Research Topics
| K H PoldermanSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Mechanisms of action, physiological effects, and complications of hypothermiaKees H Polderman
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, USA
Crit Care Med 37:S186-202. 2009..In recent years important insights have been gained into the mechanisms underlying hypothermia's protective effects; in addition, physiological and pathophysiological changes associated with cooling have become better understood...
Induction of hypothermia in patients with various types of neurologic injury with use of large volumes of ice-cold intravenous fluidKees H Polderman
Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands
Crit Care Med 33:2744-51. 2005..This should be combined with another method to safely and accurately maintain hypothermia once target temperatures have been reached...- Therapeutic hypothermia and controlled normothermia in the intensive care unit: practical considerations, side effects, and cooling methodsKees H Polderman
Department of Intensive Care, University Medical Center Utrecht, The Netherlands
Crit Care Med 37:1101-20. 2009..However, effectively controlling fever and inducing hypothermia poses special challenges to the intensive care unit team and others involved in the care of critically ill patients... 
Novel applications of therapeutic hypothermia: report of three casesKoen J Hartemink
Department of Intensive Care and Surgery, VU University Medical Center, Amsterdam, The Netherlands
Crit Care 8:R343-6. 2004..We describe three patients with unusual causes of neurological injury, whose clinical situation was in fundamental aspects analogous to conditions where hypothermia has been shown to be effective...- Percutaneous dilatational tracheostomy in the ICU: optimal organization, low complication rates, and description of a new complicationKees H Polderman
Departments of Intensive Care, University Medical Center, Amsterdam, The Netherlands
Chest 123:1595-602. 2003..To assess short-term and long-term complications of bronchoscopy-guided, percutaneous dilatational tracheostomy (PDT) and surgical tracheostomy (ST) and to report a complication of PDT that has not been described previously... - Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: Indications and evidenceKees H Polderman
Department of Intensive Care, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 30:556-75. 2004..Hypothermia has been used for medicinal purposes since ancient times. This paper reviews the current potential clinical applications for mild hypothermia (32-35 degrees C)... - Induced hypothermia and fever control for prevention and treatment of neurological injuriesKees H Polderman
Department of Intensive Care, University Medical Center Utrecht, Utrecht, Netherlands
Lancet 371:1955-69. 2008..In particular, the rate of rewarming seems to be an important factor in establishing successful use of hypothermia in the treatment of neurological injuries... - Severe electrolyte disorders following cardiac surgery: a prospective controlled observational studyKees H Polderman
Intensive Care Medicine, Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands
Crit Care 8:R459-66. 2004..We hypothesized that patients undergoing cardiac surgical procedures might be at risk for electrolyte depletion, and we therefore conducted the present study to assess electrolyte levels in such patients... 
Hypothermia, immune suppression and SDD: can we have our cake and eat it?Kees H Polderman
Department of Critical Care Medicine, University of Pittsburgh Medical Center, 3550 Terrace Street, 601A Scaife Hall, Pittsburgh, PA 15261, USA
Crit Care 15:144. 2011..We may be able to have our cake and eat it...- Equipment review: cooling catheters to induce therapeutic hypothermia?Kees H Polderman
Department of Intensive Care, University Medical Center Utrecht, Utrecht, The Netherlands
Crit Care 10:234. 2006..In addition, the current state of the evidence for use of induced hypothermia for various indications is briefly reviewed... - Increases in spinal fluid osmolarity induced by mannitolK H Polderman
Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands
Crit Care Med 31:584-90. 2003..However, relatively little is known regarding long-term effects of mannitol on osmolarity of cerebrospinal fluid. We therefore sought to determine the effects of mannitol administration on the osmolarity of cerebrospinal fluid... - Effects of therapeutic hypothermia on intracranial pressure and outcome in patients with severe head injuryKees H Polderman
Department of Intensive Care, VU University Medical Center PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 28:1563-73. 2002.... - Hypernatremia in the intensive care unit: an indicator of quality of care?K H Polderman
