Ben Slotman

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Stereotactic ablative radiotherapy for comprehensive treatment of oligometastatic tumors (SABR-COMET): study protocol for a randomized phase II trial
    David A Palma
    Department of Radiation Oncology, London Regional Cancer Program, 790 Commissioners Rd, E, London, ON, Canada
    BMC Cancer 12:305. 2012
  2. doi request reprint Planning of radiotherapy capacity and productivity
    Ben J Slotman
    Dept of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 106:266-70. 2013
  3. pmc Sparing the contralateral submandibular gland without compromising PTV coverage by using volumetric modulated arc therapy
    Patricia Doornaert
    Department of Radiation Oncology, VU University Medical Center, PB 7057, 1007 MB Amsterdam, The Netherlands
    Radiat Oncol 6:74. 2011
  4. pmc Verifying 4D gated radiotherapy using time-integrated electronic portal imaging: a phantom and clinical study
    John R van Sörnsen de Koste
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiat Oncol 2:32. 2007
  5. pmc Reproducibility of target volumes generated using uncoached 4-dimensional CT scans for peripheral lung cancer
    Ylanga G van der Geld
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiat Oncol 1:43. 2006
  6. ncbi request reprint Prophylactic cranial irradiation in extensive small-cell lung cancer
    Ben Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    N Engl J Med 357:664-72. 2007
  7. doi request reprint Radiotherapy for extensive stage small cell lung cancer
    B J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Front Radiat Ther Oncol 42:187-92. 2010
  8. doi request reprint Radiotherapy in small-cell lung cancer: lessons learned and future directions
    Ben J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 79:998-1003. 2011
  9. pmc Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology and Lu
    Berend J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 27:78-84. 2009
  10. ncbi request reprint 4D imaging for target definition in stereotactic radiotherapy for lung cancer
    Ben J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Oncol 45:966-72. 2006

Detail Information

Publications96

  1. pmc Stereotactic ablative radiotherapy for comprehensive treatment of oligometastatic tumors (SABR-COMET): study protocol for a randomized phase II trial
    David A Palma
    Department of Radiation Oncology, London Regional Cancer Program, 790 Commissioners Rd, E, London, ON, Canada
    BMC Cancer 12:305. 2012
    ....
  2. doi request reprint Planning of radiotherapy capacity and productivity
    Ben J Slotman
    Dept of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 106:266-70. 2013
    ..Investments in treatment vaults, equipment and training capacity were made. The developments since then are described and the actual situation is compared with the predictions throughout the years...
  3. pmc Sparing the contralateral submandibular gland without compromising PTV coverage by using volumetric modulated arc therapy
    Patricia Doornaert
    Department of Radiation Oncology, VU University Medical Center, PB 7057, 1007 MB Amsterdam, The Netherlands
    Radiat Oncol 6:74. 2011
    ..Currently, submandibular glands are not routinely spared. We implemented a technique for sparing contralateral submandibular glands (CLSM) during contralateral elective neck irradiation without compromising PTV coverage...
  4. pmc Verifying 4D gated radiotherapy using time-integrated electronic portal imaging: a phantom and clinical study
    John R van Sörnsen de Koste
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiat Oncol 2:32. 2007
    ..RGRT is commonly performed using external surrogates of tumor motion. We describe the use of time-integrated electronic portal imaging (TI-EPI) to verify the position of internal structures during RGRT delivery..
  5. pmc Reproducibility of target volumes generated using uncoached 4-dimensional CT scans for peripheral lung cancer
    Ylanga G van der Geld
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiat Oncol 1:43. 2006
    ..As variations in respiratory patterns can alter observed motion, with consequent changes in the generated target volumes, we evaluated the reproducibility of 4D target volumes generated during repeat uncoached quiet respiration...
  6. ncbi request reprint Prophylactic cranial irradiation in extensive small-cell lung cancer
    Ben Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    N Engl J Med 357:664-72. 2007
    ..We conducted a randomized trial of prophylactic cranial irradiation in patients with extensive small-cell lung cancer who had had a response to chemotherapy...
