P Scheltens

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, VU University Medical Center, P, O, Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 2:57. 2012
  2. pmc Reproducibility of quantitative (R)-[11C]verapamil studies
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, PK 1Z035, VU University Medical Center, P, O, Box 7057, Amsterdam 1007 MB, The Netherlands
    EJNMMI Res 2:1. 2012
  3. pmc Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands
    BMC Neurosci 13:85. 2012
  4. pmc Study protocol: EXERcise and cognition in sedentary adults with early-ONset dementia (EXERCISE-ON)
    Astrid M Hooghiemstra
    Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands
    BMC Neurol 12:75. 2012
  5. pmc Diagnostic and economic evaluation of new biomarkers for Alzheimer's disease: the research protocol of a prospective cohort study
    Ron L H Handels
    Alzheimer Centre Limburg, School for Mental Health and NeuroScience MHeNS, University Medical Centre, P O Box 5800, 6202, AZ Maastricht, The Netherlands
    BMC Neurol 12:72. 2012
  6. doi request reprint Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial
    Philip Scheltens
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 31:225-36. 2012
  7. pmc Prevention of depression and sleep disturbances in elderly with memory-problems by activation of the biological clock with light--a randomized clinical trial
    Els I S Most
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Trials 11:19. 2010
  8. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
  9. pmc Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory
    Willem de Haan
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    BMC Neurosci 10:101. 2009
  10. pmc (Cost)-effectiveness of family meetings on indicated prevention of anxiety and depressive symptoms and disorders of primary family caregivers of patients with dementia: design of a randomized controlled trial
    Karlijn J Joling
    Department of General Practice, Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    BMC Geriatr 8:2. 2008

Collaborators

Detail Information

Publications167 found, 100 shown here

  1. pmc Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, VU University Medical Center, P, O, Box 7057, Amsterdam, 1007 MB, The Netherlands
    EJNMMI Res 2:57. 2012
    ..abstract:..
  2. pmc Reproducibility of quantitative (R)-[11C]verapamil studies
    Daniëlle Me van Assema
    Department of Neurology and Alzheimer Center, PK 1Z035, VU University Medical Center, P, O, Box 7057, Amsterdam 1007 MB, The Netherlands
    EJNMMI Res 2:1. 2012
    ..abstract:..
  3. pmc Disturbed oscillatory brain dynamics in subcortical ischemic vascular dementia
    Elisabeth C W van Straaten
    Department of Clinical Neurophysiology, VU University Medical Center, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands
    BMC Neurosci 13:85. 2012
    ....
  4. pmc Study protocol: EXERcise and cognition in sedentary adults with early-ONset dementia (EXERCISE-ON)
    Astrid M Hooghiemstra
    Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands
    BMC Neurol 12:75. 2012
    ..The main aim of the EXERCISE-ON study is to assess whether exercise slows down the progressive course of the symptoms of dementia...
  5. pmc Diagnostic and economic evaluation of new biomarkers for Alzheimer's disease: the research protocol of a prospective cohort study
    Ron L H Handels
    Alzheimer Centre Limburg, School for Mental Health and NeuroScience MHeNS, University Medical Centre, P O Box 5800, 6202, AZ Maastricht, The Netherlands
    BMC Neurol 12:72. 2012
    ....
  6. doi request reprint Efficacy of Souvenaid in mild Alzheimer's disease: results from a randomized, controlled trial
    Philip Scheltens
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    J Alzheimers Dis 31:225-36. 2012
    ..EEG outcomes suggest that Souvenaid has an effect on brain functional connectivity, supporting the underlying hypothesis of changed synaptic activity...
  7. pmc Prevention of depression and sleep disturbances in elderly with memory-problems by activation of the biological clock with light--a randomized clinical trial
    Els I S Most
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Trials 11:19. 2010
    ....
  8. pmc Visual assessment of posterior atrophy development of a MRI rating scale
    Esther L G E Koedam
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 21:2618-25. 2011
    ..To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer's disease (AD) and other dementias...
