Walter J Paulus

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Treatment of heart failure with normal ejection fraction
    Nazha Hamdani
    Laboratory for Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Curr Treat Options Cardiovasc Med 13:26-34. 2011
  2. doi A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation
    Walter J Paulus
    Department of Physiology, Institute for Cardiovascular Research VU, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 62:263-71. 2013
  3. ncbi Nitric oxide's role in the heart: control of beating or breathing?
    Walter J Paulus
    Institute for Cardiovascular Research, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 287:H8-13. 2004
  4. doi Treatment of heart failure with normal ejection fraction: an inconvenient truth!
    Walter J Paulus
    Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:526-37. 2010
  5. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
  6. doi Low myocardial protein kinase G activity in heart failure with preserved ejection fraction
    Loek van Heerebeek
    Department of Physiology, Cardiology, Pathology, and Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 126:830-9. 2012
  7. doi Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium
    Attila Borbely
    Laboratory of Physiology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Circ Res 104:780-6. 2009
  8. doi Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness
    Ines Falcao-Pires
    Department of Physiology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Circulation 124:1151-9. 2011
  9. doi Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension
    Frances S de Man
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Circ Heart Fail 5:97-105. 2012
  10. doi Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart
    M Louis Handoko
    Department of Physiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H1752-9. 2009

Detail Information

Publications56

  1. pmc Treatment of heart failure with normal ejection fraction
    Nazha Hamdani
    Laboratory for Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Curr Treat Options Cardiovasc Med 13:26-34. 2011
    ..Heart rate control in atrial fibrillation can be achieved with β-blockers and digoxin. Finally, ACE inhibitors and ARBs could potentially decrease LV hypertrophy in hypertensive patients with HFNEF...
  2. doi A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation
    Walter J Paulus
    Department of Physiology, Institute for Cardiovascular Research VU, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 62:263-71. 2013
    ..The new HFPEF paradigm proposes comorbidities, plasma markers of inflammation, or vascular hyperemic responses to be included in diagnostic algorithms and aims at restoring myocardial PKG activity. ..
  3. ncbi Nitric oxide's role in the heart: control of beating or breathing?
    Walter J Paulus
    Institute for Cardiovascular Research, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 287:H8-13. 2004
    ..A drop in these concerted actions of NO on diastolic LV distensibility and on myocardial energetics could well be instrumental for the relentless deterioration of failing myocardium...
  4. doi Treatment of heart failure with normal ejection fraction: an inconvenient truth!
    Walter J Paulus
    Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Am Coll Cardiol 55:526-37. 2010
    ..Nonadherence to guidelines also led to underpowered HFNEF trials with a low incidence of outcome events such as death or HF hospitalizations. Future HFNEF trials should therefore adhere to diagnostic guidelines for HFNEF...
  5. ncbi How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology
    Walter J Paulus
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat, 7, 1081 BT, Amsterdam, The Netherlands
    Eur Heart J 28:2539-50. 2007
    ..The updated strategies for the diagnosis and exclusion of HFNEF are useful not only for individual patient management but also for patient recruitment in future clinical trials exploring therapies for HFNEF...
  6. doi Low myocardial protein kinase G activity in heart failure with preserved ejection fraction
    Loek van Heerebeek
    Department of Physiology, Cardiology, Pathology, and Surgery, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 126:830-9. 2012
    ..To discern altered control of myocardial remodeling by PKG, HFPEF was compared with aortic stenosis and HF with reduced EF (HFREF)...
  7. doi Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium
    Attila Borbely
    Laboratory of Physiology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Circ Res 104:780-6. 2009
    ..77+/-0.05) than in AS (P-N2BA/P-N2B=0.54+/-0.05; P<0.01). Relative hypophosphorylation of the stiff N2B titin isoform is a novel mechanism responsible for raised F(passive) of human HF cardiomyocytes...
  8. doi Diabetes mellitus worsens diastolic left ventricular dysfunction in aortic stenosis through altered myocardial structure and cardiomyocyte stiffness
    Ines Falcao-Pires
    Department of Physiology, VU University Medical Center Amsterdam, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Circulation 124:1151-9. 2011
    ..Effects of DM on diastolic LV function were therefore assessed in aortic stenosis, and underlying myocardial mechanisms were identified...