  7. doi request reprint Radiotherapy for extensive stage small cell lung cancer
    B J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Front Radiat Ther Oncol 42:187-92. 2010
    ....
  8. doi request reprint Radiotherapy in small-cell lung cancer: lessons learned and future directions
    Ben J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 79:998-1003. 2011
    ..The aim of the present study was to review the key developments in thoracic radiotherapy and prophylactic cranial radiotherapy and to discuss the rationale behind key ongoing studies in small-cell lung cancer...
  9. pmc Prophylactic cranial irradiation in extensive disease small-cell lung cancer: short-term health-related quality of life and patient reported symptoms: results of an international Phase III randomized controlled trial by the EORTC Radiation Oncology and Lu
    Berend J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 27:78-84. 2009
    ..Detailed effects of PCI on health-related quality of life (HRQOL) are reported here...
  10. ncbi request reprint 4D imaging for target definition in stereotactic radiotherapy for lung cancer
    Ben J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Acta Oncol 45:966-72. 2006
    ..We describe our experience with the use of 4DCT scanning for this group of patients, the use of post-processing tools and the potential benefits of respiratory gating...
  11. ncbi request reprint Risk-group definition by recursive partitioning analysis of patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy
    Johannes A Langendijk
    Department of Radiation Oncology, Vrije University Medical Center, Amsterdam, The Netherlands
    Cancer 104:1408-17. 2005
    ..The objective of this study was to define different prognostic groups with regard to locoregional control (LRC) derived from recursive partitioning analysis (RPA)...
  12. ncbi request reprint Differential radiosensitizing potential of temozolomide in MGMT promoter methylated glioblastoma multiforme cell lines
    Krista A van Nifterik
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 69:1246-53. 2007
    ..To investigate the radiosensitizing potential of temozolomide (TMZ) for human glioblastoma multiforme (GBM) cell lines using single-dose and fractionated gamma-irradiation...
  13. ncbi request reprint Radiosensitizing potential of the selective cyclooygenase-2 (COX-2) inhibitor meloxicam on human glioma cells
    Irene V Bijnsdorp
    Department of Radiation Oncology, Division Radiobiology, VU University Medical Center, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands
    J Neurooncol 85:25-31. 2007
    ..19) and U87 (DMF:1.25) cells, but not U251 cells (DMF:1.08). The selective COX-2 inhibitor meloxicam exerted COX-2 independent growth inhibition and radiosensitization of human glioma cells...
  14. doi request reprint Evaluation of four-dimensional computed tomography-based intensity-modulated and respiratory-gated radiotherapy techniques for pancreatic carcinoma
    Ylanga G van der Geld
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 72:1215-20. 2008
    ..All target volumes were determined using four-dimensional computed tomography scans (4D CT)...
  15. doi request reprint Treatment of stage I NSCLC in elderly patients: a population-based matched-pair comparison of stereotactic radiotherapy versus surgery
    David Palma
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 101:240-4. 2011
    ..Elderly patients with stage I NSCLC who undergo surgical resection are at high risk of treatment-related toxicity. Stereotactic body radiation therapy (SBRT) may provide an alternative treatment with a favorable toxicity profile...
  16. ncbi request reprint A phase II study of primary reirradiation in squamous cell carcinoma of head and neck
    Johannes A Langendijk
    Department of Radiation Oncology, V U University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 78:306-12. 2006
    ....
  17. ncbi request reprint Benefit of respiration-gated stereotactic radiotherapy for stage I lung cancer: an analysis of 4DCT datasets
    René W M Underberg
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 62:554-60. 2005
    ....
  18. doi request reprint Analysis of reproducibility of respiration-triggered gated radiotherapy for lung tumors
    Femke O B Spoelstra
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 87:59-64. 2008
    ..Time-integrated electronic portal imaging (TI-EPI) identifies mean intra-fractional positions of moving structures, and was used to study reproducibility of anatomy during RGRT for lung tumors...
  19. doi request reprint Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 74:1-8. 2009
    ....
  20. ncbi request reprint A four-dimensional CT-based evaluation of techniques for gastric irradiation
    Ylanga G van der Geld
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 69:903-9. 2007
    ..All techniques were four-dimensional (4D)-CT based, incorporating the intrafractional mobility of the target volume and organs at risk (OAR)...
