F M Raaphorst

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene
    Frank M Raaphorst
    Department of Pathology, VU University Medical Center, BioCentrum Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Neoplasia 5:481-8. 2003
  2. ncbi Of mice, flies, and man: the emerging role of polycomb-group genes in human malignant lymphomas
    Frank M Raaphorst
    Department of Pathology, VU Medical Center, 1081 HV Amsterdam, The Netherlands
    Int J Hematol 81:281-7. 2005
  3. ncbi Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors
    Frank M Raaphorst
    Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Hum Mol Genet 14:R93-R100. 2005
  4. ncbi Polycomb-group genes as regulators of mammalian lymphopoiesis
    F M Raaphorst
    VU Medical Center, Department of Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Trends Immunol 22:682-90. 2001
  5. pmc Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas
    Frank M Raaphorst
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 164:533-42. 2004
  6. ncbi Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1
    Frank M Raaphorst
    Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Trends Immunol 24:522-4. 2003
  7. ncbi Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma
    F J van Kemenade
    Department of Pathology, VU University Hospital, Rm PA 001, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Blood 97:3896-901. 2001
  8. pmc Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease
    F M Raaphorst
    Department of Pathology, VU University Hospital, Amsterdam University of Amsterdam, Amsterdam, The Netherlands
    Am J Pathol 157:709-15. 2000
  9. ncbi Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers
    F M Raaphorst
    Department of Pathology, Vrÿe Universiteit University Hospital, Amsterdam, The Netherlands
    J Immunol 164:1-4. 2000
  10. ncbi Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation
    F M Raaphorst
    Department of Pathology, Vrÿe Universiteit University Hospital, Amsterdam, The Netherlands
    J Immunol 166:5925-34. 2001

