Serge Rombouts

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 26:1078-85. 2005
  2. ncbi request reprint Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 26:231-9. 2005
  3. pmc Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease
    S A R B Rombouts
    Department of Neurology Alzheimer Centre, Vrije Universiteit Medical Centre, Amsterdam, Netherlands
    J Neurol Neurosurg Psychiatry 73:665-71. 2002
  4. ncbi request reprint Identifying confounds to increase specificity during a "no task condition". Evidence for hippocampal connectivity using fMRI
    S A R B Rombouts
    Department of Physics and Medical Technology, VU Medical Center, Amsterdam, The Netherlands
    Neuroimage 20:1236-45. 2003
  5. ncbi request reprint Loss of frontal fMRI activation in early frontotemporal dementia compared to early AD
    S A R B Rombouts
    Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neurology 60:1904-8. 2003
  6. ncbi request reprint Functional connectivity in elderly controls and AD patients using resting state fMRI: a pilot study
    Serge Rombouts
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Curr Alzheimer Res 2:115-6. 2005
  7. pmc Prefrontal hypoactivation and recovery in insomnia
    Ellemarije Altena
    Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Sleep 31:1271-6. 2008
  8. ncbi request reprint Model-free group analysis shows altered BOLD FMRI networks in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:256-66. 2009
  9. ncbi request reprint Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Brain 129:141-57. 2006
  10. ncbi request reprint Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males
    Rutger Goekoop
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 31:1508-18. 2006

Detail Information

Publications32

  1. ncbi request reprint Delayed rather than decreased BOLD response as a marker for early Alzheimer's disease
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 26:1078-85. 2005
    ..Analyzing differences in different phases of the BOLD response introduces new opportunities to understand changes in regional brain dynamics in MCI and how well this may serve as an early marker of AD pathology...
  2. ncbi request reprint Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 26:231-9. 2005
    ..These findings suggest that altered activity in the default mode network may act as an early marker for AD pathology...
  3. pmc Alterations in brain activation during cholinergic enhancement with rivastigmine in Alzheimer's disease
    S A R B Rombouts
    Department of Neurology Alzheimer Centre, Vrije Universiteit Medical Centre, Amsterdam, Netherlands
    J Neurol Neurosurg Psychiatry 73:665-71. 2002
    ..It remains unclear where in the brain it exerts its effect. Functional magnetic resonance imaging (fMRI) can be used to measure changes in brain function and relate these to cognition...
  4. ncbi request reprint Identifying confounds to increase specificity during a "no task condition". Evidence for hippocampal connectivity using fMRI
    S A R B Rombouts
    Department of Physics and Medical Technology, VU Medical Center, Amsterdam, The Netherlands
    Neuroimage 20:1236-45. 2003
    ..Both maps of hippocampal connectivity caused by BOLD signal and connectivity caused by spurious signals could be identified...
  5. ncbi request reprint Loss of frontal fMRI activation in early frontotemporal dementia compared to early AD
    S A R B Rombouts
    Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neurology 60:1904-8. 2003
    ..To compare frontal cortex activation in patients with early frontotemporal dementia (FTD) with that in patients with early AD...
  6. ncbi request reprint Functional connectivity in elderly controls and AD patients using resting state fMRI: a pilot study
    Serge Rombouts
    Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Curr Alzheimer Res 2:115-6. 2005
    ....
  7. pmc Prefrontal hypoactivation and recovery in insomnia
    Ellemarije Altena
    Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    Sleep 31:1271-6. 2008
    ..This study was designed to investigate functional brain activation differences as a possible result of chronic insomnia, and the reversibility of these differences after nonmedicated sleep therapy...
  8. ncbi request reprint Model-free group analysis shows altered BOLD FMRI networks in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:256-66. 2009
    ..The technique is more sensitive than the commonly applied model-based method. Consistent with other research, we show that networks of activation and deactivation show decreased reactivity in dementia...
  9. ncbi request reprint Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Brain 129:141-57. 2006
    ....
  10. ncbi request reprint Raloxifene treatment enhances brain activation during recognition of familiar items: a pharmacological fMRI study in healthy elderly males
    Rutger Goekoop
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 31:1508-18. 2006
    ..Behaviorally, such neurofunctional effects may actively block decreased memory performance as a result of context-dependency. The validity of these predictions can be tested in large-scale clinical trials...