  9. pmc Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory
    Willem de Haan
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    BMC Neurosci 10:101. 2009
    ..All results were normalized for network size and compared with random control networks...
  10. pmc (Cost)-effectiveness of family meetings on indicated prevention of anxiety and depressive symptoms and disorders of primary family caregivers of patients with dementia: design of a randomized controlled trial
    Karlijn J Joling
    Department of General Practice, Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    BMC Geriatr 8:2. 2008
    ....
  11. pmc Can novel therapeutics halt the amyloid cascade?
    Niels D Prins
    Alzheimer Center, VU University Medical Center, Boelelaan 1118, Amsterdam, The Netherlands
    Alzheimers Res Ther 2:5. 2010
    ..However, it may also be that these negative findings reflect our still incomplete understanding of, at least part of, the pathogenesis of Alzheimer's disease...
  12. ncbi request reprint White-matter changes on MRI as surrogate marker
    Philip Scheltens
    Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Int Psychogeriatr 15:261-5. 2003
    ....
  13. doi request reprint Efficacy of a medical food in mild Alzheimer's disease: A randomized, controlled trial
    Philip Scheltens
    VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 6:1-10.e1. 2010
    ..To investigate the effect of a medical food on cognitive function in people with mild Alzheimer's disease (AD)...
  14. ncbi request reprint All patients with suspected dementia should be scanned at least once with CT or MRI
    Philip Scheltens
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Int Psychogeriatr 19:533-4; discussion 534-8. 2007
  15. ncbi request reprint Moving forward with nutrition in Alzheimer's disease
    P Scheltens
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Neurol 16:19-22. 2009
    ..The Souvenir study is the first randomized, controlled, double-blind, multi-centre study designed to evaluate the efficacy of a multi-nutrient dietary approach on cognitive performance in drug-naïve early AD patients...
  16. ncbi request reprint Structural neuroimaging outcomes in clinical dementia trials, with special reference to disease modifying designs
    P Scheltens
    Dept Neurology and Alzheimer Center VU University Medical Center
    J Nutr Health Aging 10:123-8; discussion 129-30. 2006
    ....
  17. pmc Imaging in Alzheimer's disease
    Philip Scheltens
    Dept Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Dialogues Clin Neurosci 11:191-9. 2009
    ..In this review, the various imaging techniques will be highlighted, with an emphasis on their ability to diagnose Alzheimer's disease and separate it from other entities...
  18. ncbi request reprint Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion
    Philip Scheltens
    Department of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, Amsterdam, Netherlands
    Lancet Neurol 1:13-21. 2002
    ..Imaging research is also likely to focus on measuring progression and detecting therapeutic effect. As such, MRI is already become an indispensable tool in clinical trials in dementia...
  19. doi request reprint How golden is the gold standard of neuropathology in dementia?
    Philip Scheltens
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 7:486-9. 2011
    ..As an alternative, we propose to abandon thinking in standards and value neuropathology as any other biomarker, and to strive to use and integrate multiple sources of information to make the diagnosis of AD in all its complexity...
  20. pmc Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease
    W J P Henneman
    Department of Radiology and Alzheimer Center, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Neurology 73:935-40. 2009
    ....
  21. ncbi request reprint New research criteria for the diagnosis of Alzheimer's disease applied in a memory clinic population
    F H Bouwman
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 30:1-7. 2010
    ..This study applies the criteria in a memory clinic population, using clinical criteria as the reference criterion...
  22. ncbi request reprint Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment
    L A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, Amsterdam, The Netherlands
    Neurology 69:1491-7. 2007
    ..We compared baseline clinical, neuropsychological, and MRI measures to characterize these MCI subgroups...
  23. ncbi request reprint Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors
    J D Sluimer
    Department of Radiology and Alzheimer Centre, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 70:1836-41. 2008
    ..To assess which baseline clinical and MRI measures influence whole-brain atrophy rates, measured from serial MR imaging...
  24. ncbi request reprint CSF biomarkers predict rate of cognitive decline in Alzheimer disease
    M I Kester
    Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 73:1353-8. 2009
    ..We hypothesized that high tau, especially in combination with relatively low p-tau-181, is a marker of rapid decline, since it has been associated with fast neuronal degeneration...