  21. ncbi request reprint Time trends in target volumes for stage I non-small-cell lung cancer after stereotactic radiotherapy
    René W M Underberg
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 64:1221-8. 2006
    ..To identify potential time trends in target volumes and tumor mobility after stereotactic radiotherapy (SRT) for Stage I non-small-cell lung cancer...
  22. doi request reprint Analysis of carina position as surrogate marker for delivering phase-gated radiotherapy
    Lineke van der Weide
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 71:1111-7. 2008
    ..Because the tumor is generally not visualized, external surrogates of tumor position are used to trigger respiration-gated RT. We evaluated the suitability of the carina position as a surrogate in respiration-gated RT...
  23. ncbi request reprint Can mediastinal nodal mobility explain the low yield rates for transbronchial needle aspiration without real-time imaging?
    Anna H M Piet
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Chest 131:1783-7. 2007
    ..Nodal positions, as assessed on a breath-hold conventional CT scan, do not account for nodal motion. We studied nodal motion on four-dimensional (4D) CT scans...
  24. doi request reprint Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy
    Johannes A Langendijk
    Department of Radiation Oncology, VU University Medical Center, Groningen, The Netherlands
    J Clin Oncol 26:3770-6. 2008
    ....
  25. ncbi request reprint Unilateral versus bilateral irradiation in squamous cell head and neck cancer in relation to patient-rated xerostomia and sticky saliva
    Anke Petra Jellema
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 85:83-9. 2007
    ..To investigate the association between radiation technique with patient-rated moderate and severe xerostomia and sticky saliva...
  26. doi request reprint An analysis of patient positioning during stereotactic lung radiotherapy performed without rigid external immobilization
    Max Dahele
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 104:28-32. 2012
    ..In contrast, we deliver the vast majority of SBRT using simple supporting devices, simultaneously emphasizing comfort, frequent position checks and progressive reduction in treatment times. We report spine stability during lung SBRT...
  27. doi request reprint Volumetric modulated arc therapy for advanced pancreatic cancer
    Wietse Eppinga
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Strahlenther Onkol 186:382-7. 2010
    ..A planning study evaluated if volumetric modulated arc therapy (RapidArc [RA]) could be used as an alternative to IMRT in such cases...
  28. doi request reprint Radiological changes after stereotactic radiotherapy for stage I lung cancer
    Max Dahele
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Thorac Oncol 6:1221-8. 2011
    ..The aim of this study is to describe the incidence, radiological severity, and long-term morphology of these changes...
  29. ncbi request reprint The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy
    Ernst J Smid
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 65:1323-9. 2006
    ..The aim of this study was to investigate the prognostic significance of epidermal growth factor (EGFr) expression in oral cavity squamous cell carcinoma (OCSCC) treated with curative surgery and postoperative radiotherapy...
  30. ncbi request reprint Four-dimensional CT scans for treatment planning in stereotactic radiotherapy for stage I lung cancer
    René W M Underberg
    Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 60:1283-90. 2004
    ..Two computed tomography (CT) scan techniques for defining internal target volumes (ITV) were evaluated...
  31. doi request reprint Improving target delineation on 4-dimensional CT scans in stage I NSCLC using a deformable registration tool
    Iris E van Dam
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 96:67-72. 2010
    ..Correct target definition is crucial in stereotactic radiotherapy for lung tumors. We evaluated use of deformable registration (DR) for target contouring on 4-dimensional (4D) CT scans...
  32. doi request reprint Strategies for the analysis of in vitro radiation sensitivity and prediction of interaction with potential radiation modifying agents
    Mark Luttjeboer
    Department of Pediatric Oncology Hematology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Biol 86:458-66. 2010
    ..The aim of this article is to show that both clonogenic capacity and cellular proliferation, which represent important different elements of tumour conduct, can be considered when assessing in vitro radio sensitisation...
  33. ncbi request reprint Results of postoperative reirradiation for recurrent or second primary head and neck carcinoma
    Nicolien Kasperts
    Department of Radiation Oncology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Cancer 106:1536-47. 2006
    ....
