Brenda W J H Penninx

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  2. pmc Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile
    Brenda W J H Penninx
    Department of Psychiatry, EMGO Institute and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med 11:129. 2013
  3. pmc Outcomes for depression and anxiety in primary care and details of treatment: a naturalistic longitudinal study
    Marijn A Prins
    NIVEL, Netherlands Institute for Health Services Research, Postbus 1568, Utrecht, 3500 BN, The Netherlands
    BMC Psychiatry 11:180. 2011
  4. pmc Seasonality in depressive and anxiety symptoms among primary care patients and in patients with depressive and anxiety disorders; results from the Netherlands Study of Depression and Anxiety
    Wim H Winthorst
    Department of Psychiatry, University Medical Centre Groningen, University of Groningen, The Netherlands
    BMC Psychiatry 11:198. 2011
  5. pmc The course of untreated anxiety and depression, and determinants of poor one-year outcome: a one-year cohort study
    Ilse Mj van Beljouw
    Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    BMC Psychiatry 10:86. 2010
  6. pmc Is the Beck Anxiety Inventory a good tool to assess the severity of anxiety? A primary care study in the Netherlands Study of Depression and Anxiety (NESDA)
    Anna D T Muntingh
    Netherlands Institute of Mental Health and Addiction Trimbos institute, PO Box 725, Utrecht, 3500 AS, The Netherlands
    BMC Fam Pract 12:66. 2011
  7. pmc Referral of patients with depression to mental health care by Dutch general practitioners: an observational study
    Ellen Piek
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Fam Pract 12:41. 2011
  8. pmc Metabolic syndrome and physical decline in older persons: results from the Health, Aging And Body Composition Study
    Brenda W J H Penninx
    EMGO Institute Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 64:96-102. 2009
  9. doi request reprint Two-year course of depressive and anxiety disorders: results from the Netherlands Study of Depression and Anxiety (NESDA)
    Brenda W J H Penninx
    Department of Psychiatry EMGO Institute for Health and Care Research Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 133:76-85. 2011
  10. ncbi request reprint Anemia in old age is associated with increased mortality and hospitalization
    Brenda W J H Penninx
    EMGO Institute Department of Psychiatry, VU University School of Medicine, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:474-9. 2006

Detail Information

Publications147 found, 100 shown here

  1. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  2. pmc Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile
    Brenda W J H Penninx
    Department of Psychiatry, EMGO Institute and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    BMC Med 11:129. 2013
    ..This review finishes with potential treatment implications for the downward spiral in which different depressive symptom profiles and biological dysregulations may impact on each other and interact with somatic health decline...
  3. pmc Outcomes for depression and anxiety in primary care and details of treatment: a naturalistic longitudinal study
    Marijn A Prins
    NIVEL, Netherlands Institute for Health Services Research, Postbus 1568, Utrecht, 3500 BN, The Netherlands
    BMC Psychiatry 11:180. 2011
    ....
  4. pmc Seasonality in depressive and anxiety symptoms among primary care patients and in patients with depressive and anxiety disorders; results from the Netherlands Study of Depression and Anxiety
    Wim H Winthorst
    Department of Psychiatry, University Medical Centre Groningen, University of Groningen, The Netherlands
    BMC Psychiatry 11:198. 2011
    ....
  5. pmc The course of untreated anxiety and depression, and determinants of poor one-year outcome: a one-year cohort study
    Ilse Mj van Beljouw
    Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    BMC Psychiatry 10:86. 2010
    ..The aim of the present study was to examine the one-year course of untreated anxiety and depression, and to determine predictors of a poor outcome...
  6. pmc Is the Beck Anxiety Inventory a good tool to assess the severity of anxiety? A primary care study in the Netherlands Study of Depression and Anxiety (NESDA)
    Anna D T Muntingh
    Netherlands Institute of Mental Health and Addiction Trimbos institute, PO Box 725, Utrecht, 3500 AS, The Netherlands
    BMC Fam Pract 12:66. 2011
    ....
  7. pmc Referral of patients with depression to mental health care by Dutch general practitioners: an observational study
    Ellen Piek
    Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Fam Pract 12:41. 2011
    ..We wanted to evaluate general practitioner's referral of depressed patients to mental health care and to what extent this is in agreement with (Dutch) guideline recommendations...
  8. pmc Metabolic syndrome and physical decline in older persons: results from the Health, Aging And Body Composition Study
    Brenda W J H Penninx
    EMGO Institute Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 64:96-102. 2009
    ..We investigated whether metabolic abnormalities have independent consequences on loss of mobility function of older persons...