  25. doi request reprint CSF biomarkers in relationship to cognitive profiles in Alzheimer disease
    A E van der Vlies
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 72:1056-61. 2009
    ..To investigate the relationship between CSF biomarkers and cognitive profiles in Alzheimer disease (AD)...
  26. doi request reprint Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort
    N S M Schoonenboom
    Departments of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Neurology 78:47-54. 2012
    ..To determine how amyloid β 42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) levels in CSF behave in a large cohort of patients with different types of dementia...
  27. ncbi request reprint Distribution of APOE genotypes in a memory clinic cohort
    W M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 25:433-8. 2008
    ..To describe the distribution of apolipoprotein E (APOE) genotypes in a cohort of memory clinic patients...
  28. doi request reprint Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease
    C J Stam
    Department of Clinical Neurophysiology and MEG, Amsterdam, The Netherlands
    Brain 132:213-24. 2009
    ..The modelling results suggest that highly connected neural network 'hubs' may be especially at risk in Alzheimer's disease...
  29. pmc Hippocampal atrophy rates in Alzheimer disease: added value over whole brain volume measures
    W J P Henneman
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 72:999-1007. 2009
    ..To investigate the added value of hippocampal atrophy rates over whole brain volume measurements on MRI in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and controls...
  30. pmc CSF biomarkers in frontotemporal lobar degeneration: relations with clinical characteristics, apolipoprotein E genotype, and neuroimaging
    Y A L Pijnenburg
    Alzheimer Center, Department of Neurology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:246-8. 2006
    ..CSF Abeta42 variability remained unexplained. Future research could study the role of ApoE genotype and Abeta42 in FTLD, as well as establish measures for disease intensity...
  31. ncbi request reprint Anterior medial temporal lobe activation during attempted retrieval of encoded visuospatial scenes: an event-related fMRI study
    S A Rombouts
    Department of Clinical Physics and Informatics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neuroimage 14:67-76. 2001
    ..We conclude that the left posterior parahippocampal gyrus responds during encoding, while on the other hand the left anterior parahippocampal gyrus and the right anterior hippocampus were more strongly involved in retrieval...
  32. ncbi request reprint Neurological signs in relation to white matter hyperintensity volumes in memory clinic patients
    S S Staekenborg
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands s staekenborg vumc nl
    Dement Geriatr Cogn Disord 29:301-8. 2010
    ..To determine the frequency of neurological signs in a memory clinic population and to explore their associations with white matter hyperintensity (WMH)...
  33. ncbi request reprint Prevalence and severity of microbleeds in a memory clinic setting
    C Cordonnier
    Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 66:1356-60. 2006
    ..To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic...
  34. ncbi request reprint Diabetes mellitus, hypertension and medial temporal lobe atrophy: the LADIS study
    E S C Korf
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Diabet Med 24:166-71. 2007
    ....
  35. doi request reprint Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  36. ncbi request reprint CSF tau and Abeta42 are not useful in the diagnosis of frontotemporal lobar degeneration
    Y A L Pijnenburg
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 62:1649. 2004
  37. doi request reprint White matter hyperintensities and medial temporal lobe atrophy in clinical subtypes of mild cognitive impairment: the DESCRIPA study
    L A van de Pol
    VUMC, Department of Neurology, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:1069-74. 2009
    ..Clinical subtypes of mild cognitive impairment (MCI) may represent different underlying aetiologies...
  38. doi request reprint Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset
    A E van der Vlies
    Department of Neurology and Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Psychol Med 39:1907-11. 2009
    ..We aimed to compare the rate of cognitive decline in patients with early and late onset Alzheimer's disease (AD) and to investigate the potentially modifying influence of the apolipoprotein E (APOE) genotype...
  39. ncbi request reprint Improved reliability of hippocampal atrophy rate measurement in mild cognitive impairment using fluid registration
    L A van de Pol
    Department of Neurology, Alzheimer Centre, VU Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 34:1036-41. 2007
    ..This method may be useful to quantify hippocampal volume change, given the reduction in operator time and improved precision...