  34. ncbi request reprint Use of maximum intensity projections (MIP) for target volume generation in 4DCT scans for lung cancer
    René W M Underberg
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 63:253-60. 2005
    ..We investigated the use of maximum intensity projection (MIP) protocols for rapid generation of ITVs...
  35. ncbi request reprint Oxygenation and response to irradiation of organotypic multicellular spheroids of human glioma
    Peter Sminia
    Department of Radiation Oncology, Section Radiobiology, VU Universtity Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Anticancer Res 23:1461-6. 2003
    ..Investigation of the oxygenation status of organotypic multicellular spheroids (OMS) and their response to irradiation...
  36. doi request reprint Ipsilateral irradiation for oral and oropharyngeal carcinoma treated with primary surgery and postoperative radiotherapy
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 78:682-8. 2010
    ..Late radiation-induced morbidity was also evaluated...
  37. doi request reprint Clinical outcome after repeated radiosurgery for brain arteriovenous malformations
    Dennis R Buis
    Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 95:250-6. 2010
    ..We assessed the clinical and radiological outcome after repeated radiosurgery for brain arteriovenous malformations (bAVMs) after failure of initial radiosurgery...
  38. pmc Health-related quality of life of long-term high-grade glioma survivors
    Ingeborg Bosma
    VU University Medical Center, Department of Neurology, Amsterdam, The Netherlands
    Neuro Oncol 11:51-8. 2009
    ..We concluded that baseline HRQOL is not related to duration of survival and that long-term survivors show improvement of HRQOL to a level comparable to that of the healthy...
  39. doi request reprint Linear accelerator-based stereotactic radiosurgery for bilateral vestibular schwannomas in patients with neurofibromatosis type 2
    Otto W M Meijer
    Department of Radiation Oncology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Neurosurgery 62:A37-42; discussion A42-3. 2008
    ..We studied our treatment results in patients with NF2 with bilateral VS, treated with linear accelerator-based RS and SRT...
  40. doi request reprint Critical review of nonsurgical treatment options for stage I non-small cell lung cancer
    Cornelis J A Haasbeek
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Oncologist 13:309-19. 2008
    ..Reported 2-year local control rates after SRT are comparable with those achieved with surgery, and prospective randomized trials comparing surgery with SRT in patients who are fit to undergo surgery are now being planned...
  41. doi request reprint Whole-brain radiotherapy with simultaneous integrated boost to multiple brain metastases using volumetric modulated arc therapy
    Frank J Lagerwaard
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 75:253-9. 2009
    ..We used RA to plan and deliver whole-brain radiotherapy (WBRT) with a simultaneous integrated boost in patients with multiple brain metastases...
  42. doi request reprint Radiotherapy for lung cancer: clinical impact of recent technical advances
    Cornelis J A Haasbeek
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Lung Cancer 64:1-8. 2009
    ..Aspects of cost-effectiveness of technical innovations, as well as the level of evidence required before widespread clinical implementation, will be addressed...
  43. doi request reprint Stereotactic radiation therapy for large vestibular schwannomas
    Ellen S Mandl
    Neurosurgical Center Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Radiother Oncol 95:94-8. 2010
    ..To evaluate the morbidity and tumor-control rate in the treatment of large vestibular schwannomas (VS) after stereotactic radiation therapy in our institution...
  44. doi request reprint Volumetric intensity-modulated arc therapy vs. conventional IMRT in head-and-neck cancer: a comparative planning and dosimetric study
    Wilko F A R Verbakel
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 74:252-9. 2009
    ..In this study, planning and dosimetry of RA were compared with conventional intensity-modulated radiation therapy (IMRT) plans of head-and-neck cancer patients...
  45. doi request reprint An evaluation of two internal surrogates for determining the three-dimensional position of peripheral lung tumors
    Femke O B Spoelstra
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 74:623-9. 2009
    ..Both carina and diaphragm positions have been used as surrogates during respiratory-gated radiotherapy. We studied the correlation of both surrogates with three-dimensional (3D) tumor position...
