A S Pena

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Acquired homotypic and heterotypic immunity against oculogenital Chlamydia trachomatis serovars following female genital tract infection in mice
    Joseph M Lyons
    Department of Infectious Diseases, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA
    BMC Infect Dis 5:105. 2005
  2. pmc Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women?
    Janneke E den Hartog
    Research Institute Growth and Development GROW and Department of Obstetrics and Gynaecology, Academic Hospital Maastricht, P, O, Box 5800, 6202 AZ Maastricht, The Netherlands
    BMC Infect Dis 6:122. 2006
  3. ncbi request reprint Genetics of inflammatory bowel diseases--past, present, and future
    A S Pena
    Gastroenterology and Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands
    Dig Dis 21:85-90. 2003
  4. ncbi request reprint Probiotics: Isolated bacteria strain or mixtures of different strains? Two different approaches in the use of probiotics as therapeutics
    O Karimi
    Laboratory of Immunogenetics and Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands
    Drugs Today (Barc) 39:565-97. 2003
  5. ncbi request reprint Genetic factors underlying gluten-sensitive enteropathy
    A S Pena
    Department of Gastroenterology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 1:526-33. 2001
  6. ncbi request reprint Genetic susceptibility and regulation of inflammation in Crohn's disease. Relationship with the innate immune system
    A S Pena
    Department of Gastroenterology, Laboratory of Inmunogenetics, University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Rev Esp Enferm Dig 94:351-60. 2002
  7. ncbi request reprint Contribution of genetics to a new vision in the understanding of inflammatory bowel disease
    A S Pena
    VU University Medical Centre, Head, Department of Gastroenterology, 1007 MB Amsterdam, The Netherlands
    World J Gastroenterol 12:4784-7. 2006
  8. ncbi request reprint [Intestinal flora, probiotics, prebiotics, symbiotics and novel foods]
    A S Pena
    Immunogenetics, Department of Pathology, VU University Medical Centre, De Boelelaan 117, Amsterdam, Netherlands
    Rev Esp Enferm Dig 99:653-8. 2007
  9. pmc No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis
    M van der Paardt
    Jan van Breemen Institute, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 64:235-8. 2005
  10. ncbi request reprint Association of FAS (TNFRSF6)-670 gene polymorphism with villous atrophy in coeliac disease
    Jing Wu
    VU University Medical Centre, Department of Gastroenterology, Laboratory of Immunogenetics, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Gastroenterol 10:717-20. 2004