  9. doi request reprint Two-year course of depressive and anxiety disorders: results from the Netherlands Study of Depression and Anxiety (NESDA)
    Brenda W J H Penninx
    Department of Psychiatry EMGO Institute for Health and Care Research Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 133:76-85. 2011
    ..This longitudinal study compares depressive and anxiety disorders in terms of diagnostic and symptom course trajectories, and examines clinical prognostic factors...
  10. ncbi request reprint Anemia in old age is associated with increased mortality and hospitalization
    Brenda W J H Penninx
    EMGO Institute Department of Psychiatry, VU University School of Medicine, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:474-9. 2006
    ..To more fully understand the detrimental health effects of anemia, we examined the relationship of anemia with death and hospitalization outcomes in a large community-based sample of older persons...
  11. ncbi request reprint [Depression and somatic comorbidity]
    Brenda W J H Penninx
    VU Medisch Centrum, afd Psychiatrie en EMGO Instituut, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1784. 2010
    ..When treating a depressed patient, their somatic health should also be monitored. Further research is needed to examine whether specific interventions may prevent somatic comorbidity in depression...
  12. pmc Late-life depressive symptoms are associated with both hyperactivity and hypoactivity of the hypothalamo-pituitary-adrenal axis
    Brenda W J H Penninx
    Department of Psychiatry and EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 15:522-9. 2007
    ..The authors examined the relationship between urinary cortisol level and late-life depressive symptoms. The authors also explored whether hypo- and hypercortisolemic depressive symptoms are qualitatively different...
  13. doi request reprint The Netherlands Study of Depression and Anxiety (NESDA): rationale, objectives and methods
    Brenda W J H Penninx
    Department of Psychiatry EMGO Institute Institute for Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands
    Int J Methods Psychiatr Res 17:121-40. 2008
    ..Besides its scientific relevance, this may contribute to more effective prevention and treatment of depressive and anxiety disorders...
  14. doi request reprint Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study
    Sophie A Vreeburg
    Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Arch Gen Psychiatry 66:617-26. 2009
    ..There is a central belief that depression is associated with hyperactivity of the hypothalamic-pituitary-adrenal axis, resulting in higher cortisol levels. However, results are inconsistent...
  15. doi request reprint Comorbidity patterns of anxiety and depressive disorders in a large cohort study: the Netherlands Study of Depression and Anxiety (NESDA)
    Femke Lamers
    Department of Psychiatry EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Psychiatry 72:341-8. 2011
    ..This study examines comorbidity patterns and temporal sequencing of separate depressive and anxiety disorders using data from a large psychiatric cohort...
  16. doi request reprint Identifying depressive subtypes in a large cohort study: results from the Netherlands Study of Depression and Anxiety (NESDA)
    Femke Lamers
    Department of Psychiatry, VU University Medical Center Amsterdam, AJ Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    J Clin Psychiatry 71:1582-9. 2010
    ..Data-driven techniques may help to come to a more empirically based classification. This study aimed to identify depressive subtypes within a large cohort of subjects with depression...
  17. doi request reprint Salivary cortisol levels in persons with and without different anxiety disorders
    Sophie A Vreeburg
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands
    Psychosom Med 72:340-7. 2010
    ..No earlier studies have examined consistency of HPA axis findings across several anxiety subtypes and whether associations are state or trait dependent...
  18. doi request reprint Salivary testosterone: associations with depression, anxiety disorders, and antidepressant use in a large cohort study
    Erik J Giltay
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Psychosom Res 72:205-13. 2012
    ..The use of selective serotonin reuptake inhibitors (SSRIs) and other antidepressants is associated with sexual side effects, warranting testing for interactions with testosterone...
  19. doi request reprint Antidepressant use and salivary cortisol in depressive and anxiety disorders
    Leonie Manthey
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Eur Neuropsychopharmacol 21:691-9. 2011
    ..03). These findings suggest that antidepressant subtypes are associated with distinct alterations of the HPA axis. TCA users, who showed a flattened CAR, displayed the strongest alterations of salivary cortisol...
  20. doi request reprint Depressive and anxiety disorders and the association with obesity, physical, and social activities
    Leonore M de Wit
    Department of Clinical Psychology and EMGO Institute, VU University Amsterdam, Amsterdam, The Netherlands
    Depress Anxiety 27:1057-65. 2010
    ....
  21. doi request reprint Late-life depression, cortisol, and the metabolic syndrome
    Nicole Vogelzangs
    Department of Psychiatry, VU University Medical Center, A J Ernststraat 887, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 17:716-21. 2009
    ..This study investigated cross-sectionally whether depression and high-cortisol levels increased the odds of metabolic syndrome in an older community-based sample...