  9. doi Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension
    Frances S de Man
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Circ Heart Fail 5:97-105. 2012
    ..We therefore investigated whether chronic low-dose treatment with bisoprolol (a cardioselective β-blocker) has beneficial effects on cardiac function in experimental PH...
  10. doi Right ventricular pacing improves right heart function in experimental pulmonary arterial hypertension: a study in the isolated heart
    M Louis Handoko
    Department of Physiology, VU University Medical Center, Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 297:H1752-9. 2009
    ..Taken together, we demonstrate that, in experimental PH, RV pacing improves RV function and diminishes adverse diastolic interaction. These findings provide a strong rationale for further in vivo explorations...
  11. doi Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction
    Nazha Hamdani
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Eur Heart J 30:1863-72. 2009
    ....
  12. doi Antioxidant treatment attenuates pulmonary arterial hypertension-induced heart failure
    Everaldo M Redout
    Institute for Cardiovascular Research, VU Univ Medical Center Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 298:H1038-47. 2010
    ..These data indicate an important role of ROS in RV cardiomyocyte hypertrophy and contractile dysfunction due to PAH and show the potential of EUK-class antioxidants as complementary therapeutics in the treatment of RV dysfunction in PAH...
  13. pmc Independent associations of glucose status and arterial stiffness with left ventricular diastolic dysfunction: an 8-year follow-up of the Hoorn Study
    Katja van den Hurk
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 35:1258-64. 2012
    ..To investigate relative contributions of glucose status and arterial stiffness to markers of left ventricular (LV) systolic and diastolic dysfunction after 8 years of follow-up...
  14. doi NOX2, p22phox and p47phox are targeted to the nuclear pore complex in ischemic cardiomyocytes colocalizing with local reactive oxygen species
    Nynke E Hahn
    Department of Pathology, VU University Medical Centre, De Boelelaan 1117, Amsterdam, The Netherlands
    Cell Physiol Biochem 27:471-8. 2011
    ..g. under ischemia or high concentrations of homocysteine, is an important step in the induction of apoptosis in these cells. Here this ischemia-induced nuclear targeting and activation of NOX2 was specified in cardiomyocytes...
  15. ncbi The failing diabetic heart: focus on diastolic left ventricular dysfunction
    Loek van Heerebeek
    Laboratory of Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Curr Diab Rep 9:79-86. 2009
    ..As HF mortality remains high in DM despite proven efficacy of current treatments, better understanding of the pathophysiology of high LV diastolic stiffness could be beneficial for novel therapeutic strategies...
  16. doi NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans
    Nynke E Hahn
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Pathol 180:2222-9. 2012
    ..For the first time to our knowledge, we demonstrate NOX5 expression in human intramyocardial blood vessels and cardiomyocytes, with significant increases in the affected myocardium after acute myocardial infarction...
  17. doi Circulating white blood cells and platelets amplify oxidative stress in heart failure
    Alexander J J Ijsselmuiden
    Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    Nat Clin Pract Cardiovasc Med 5:811-20. 2008
    ..Although evidence indicates that congestive heart failure (CHF) is associated with oxidative stress, the role of WBC and platelets as mediators in CHF has not been investigated...
  18. ncbi Functional effects of protein kinase C-mediated myofilament phosphorylation in human myocardium
    Jolanda van der Velden
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 69:876-87. 2006
    ..This study was designed to reveal the effects of PKC on myofilament function in human myocardium under basal conditions and upon modulation of protein phosphorylation by PKA and phosphatases...
  19. doi The basement membrane of intramyocardial capillaries is thickened in patients with acute myocardial infarction
    Mark P V Begieneman
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Vasc Res 47:54-60. 2010
    ..Recently, we found that intramyocardial capillaries may also play a role in AMI induction. We have now evaluated intramyocardial capillaries using ultrastructural analysis in AMI patients...
  20. ncbi Diastolic stiffness of the failing diabetic heart: importance of fibrosis, advanced glycation end products, and myocyte resting tension
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circulation 117:43-51. 2008
    ..The contribution to diastolic stiffness of fibrosis, AGEs, and cardiomyocyte resting tension was assessed in diabetic heart failure patients with normal or reduced LVEF...
