Alie Schuitemaker

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. doi Microglial activation in healthy aging
    Alie Schuitemaker
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Neurobiol Aging 33:1067-72. 2012
  2. doi Inflammatory markers in AD and MCI patients with different biomarker profiles
    Alie Schuitemaker
    Department of Neurology Alzheimer Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Neurobiol Aging 30:1885-9. 2009
  3. doi Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study
    Alie Schuitemaker
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:128-36. 2013
  4. ncbi Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1965-74. 2007
  5. pmc Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 32:1600-8. 2012
  6. ncbi SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1081 MB Amsterdam, The Netherlands
    Neuroimage 35:1473-9. 2007
  7. ncbi Evaluation of methods for generating parametric (R-[11C]PK11195 binding images
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1603-15. 2007
  8. doi Serum amyloid p component as a biomarker in mild cognitive impairment and Alzheimer's disease
    Nicolaas A Verwey
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 26:522-7. 2008
  9. ncbi Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 26:1431-41. 2006
  10. doi Image-derived input functions for PET brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:463-71. 2009

Detail Information

Publications12

  1. doi Microglial activation in healthy aging
    Alie Schuitemaker
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Neurobiol Aging 33:1067-72. 2012
    ..This indicates that activated microglia appear in several cortical and subcortical areas during healthy aging, suggesting widespread neuronal loss...
  2. doi Inflammatory markers in AD and MCI patients with different biomarker profiles
    Alie Schuitemaker
    Department of Neurology Alzheimer Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Neurobiol Aging 30:1885-9. 2009
    ..The aim of this study was to demonstrate the involvement of the inflammatory proteins IL-6, ACT and CRP early in the pathology process of AD in patients with mild cognitive impairment (MCI) and AD...
  3. doi Microglial activation in Alzheimer's disease: an (R)-[¹¹C]PK11195 positron emission tomography study
    Alie Schuitemaker
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Aging 34:128-36. 2013
    ..The purpose of this study was to assess whether increased (R)-[(11)C]PK11195 binding is present in AD and mild cognitive impairment (MCI), currently also known as "prodromal AD."..
  4. ncbi Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1965-74. 2007
    ..Most anatomic regions outperformed cluster analysis in terms of absence of both scan rejection and bias. Total cerebellum is the optimal reference region in this patient category...
  5. pmc Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 32:1600-8. 2012
    ..Incorporation of V(b) within RPM, together with SVCA4, appears to be the method of choice for analyzing cerebral (R)-[(11)C]PK11195 neurodegeneration studies...
  6. ncbi SPM analysis of parametric (R)-[11C]PK11195 binding images: plasma input versus reference tissue parametric methods
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1081 MB Amsterdam, The Netherlands
    Neuroimage 35:1473-9. 2007
    ..Vd images could only demonstrate differences in (R)-[11C]PK11195 binding when analysed with proportional scaling due to intersubject variation in K1/k2 (blood-brain barrier transport and non-specific binding)...
  7. ncbi Evaluation of methods for generating parametric (R-[11C]PK11195 binding images
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1603-15. 2007
    ..In pathological conditions with reduced flow rates or large variations in blood volume, the basis function method is preferred because it produces less bias and is more precise...
  8. doi Serum amyloid p component as a biomarker in mild cognitive impairment and Alzheimer's disease
    Nicolaas A Verwey
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 26:522-7. 2008
    ..The aim was to investigate if SAP levels in cerebrospinal fluid (CSF) and serum can be used to discriminate controls, AD and mild cognitive impairment (MCI) patients, and to identify incipient AD among MCI patients...
  9. ncbi Evaluation of reference tissue models for the analysis of [11C](R)-PK11195 studies
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 26:1431-41. 2006
    ..82 and 0.78, respectively). SRTM(pl_corr) is optimal when an arterial plasma input curve is available. Simplified reference tissue model is the best alternative when no plasma input is available...
  10. doi Image-derived input functions for PET brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:463-71. 2009
    ..To assess the robustness of a previously introduced method to obtain accurate image-derived input functions (IDIF) for three other tracers...
  11. ncbi Impact of wavelet based denoising of [11C](R)-PK11195 time activity curves on accuracy and precision of kinetic analysis
    Maqsood Yaqub
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Med Phys 35:5069-78. 2008
    ..Wavelet denoising of TACs for [11C](R)-PK11195 PET studies is therefore useful when parametric Logan based V(T) is the parameter of interest...
  12. ncbi Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 25:842-51. 2005
    ..It was concluded that a two-tissue reversible compartment model with K(1)/k(2) fixed to whole cortex value is optimal for analyzing (R)-[(11)C]PK11195 PET brain studies...