  22. pmc Depressive symptoms and change in abdominal obesity in older persons
    Nicole Vogelzangs
    Department of Psychiatry and EMGO Institute, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Arch Gen Psychiatry 65:1386-93. 2008
    ..Depression has been hypothesized to result in abdominal obesity through the accumulation of visceral fat. No large study has tested this hypothesis longitudinally...
  23. doi request reprint Association between anxiety disorders and heart rate variability in The Netherlands Study of Depression and Anxiety (NESDA)
    Carmilla M M Licht
    Department of Psychiatry, EMGO Institute, VU University Medical Center, AJ Ernststraat 887, 1081 HL, Amsterdam, The Netherlands
    Psychosom Med 71:508-18. 2009
    ....
  24. doi request reprint Heavy alcohol use, rather than alcohol dependence, is associated with dysregulation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system
    Lynn Boschloo
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Drug Alcohol Depend 116:170-6. 2011
    ..However, the relative contribution of alcohol use and AD is unclear...
  25. doi request reprint Insomnia and sleep duration in a large cohort of patients with major depressive disorder and anxiety disorders
    Josine G van Mill
    NeuroCampus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Psychiatry 71:239-46. 2010
    ....
  26. doi request reprint Comorbidity and risk indicators for alcohol use disorders among persons with anxiety and/or depressive disorders: findings from the Netherlands Study of Depression and Anxiety (NESDA)
    Lynn Boschloo
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 131:233-42. 2011
    ..This study examines comorbidity of alcohol abuse and alcohol dependence as well as its risk indicators among anxious and/or depressed persons, also considering temporal sequencing of disorders...
  27. doi request reprint Course and risk factors of functional impairment in subthreshold depression and anxiety
    Julie Karsten
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Depress Anxiety 30:386-94. 2013
    ..Furthermore, we evaluate which illness, personal, and environmental risk factors influence its course...
  28. pmc Cardiovascular disease in persons with depressive and anxiety disorders
    Nicole Vogelzangs
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 125:241-8. 2010
    ..In addition, the role of specific clinical characteristics of depressive and anxiety disorders in the association with cardiovascular disease was explored...
  29. doi request reprint Determinants of initiated and continued benzodiazepine use in the Netherlands study of depression and anxiety
    Leonie Manthey
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Clin Psychopharmacol 31:774-9. 2011
    ..We aimed to identify the most important predictors of initiated and continued BZD use. Therefore, we analyzed the most consistently identified determinants from previous research plus some new determinants...
  30. doi request reprint Depression is associated with decreased blood pressure, but antidepressant use increases the risk for hypertension
    Carmilla M M Licht
    Vrije Universiteit Medical Center, Department of Psychiatry, AJ Ernststraat 887, 1081 HL, Amsterdam, The Netherlands
    Hypertension 53:631-8. 2009
    ....
  31. doi request reprint Two-year course of anxiety disorders: different across disorders or dimensions?
    Sanne M Hendriks
    Department of Psychiatry, Pro Persona Mental Health Care, Ede, The Netherlands
    Acta Psychiatr Scand 128:212-21. 2013
    ..This study compares diagnostic and symptom course trajectories across different anxiety disorders, and examines the role of anxiety arousal vs. avoidance behaviour symptoms in course prediction...
  32. ncbi request reprint Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study
    Nicole Vogelzangs
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:563-9. 2007
    ..This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons...
  33. pmc Correlates of (inappropriate) benzodiazepine use: the Netherlands Study of Depression and Anxiety (NESDA)
    Leonie Manthey
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Br J Clin Pharmacol 71:263-72. 2011
    ..The relative importance of sociodemographic, psychological and physical determinants has never been investigated in a comprehensive, multivariate model...
  34. doi request reprint Panic attacks as a dimension of psychopathology: evidence for associations with onset and course of mental disorders and level of functioning
    Neeltje M Batelaan
    Department of Psychiatry and EMGO Institute, VU University Medical Center and GGZ inGeest, A J Ernststraat 1187, 1081 HL Amsterdam, The Netherlands
    J Clin Psychiatry 73:1195-202. 2012
    ..The aim of this study was to validate the proposition for DSM-5 that panic attacks have predictive value for overall psychopathology onset, course, and functioning...
  35. doi request reprint Carotid atherosclerosis in depression and anxiety: associations for age of depression onset
    Adrie Seldenrijk
    EMGO Institute for Health and Care Research, Amsterdam, The Netherlands
    World J Biol Psychiatry 12:549-58. 2011
    ..Our aims were to examine the presence of subclinical atherosclerosis in subjects with depressive or anxiety disorder, also taking into account disorder characteristics (subtype, severity, duration, age of onset, medication)...