  46. pmc Cognitive functioning in glioblastoma patients during radiotherapy and temozolomide treatment: initial findings
    Karen Hilverda
    Department of Medical Psychology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurooncol 97:89-94. 2010
    ..In the course of the first 6 months of their disease, however, progression-free GBM patients undergoing radiotherapy plus concomitant and adjuvant temozolomide treatment do not deteriorate in cognitive functioning...
  47. doi request reprint Outcomes of stereotactic radiotherapy for a new clinical stage I lung cancer arising postpneumonectomy
    Cornelis J A Haasbeek
    Department of Radiation Oncology, Vrije University Medical Center, Amsterdam, The Netherlands
    Cancer 115:587-94. 2009
    ..Resection of second primary lung tumors that arise after previous pneumonectomy is associated with a high risk of complications. In this study, the authors reviewed outcomes after stereotactic radiation therapy (SRT) for such patients...
  48. doi request reprint Volumetric modulated arc radiotherapy for vestibular schwannomas
    Frank J Lagerwaard
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 74:610-5. 2009
    ..To evaluate volumetric modulated arc radiotherapy (RapidArc [RA]), a novel approach allowing for rapid treatment delivery, for the treatment of vestibular schwannoma (VS)...
  49. doi request reprint Rapid delivery of stereotactic radiotherapy for peripheral lung tumors using volumetric intensity-modulated arcs
    Wilko F A R Verbakel
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 93:122-4. 2009
    ..In addition, in comparison to the conventional plans using 10 static non-coplanar fields, RA plans achieved superior dose conformity around the PTV and reduced chest wall doses...
  50. doi request reprint Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up
    Linda Douw
    Department of Neurology, VU University Medical Center, Amsterdam, Netherlands
    Lancet Neurol 8:810-8. 2009
    ..The present study assesses the radiological and cognitive abnormalities in survivors of LGG at a mean of 12 years after first diagnosis...
  51. doi request reprint Reproducibility of quantitative 18F-3'-deoxy-3'-fluorothymidine measurements using positron emission tomography
    Adrianus J de Langen
    Department of Respiratory Medicine, VU University Medical Centre, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:389-95. 2009
    ..For serial imaging in individual patients, good reproducibility is essential. The purpose of the present study was to evaluate the reproducibility of quantitative [(18)F]FLT measurements...
  52. doi request reprint Stage I nonsmall cell lung cancer in patients aged > or =75 years: outcomes after stereotactic radiotherapy
    Cornelis J A Haasbeek
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cancer 116:406-14. 2010
    ..Furthermore, surgery in the elderly is associated with increased mortality and morbidity. In this study, the authors evaluated the outcomes of stereotactic radiotherapy (SRT) in elderly patients...
  53. doi request reprint Role of adaptive radiotherapy during concomitant chemoradiotherapy for lung cancer: analysis of data from a prospective clinical trial
    Femke O B Spoelstra
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 75:1092-7. 2009
    ..A prospective study was performed to evaluate the dosimetric consequences of time-trend changes in patients with lung cancer who were treated with concomitant chemoradiotherapy...
  54. doi request reprint Impact of audio-coaching on the position of lung tumors
    Cornelis J A Haasbeek
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 71:1118-23. 2008
    ..To assess the impact of coaching on average tumor position during gating, we analyzed four-dimensional computed tomography (4DCT) scans performed both with and without audio-coaching...
  55. ncbi request reprint Radiation therapy in early stage Hodgkin's disease: long-term results and adverse effects
    Josee M Zijlstra
    Department of Hematology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Hematol J 3:179-84. 2002
    ..Radiation therapy (RT) was the first treatment modality demonstrating cure of Hodgkin's disease. Long-term side-effects of this treatment, however, have become evident in the past few years...
  56. ncbi request reprint Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?
    Anke Petra Jellema
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 77:164-71. 2005
    ..To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva...
  57. ncbi request reprint The significance of anemia in squamous cell head and neck cancer treated with surgery and postoperative radiotherapy
    Sandrine M G van de Pol
    Department of Radiation Oncology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Oral Oncol 42:131-8. 2006
    ..Hb level between surgery and radiotherapy is an important prognostic factor for both LRC and OS among patients with SCCHN treated with surgery and postoperative radiotherapy...