  40. ncbi request reprint Longitudinal changes of CSF biomarkers in memory clinic patients
    F H Bouwman
    Alzheimer Center and Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    Neurology 69:1006-11. 2007
    ..We evaluated the natural course of CSF biomarkers in patients with AD, subjective complaints, and mild cognitive impairment (MCI)...
  41. doi request reprint EEG functional connectivity and ApoE genotype in Alzheimer's disease and controls
    Gerdien Kramer
    Department of Neurology, Alzheimer Centre, VU University Medical Center, PO Box 7057, De Boelelaan 1118, 1007 MB Amsterdam, Noord Holland, The Netherlands
    Clin Neurophysiol 119:2727-32. 2008
    ....
  42. ncbi request reprint Profile of cognitive impairment in chronic heart failure
    Raymond L C Vogels
    Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    J Am Geriatr Soc 55:1764-70. 2007
    ..To determine the frequency and pattern of cognitive dysfunction in outpatients with chronic congestive heart failure (CHF) and to identify the corresponding demographic and clinical correlates...
  43. ncbi request reprint The use of EEG in the diagnosis of dementia with Lewy bodies
    G Roks
    Alzheimer Center, VU University Medical Center, Department of Neurology, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 79:377-80. 2008
    ..9% of the patients with AD and in 33.3% of the patients with DLB. The GTE is a simple EEG scoring method that can be helpful in the differential diagnosis between DLB and AD with good sensitivity and specificity...
  44. ncbi request reprint Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease
    C Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
    J Neural Transm 110:949-55. 2003
    ....
  45. ncbi request reprint White matter changes on CT and MRI: an overview of visual rating scales. European Task Force on Age-Related White Matter Changes
    P Scheltens
    Department of Neurology, Academisch Ziekenhuis VU, Amsterdam, The Netherlands
    Eur Neurol 39:80-9. 1998
    ..The ideal rating scale does not yet exist, but different rating scales may serve different purposes, for which some recommendations are made...
  46. ncbi request reprint Hippocampal atrophy in Alzheimer disease: age matters
    L A van de Pol
    Department of Neurology, Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Neurology 66:236-8. 2006
    ..Aging and AD were independently associated with smaller hippocampal volume. Both young and old AD patients have hippocampal atrophy abnormal for age. Age-dependent criteria for hippocampal atrophy, suggestive of AD, are needed...
  47. ncbi request reprint Diagnostic accuracy of consensus diagnostic criteria for frontotemporal dementia in a memory clinic population
    Yolande A L Pijnenburg
    Alzheimer Centre, VU University Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 25:157-64. 2008
    ..The goal of the present study was to evaluate the diagnostic accuracy of the core diagnostic criteria for frontotemporal dementia (FTD) [Neary D, et al: Neurology 1998;51:1546-1554] within a memory clinic population...
  48. ncbi request reprint Attention modulates hemispheric differences in functional connectivity: evidence from MEG recordings
    Liselotte Gootjes
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Neuroimage 30:245-53. 2006
    ..This supports the idea of a supervisory role for the frontal cortex in attention processes...
  49. ncbi request reprint Model-free group analysis shows altered BOLD FMRI networks in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:256-66. 2009
    ..The technique is more sensitive than the commonly applied model-based method. Consistent with other research, we show that networks of activation and deactivation show decreased reactivity in dementia...
  50. doi request reprint Disrupted modular brain dynamics reflect cognitive dysfunction in Alzheimer's disease
    W de Haan
    Department of Clinical Neurophysiology and MEG, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 59:3085-93. 2012
    ..These findings imply the relevance of regarding dementia as a functional network disorder...
  51. doi request reprint Differential association of [11C]PIB and [18F]FDDNP binding with cognitive impairment
    N Tolboom
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    Neurology 73:2079-85. 2009
    ....
  52. pmc Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
    G J Biessels
    The Alzheimer Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:304-7. 2006
    ..The risk of Alzheimer's disease (AD) is increased in type 2 diabetes (DM2). This increased risk has been attributed to vascular comorbidity, but other mechanisms, such as accelerated ageing of the brain, have also been implicated...