  36. doi request reprint Co-occurring manic symptomatology as a dimension which may help explaining heterogeneity of depression
    Nienke Jabben
    Department of Psychiatry EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 131:224-32. 2011
    ..To test this, it is hypothesized that heterogeneity in clinical and other features of subjects selected for unipolar depression can be partly explained by coexisting manic symptoms...
  37. doi request reprint Co-occurring manic symptomatology influences HPA axis alterations in depression
    Nienke Jabben
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernststraat 1187, 1081 HL Amsterdam, The Netherlands
    J Psychiatr Res 45:1208-13. 2011
    ....
  38. doi request reprint Determinants of salivary evening α-amylase in a large sample free of psychopathology
    Gerthe Veen
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Int J Psychophysiol 84:33-8. 2012
    ..In this paper, we report about correlates of evening sAA in saliva...
  39. doi request reprint Long-term benzodiazepine use and salivary cortisol: the Netherlands Study of Depression and Anxiety (NESDA)
    Leonie Manthey
    Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
    J Clin Psychopharmacol 30:160-8. 2010
    ..During short-term treatment, BZD use was found to suppress cortisol levels. However, little research has been done on the effects of long-term BZD administration on the hypothalamic-pituitary-adrenal (HPA) axis...
  40. doi request reprint The structure and dimensionality of the Inventory of Depressive Symptomatology Self Report (IDS-SR) in patients with depressive disorders and healthy controls
    Klaas J Wardenaar
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Affect Disord 125:146-54. 2010
    ..However previous factoranalytical studies have found mixed results. Therefore, the present study tested which factor structure underlies the IDS-SR and, in addition, if the factors can be used as unidimensional subscales...
  41. doi request reprint Predictors of the 2-year recurrence and persistence of alcohol dependence
    Lynn Boschloo
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Addiction 107:1639-40. 2012
    ..To identify independent risk factors of the recurrence of alcohol dependence (AD) in people with a remitted disorder at baseline and persistence of AD in people with a current disorder at baseline...
  42. doi request reprint The relationships of working conditions, recent stressors and childhood trauma with salivary cortisol levels
    Michiel Holleman
    Research Department of Arkin Mental Health Institute, Amsterdam, The Netherlands
    Psychoneuroendocrinology 37:801-9. 2012
    ..To evaluate this model we examined the association of different stressors (working conditions, recent life events and childhood trauma) with various cortisol indicators in a large cohort study...
  43. doi request reprint Trajectories of recovery of social and physical functioning in major depression, dysthymic disorder and double depression: a 3-year follow-up
    Didi Rhebergen
    Department of Psychiatry and EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 124:148-56. 2010
    ..Since lower functioning predicts recurrence of a depressive episode, insight into the post-morbid course of psychosocial functioning of persons with different depressive disorders may facilitate recurrence prevention...
  44. doi request reprint Perceived need for care and health care utilization among depressed and anxious patients with and without suicidal ideation
    Barbara Stringer
    Department of Psychiatry, VU University Medical Center Amsterdam GGZ inGeest, Amsterdam, The Netherlands
    Crisis 34:192-9. 2013
    ..Information is scarce concerning the perceived needs and the amount of health-care utilization of persons with suicidal ideation (SI) compared to those without SI...
  45. doi request reprint Sensitivity to depression or anxiety and subclinical cardiovascular disease
    Adrie Seldenrijk
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 146:126-31. 2013
    ..Our aim is to examine sensitivity to depression or anxiety in association with indicators of subclinical CVD...
  46. doi request reprint Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity
    Arianne K B van Reedt Dortland
    Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
    Psychosom Med 75:83-9. 2013
    ..Previous research indicates that patients with severe symptoms of depression or anxiety are prone toward the development of dyslipidemia and abdominal obesity. We sought to study these associations longitudinally...
  47. doi request reprint Dimensions of depression and anxiety and the hypothalamo-pituitary-adrenal axis
    Klaas J Wardenaar
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    Biol Psychiatry 69:366-73. 2011
    ..Specific symptom-dimensions could be used as a more homogenous phenotype in HPA-axis research...
  48. doi request reprint Psychiatric history and subthreshold symptoms as predictors of the occurrence of depressive or anxiety disorder within 2 years
    Julie Karsten
    University Medical Center Groningen, Department of Psychiatry, University of Groningen, The Netherlands
    Br J Psychiatry 198:206-12. 2011
    ..It is unclear to what extent the two factors interact or predict these disorders independently...