  58. ncbi request reprint Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and recurrent glioblastoma multiforme
    Peter Sminia
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    J Cancer Res Clin Oncol 131:653-61. 2005
    ..The relationship between COX-2 and epidermal growth factor receptor (EGFR) immunoreactivities was evaluated...
  59. ncbi request reprint Stereotactic radiosurgery for brain AVMs: role of interobserver variation in target definition on digital subtraction angiography
    Dennis R Buis
    Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 62:246-52. 2005
    ....
  60. ncbi request reprint Radiologic findings in patients treated with boron neutron capture therapy for glioblastoma multiforme within EORTC trial 11961
    Maaike J Vos
    Department of Neurology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 61:392-9. 2005
    ....
  61. ncbi request reprint Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution
    Gitta K Kuipers
    Department of Radiation Oncology, Section Radiobiology, Medical Faculty, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    Mutat Res 568:171-7. 2004
    ..Furthermore, the results of this study indicate that nucleotide excision repair is involved in repair of both inactivating and mutagenic damage induced by phenylalanine radicals under anoxic conditions...
  62. ncbi request reprint Quality of life after curative radiotherapy in Stage I non-small-cell lung cancer
    Johannes A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    Int J Radiat Oncol Biol Phys 53:847-53. 2002
    ..The aim of this study was to investigate changes in quality of life (QOL) among medically inoperable Stage I non-small-cell lung cancer (NSCLC) patients treated with curative radiotherapy...
  63. ncbi request reprint Serum levels of S-100B protein and neuron-specific enolase in glioma patients: a pilot study
    Maaike J Vos
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Anticancer Res 24:2511-4. 2004
    ..In brain tumor patients, literature data on the prognostic value of serum S-100(B) and NSE levels are scarse and conflicting...
  64. ncbi request reprint Thallium-201 single-photon emission computed tomography as an early predictor of outcome in recurrent glioma
    Maaike J Vos
    Department of Neurology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Oncol 21:3559-65. 2003
    ....
  65. ncbi request reprint Past, current and future protocols for combined modality therapy in childhood medulloblastoma
    Patricia Kaaijk
    VU University Medical Center, Dept Pediatric Hematology Oncology, Amsterdam, The Netherlands
    Expert Rev Anticancer Ther 3:79-90. 2003
    ..This review will evaluate past, current and future treatment approaches of combined modality therapy in childhood medulloblastoma...
  66. ncbi request reprint Matching PET and CT scans of the head and neck area: development of method and validation
    Bianca M Klabbers
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Med Phys 29:2230-8. 2002
    ....
  67. ncbi request reprint Re-irradiation of the human spinal cord
    Peter Sminia
    Department of Radiation Oncology, Section Radiobiology, VU University Medical Center, Amsterdam, The Netherlands
    Strahlenther Onkol 178:453-6. 2002
    ..As a consequence of re-irradiation, their spinal cords were exposed to cumulative doses exceeding the tolerance dose. Radiobiological and clinical data are presented...
  68. ncbi request reprint Control of nodal metastases in squamous cell head and neck cancer treated by radiation therapy or chemoradiation
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 79:39-44. 2006
    ..In the present study, prognostic values of several CT-based pre-treatment nodal and treatment-related characteristics were evaluated among patients with squamous cell head and neck cancer treated with non-surgical modalities...
  69. pmc Monitoring response to radiotherapy in human squamous cell cancer bearing nude mice: comparison of 2'-deoxy-2'-[18F]fluoro-D-glucose (FDG) and 3'-[18F]fluoro-3'-deoxythymidine (FLT)
    Carla F M Molthoff
    Department of Nuclear Medicine and PET Research, VU University Medical Center, P O Box 7057, 1007, Amsterdam, The Netherlands
    Mol Imaging Biol 9:340-7. 2007
    ....
  70. ncbi request reprint Delineation of brain AVMs on MR-Angiography for the purpose of stereotactic radiosurgery
    Dennis R Buis
    Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 67:308-16. 2007
    ..To assess the dosimetric consequences of brain arteriovenous malformation (bAVM) delineation on magnetic resonance angiography (MRA) for the purpose of stereotactic radiosurgery...