  11. ncbi request reprint Precuneus atrophy in early-onset Alzheimer's disease: a morphometric structural MRI study
    Giorgos Karas
    Department of Diagnostic Radiology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Neuroradiology 49:967-76. 2007
    ..In this study we set out to investigate whether age at onset in patients with AD determines the pattern of atrophy on cerebral MRI scans...
  12. ncbi request reprint Microvascular disease in type 1 diabetes alters brain activation: a functional magnetic resonance imaging study
    Alette M Wessels
    Department of Medical Psychology, Vrije University VU Medical Center, Amsterdam, Netherlands
    Diabetes 55:334-40. 2006
    ..Task performance and reaction time were not significantly different for either group. We conclude that microvascular damage in the brain of patients with retinopathy caused this increased brain response to compensate for functional loss...
  13. doi request reprint White matter tract integrity in aging and Alzheimer's disease
    Jessica S Damoiseaux
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 30:1051-9. 2009
    ..This different pattern of decreased anatomical connectivity in normal aging and AD suggests that AD is not merely accelerated aging...
  14. ncbi request reprint Medial temporal lobe activity during semantic classification using a flexible fMRI design
    Sander M Daselaar
    Institute for Research in Extramural Medicine, Vrije Universiteit Medical Center, c o Secr EMGO Dept vd Boechorstraat 7, 1081 BT Amsterdam, The Netherlands
    Behav Brain Res 136:399-404. 2002
    ..Additional activity was seen in the right, and, at a slightly lower threshold, also in the left MTL, providing support for the involvement of the MTL in retrieval from semantic memory...
  15. ncbi request reprint Maintenance versus manipulation in verbal working memory revisited: an fMRI study
    Dick J Veltman
    PET Center and Department of Psychiatry, Vrije Universiteit Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    Neuroimage 18:247-56. 2003
    ..Therefore, our data support a functional rather than a neuroanatomical distinction between maintenance and manipulation, given our finding that these tasks differentially activate virtually identical systems...
  16. ncbi request reprint A paced visual serial addition test for fMRI
    Richard H C Lazeron
    Department of Neurology, Vrije Universiteit Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neurol Sci 213:29-34. 2003
    ..Based on the PASAT we used a adapted version of the test to assess several cognitive functions with fMRI. In this study we investigated the activation pattern on a group and individual level and upon parametric stimulation...
  17. doi request reprint No structural cerebral differences between children with a history of bacterial meningitis and healthy siblings
    Rogier C J de Jonge
    Department of Pediatrics and Infectious Diseases, VU University Medical Center, Amsterdam, The Netherlands
    Acta Paediatr 97:1390-6. 2008
    ....
  18. ncbi request reprint An fMRI study of planning-related brain activity in patients with moderately advanced multiple sclerosis
    Richard H C Lazeron
    Department of Radiology and the MS MRI Centre, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Mult Scler 10:549-55. 2004
    ..We used functional magnetic resonance imaging (fMRI) to study planning, an executive function, in moderately impaired MS patients...
  19. ncbi request reprint Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study
    Rutger Goekoop
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 23:1450-9. 2004
    ..This should encourage further functional imaging studies to examine the status of neurotransmitter systems in disease...
  20. ncbi request reprint Whole brain analysis of T2* weighted baseline FMRI signal in dementia
    Serge A R B Rombouts
    Department of Physics and Medical Technology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 28:1313-7. 2007
    ..We conclude that in FMRI studies of dementia, not only the dynamic BOLD signal (activation and deactivation) but also the average baseline signal is diminished in certain regions. The method we applied may also be used in task-rel..
  21. ncbi request reprint Neurophysiological correlates of increased verbal working memory in high-dissociative participants: a functional MRI study
    Dick J Veltman
    Department of Psychiatry and Clinical PET Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Psychol Med 35:175-85. 2005
    ..In contrast, in high-dissociative subjects increased performance has been found for episodic memory and dual task performance. These findings have been linked to changes in working memory capacity...
  22. ncbi request reprint Interaction of endogenous cortisol and noradrenaline in the human amygdala
    Anda H van Stegeren
    Department of Clinical Psychology and Cognitive Science Center, University of Amsterdam, Roetersstraat 15, 1018 WB, Amsterdam, The Netherlands
    Prog Brain Res 167:263-8. 2008
    ..These data support the hypothesis that high endogenous cortisol levels at the time of encoding interact with noradrenergic activation in the amygdala in man...