  49. doi request reprint The state effect of depressive and anxiety disorders on big five personality traits
    Julie Karsten
    Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Psychiatr Res 46:644-50. 2012
    ..Here, we aim to determine the extent of change in all five personality traits associated with the occurrence of or recovery from depressive and anxiety disorders...
  50. pmc Leptin, abdominal obesity, and onset of depression in older men and women
    Yuri Milaneschi
    Department of Psychiatry, VU University Medical Center GGZ inGeest, A J Ernststraat 1187, 1081 HL Amsterdam, The Netherlands
    J Clin Psychiatry 73:1205-11. 2012
    ..We tested whether high circulatory concentration of leptin, alone and in combination with visceral adiposity, is associated with onset of depression in a sample of older persons...
  51. doi request reprint Alcohol use disorders and the course of depressive and anxiety disorders
    Lynn Boschloo
    Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands
    Br J Psychiatry 200:476-84. 2012
    ..Inconsistent findings have been reported on the role of comorbid alcohol use disorders as risk factors for a persistent course of depressive and anxiety disorders...
  52. pmc Depression and body mass index, a u-shaped association
    Leonore M de Wit
    Department of Clinical Psychology and EMGO Institute, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands
    BMC Public Health 9:14. 2009
    ..The present study investigates if a nonlinear (U-shaped) trend is preferable over a linear trend to describe the relationship between BMI and depression, which means that both underweight and obesity are associated with depression...
  53. ncbi request reprint The importance of childhood trauma and childhood life events for chronicity of depression in adults
    Jenneke E Wiersma
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center and Academic Outpatient Clinic for Affective Disorders, GGZ inGeest, Amsterdam, The Netherlands
    J Clin Psychiatry 70:983-9. 2009
    ....
  54. doi request reprint Objective physical functioning in patients with depressive and/or anxiety disorders
    Bianca A van Milligen
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 131:193-9. 2011
    ..This study examined the association between depression and anxiety and physical function using objective measures in a large cohort, and investigated which psychiatric characteristics are associated with physical function...
  55. doi request reprint Accumulated and differential effects of life events on cognitive decline in older persons: depending on depression, baseline cognition, or ApoE epsilon4 status?
    Hannie C Comijs
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol B Psychol Sci Soc Sci 66:i111-20. 2011
    ....
  56. pmc Clinical effectiveness of usual care with or without antidepressant medication for primary care patients with minor or mild-major depression: a randomized equivalence trial
    Marleen L M Hermens
    Department of General Practice, Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    BMC Med 5:36. 2007
    ..We compared the effectiveness of usual primary care treatment, with or without antidepressants, in minor and mild-major depression...
  57. doi request reprint Evening salivary alpha-amylase, major depressive disorder, and antidepressant use in the Netherlands Study of Depression and Anxiety (NESDA)
    Gerthe Veen
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Psychiatry Res 208:41-6. 2013
    ..The present study shows that higher evening sAA levels in depressed patients, indicative of an increased sympathetic activity, may be induced by TCAs...
  58. doi request reprint Anxiety and depression are associated with migraine and pain in general: an investigation of the interrelationships
    Lannie Ligthart
    Department of Biological Psychology, VU University, Amsterdam, The Netherlands
    J Pain 14:363-70. 2013
    ..These findings emphasize the importance of accounting for A/D in studies of pain comorbidity. This will contribute to a better understanding of the mechanisms underlying A/D and pain...
  59. pmc Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: a longitudinal study
    Carmilla M M Licht
    Department of Psychiatry EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Neuropsychopharmacology 37:2487-95. 2012
    ..However, results pose that TCA and SNRI use increases sympathetic control, whereas SSRI use decreases sympathetic control...
  60. doi request reprint Dimensions of the inventory of depressive symptomatology as predictors of the course of depressive and anxiety disorders
    Klaas J Wardenaar
    Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
    J Psychiatr Res 46:1655-61. 2012
    ..In conclusion, the widely used IDS-SR can be used to measure two dimensions that contribute prognostic value on top of other, previously known prognostic factors...
  61. doi request reprint Personality traits and childhood trauma as correlates of metabolic risk factors: the Netherlands Study of Depression and Anxiety (NESDA)
    Arianne K B van Reedt Dortland
    Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 36:85-91. 2012
    ..Moreover, despite their interrelatedness, personality and childhood trauma were not yet studied simultaneously. Therefore, we aimed to explore whether personality and childhood trauma are correlates of metabolic risk factors...
  62. doi request reprint The association between serum cortisol and cognitive decline in older persons
    Hannie C Comijs
    Department of Psychiatry, VU University Medical Center, EMGO Institute, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 18:42-50. 2010
    ..To investigate whether serum cortisol levels are associated with cognitive performance and cognitive decline in elderly persons and whether this association differs by age, sex, and depression status...