  53. ncbi request reprint Loss of frontal fMRI activation in early frontotemporal dementia compared to early AD
    S A R B Rombouts
    Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neurology 60:1904-8. 2003
    ..To compare frontal cortex activation in patients with early frontotemporal dementia (FTD) with that in patients with early AD...
  54. pmc Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease
    L A van de Pol
    VUMC, Department of Neurology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:439-42. 2006
    ..Hippocampal atrophy on magnetic resonance imaging (MRI) is an early characteristic of Alzheimer's disease. However, hippocampal atrophy may also occur in other dementias, such as frontotemporal lobar degeneration (FTLD)...
  55. ncbi request reprint Magnetoencephalographic analysis of cortical activity in Alzheimer's disease: a pilot study
    H W Berendse
    Department of Clinical Neurophysiology, Research Institute Neurosciences VU, University Hospital Vrije Universiteit, Amsterdam, Netherlands
    Clin Neurophysiol 111:604-12. 2000
    ..In the present study, MEG was used to analyze spectral power and reference-free coherence in patients with probable Alzheimer's disease (AD)...
  56. ncbi request reprint The effect of anxiety and depression on decline of memory function in Alzheimer's disease
    E J M Bierman
    Department of Psychiatry, EMGO Institute, VU Medical Centre, Amsterdam, The Netherlands
    Int Psychogeriatr 21:1142-7. 2009
    ..The present study investigated whether symptoms of anxiety and depression predict decline of memory function in elderly people diagnosed with early stage AD...
  57. ncbi request reprint Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Brain 129:141-57. 2006
    ....
  58. ncbi request reprint Head trauma and Alzheimer's disease
    Rishi D S Nandoe
    Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Alzheimers Dis 4:303-8. 2002
    ..Extensive history taking disclosed no cognitive changes prior to the car accident. The case is discussed in view of the inflammation hypothesis regarding Alzheimer's disease and the role of the apolipoprotein E4 genotype of the patient...
  59. ncbi request reprint No evidence for increased self-reported cognitive failure in Type 1 and Type 2 diabetes: a cross-sectional study
    A M Wessels
    Department of Medical Psychology, VU University Medical Centre, Amsterdam, The Netherlands
    Diabet Med 24:735-40. 2007
    ..This study set out to investigate the magnitude and correlates of self-reported cognitive failure in adult out-patients with Type 1 and Type 2 diabetes...
  60. ncbi request reprint The effect of APOE genotype on clinical phenotype in Alzheimer disease
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 67:526-7. 2006
    ..2 to 7.8), suggesting that two subtypes of AD can be identified. The typical amnestic phenotype seems to be promoted by the APOE-epsilon4 allele, whereas the atypical nonmemory phenotype occurs in the absence of the APOE-epsilon4 allele...
  61. ncbi request reprint Nonlinear changes in brain activity during continuous word repetition: an event-related multiparametric functional MR imaging study
    R E Hagenbeek
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 28:1715-21. 2007
    ..Our aim was to identify linear changes in brain activation and, what is more interesting, nonlinear changes in brain activation as a function of extended word repetition...
  62. ncbi request reprint The auditory oddball paradigm in patients with vascular cognitive impairment: a prolonged latency of the N2 complex
    B van Harten
    Department of Neurology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 21:322-7. 2006
    ..The aim of this study was to investigate the diagnostic value of the different elements of this response (N(1), N(2) complex and P(3) latencies) in a group of elderly patients with VCI caused by SIVD...
  63. doi request reprint Small vessel versus large vessel vascular dementia: risk factors and MRI findings
    S S Staekenborg
    Dept of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol 255:1644-51; discussion 1813-4. 2008
    ....
  64. doi request reprint Heterogeneity of white matter hyperintensities in Alzheimer's disease: post-mortem quantitative MRI and neuropathology
    A A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Brain 131:3286-98. 2008
    ..Quantitative MRI techniques reveal differences in WMH between Alzheimer's disease and non-demented elderly, and are able to reflect the severity of the neuropathological changes involved...