Collaborators

Detail Information

Publications33

  1. pmc Acquired homotypic and heterotypic immunity against oculogenital Chlamydia trachomatis serovars following female genital tract infection in mice
    Joseph M Lyons
    Department of Infectious Diseases, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA
    BMC Infect Dis 5:105. 2005
    ..trachomatis belonging to two serovars (D and H) that have been shown to vary significantly in the course of infection in the murine model...
  2. pmc Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women?
    Janneke E den Hartog
    Research Institute Growth and Development GROW and Department of Obstetrics and Gynaecology, Academic Hospital Maastricht, P, O, Box 5800, 6202 AZ Maastricht, The Netherlands
    BMC Infect Dis 6:122. 2006
    ..trachomatis infection. The genes studied all encode for pattern recognition receptors (PRRs) involved in sensing bacterial components...
  3. ncbi request reprint Genetics of inflammatory bowel diseases--past, present, and future
    A S Pena
    Gastroenterology and Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands
    Dig Dis 21:85-90. 2003
    ..The genome-wide screening has led to the first gene of IBD and has given a new insight into the regulation of chronic inflammation. The future of IBD will be under scrutiny of the visionaries, but also the skeptics and the enthusiasts...
  4. ncbi request reprint Probiotics: Isolated bacteria strain or mixtures of different strains? Two different approaches in the use of probiotics as therapeutics
    O Karimi
    Laboratory of Immunogenetics and Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands
    Drugs Today (Barc) 39:565-97. 2003
    ..Finally, with a view to future perspectives we provide some examples of probiotics that are being assessed and have great potential in improving the health of animals and man...
  5. ncbi request reprint Genetic factors underlying gluten-sensitive enteropathy
    A S Pena
    Department of Gastroenterology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 1:526-33. 2001
    ..The exact role of these additional genes (i.e., whether they are involved in the initiation or the progression of the disease) remains to be determined...
  6. ncbi request reprint Genetic susceptibility and regulation of inflammation in Crohn's disease. Relationship with the innate immune system
    A S Pena
    Department of Gastroenterology, Laboratory of Inmunogenetics, University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Rev Esp Enferm Dig 94:351-60. 2002
  7. ncbi request reprint Contribution of genetics to a new vision in the understanding of inflammatory bowel disease
    A S Pena
    VU University Medical Centre, Head, Department of Gastroenterology, 1007 MB Amsterdam, The Netherlands
    World J Gastroenterol 12:4784-7. 2006
    ..On a world scale, a major challenge is to generate interventions to prevent the development of these diseases in Asia, Latin America and Africa...
  8. ncbi request reprint [Intestinal flora, probiotics, prebiotics, symbiotics and novel foods]
    A S Pena
    Immunogenetics, Department of Pathology, VU University Medical Centre, De Boelelaan 117, Amsterdam, Netherlands
    Rev Esp Enferm Dig 99:653-8. 2007
  9. pmc No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis
    M van der Paardt
    Jan van Breemen Institute, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 64:235-8. 2005
    ..CD14 and Toll-like receptor 4 (TLR4) are key receptors for the sensing of bacteria. The CD14 C-260T and TLR4 A896G single nucleotide polymorphims are associated with aberrant signal transduction for bacterial agonists...
  10. ncbi request reprint Association of FAS (TNFRSF6)-670 gene polymorphism with villous atrophy in coeliac disease
    Jing Wu
    VU University Medical Centre, Department of Gastroenterology, Laboratory of Immunogenetics, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Gastroenterol 10:717-20. 2004
    ..To investigate the association of FAS gene polymorphism with coeliac disease (CD) development...
  11. ncbi request reprint [Alpha]B-crystallin genotype has impact on the multiple sclerosis phenotype
    T van Veen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 61:1245-9. 2003
    ..Alpha]B-crystallin is a candidate autoantigen in MS, and there are three polymorphisms in the promoter region of the encoding gene (CRYAB): at positions -C249G, -C650G, and -A652G...
  12. pmc Susceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor beta 1 (TGFB1) gene polymorphisms
    M van der Paardt
    The Jan van Breemen Institute, VU University Medical Centre, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Ann Rheum Dis 64:616-9. 2005
    ..Transforming growth factor beta 1 (TGF beta 1) is a multifunctional cytokine that plays a key role in inflammation. Two functional single nucleotide polymorphisms (SNPs) in the TGFB1 gene have been described: TGFB1 T869C and TGFB1 G915C...
  13. ncbi request reprint CARD15 gene mutations are not associated with ankylosing spondylitis
    M van der Paardt
    The Jan van Breeman Institute, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Genes Immun 4:77-8. 2003
    ..36, 95% CI: 0.27-6.84, P = 0.70 and OR = 0.58; 95% CI: 0.18-1.94; P = 0.38, respectively. We conclude that the insertion 3020insC mutation and the G2722C missense mutation in the CARD15 gene are not involved in the susceptibility to AS...
  14. ncbi request reprint Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease
    A Zwiers
    Laboratory of Immunogenetics, Vrije Universiteit Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Genes Immun 5:675-7. 2004
    ..The high level of conservation is consistent with the key regulatory role of IL-12. The lack of association with IL12B makes it unlikely that this gene is directly involved in the susceptibility to CD...
  15. doi request reprint Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST)
    J B A Crusius
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Oncol 19:1894-902. 2008
    ..The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent...
  16. ncbi request reprint Role of the CARD15 gene in the pathogenesis of Crohn disease: phenotypic classification and prognostic implications
    L S Murillo
    VU University Medical Centre, Department of Gastroenterology, Laboratory of Immunogenetics, Amsterdam, The Netherlands
    Scand J Gastroenterol 38:1107-14. 2003
  17. ncbi request reprint TLR2 haplotypes in the susceptibility to and severity of Chlamydia trachomatis infections in Dutch women
    O Karimi
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, Amsterdam 1007MB, The Netherlands