  63. doi request reprint Metabolic depression: a chronic depressive subtype? Findings from the InCHIANTI study of older persons
    Nicole Vogelzangs
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Psychiatry 72:598-604. 2011
    ..However, such a longitudinal link has not yet been confirmed. This study examines whether metabolic syndrome or its components are associated with onset and chronicity of depression...
  64. doi request reprint Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interaction
    Pierre M Bet
    Department of Clinical Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 150:660-9. 2009
    ..This G x E interaction also influenced HPA-axis markers providing support for the involvement of the HPA-axis in both stress regulation and the pathogenesis of depression...
  65. ncbi request reprint Change in serum albumin and subsequent decline in functional status in older persons
    Bianca W M Schalk
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Aging Clin Exp Res 17:297-305. 2005
    ..This study examines whether a three-year change in serum albumin concentration is associated with subsequent decline in functional status in older persons...
  66. ncbi request reprint Associations between sex steroid hormone levels and depressive symptoms in elderly men and women: results from the Health ABC study
    Lisette F J Morsink
    EMGO Institute Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Psychoneuroendocrinology 32:874-83. 2007
    ..This study investigates the association between total testosterone, free testosterone, and DHEAS levels with depressive symptoms in a well-functioning elderly population...
  67. doi request reprint Economic costs of neuroticism: a population-based study
    Pim Cuijpers
    EMGO Institute for Health and Care Research, VU University and VU University Medical Center, Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1086-93. 2010
    ..However, most research has focused on the association between neuroticism and a single specific disorder or health outcome, and the overall effect of neuroticism on use of somatic and mental health care and on society is not clear...
  68. doi request reprint Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies
    Floriana S Luppino
    Department of Psychiatry, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Arch Gen Psychiatry 67:220-9. 2010
    ..Association between obesity and depression has repeatedly been established. For treatment and prevention purposes, it is important to acquire more insight into their longitudinal interaction...
  69. doi request reprint Development and validation of a 30-item short adaptation of the Mood and Anxiety Symptoms Questionnaire (MASQ)
    Klaas J Wardenaar
    Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
    Psychiatry Res 179:101-6. 2010
    ..In conclusion, the MASQ-D30 is a valid instrument to assess dimensional aspects of depression and anxiety and can easily be implemented in psychopathology studies...
  70. doi request reprint Physical function as predictor for the persistence of depressive and anxiety disorders
    Bianca A van Milligen
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 136:828-32. 2012
    ..Depressive and anxiety disorders often involve a chronic course. This study examined whether objective physical function is a predictor for the persistence of depressive and anxiety disorders...
  71. doi request reprint Dysregulation of the autonomic nervous system and its association with the presence and intensity of chronic widespread pain
    Ansam Barakat
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Care Res (Hoboken) 64:1209-16. 2012
    ..To test the hypotheses that dysregulation of the autonomic nervous system (ANS) is associated with the presence of chronic widespread pain (CWP), and that dysregulation of the ANS is associated with higher pain intensity in CWP...
  72. doi request reprint One-year severity of depressive symptoms: results from the NESDA study
    Femke Lamers
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Psychiatry Res 190:226-31. 2011
    ..The findings indicate that the prediction of prognosis and identification of persons at risk of a poor outcome should not only be based on clinical characteristics, but on risk factors as well...
  73. doi request reprint Longitudinal evidence for unfavorable effects of antidepressants on heart rate variability
    Carmilla M M Licht
    Department of Psychiatry, EMGO Institute for Health and Care Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 68:861-8. 2010
    ..It was previously shown that antidepressants are associated with diminished vagal control over the heart. Longitudinal studies are needed to test the causality of this association further...
  74. doi request reprint Associations between sociodemographic, sampling and health factors and various salivary cortisol indicators in a large sample without psychopathology
    Sophie A Vreeburg
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, A J Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    Psychoneuroendocrinology 34:1109-20. 2009
    ..Sociodemographic, health and sampling-related determinants of salivary cortisol levels were examined in a sample without potential disturbances because of psychopathology...
  75. doi request reprint Manic symptoms in patients with depressive and/or anxiety disorders
    Belinda van den Berg
    Department of Psychiatry EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    J Affect Disord 126:252-6. 2010
    ....
  76. doi request reprint Depressive and anxiety disorders and risk of subclinical atherosclerosis Findings from the Netherlands Study of Depression and Anxiety (NESDA)
    Adrie Seldenrijk
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Psychosom Res 69:203-10. 2010
    ..The present study examined whether subclinical atherosclerosis was more prevalent in a large cohort of persons with depressive or anxiety disorders as compared to non-depressed and non-anxious controls...