  21. pmc More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease
    Nazha Hamdani
    Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    J Muscle Res Cell Motil 31:289-301. 2010
    ..Alterations in the βAR pathway are more pronounced in IDCM than in ISHD and may reflect sequential changes in cellular protein composition and function. Our data indicate that cellular dysfunction is more severe in IDCM than in ISHD...
  22. doi Molecular and cellular basis for diastolic dysfunction
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Curr Heart Fail Rep 9:293-302. 2012
    ....
  23. pmc Prospective associations of B-type natriuretic peptide with markers of left ventricular function in individuals with and without type 2 diabetes: an 8-year follow-up of the Hoorn Study
    Maria H Kroon
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Diabetes Care 35:2510-4. 2012
    ....
  24. ncbi Myocardial structure and function differ in systolic and diastolic heart failure
    Loek van Heerebeek
    Department of Physiology, Institute for Cardiovascular Research, VU Medical Center, Amsterdam, The Netherlands
    Circulation 113:1966-73. 2006
    ....
  25. doi Heart failure and cognitive function in the general population: the Hoorn Study
    Katja van den Hurk
    Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam, The Netherlands
    Eur J Heart Fail 13:1362-9. 2011
    ..To examine whether reduced cognitive functioning can be observed in early stages of left ventricular (LV) dysfunction and heart failure...
  26. doi Left ventricular torsion: an expanding role in the analysis of myocardial dysfunction
    Iris K Rüssel
    Department of Physics and Medical Technology, VU University Medical Center, Amsterdam, The Netherlands
    JACC Cardiovasc Imaging 2:648-55. 2009
    ..The results obtained over the years are helpful for developing a standardized method to quantify LV torsion and have facilitated the interpretation and value of LV torsion before it can be used as a clinical tool...
  27. ncbi Effects of aging on left atrioventricular coupling and left ventricular filling assessed using cardiac magnetic resonance imaging in healthy subjects
    Tjeerd Germans
    Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Cardiol 100:122-7. 2007
    ..Conduit volume contributed most to LV filling and decreased with age, suggesting it to be an indicator of diastolic function...
  28. doi Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies
    Ruud Zaremba
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Proteomics Clin Appl 1:1285-90. 2007
    ..The present study describes quantitative analysis of phosphorylation status of multiple myofilament proteins by 2-DE and Pro-Q® Diamond stained gradient gels using minor amounts (˜0.5 mg dry weight) of human and pig cardiac tissue...
  29. ncbi Sarcomeric dysfunction in heart failure
    Nazha Hamdani
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam, The Netherlands
    Cardiovasc Res 77:649-58. 2008
    ..Novel therapies, which specifically target phosphorylation sites within sarcomeric proteins or the kinases and phosphatases involved, might improve cardiac function in heart failure...
  30. doi Myocardial titin hypophosphorylation importantly contributes to heart failure with preserved ejection fraction in a rat metabolic risk model
    Nazha Hamdani
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Circ Heart Fail 6:1239-49. 2013
    ..The relative importance for myocardial DD of collagen deposition and titin modification was investigated in obese, diabetic ZSF1 rats after heart failure with preserved ejection fraction development at 20 weeks...
  31. ncbi Does myocardial fibrosis hinder contractile function and perfusion in idiopathic dilated cardiomyopathy? PET and MR imaging study
    Paul Knaapen
    Department of Cardiology, VU University Medical Center, De Boelelaan 1117, Room 6D 120, 1081 HV Amsterdam, The Netherlands
    Radiology 240:380-8. 2006
    ....
  32. doi Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase
    Paul A J Krijnen
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Mol Cell Cardiol 49:781-90. 2010
    ..In this study, we show a regulatory role for a novel signaling route, Rho-ROCK-flippase signaling, in maintaining asymmetrical membrane phospholipid distribution in cardiomyocytes...