  71. ncbi request reprint Is adaptive treatment planning required for stereotactic radiotherapy of stage I non-small-cell lung cancer?
    Cornelis J A Haasbeek
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 67:1370-4. 2007
    ..The need for adaptive treatment planning during stereotactic radiotherapy of Stage I tumors was retrospectively analyzed using repeat four-dimensional computed tomography (4DCT) scans...
  72. pmc The course of neurocognitive functioning in high-grade glioma patients
    Ingeborg Bosma
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Neuro Oncol 9:53-62. 2007
    ..The possibility of deleterious effects is important to consider when prescribing antiepileptic drug treatment...
  73. doi request reprint Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer
    Frank J Lagerwaard
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 70:685-92. 2008
    ..We evaluated early clinical outcomes of "risk-adapted" fractionation schemes in patients treated in a single institution...
  74. ncbi request reprint Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration
    Gitta K Kuipers
    Department of Radiation Oncology, Division Radiobiology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Biol 83:677-85. 2007
    ..Cyclooxygenase-2 (COX-2) protein is regularly upregulated in gliomas and might be a potential therapeutic target. The effects of three selective COX-2 inhibitors were studied on three human glioma cell lines...
  75. doi request reprint RapidArc planning and delivery in patients with locally advanced head-and-neck cancer undergoing chemoradiotherapy
    Patricia Doornaert
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 79:429-35. 2011
    ..We studied planning and delivery in patients who underwent RapidArc for locally advanced head-and-neck cancer (HNC)...
  76. doi request reprint Treatment of large stage I-II lung tumors using stereotactic body radiotherapy (SBRT): planning considerations and early toxicity
    Chin Loon Ong
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 97:431-6. 2010
    ..To study the dosimetric predictors of early clinical toxicity following SBRT in patients with lung tumors and planning target volumes (PTV) exceeding 80 cm(3)...
  77. doi request reprint The accuracy of frameless stereotactic intracranial radiosurgery
    Wilko F A R Verbakel
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 97:390-4. 2010
    ....
  78. doi request reprint A novel simple approach for incorporation of respiratory motion in stereotactic treatments of lung tumors
    Johan P Cuijpers
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 97:443-8. 2010
    ..We describe a pragmatic approach using maximum- and minimum-intensity projections (MIP and Min-IP) only, for reducing ITVs in stereotactic radiotherapy by using dosimetric margins that compensate for motion-induced dose blurring...
  79. doi request reprint Dosimetric impact of interplay effect on RapidArc lung stereotactic treatment delivery
    ChinLoon Ong
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 79:305-11. 2011
    ..We investigated discrepancies between the calculated and delivered dose distributions, as well as the dosimetric impact of leaf interplay with breathing-induced tumor motion...
  80. doi request reprint Stereotactic radiotherapy for peripheral lung tumors: a comparison of volumetric modulated arc therapy with 3 other delivery techniques
    Chin Loon Ong
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 97:437-42. 2010
    ..We compared dose distributions and delivery times between RapidArc and common delivery techniques in small tumors...
  81. doi request reprint Anti-tumour effects by a trimodal combination of temozolomide, meloxicam and X-rays in cultures of human glioma cells
    Krista A van Nifterik
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Biol 87:192-201. 2011
    ....
  82. ncbi request reprint The importance of pre-treatment haemoglobin level in inoperable non-small cell lung carcinoma treated with radical radiotherapy
    Hans Langendijk
    Department of Radiation Oncology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Radiother Oncol 67:321-5. 2003
    ....
  83. ncbi request reprint Patients' appreciation of single fraction radiotherapy for painful bone metastases
    Ben J Slotman
    Palliat Med 18:72-3. 2004
  84. ncbi request reprint Renal mobility during uncoached quiet respiration: an analysis of 4DCT scans
    John R van Sörnsen de Koste
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 64:799-803. 2006
    ..Data on organ mobility is required for optimizing radiotherapy. Renal mobility was studied in four-dimensional computed tomography (4DCT) scans acquired during uncoached respiration...