Medical Intensive Care Unit, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
Crit Care Med 27:1105-8. 1999.... - Intra-observer variability in APACHE II scoringK H Polderman
Department of Intensive Care, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 27:1550-2. 2001..These findings are in agreement with previous observations regarding inter-observer variability in APACHE II scoring, and strongly suggest that there is an inherent score variability of about 15%... - Hypophosphatemia and hypomagnesemia induced by cooling in patients with severe head injuryK H Polderman
Surgical Intensive Care Unit, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
J Neurosurg 94:697-705. 2001..The authors hypothesized that these arrhythmias might be caused by electrolyte disorders and therefore studied the effects of induced hypothermia on urine production and electrolyte levels in patients with severe head injury... - Central venous catheter use. Part 1: mechanical complicationsKees H Polderman
Department of Intensive Care, University Medical Centre, Vrije Universiteit, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 28:1-17. 2002..Placement aids, such as ultrasound-guided catheter insertion, are also discussed... - Central venous catheter use. Part 2: infectious complicationsK H Polderman
Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 28:18-28. 2002..Reducing catheter infection rates requires a multiple-strategy approach. Therefore, ICUs and other locations where CVCs are used should implement strict guidelines and protocols for catheter insertion, care, and maintenance... - Inter-observer variability in APACHE II scoring: effect of strict guidelines and trainingK H Polderman
Surgical Intensive Care Unit, University Hospital Vrije Universiteit, P O Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 27:1365-9. 2001..To assess the effect of strict guidelines and a rigorous training program on variability in scoring the revised Acute Physiology and Chronic Health Evaluation (APACHE II)... - Reliability of PRISM and PIM scores in paediatric intensive careJ G van Keulen
Department of Pediatrics, VU University Medical Center, Amsterdam, Netherlands
Arch Dis Child 90:211-4. 2005..Reliable assessment of PRISM and PIM scores requires rigorous specific training and strict adherence to guidelines. Consequently, assessment should probably be performed by a limited number of well trained professionals... - Mechanical and infectious complications of central venous cathetersA R J Girbes
Department of Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
Minerva Anestesiol 69:330-2. 2003..Catheter-related factors, patient-related factors, selection of the site of puncture and catheter use and care related factors, all play a contributive role in the risk on complications... - Piperacillin-induced magnesium and potassium loss in intensive care unit patientsKees H Polderman
Department of Intensive Care, Vrije Universiteit Medical Centre, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 28:520-2. 2002..We therefore decided to measure serum electrolyte levels in patients before and after piperacillin administration... - Hypothermia and neurological outcome after cardiac arrest: state of the artK H Polderman
University Medical Center Utrecht, Department of Intensive Care, Utrecht, The Netherlands
Eur J Anaesthesiol Suppl 42:23-30. 2008..Educational activities to increase awareness and acceptance of new therapeutic options and European Resuscitation Council guidelines are urgently required... - Continuous vs. intermittent cefotaxime administration in patients with chronic obstructive pulmonary disease and respiratory tract infections: pharmacokinetics/pharmacodynamics, bacterial susceptibility and clinical efficacyA R H van Zanten
Department of Intensive Care, Gelderse Vallei Hospital, Ede, The Netherlands
Br J Clin Pharmacol 63:100-9. 2007..To compare the pharmacokinetics/pharmacodynamics, antibiotic resistance and clinical efficacy of continuous (CA) vs. intermittent administration (IA) of cefotaxime in patients with obstructive pulmonary disease and respiratory infections... - Application of therapeutic hypothermia in the intensive care unit. Opportunities and pitfalls of a promising treatment modality--Part 2: Practical aspects and side effectsKees H Polderman
Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 30:757-69. 2004..These and other, related issues are dealt with in this review... - A definite role for treatment with activated protein C in sepsis? Standard use is prematureA R J Girbes
Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands
J Thromb Haemost 1:2469-71. 2003 - Central venous catheter use in the pediatric patient: mechanical and infectious complicationsRogier C J de Jonge
Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands
Pediatr Crit Care Med 6:329-39. 2005..New developments such as the use of impregnated catheters might help reduce infection rates; however, additional research will be required to provide more evidence of benefit in the pediatric population... - Hospital-acquired sinusitis is a common cause of fever of unknown origin in orotracheally intubated critically ill patientsArthur R H van Zanten
Department of Intensive Care, Gelderse Vallei Hospital, Ede, The Netherlands
Crit Care 9:R583-90. 2005..We studied the incidence of sinusitis in patients with fever of unknown origin (FUO) in our intensive care unit with the aim of establishing a protocol that would be applicable in everyday clinical practice... - Dealing with the delirium dilemmaKees H Polderman
Intensive Care Medicine, Department of Intensive Care, VU University Medical Center, Amsterdam, The Netherlands
Crit Care 9:335-6. 2005..This commentary aims to provide context for this study, discussing its potential implications as well as the potential therapeutic and preventive measures in patients with hyperactive or hypoactive delirium... - Immunoparalysis as a cause for invasive aspergillosis?Koen J Hartemink
Department of Intensive Care, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
Intensive Care Med 29:2068-71. 2003..Physicians treating critically ill patients in the ICU should be aware of the CARS/immunoparalysis syndrome and its potential to cause opportunistic infections, even in patients with normal immune function prior to ICU admission... - Ciprofloxacin pharmacokinetics in critically ill patients: a prospective cohort studyArthur R H van Zanten
Department of Intensive Care, Gelderse Vallei Hospital, 6710 HN Ede, The Netherlands
J Crit Care 23:422-30. 2008..Fluoroquinolones are frequently used to treat severe infections in critically ill patients. We studied ciprofloxacin pharmacokinetics after administration of 400 mg twice a day (bid) intravenously (IV)... - Changes in cerebral interstitial glycerol concentration in head-injured patients; correlation with secondary eventsSaskia M Peerdeman
Department of Neurosurgery, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
Intensive Care Med 29:1825-8. 2003..To investigate the association between the occurrence of secondary events, clinical outcome and the interstitial glycerol levels as measured with cerebral microdialysis... - Importance of nondrug costs of intravenous antibiotic therapyArthur R H van Zanten
Senior Consultant in Intensive Care, Director of Intensive Care, Department of Intensive Care, Gelderse Vallei Hospital, Ede, The Netherlands
Crit Care 7:R184-90. 2003..We therefore decided to assess true overall costs of intravenous (IV) antibiotic administration by performing an activity-based costing approach... - Intensive insulin therapy: of harm and health, of hypes and hypoglycemiaKees H Polderman
Crit Care Med 34:246-8. 2006 - Induced hypothermia in traumatic brain injury: effective if properly employedKees H Polderman
Crit Care Med 32:313-4. 2004 - Induced hypothermia in traumatic brain injury: considering the conflicting results of meta-analyses and moving forwardKees H Polderman
Intensive Care Med 30:1860-4. 2004 - Keeping a cool head: How to induce and maintain hypothermiaKees H Polderman
Crit Care Med 32:2558-60. 2004 - Potential mechanisms of hypothermia-induced electrolyte depletionKees H Polderman
Crit Care Med 30:1932; author reply 1932-3. 2002 - The importance of magnesium in critically ill patients: a role in mitigating neurological injury and in the prevention of vasospasmsKees H Polderman
Intensive Care Med 29:1202-3. 2003 - Hypothermia therapy after traumatic brain injury in childrenKees H Polderman
N Engl J Med 359:1178; author reply 1180. 2008 - Family satisfaction with intensive care unit care: influenced by workload, staffing, and patient selection?Kees H Polderman
Crit Care Med 31:1597-8. 2003 - Using risk adjustment systems in the ICU: avoid scoring an "own goal"Kees H Polderman
Intensive Care Med 31:1471-3. 2005 - Therapeutic hypothermia after cardiac arrestKees H Polderman
N Engl J Med 347:63-5; author reply 63-5. 2002 - Preventing nosocomial sinusitis in the ICU: Comment on article by Pneumatikos et alArthur R H van Zanten
Intensive Care Med 32:1451; author reply 1452-3. 2006 - Early induction of hypothermia: will sooner be better?Arthur R H van Zanten
Crit Care Med 33:1449-52. 2005 - Hypothermia for neonates with hypoxic-ischemic encephalopathyKees H Polderman
N Engl J Med 354:1643-5; author reply 1643-5. 2006