  33. doi H9c2 cardiomyoblasts produce thyroid hormone
    Christof Meischl
    VU University Medical Center, Department of Pathology, Amsterdam, The Netherlands
    Am J Physiol Cell Physiol 294:C1227-33. 2008
    ..In conclusion, our findings demonstrate for the first time that cardiomyocytes produce thyroid hormone in a manner adapted to the cell's environment...
  34. pmc RhoA-ROCK signaling is involved in contraction-mediated inhibition of SERCA2a expression in cardiomyocytes
    Ronald Vlasblom
    Laboratory for Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Pflugers Arch 458:785-93. 2009
    ..This study shows that contractile activity suppresses SERCA2a gene expression via RhoA-ROCK-dependent transcription modulation. This modulation is likely to be accomplished by a transcription factor other than SRF, myocardin, or GATA4...
  35. ncbi Right ventricular diastolic dysfunction and the acute effects of sildenafil in pulmonary hypertension patients
    C Tji Joong Gan
    VU University Medical Center, De Boelelaan 1117 PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Chest 132:11-7. 2007
    ..In addition, the effects of an acute reduction of RV afterload by the oral intake of sildenafil were studied. Finally, we assessed whether diastolic function is related to cardiac parameters of disease severity...
  36. ncbi Cardiomyocyte stiffness in diastolic heart failure
    Attila Borbely
    Laboratory for Physiology, Institute for Cardiovascular Research, VUMC, Amsterdam, The Netherlands
    Circulation 111:774-81. 2005
    ..Single cardiomyocytes were isolated from these biopsy samples to assess cellular contractile performance...
  37. doi Left-ventricular remodeling after myocardial infarction is associated with a cardiomyocyte-specific hypothyroid condition
    Christine J Pol
    Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit University Medical Center, 1081 HV Amsterdam, The Netherlands
    Endocrinology 152:669-79. 2011
    ..In conclusion, pathological ventricular remodeling after MI in the mouse leads to high and stable induction of D3 activity in cardiomyocytes and a local hypothyroid condition...
  38. ncbi Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species
    Everaldo M Redout
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Cardiovasc Res 75:770-81. 2007
    ..Reactive oxygen species (ROS) have been implicated in the progression of ventricular hypertrophy to congestive heart failure. However, the source of increased oxidative stress in cardiomyocytes remains unclear...
  39. doi Intravenous clusterin administration reduces myocardial infarct size in rats
    Annemieke van Dijk
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 40:893-902. 2010
    ..We therefore hypothesized that intravenous clusterin administration would reduce myocardial infarction damage...
  40. doi Effects of mechanical left ventricular unloading by Impella on left ventricular dynamics in high-risk and primary percutaneous coronary intervention patients
    Maurice Remmelink
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands
    Catheter Cardiovasc Interv 75:187-94. 2010
    ..We studied online left ventricular (LV) dynamic effects of mechanical LV unloading directly after percutaneous coronary intervention (PCI)...
  41. ncbi Myocardial energetics and efficiency: current status of the noninvasive approach
    Paul Knaapen
    Department of Cardiology, 6D 120, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Circulation 115:918-27. 2007
  42. doi The role of asymmetric dimethylarginine and arginine in the failing heart and its vasculature
    Marlieke Visser
    Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Heart Fail 12:1274-81. 2010
    ..This review discusses the roles of ADMA and arginine in the failing heart and its vasculature. Furthermore, it proposes nutritional therapies to improve NO availability...
  43. ncbi Cardioprotection via activation of protein kinase C-delta depends on modulation of the reverse mode of the Na+/Ca2+ exchanger
    R Arthur Bouwman
    Department of Anesthesiology, VU University Medical Center, De Boelelaan 1118, PO Box 7057, 1007 MB Amsterdam, Netherlands
    Circulation 114:I226-32. 2006
    ....
  44. ncbi Contractile arrest reveals calcium-dependent stimulation of SERCA2a mRNA expression in cultured ventricular cardiomyocytes
    Ronald Vlasblom
    Laboratory for Physiology, Institute for Cardiovascular Research ICaR VU, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Cardiovasc Res 63:537-44. 2004
    ....
  45. ncbi Endomyocardial nitric oxide synthase and the hemodynamic phenotypes of human dilated cardiomyopathy and of athlete's heart
    Jean G F Bronzwaer
    Cardiology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Cardiovasc Res 55:270-8; discussion 225-8. 2002
    ....