  65. doi request reprint Associations between patterns of EEG abnormalities and diagnosis in a large memory clinic cohort
    M Liedorp
    Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 27:18-23. 2009
    ..To describe associations of abnormalities in the electroencephalogram (EEG) with the most prevalent diagnoses in a memory clinic cohort...
  66. ncbi request reprint Total tau and phosphorylated tau 181 levels in the cerebrospinal fluid of patients with frontotemporal dementia due to P301L and G272V tau mutations
    Sonia M Rosso
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Neurol 60:1209-13. 2003
    ..Mutations in the tau gene have been found in the familial form of FTD, linked to chromosome 17q21-22, showing a spectrum of tauopathy...
  67. ncbi request reprint Validation of the HIV Dementia Scale in an elderly cohort of patients with subcortical cognitive impairment caused by subcortical ischaemic vascular disease or a normal pressure hydrocephalus
    Barbera van Harten
    Department of Neurology, Sint Lucas Andreas Hospital, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Dement Geriatr Cogn Disord 18:109-14. 2004
    ....
  68. doi request reprint Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease
    Cees Mulder
    Department of Clinical Chemistry, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
    Clin Chem 56:248-53. 2010
    ..We have used these markers and evaluated their performance...
  69. ncbi request reprint Whole brain analysis of T2* weighted baseline FMRI signal in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 28:1313-7. 2007
    ..We conclude that in FMRI studies of dementia, not only the dynamic BOLD signal (activation and deactivation) but also the average baseline signal is diminished in certain regions. The method we applied may also be used in task-rel..
  70. ncbi request reprint Frontotemporal dementia in The Netherlands: patient characteristics and prevalence estimates from a population-based study
    Sonia M Rosso
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 126:2016-22. 2003
    ..The finding of tau mutations in 32% of patients with a positive family history for dementia justifies mutation screening in FTD patients with a positive family history, while tau mutations in non-familiar cases are rare...
  71. ncbi request reprint The contribution of medial temporal lobe atrophy and vascular pathology to cognitive impairment in vascular dementia
    Antonio J Bastos-Leite
    Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    Stroke 38:3182-5. 2007
    ..Therefore, our purpose was to investigate the relative contribution of cerebrovascular disease and MTA to cognitive impairment in patients fulfilling diagnostic criteria for VaD...
  72. ncbi request reprint Unbiased whole-brain analysis of gray matter loss in Alzheimer's disease
    S A Rombouts
    Department of Clinical Physics and Informatics, University Hospital Vrije Universiteit, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Neurosci Lett 285:231-3. 2000
    ..The exact role of these two structures in the symptomatology of Alzheimer's disease deserves further attention...
  73. ncbi request reprint Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities
    A J Bastos-Leite
    Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 29:1296-301. 2008
    ..We hypothesized that elderly subjects with diffuse confluent WMH should have lower cerebral blood flow (CBF) measurements than subjects with punctiform or beginning confluent WMH...
  74. ncbi request reprint Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease
    G B Karas
    Department of Diagnostic Radiology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neuroimage 23:708-16. 2004
    ..Mild cognitive impairment (MCI) is thought to be the prodromal phase to Alzheimer's disease (AD). We analyzed patterns of gray matter (GM) loss to examine what characterizes MCI and what determines the difference with AD...
  75. ncbi request reprint Hippocampal sulcus width and cavities: comparison between patients with Alzheimer disease and nondemented elderly subjects
    A J Bastos-Leite
    Department of Radiology and Image Analysis Center, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 27:2141-5. 2006
    ..We hypothesized that either hippocampal sulcus enlargement or an increase in number or size of hippocampal cavities could be associated with medial temporal lobe atrophy (MTA) occurring in Alzheimer disease...
  76. ncbi request reprint Amnestic mild cognitive impairment: structural MR imaging findings predictive of conversion to Alzheimer disease
    G Karas
    Department of Diagnostic Radiology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 29:944-9. 2008
    ..We used voxel-based morphometry (VBM) to find out whether structural differences on MR imaging could offer insight into the development of clinical AD in patients with amnestic MCI at 3-year follow-up...
