  25. ncbi request reprint Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap
    Y M Smulders
    Department of Internal Medicine, Institute for Cardiovascular Research ICaR VU, VU University Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 132:623-9. 2006
    ..This is the first time that virtually all features of the methylfolate trap hypothesis have been demonstrated in a human with vitamin B12 deficiency...
  26. doi request reprint Angiotensin II enhances insulin-stimulated whole-body glucose disposal but impairs insulin-induced capillary recruitment in healthy volunteers
    Amy M Jonk
    Department of Internal Medicine, Maastricht University Medical Centre, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Clin Endocrinol Metab 95:3901-8. 2010
    ..The underlying mechanisms are undefined. AngII may increase glucose uptake through a direct effect on muscle cell insulin signaling or through increasing insulin delivery to muscle cells through effects on the microvasculature...
  27. ncbi request reprint Steroids in adult men with type 1 diabetes: a tendency to hypogonadism
    Eveline W C M van Dam
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes Care 26:1812-8. 2003
    ..To compare steroids and their associations in men with type 1 diabetes and healthy control subjects...
  28. ncbi request reprint [Chlorthalidone better than hydrochlorothiazide in hypertension]
    Albertus J Kooter
    VU Medisch Centrum, Amsterdam, afd Interne Geneeskunde, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1608. 2010
    ..These beneficial effects on blood pressure and cardiovascular events make chlorthalidone a tenable choice for the treatment of hypertension...
  29. doi request reprint Microvascular function has no menstrual-cycle-dependent variation in healthy ovulatory women
    Iris J G Ketel
    Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Microcirculation 16:714-24. 2009
    ..Hyper- and hypoestrogenism that persist for a long time can affect vascular and metabolic function. However, it is not clear whether the same is true for subtle sex hormone changes (i.e., during the menstrual cycle)...
  30. ncbi request reprint Turtle-associated human salmonellosis
    Frank Stam
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Clin Infect Dis 37:e167-9. 2003
    ..The literature about reptile-associated salmonellosis is briefly reviewed...
  31. doi request reprint Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD
    Prabath W B Nanayakkara
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Am J Kidney Dis 53:41-50. 2009
    ..The aim of this study is to assess effects of the multistep intervention on plasma ADMA concentrations in the ATIC Study...
  32. ncbi request reprint [Raynaud's phenomenon; diagnosis and treatment]
    Herman M A Hofstee
    VU Medisch Centrum, afd Interne Geneeskunde, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 153:B216. 2009
    ..Calcium antagonists are the cornerstone of RP pharmacotherapy...
  33. pmc Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis
    Jessica A Sipkens
    Department of Pathology, VU University Medical Centre, Room 0E46, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands
    Apoptosis 12:1407-18. 2007
    ..While numerous studies have analyzed the role of homocysteine (Hcy) in the vasculature, only a few studies investigated the role of Hcy in the heart. Therefore we have analyzed the effects of Hcy on isolated cardiomyocytes...
  34. ncbi request reprint [Visual loss as a sign of hypertension]
    Bettine C P Polak
    VU Medisch Centrum, afd Oogheelkunde, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 153:A379. 2009
    ..Fundoscopy is sometimes indicated in patients with severe hypertension to assess damage to the eye and to decide whether the patient must be hospitalised...
  35. doi request reprint Association between global leukocyte DNA methylation, renal function, carotid intima-media thickness and plasma homocysteine in patients with stage 2-4 chronic kidney disease
    Prabath W B Nanayakkara
    Department of Internal Medicine, Institute for Cardiovascular Research, VU University Medical Center, VU University, Amsterdam, The Netherlands
    Nephrol Dial Transplant 23:2586-92. 2008
    ....
  36. doi request reprint Birth weight relates to salt sensitivity of blood pressure in healthy adults
    Michiel P de Boer
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, University Medical Center Amsterdam, The Netherlands
    Hypertension 51:928-32. 2008
    ..Birth weight is associated with salt sensitivity of blood pressure, and this may play a role in the maintenance of elevated blood pressure in individuals with a low birth weight...
  37. ncbi request reprint Regulation of vascular function and insulin sensitivity by adipose tissue: focus on perivascular adipose tissue
    Etto C Eringa
    Laboratory for Physiology, UV University Medical Center, Amsterdam, The Netherlands
    Microcirculation 14:389-402. 2007
    ....
  38. ncbi request reprint Global DNA methylation measured by liquid chromatography-tandem mass spectrometry: analytical technique, reference values and determinants in healthy subjects
    Robert M Kok
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    Clin Chem Lab Med 45:903-11. 2007
    ..We describe a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method for determination of cytosine and 5-methylcytosine in DNA...
  39. doi request reprint Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons
    N M van Schoor
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 66:174-81. 2012
    ..The objective of this study was to examine whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance, both cross-sectionally and longitudinally...
  40. ncbi request reprint Folate metabolism and cardiovascular disease
    Yvo M Smulders
    Department of Internal Medicine, VU University Medical Center, Amsterdam
    Semin Vasc Med 5:87-97. 2005
    ..As cardiovascular researchers, we should try to develop a more integrative view on folate metabolism, rather than focusing merely on hyperhomocysteinemia...