  46. doi Slightly elevated B-type natriuretic peptide levels in a non-heart failure range indicate a worse left ventricular diastolic function in individuals with, as compared with individuals without, type 2 diabetes: the Hoorn Study
    Katja van den Hurk
    Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Heart Fail 12:958-65. 2010
    ..We therefore aimed to explore (i) the association of BNP levels in a non-HF range with structural and functional markers of LV function, and (ii) possible effect modification by glucose tolerance categories...
  47. doi Inhibition of type 2A secretory phospholipase A2 reduces death of cardiomyocytes in acute myocardial infarction
    Annemieke van Dijk
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Apoptosis 14:753-63. 2009
    ..In conclusion, PX-18 is a potent therapeutic to reduce infarct size by inhibiting sPLA(2)-IIA, and possibly also by inhibiting apoptosis of cardiomyocytes in a sPLA(2)-IIA independent manner...
  48. ncbi Diastolic and systolic heart failure: different stages or distinct phenotypes of the heart failure syndrome?
    Jean G F Bronzwaer
    Department of Physiology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Curr Heart Fail Rep 6:281-6. 2009
    ..This review analyzes arguments supporting DHF and SHF as successive stages or distinct phenotypes of the HF syndrome...
  49. ncbi Myocardial fibrosis blunts nitric oxide synthase-related preload reserve in human dilated cardiomyopathy
    Jean G F Bronzwaer
    VU University Medical Center and Institute for Cardiovascular Research VU, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 284:H10-6. 2003
    ..In DCM, myocardial fibrosis is unrelated to the intensity of myocardial gene expression of NOS, antioxidative enzymes (HO-1), or cytokines (TNF-alpha) and blunts NOS2-related recruitment of LV preload reserve...
  50. ncbi What mechanisms underlie diastolic dysfunction in heart failure?
    David A Kass
    Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Circ Res 94:1533-42. 2004
    ..This review puts these developments into perspective with the major aim of highlighting current knowledge gaps and controversies...
  51. ncbi Myocardial contractile effects of nitric oxide
    Walter J Paulus
    Cardiovascular Center, OLV Ziekenhuis, Aalst, Belgium
    Heart Fail Rev 7:371-83. 2002
    ..Finally, shifts in isoforms or in concentrations of myofilaments can affect NO-mediated myofilamentary desensitization and alter the myocardial contractile effects of NO in hypertrophied or failing myocardium...
  52. ncbi Matrix, cytoskeleton, or myofilaments: which one to blame for diastolic left ventricular dysfunction?
    Jean G F Bronzwaer
    Department of Physiology and Cardiology, Institute for Cardiovascular Research ICaR VU, Vrije Universitrit Amsterdam, The Netherlands
    Prog Cardiovasc Dis 47:276-84. 2005
    ....
  53. ncbi Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells
    Attila Borbely
    Division of Clinical Physiology, Institute of Cardiology, UD MHSC, P O Box 1, H 4004 Debrecen, Hungary
    Cardiovasc Res 67:225-33. 2005
    ..In the present study, an attempt was made to elucidate the molecular background of peroxynitrite-evoked alterations in the human myocardium...
  54. pmc Myofilament degradation and dysfunction of human cardiomyocytes in Fabry disease
    Cristina Chimenti
    Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele La Pisana, Rome, Italy
    Am J Pathol 172:1482-90. 2008
    ..Partial reversal of high resting tension after pharmacological PKA treatment of cardiomyocytes suggests potential benefits from enzyme replacement therapy and/or energy-releasing agents...
  55. ncbi SIH--a novel lipophilic iron chelator--protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death
    Tomas Simunek
    Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
    J Mol Cell Cardiol 39:345-54. 2005
    ..Thus, in this study, we present iron chelation as a very powerful tool by which oxidative stress-induced myocardial damage can be prevented...
  56. ncbi New statement of the European Society of Cardiology on diagnosing diastolic heart failure: what are the key messages
    M Louis Handoko
    Pol Arch Med Wewn 118:100-1. 2008