  77. ncbi request reprint Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic
    Geert Jan Biessels
    Department of Neurology, G03 228, University Medical Center Utrecht, 85500, 3508 GA, Utrecht, The Netherlands
    J Neurol 253:477-82. 2006
    ....
  78. ncbi request reprint Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males
    Rutger Goekoop
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 31:1508-18. 2006
    ..Behaviorally, such neurofunctional effects may actively block decreased memory performance as a result of context-dependency. The validity of these predictions can be tested in large-scale clinical trials...
  79. ncbi request reprint Evaluation of reference regions for (R)-[(11)C]PK11195 studies in Alzheimer's disease and mild cognitive impairment
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1965-74. 2007
    ..Most anatomic regions outperformed cluster analysis in terms of absence of both scan rejection and bias. Total cerebellum is the optimal reference region in this patient category...
  80. doi request reprint An MRI rating scale for amyloid-related imaging abnormalities with edema or effusion
    F Barkhof
    Image Analysis Centre, Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 34:1550-5. 2013
    ..To assess the intensity of ARIA-E presentation, an MR imaging scale that is both reproducible and easily implemented would assist in monitoring and evaluating this adverse event...
  81. pmc Use of laboratory and imaging investigations in dementia
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:v45-52. 2005
  82. ncbi request reprint Effect of hydroxychloroquine on progression of dementia in early Alzheimer's disease: an 18-month randomised, double-blind, placebo-controlled study
    W A van Gool
    Department of Neurology, Academic Medical Centre, PO Box 22700, 1100 DE, Amsterdam, Netherlands
    Lancet 358:455-60. 2001
    ..We aimed to establish the effect of the anti-inflammatory drug hydroxychloroquine on the progression of dementia...
  83. pmc Consistent resting-state networks across healthy subjects
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 103:13848-53. 2006
    ..These findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments...
  84. ncbi request reprint Cognitive slowing in multiple sclerosis is strongly associated with brain volume reduction
    R H C Lazeron
    Department of Neurology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Mult Scler 12:760-8. 2006
    ..Since MS is characterized by cognitive slowing rather than impaired accuracy, we used the Amsterdam Neuropsychological Tasks (ANT) program, a computerized test proven to be very sensitive to cognitive slowing in MS patients...
  85. ncbi request reprint The diagnostic value of electroencephalography in mild senile Alzheimer's disease
    J J Claus
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    Clin Neurophysiol 110:825-32. 1999
    ..We investigated the diagnostic value of the visually assessed electroencephalogram (EEG) in patients with mild Alzheimer's disease (AD), using the grand total of EEG (GTE) score...
  86. pmc Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study
    W M van der Flier
    Department of Neurology and Alzheimer Centre, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:1497-500. 2005
    ..To assess the associations of medial temporal lobe atrophy (MTA) and white matter hyperintensities (WMH) with cognitive function in a large group of independently functioning elderly people...
  87. ncbi request reprint Alzheimer's disease is not associated with altered concentrations of the nitric oxide synthase inhibitor asymmetric dimethylarginine in cerebrospinal fluid
    C Mulder
    Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands, Sweden
    J Neural Transm 109:1203-8. 2002
    ..Our results suggest that in early stages of AD overall regulation of NO production by ADMA is not aberrant...
  88. ncbi request reprint Efficacy of a medical food on cognition in Alzheimer's disease: results from secondary analyses of a randomized, controlled trial
    P J G H Kamphuis
    Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands
    J Nutr Health Aging 15:720-4. 2011
    ..0) and patients with 'high' baseline ADAS-cog scores (≥25.0). Repeated Measures Models (RMM) were used to determine the relationship between ADAS-cog score and intervention...
  89. ncbi request reprint Effect of a medical food on body mass index and activities of daily living in patients with Alzheimer's disease: secondary analyses from a randomized, controlled trial
    P J G H Kamphuis
    Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, Wageningen, The Netherlands
    J Nutr Health Aging 15:672-6. 2011
    ..Both ADCS-ADL and BMI were assessed at baseline and Weeks 6, 12 and 24. Data were analyzed using a repeated-measures mixed model...