  85. ncbi request reprint Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy with amifostine 5 times weekly: A prospective randomized study in squamous cell head and neck cancer
    Anke Petra Jellema
    Department of Radiation Oncology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Cancer 107:544-53. 2006
    ....
  86. ncbi request reprint Use of CD-ROM-based tool for analyzing contouring variations in involved-field radiotherapy for Stage III NSCLC
    John R van Sörnsen de Koste
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, Postbox 7057, Amsterdam 1007 MB, The Netherlands
    Int J Radiat Oncol Biol Phys 63:334-9. 2005
    ..A CD-ROM-based contouring tool was used to conduct a dummy run in an international trial of involved-field chemoradiotherapy for Stage III non-small-cell lung cancer...
  87. ncbi request reprint Genetic profiling of a distant second glioblastoma multiforme after radiotherapy: Recurrence or second primary tumor?
    Krista A van Nifterik
    Department of Radiation Oncology, Division of Radiobiology, Vrije Universiteit Medical Center, Faculty of Medicine, Amsterdam, The Netherlands
    J Neurosurg 105:739-44. 2006
    ..The genetic profiles of the tumors were compared to discriminate between distant recurrence and a second primary tumor...
  88. ncbi request reprint Overview of national guidelines for infrastructure and staffing of radiotherapy. ESTRO-QUARTS: work package 1
    Ben J Slotman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 75:349-54. 2005
    ..The aim of this study was to collect the available guidelines for infrastructure and staffing throughout Europe and to develop general guidelines...
  89. ncbi request reprint Four-dimensional computed tomographic analysis of esophageal mobility during normal respiration
    Edith M T Dieleman
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 67:775-80. 2007
    ..Treatment planning to reduce esophageal irradiation requires organ motion to be accounted for. In this study, esophageal mobility was assessed using four-dimensional computed tomography (4DCT)...
  90. ncbi request reprint Color intensity projection of digitally subtracted angiography for the visualization of brain arteriovenous malformations
    Keith S Cover
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Neurosurgery 60:511-4; discussion 514-5. 2007
    ..We describe a new method to improve the speed and reliability of visualizing the flow of contrast images with digital subtraction angiography...
  91. ncbi request reprint Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer
    Anke Petra Jellema
    Department of Radiation Oncology, University Medical Center, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 69:751-60. 2007
    ..To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among head and neck cancer patients treated with primary radiotherapy...
  92. ncbi request reprint Evaluating mobility for radiotherapy planning of lung tumors: a comparison of virtual fluoroscopy and 4DCT
    Ylanga G van der Geld
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, Postbox 7057, 1007 MB, Amsterdam, The Netherlands
    Lung Cancer 53:31-7. 2006
    ..Lung tumor mobility was scored using virtual fluoroscopy, and this was compared to mobility derived from contoured tumors in all phases of a respiration-correlated (or 4D) CT scan...
  93. ncbi request reprint Palliative-care trials: how best to publish findings?
    Murielle E Mauer
    Lancet Oncol 9:411-2. 2008
  94. pmc Re-irradiation of a second localization of idiopathic midline destructive disease in the head and neck area
    Robert L Poorter
    Department of Radiation Oncology, Dr Bernard Verbeeten Institute, Tilburg, The Netherlands
    Eur Arch Otorhinolaryngol 264:1521-3. 2007
    ..Later she developed a second localization on the posterior pharyngeal wall for which she was re-irradiated, without severe sequels. Twice a complete regression was observed...
  95. ncbi request reprint The value of positron emission tomography for monitoring response to radiotherapy in head and neck cancer
    Bianca M Klabbers
    Department of Radiation Oncology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Imaging Biol 5:257-70. 2003
    ..In addition, the potential use of FDG for predicting and monitoring response to radiotherapy is discussed. Finally, the potential of some other tracers for monitoring response is reviewed...
  96. ncbi request reprint Infrastructure of radiotherapy in the Netherlands: evaluation of prognoses and introduction of a new model for determining the needs
    Ben J Slotman
    Department of Radiation Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiother Oncol 66:345-9. 2003
    ..In the present study, the latest prognoses (1993) and the realized changes in infrastructure are evaluated and a new prognosis for the period until 2010, which has been calculated using a new model, is presented...