  23. ncbi request reprint Determination of individual stimulus--response curves in the visual cortex
    Rogier E Hagenbeek
    Department of Radiology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Hum Brain Mapp 17:244-50. 2002
    ..Based on our findings, the peak response and the slope of response seem highly reproducible within subjects. A similar analysis of the stimulus-response curve may be applicable to other types of stimuli...
  24. doi request reprint Evaluating the negative or valuing the positive? Neural mechanisms supporting feedback-based learning across development
    Anna C K van Duijvenvoorde
    Leiden University Institute for Psychological Research, Leiden University, 2333 AK Leiden, The Netherlands
    J Neurosci 28:9495-503. 2008
    ..This is the first developmental fMRI study to compare qualitative changes in brain activation during feedback learning across distinct stages of development...
  25. ncbi request reprint Changes in brain electrical activity during extended continuous word recognition
    Jan W Van Strien
    Department of Psychology, Faculty of Social Sciences, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Neuroimage 26:952-9. 2005
    ..Correlation analysis suggests that decreased delta power is moderately associated with faster decision speed and higher accuracy...
  26. ncbi request reprint Aging affects both perceptual and lexical/semantic components of word stem priming: An event-related fMRI study
    Sander M Daselaar
    Center for Cognitive Neuroscience, Duke University, Box 90999, LSRC Bldg, Rm B243N, Durham, NC 27708, USA
    Neurobiol Learn Mem 83:251-62. 2005
    ..These findings suggest that, converse to current psychological views, aging affects both perceptual and lexical/semantic components of repetition priming...
  27. doi request reprint Switching between colors and shapes on the basis of positive and negative feedback: an fMRI and EEG study on feedback-based learning
    Kiki Zanolie
    Leiden University Institute for Psychological Research LU IPR, Leiden University, Leiden, The Netherlands
    Cortex 44:537-47. 2008
    ..These results indicate that both medial PFC and DLPFC signal the need for performance adjustment, and both regions are sensitive to the increased demands of set shifting in hypothesis testing...
  28. ncbi request reprint Deep processing activates the medial temporal lobe in young but not in old adults
    Sander M Daselaar
    Center for Cognitive Neuroscience, Duke University, Box 90999, LSRC Bldg, Rm B243N, Durham, NC 27708, USA
    Neurobiol Aging 24:1005-11. 2003
    ..This finding is in line with the idea that age-related impairments in episodic encoding are, at least partly, due to an under-recruitment of the medial temporal lobe memory system...
  29. ncbi request reprint Neural mechanisms supporting flexible performance adjustment during development
    Eveline A Crone
    Department of Developmental Psychology, Leiden University, Leiden, The Netherlands
    Cogn Affect Behav Neurosci 8:165-77. 2008
    ..Supplementary data from this study are available online at the Psychonomic Society Archive of Norms, Stimuli, and Data, at www.psychonomic.org/archive...
  30. ncbi request reprint Similar network activated by young and old adults during the acquisition of a motor sequence
    Sander M Daselaar
    Center for Cognitive Neuroscience, Duke University, Box 90999, LSRC Bldg, Rm B243N, Durham, NC 27708, USA
    Neurobiol Aging 24:1013-9. 2003
    ....
  31. ncbi request reprint Noradrenaline mediates amygdala activation in men and women during encoding of emotional material
    Anda H van Stegeren
    Department of Clinical Psychology and Cognitive Science Center Amsterdam, University of Amsterdam, 1018 WB Amsterdam, The Netherlands
    Neuroimage 24:898-909. 2005
    ..This study supports the hypothesis that the neurotransmitter noradrenaline also mediates amygdala activity in humans when processing emotional stimuli and that betablockers can disrupt the normal activation pattern in the amygdala...
  32. ncbi request reprint Endogenous cortisol level interacts with noradrenergic activation in the human amygdala
    Anda H van Stegeren
    University of Amsterdam, Department of Clinical Psychology and Cognitive Science Center, Roetersstraat 15, 1018 WB Amsterdam, The Netherlands
    Neurobiol Learn Mem 87:57-66. 2007
    ....