  90. ncbi request reprint Midlife blood pressure and the risk of hippocampal atrophy: the Honolulu Asia Aging Study
    Esther S C Korf
    Department of Neurology and Alzheimer Center, Universiteit Medical Center, Amsterdam, The Netherlands
    Hypertension 44:29-34. 2004
    ..51; CI=1.26; 9.74). In conclusion, treatment with antihypertensive treatment modifies the association of BP and HA, such that high levels of BP adversely affect the hippocampus in persons never treated with antihypertensives...
  91. ncbi request reprint Effects of transcutaneous electrical nerve stimulation (TENS) on non-pain related cognitive and behavioural functioning
    Koene R A van Dijk
    Department of Clinical Neuropsychology, Vrije Universiteit, Amsterdam, The Netherlands
    Rev Neurosci 13:257-70. 2002
    ..It is argued that arousal may underlie the beneficial influence of TENS in various conditions. Finally, suggestions are offered for future research...
  92. ncbi request reprint Evaluation of methods for generating parametric (R-[11C]PK11195 binding images
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1603-15. 2007
    ..In pathological conditions with reduced flow rates or large variations in blood volume, the basis function method is preferred because it produces less bias and is more precise...
  93. ncbi request reprint Emerging treatments in dementia
    P Scheltens
    Department of Neurology, Academisch Ziekenhuis VU, Amsterdam, The Netherlands
    Eur Neurol 38:184-9. 1997
    ..The question of heterogeneity may be solved when different therapeutic strategies are found for different subtypes. The focus of future plans should be on preventive strategies combined with an early diagnosis...
  94. doi request reprint A systematic review of Instrumental Activities of Daily Living scales in dementia: room for improvement
    S A M Sikkes
    Department of Epidemiology and Biostatistics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:7-12. 2009
    ..Despite the large number of questionnaires, their quality has received little attention...
  95. doi request reprint A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease
    N A Verwey
    Department of Clinical Chemistry, VU University Medical Center, HV, The Netherlands
    Ann Clin Biochem 46:235-40. 2009
    ..The aim of this study was to compare the measurements of these CSF biomarkers, between and within centres...
  96. ncbi request reprint Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy
    A M Wessels
    Department of Medical Psychology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Diabetologia 49:2474-80. 2006
    ..The aim of our study was to use magnetic resonance imaging (MRI) to establish whether long-term hyperglycaemia, resulting in advanced retinopathy, contributes to structural changes in the brain (reduced grey matter)...
  97. pmc Epidemiology and risk factors of dementia
    W M van der Flier
    Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 76:v2-7. 2005
  98. ncbi request reprint Magnetoencephalographic evaluation of resting-state functional connectivity in Alzheimer's disease
    C J Stam
    Department of Clinical Neurophysiology and MEG, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 32:1335-44. 2006
    ..These changes may reflect loss of anatomical connections and/or reduced central cholinergic activity and could underlie part of the cognitive impairment...
  99. ncbi request reprint The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old
    F Barkhof
    Department of Radiology, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurology 69:1521-7. 2007
    ..Medial temporal lobe atrophy (MTA) is a sensitive radiologic marker for Alzheimer disease (AD) and associated with cognitive impairment. The value of MTA in the oldest old (>85 years old) is largely unknown...
  100. ncbi request reprint [The immune system and Alzheimer's disease]
    E van Exel
    VUMC GGZ inGeest, Amsterdam
    Tijdschr Psychiatr 53:637-43. 2011
    ..It has still not been established unequivocally whether vascular risk factors and inflammatory reactions, determined by heredity, are a cause or a result of Alzheimer's disease..
  101. pmc Decreased cerebrospinal fluid amyloid beta (1-40) levels in frontotemporal lobar degeneration
    Y A L Pijnenburg
    Alzheimer Centre and Department of Neurology, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 78:735-7. 2007
    ..These findings favour a differential involvement of amyloid beta peptides in FTLD compared with AD...