  41. doi request reprint Carotid intima-media thickness and arterial stiffness in HIV-infected patients: the role of HIV, antiretroviral therapy, and lipodystrophy
    Marit G A van Vonderen
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Acquir Immune Defic Syndr 50:153-61. 2009
    ..We aimed to identify the effects of HIV, ART, and lipodystrophy (LD) on carotid artery intima-media thickness (C-IMT), a surrogate measure of atherosclerosis, and arterial stiffness, a marker of cardiovascular risk...
  42. doi request reprint Reduction in skin microvascular density and changes in vessel morphology in patients treated with sunitinib
    Astrid A M van der Veldt
    Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Anticancer Drugs 21:439-46. 2010
    ..044). In conclusion, reduction in skin capillary density is associated with a rise in blood pressure during sunitinib therapy and, by itself, might be useful as a predictive marker of clinical outcome...
  43. doi request reprint Signs of accelerated preclinical atherosclerosis in patients with ankylosing spondylitis
    Mike J L Peters
    VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Rheumatol 37:161-6. 2010
    ..We investigated subclinical atherosclerosis and arterial stiffness in patients with AS compared with controls, and identified CV and AS related risk factors for atherosclerotic disease...
  44. ncbi request reprint Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry
    Desiree E C Smith
    Department of Clinical Chemistry, ICaR VU, VU University Medical Center, Amsterdam, The Netherlands
    Clin Chem Lab Med 44:450-9. 2006
    ..In particular, accumulation of non-methyltetrahydrofolates due to altered partitioning of folate metabolism at the level of methylenetetrahydrofolate is of interest...
  45. ncbi request reprint Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects
    Frank Stam
    Department of Internal Medicine, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Clin Sci (Lond) 108:449-56. 2005
    ..In conclusion, folic acid treatment lowered plasma homocysteine concentration and increased whole-body remethylation and transmethylation flux in healthy subjects...
  46. doi request reprint Bariatric surgery as a novel treatment for type 2 diabetes mellitus: a systematic review
    Rick I Meijer
    Department of Internal Medicine, VU Medical Center, Amsterdam, The Netherlands
    Arch Surg 146:744-50. 2011
    ..To systematically review the literature pertaining to the reversal of type 2 diabetes mellitus (DM2) after Roux-en-Y gastric bypass and adjustable gastric banding...
  47. doi request reprint Interobserver agreement between on-call radiology residents and radiology specialists in the diagnosis of pulmonary embolism using computed tomography pulmonary angiography
    Johannes W Verweij
    Department of Internal Medicine, VU University Medical Centre, De Boelelaan, Amsterdam
    J Comput Assist Tomogr 33:952-5. 2009
    ..The objective of this study was to assess the interobserver agreement between on-call radiology residents and radiology specialists in the evaluation of pulmonary embolism (PE) using computed tomographic pulmonary angiography (CTPA)...
  48. ncbi request reprint The clinical usefulness of glucose tolerance testing in gestational diabetes to predict early postpartum diabetes mellitus
    Rob N M Weijers
    Department of Clinical Chemistry and Hematology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Clin Chem Lab Med 44:99-104. 2006
    ..5%), and that the clinical usefulness of the total area under the diagnostic 3-h OGTT is superior to all other glycemic parameters for detecting early postpartum diabetes...
  49. ncbi request reprint [Fluorodeoxyglucose F18(FDG)-probe guided biopsy]
    Koen J Hartemink
    VU Medisch Centrum, Amsterdam, afd Chirurgie, The Netherlands
    Ned Tijdschr Geneeskd 154:A1884. 2010
    ..FDG-probe guided surgery can potentially increase the sensitivity of diagnostic resections...
  50. doi request reprint Effects of breath-holding position on the QRS amplitudes in the routine electrocardiogram
    Dasten Smit
    Department of Internal and Vascular Medicine, VU University Medical Center, Amsterdam 1007MB, The Netherlands
    J Electrocardiol 42:400-4. 2009
    ..The effects of different breath-holding positions during electrocardiographic (ECG) recording on the QRS complex are unknown...
  51. doi request reprint Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study
    Mike J L Peters
    VU Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 61:1571-9. 2009
    ..We prospectively assessed the incidence of CVD in patients with RA compared with patients with type 2 diabetes mellitus (DM) and the general population...
  52. ncbi request reprint Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease
    Mieke D Trip
    Department of Cardiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 106:773-5. 2002
    ..Given the association between CVD and PXE, we hypothesized that heterozygosity of this ABCC6 mutation could also confer an increased risk for CVD...
  53. ncbi request reprint Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries
    Wineke Bakker
    Laboratory of Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, Netherlands
    Diabetes 57:706-13. 2008
    ..In this study, we investigated whether PKC theta activation impairs insulin-mediated vasoreactivity and insulin signaling in muscle resistance arteries...
  54. ncbi request reprint Analysis of published PKD1 gene sequence variants
    Alexander M Gout
    Nat Genet 39:427-8. 2007
  55. ncbi request reprint Microalbuminuria and risk for cardiovascular disease: Analysis of potential mechanisms
    Coen D A Stehouwer
    Department of Medicine, Division of General Internal Medicine, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    J Am Soc Nephrol 17:2106-11. 2006
    ....
  56. ncbi request reprint Patients with premature coronary artery disease who carry the ABCC6 R1141X mutation have no Pseudoxanthoma Elasticum phenotype
    Jurgen J Wegman
    Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Int J Cardiol 100:389-93. 2005
    ..The objective of our study was to determine if skin and/or eye abnormalities related to a PXE phenotype could be found in patients with premature coronary artery disease, with and without the R1141X mutation...