    Drugs Today (Barc) 45:67-74. 2009
    ..021) in increasing severity of C. trachomatis infections (asymptomatic > symptomatic > tubal pathology) suggesting a protective effect of this haplotype against the development of late complications...
  18. doi request reprint Genetic correlations of brain lesion distribution in multiple sclerosis: an exploratory study
    M H Sombekke
    VU University Medical Center, Department of Neurology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 32:695-703. 2011
    ..We hypothesized that spatial distribution may be partially driven by genetic predisposition, and we aimed to explore relations among candidate genes and the spatial distribution of white matter brain lesions in MS...
  19. ncbi request reprint IL12B and IRF1 gene polymorphisms and susceptibility to celiac disease
    D Seegers
    Department of Immunogenetics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Eur J Immunogenet 30:421-5. 2003
    ..The IL12B TaqI and the IRF1 HinfI gene polymorphisms do not appear to be involved in susceptibility to CD. Further studies on the factors that drive the Th1 immunopathology in CD are required...
  20. ncbi request reprint Genetic and serological markers to identify phenotypic subgroups in a Dutch Crohn' s disease population
    R K Linskens
    Department of Gastroenterology, VU Medical Center, Amsterdam, The Netherlands
    Dig Liver Dis 36:29-34. 2004
    ..Perinuclear anti-neutrophil cytoplasmic antibodies have been found in a subgroup of Crohn's disease patients, mostly with colonic involvement...
  21. ncbi request reprint Review article: a critical approach to new forms of treatment of Crohn's disease and ulcerative colitis
    D Seegers
    Department of Gastroenterology, Vrije Universiteit Hospital Medical Centre, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 16:53-8. 2002
    ....
  22. ncbi request reprint TLR9 KO mice, haplotypes and CPG indices in Chlamydia trachomatis infection
    S Ouburg
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, 1081HV Amsterdam, The Netherlands
    Drugs Today (Barc) 45:83-93. 2009
    ..trachomatis infections. Extension of the human cohorts is necessary to significantly prove the effect in humans...
  23. ncbi request reprint A new avenue to investigate: the autophagic process. From Crohn's disease to Chlamydia
    A S Pena
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Drugs Today (Barc) 45:113-7. 2009
    ..trachomatis is affected by this pathway...
  24. ncbi request reprint CD14 and TLR4 gene polymorphisms in adult periodontitis
    M L Laine
    Department of Periodontology, Section of Oral Microbiology, Academic Centre for Dentistry Amsterdam, Van der Boechorsstraat 7, 1081 BT Amsterdam, The Netherlands
    J Dent Res 84:1042-6. 2005
    ..004, OR 3.0, 95% CI 1.4-6.9). We conclude that the CD14-260T/T genotype contributes to the susceptibility to severe periodontitis in Dutch Caucasians...
  25. ncbi request reprint Polymorphisms in the genes encoding interferon-gamma and interferon-gamma receptors in multiple sclerosis
    H M Schrijver
    Department of Neurology, University Medical Center Utrecht, The Netherlands
    Eur J Immunogenet 31:133-40. 2004
    ..The IFNGR1 and IFNGR2 gene polymorphisms studied do not exert an important influence on MS susceptibility, but allele IFNGR2*Arg64 may be associated with a progressive disease onset...
  26. ncbi request reprint CARD15 gene mutations in periodontitis
    M L Laine
    Department of Basic Dental Sciences, Section Clinical Periodontal Microbiology, ACTA Amsterdam, The Netherlands
    J Clin Periodontol 31:890-3. 2004
    ..Our aim was to investigate the occurrence of CARD15 gene polymorphisms in adult patients with periodontitis taking into account smoking and presence of putative periodontal pathogens as additional variables...
  27. ncbi request reprint Probiotics in arthralgia and spondyloarthropathies in patients with inflammatory bowel disease. Prospective randomized trials are necessary
    O Karimi
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    Rev Esp Enferm Dig 97:570-4. 2005
    ....
  28. ncbi request reprint Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in ankylosing spondylitis
    M van der Paardt
    The Jan van Breemen Institute, Amsterdam, The Netherlands
    Rheumatology (Oxford) 41:1419-23. 2002
    ....
  29. ncbi request reprint Description of the ICTI consortium: an integrated approach to the study of Chlamydia trachomatis infection
    S A Morre
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Drugs Today (Barc) 42:107-14. 2006
    ..trachomatis infection. A background of the need for this integrated approach is presented and the goals and participants of the consortium are described...
  30. ncbi request reprint The FAS-670 polymorphism influences susceptibility to multiple sclerosis
    T van Veen
    Department of Neurology, VU Medical Centre, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    J Neuroimmunol 128:95-100. 2002
    ..We observed similar brain and lesion volumes in carriers and noncarriers of FAS-670*G. These data suggest that FAS-670*G decreases the risk of developing MS, but does not affect the course of disease...
  31. ncbi request reprint The EU FP6 EpiGenChlamydia Consortium: contribution of molecular epidemiology and host-pathogen genomics to understanding Chlamydia trachomatis-related disease
    S A Morre
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, 1081HV Amsterdam, The Netherlands
    Drugs Today (Barc) 45:7-13. 2009
    ..trachomatis infection and its complications. This review summarizes the consortium aims and progress, and future perspectives and directions...
  32. doi request reprint Current methods to diagnose the unresponsive and complicated forms of coeliac disease
    M Hadithi
    Department of Gastroenterology, Maasstad Hospital, Postbus 9119, Rotterdam, The Netherlands
    Eur J Intern Med 21:247-53. 2010
    ..We review the available tools that now exist and their indications that can be practiced in a modern clinical setting for the diagnosis of the complicated forms of this disease...
  33. ncbi request reprint An integrated approach to the understanding of Chlamydia infections: Introduction to the 2009 update
    S A Morréé
    Laboratory of Immunogenetics, Department of Pathology, VU University Medical Center, 1081HV Amsterdam, The Netherlands
    Drugs Today (Barc) 45:3-5. 2009
    ..trachomatis, C. psittaci and C. pneumoniae, predominantly presented at the 4th and 5th AACM, are summarized in this second Drugs of Today supplement, as well as timely mini-reviews of the advances made in the field...