  77. doi request reprint Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA)
    Carmilla M M Licht
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Arch Gen Psychiatry 65:1358-67. 2008
    ..It has been hypothesized that depression is associated with lower heart rate variability and decreased cardiac vagal control. This may play an important role in the risk of cardiovascular disease among depressed individuals...
  78. doi request reprint Recognition of anxiety disorders by family physicians after rigorous medical record case extraction: results of the Netherlands Study of Depression and Anxiety
    Evelien H C Janssen
    Department of General Practice and Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Gen Hosp Psychiatry 34:460-7. 2012
    ..Our objectives were to examine (a) which combination of indications within medical records most accurately reflects recognition of anxiety disorders and (b) whether patient and FP characteristics were related to recognition...
  79. doi request reprint Impact of pain on the course of depressive and anxiety disorders
    Marloes M J G Gerrits
    Department of Psychiatry, EMGO Institute for Health and Care Research, VU University Medical Center and Academic Outpatient Clinic for Affective Disorders, GGZ inGeest, Amsterdam, The Netherlands
    Pain 153:429-36. 2012
    ..More attention to pain seems to be necessary when diagnosing and treating these disorders. Future research should focus on treatment modalities for this co-occurrence, with joint pain in particular...
  80. pmc Urinary cortisol and six-year risk of all-cause and cardiovascular mortality
    Nicole Vogelzangs
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 95:4959-64. 2010
    ..The stress hormone cortisol has been linked with unfavorable cardiovascular risk factors, but longitudinal studies examining whether high levels of cortisol predict cardiovascular mortality are largely absent...
  81. doi request reprint Stimulated gene expression profiles as a blood marker of major depressive disorder
    Sabine Spijker
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, The Netherlands
    Biol Psychiatry 68:179-86. 2010
    ..Major depressive disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available...
  82. doi request reprint Psychological traits and the cortisol awakening response: results from the Netherlands Study of Depression and Anxiety
    Aafke van Santen
    VU University, Faculty of Psychology and Education, Amsterdam, The Netherlands
    Psychoneuroendocrinology 36:240-8. 2011
    ....
  83. doi request reprint Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults
    Witte J G Hoogendijk
    Research Institute Neurosciences and the Center for Neurogenomics and Cognitive Research, VU University Medical Center, Vrije Universiteit Amsterdam, A J Ernststraat 887, 1081 HL, Amsterdam, The Netherlands
    Arch Gen Psychiatry 65:508-12. 2008
    ..Depression has incidentally been related to altered levels of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), but this relation has never been studied systematically...
  84. doi request reprint The performance of the Alcohol Use Disorder Identification Test (AUDIT) in detecting alcohol abuse and dependence in a population of depressed or anxious persons
    Lynn Boschloo
    Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    J Affect Disord 126:441-6. 2010
    ..This study examines the performance of the Alcohol Use Disorder Identification Test (AUDIT) in detecting alcohol abuse and dependence in this high-risk group and compares it to that in healthy controls...
  85. doi request reprint Depression, anxiety, and arterial stiffness
    Adrie Seldenrijk
    EMGO Institute for Health and Care Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biol Psychiatry 69:795-803. 2011
    ..The current study aimed to examine whether subjects with a diagnosis of depressive or anxiety disorder showed increased stiffness and to explore associations between various psychiatric characteristics and arterial stiffness...
  86. doi request reprint Do depression and anxiety converge or diverge in their association with suicidality?
    Merijn Eikelenboom
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Psychiatr Res 46:608-15. 2012
    ..These findings suggest that although anxiety and depression tend to converge in many important areas, they appear to diverge with respect to suicidality...
  87. doi request reprint Migraine symptomatology and major depressive disorder
    Lannie Ligthart
    VU University Amsterdam, Department of Biological Psychology, Amsterdam, The Netherlands
    Cephalalgia 30:1073-81. 2010
    ..The objective of this study was to investigate whether migraine is qualitatively different in MDD patients (N = 1816) and non-depressed controls (N = 3428)...
  88. ncbi request reprint Major depression in late life is associated with both hypo- and hypercortisolemia
    Marijke A Bremmer
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 62:479-86. 2007
    ..We also examined whether this might represent different depression subtypes...
  89. doi request reprint The shared genetics of migraine and anxious depression
    Lannie Ligthart
    Department of Biological Psychology, VU University, Van der Boechorststraat 1, Amsterdam, The Netherlands
    Headache 50:1549-60. 2010
    ....