Collaborators

Detail Information

Publications22

  1. pmc Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene
    Frank M Raaphorst
    Department of Pathology, VU University Medical Center, BioCentrum Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    Neoplasia 5:481-8. 2003
    ..These observations suggest that deregulated expression of EZH2 is associated with loss of differentiation and development of poorly differentiated breast cancer in humans...
  2. ncbi Of mice, flies, and man: the emerging role of polycomb-group genes in human malignant lymphomas
    Frank M Raaphorst
    Department of Pathology, VU Medical Center, 1081 HV Amsterdam, The Netherlands
    Int J Hematol 81:281-7. 2005
    ..In humans, a growing body of work has now linked human PcG genes to various hematologic and epithelial cancers. This review focuses on the emerging role of PcG genes in the development of human malignant lymphomas...
  3. ncbi Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors
    Frank M Raaphorst
    Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Hum Mol Genet 14:R93-R100. 2005
    ..This review addresses the current insights in the role of PcG genes in development of human malignancies...
  4. ncbi Polycomb-group genes as regulators of mammalian lymphopoiesis
    F M Raaphorst
    VU Medical Center, Department of Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Trends Immunol 22:682-90. 2001
    ..The underlying mechanism is related, most probably, to gene silencing by chromatin modification, and might affect proliferative behavior and account for the irreversibility of lineage choice...
  5. pmc Site-specific expression of polycomb-group genes encoding the HPC-HPH/PRC1 complex in clinically defined primary nodal and cutaneous large B-cell lymphomas
    Frank M Raaphorst
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Pathol 164:533-42. 2004
    ..We propose that distinct expression profiles of PcG genes results in abnormal formation of HPC-HPH/PRC1 PcG complexes, and that this contributes to lymphomagenesis and different clinical behavior of clinically defined LBCLs...
  6. ncbi Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1
    Frank M Raaphorst
    Department of Pathology, VU Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Trends Immunol 24:522-4. 2003
    ..This identifies Polycomb-group genes as potential targets for therapeutic intervention in leukemia, and possibly other forms of cancer...
  7. ncbi Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma
    F J van Kemenade
    Department of Pathology, VU University Hospital, Rm PA 001, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Blood 97:3896-901. 2001
    ..This points to a role for abnormal PcG expression in human lymphomagenesis. (Blood. 2001;97:3896-3901)..
  8. pmc Coexpression of BMI-1 and EZH2 polycomb group genes in Reed-Sternberg cells of Hodgkin's disease
    F M Raaphorst
    Department of Pathology, VU University Hospital, Amsterdam University of Amsterdam, Amsterdam, The Netherlands
    Am J Pathol 157:709-15. 2000
    ..Because HRS cells are thought to originate from germinal center lymphocytes, these observations suggests that Hodgkin's disease is associated with coexpression of BMI-1 and EZH2 in HRS cells...
  9. ncbi Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers
    F M Raaphorst
    Department of Pathology, Vrÿe Universiteit University Hospital, Amsterdam, The Netherlands
    J Immunol 164:1-4. 2000
    ..The Pc-G expression profiles in various GC B cell differentiation stages suggest a role for Pc-G proteins in GC development...
  10. ncbi Distinct BMI-1 and EZH2 expression patterns in thymocytes and mature T cells suggest a role for Polycomb genes in human T cell differentiation
    F M Raaphorst
    Department of Pathology, Vrÿe Universiteit University Hospital, Amsterdam, The Netherlands
    J Immunol 166:5925-34. 2001
    ..The difference in PcG expression between medullar thymocytes and mature interfollicular T cells indicates that additional maturation processes occur after thymocyte transportation from the thymus...
  11. ncbi Expression of the p16(INK4a) gene product, methylation of the p16(INK4a) promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions
    R H J Breuer
    Department of Pathology, Vrije Universiteit, University Medical Center, Amsterdam, The Netherlands
    Lung Cancer 48:299-306. 2005
    ..To what extent overexpression of the polycomb-group protein BMI-1 attributes to down regulating of p16 expression remains unclear...
  12. ncbi Differential expression of human Polycomb group proteins in various tissues and cell types
    M J Gunster
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    J Cell Biochem Suppl . 2001
    ..J. Cell. Biochem. Suppl. 36: 129-143, 2001...
  13. doi Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands
    H Vékony
    Department of Oral and Maxillofacial Surgery Oral Pathology, Academic Centre for Dentistry, VU University Medical Center, Amsterdam, The Netherlands
    Histopathology 53:658-66. 2008
    ..Myoepithelial salivary gland tumours are uncommon and follow an unpredictable biological course. The aim was to examine their molecular background to acquire a better understanding of their clinical behaviour...
  14. doi High expression of Polycomb group protein EZH2 predicts poor survival in salivary gland adenoid cystic carcinoma
    H Vékony
    Department of Oral and Maxillofacial Surgery Oral Pathology, Academic Centre for Dentistry ACTA, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Pathol 61:744-9. 2008
    ..To decipher the biological behaviour of ACC, and to identify patients at risk of developing metastases, additional markers are needed...
  15. ncbi T cell expansions in lymph nodes and peripheral blood in HIV-1-infected individuals: effect of antiretroviral therapy
    S Kostense
    Department of Clinical Viro-Immunology, CLB, Amsterdam, The Netherlands
    AIDS 15:1097-107. 2001
    ..Decreased immune activation and possibly naive T cell regeneration subsequently decreased clonal expansions and perturbations in the CD8 TCR repertoire...
  16. pmc Increased expression of the EZH2 polycomb group gene in BMI-1-positive neoplastic cells during bronchial carcinogenesis
    Roderick H J Breuer
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Neoplasia 6:736-43. 2004
    ..Because PcG complexes are normally involved in the maintenance of cell characteristics, abnormal PcG expression may contribute to loss of cell identity...
  17. ncbi Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction
    Joost C van Galen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 34:1870-81. 2004
    ..We propose that these cells reflect a transitional stage between resting and dividing follicular B lymphocytes, and that they possibly represent the healthy precursors of nodal large B cell lymphomas...
  18. pmc Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL
    Joost C van Galen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Clin Pathol 60:167-72. 2007
    ..The BMI1 proto-oncogene was identified as one of the genes present in the signature of the ABC type of DLBCL, associated with a poor prognosis...
  19. ncbi Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features
    Geert J L H van Leenders
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur Urol 52:455-63. 2007
    ..In this study, we evaluated the expression of eight members of both PcG complexes in clinicopathologically defined prostate cancer...
  20. ncbi Correspondence re: S. Beá et al., BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas. Cancer Res., 61: 2409-2412, 2001
    Frank M Raaphorst
    Cancer Res 62:618-9. 2002
  21. ncbi Evidence for at least three alternative mechanisms targeting the p16INK4A/cyclin D/Rb pathway in penile carcinoma, one of which is mediated by high-risk human papillomavirus
    Emmanuelle Ferreux
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Pathol 201:109-18. 2003
    ..These data indicate that there are at least three plausible mechanisms by which the p16(INK4A)/cyclin D/Rb pathway can become disrupted during penile carcinogenesis...
  22. pmc Unique polycomb gene expression pattern in Hodgkin's lymphoma and Hodgkin's lymphoma-derived cell lines
    Danny F Dukers
    Department of Pathology, Vrije Universiteit University Medical Center VUMC, Amsterdam, The Netherlands
    Am J Pathol 164:873-81. 2004
    ..We propose that abnormal expression of BMI-1 and its binding partners in H/RS cells contributes to development of HL. However, abnormal expression of BMI-1 in HL is not necessarily associated with down-regulation of p16INK4a...