  90. ncbi request reprint Late-life anemia is associated with increased risk of recurrent falls
    Brenda W J H Penninx
    Institute of Research in Extramural Medicine and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Am Geriatr Soc 53:2106-11. 2005
    ..To examine whether anemia is associated with a higher incidence of recurrent falls...
  91. pmc The Four-Dimensional Symptom Questionnaire (4DSQ): a validation study of a multidimensional self-report questionnaire to assess distress, depression, anxiety and somatization
    Berend Terluin
    Department of General Practice, EMGO Institute, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    BMC Psychiatry 6:34. 2006
    ..The purpose of this paper is to evaluate its criterion and construct validity...
  92. doi request reprint Early and late onset depression in young and middle aged adults: differential symptomatology, characteristics and risk factors?
    Nicole C M Korten
    Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Affect Disord 138:259-67. 2012
    ..Early onset depression (EOD) and late onset depression (LOD) may be different phenomena. In this study, differences between EOD and LOD in symptomatology, psychiatric characteristics and psychosocial/somatic factors were examined...
  93. ncbi request reprint The influence of differing social ties on decline in physical functioning among older people with and without chronic diseases: the Longitudinal Aging Study Amsterdam
    M Isabella Bisschop
    VU University Medical Center, Institue for Research in Extramural Medicine, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Aging Clin Exp Res 15:164-73. 2003
    ..This study examines whether differing types of social ties and support differentially mitigate the negative effects of chronic diseases on decline in physical functioning...
  94. ncbi request reprint The natural history of late-life depression: a 6-year prospective study in the community
    Aartjan T F Beekman
    Department of Psychiatry, Institute of Extramural Medicine, Amsterdam, The Netherlands
    Arch Gen Psychiatry 59:605-11. 2002
    ..The primary aim was to study the natural history of late-life depression, systematically comparing those who did with those who did not fulfill rigorous diagnostic criteria...
  95. doi request reprint Depressive and anxiety disorders in different ethnic groups: a population based study among native Dutch, and Turkish, Moroccan and Surinamese migrants in Amsterdam
    Matty A S de Wit
    Municipal Health Service Amsterdam Epidemiology, Documentation and Health Promotion, PO Box 2200, 1000 CE, Amsterdam, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 43:905-12. 2008
    ....
  96. ncbi request reprint Effectiveness of an education programme by a general practice assistant for asthma and COPD patients: results from a randomised controlled trial
    Arlette E Hesselink
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Patient Educ Couns 55:121-8. 2004
    ..However, given the importance of improvement of patients' coping and the need for more efficient care, we recommend further exploration of the possibilities of a more structured and intensive education programme...
  97. ncbi request reprint Serum albumin and muscle strength: a longitudinal study in older men and women
    Bianca W M Schalk
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Am Geriatr Soc 53:1331-8. 2005
    ..To examine whether low serum albumin is associated with low muscle strength and future decline in muscle strength in community-dwelling older men and women...
  98. doi request reprint A minimal psychological intervention in chronically ill elderly patients with depression: a randomized trial
    Femke Lamers
    Department of Social Medicine, School for Public Health and Primary Care CAPHRI, Maastricht University, Maastricht, The Netherlands
    Psychother Psychosom 79:217-26. 2010
    ..The Depression in Elderly with Long-Term Afflictions (DELTA) study aimed to evaluate the effectiveness of a nurse-led minimal psychological intervention (MPI) in chronically ill elderly persons with depression...
  99. doi request reprint Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities
    Carmilla M M Licht
    Department of Psychiatry EMGO Institute, Vrije Universiteit Medical Center, AJ Ernststraat 887, 1081 HL Amsterdam, The Netherlands
    J Clin Endocrinol Metab 95:2458-66. 2010
    ..Stress is suggested to lead to metabolic dysregulations as clustered in the metabolic syndrome, but the underlying biological mechanisms are not yet well understood...
  100. ncbi request reprint Income differentials in functional disability in old age: relative risks of onset, recovery, decline, attrition and mortality
    Marjolein I Broese van Groenou
    Department of Sociology and Social Gerontology, Faculty of Social Sciences, Vrije University, Amsterdam, The Netherlands
    Aging Clin Exp Res 15:174-83. 2003
    ..This longitudinal study aimed at comparing income differences in the course of disability, non-mortality attrition and mortality in older adults...
  101. pmc Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations
    Luba Pardo
    Medical Genomics Section, Department of Clinical Genetics, Vrije University Medical Center, Amsterdam, The Netherlands
    Eur J Hum Genet 17:802-10. 2009
    ..This poor concordance in LD block structure suggests that large samples are required for robust estimations of local LD block structure in populations...