Research Topics
| T PattijSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Strain specificity and cholinergic modulation of visuospatial attention in three inbred mouse strainsT Pattij
Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
Genes Brain Behav 6:579-87. 2007..In conclusion, our data indicate strain specificity with particularly good performance of 129S2/SvHsd mice and strong cholinergic involvement in visuospatial attention in mice...
Acute effects of morphine on distinct forms of impulsive behavior in ratsTommy Pattij
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, Center for Neurogenomics and Cognitive Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Psychopharmacology (Berl) 205:489-502. 2009..The aim of the present study was to further investigate the role of the opioid system in varieties of impulsivity...- Unidirectional relationship between heroin self-administration and impulsive decision-making in ratsMaria C Schippers
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, Vrije Universiteit University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Psychopharmacology (Berl) 219:443-52. 2012..Recent observations in the animal models show that pre-existing levels of impulsivity predict cocaine and nicotine seeking. Whether such relationships also exist with respect to non-stimulant drugs is largely unknown... 
Cannabinoid modulation of executive functionsTommy Pattij
Department of Anatomy and Neurosciences, Center for Neurogenomics and Cognitive Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Eur J Pharmacol 585:458-63. 2008..Therefore, in this paper we will also briefly discuss some recent developments in this research field...- Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disordersTommy Pattij
Department of Anatomy, University Medical Center St Radboud, Nijmegen, The Netherlands
Eur J Neurosci 22:724-34. 2005..Further exploring the neurobiological mechanisms underlying these differences may be a promising approach to gain insights into the aetiology of sexual dysfunctions such as premature, retarded or an-ejaculation... - Effects of the cannabinoid CB1 receptor antagonist rimonabant on distinct measures of impulsive behavior in ratsTommy Pattij
Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands
Psychopharmacology (Berl) 193:85-96. 2007..Pathological impulsivity is a prominent feature in several psychiatric disorders, but detailed understanding of the specific neuronal processes underlying impulsive behavior is as yet lacking... - Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response controlTommy Pattij
Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Psychopharmacology (Berl) 191:587-98. 2007..Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect... - The neuropharmacology of impulsive behaviourTommy Pattij
Department of Anatomy and Neurosciences, Center for Neurogenomics and Cognitive Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
Trends Pharmacol Sci 29:192-9. 2008..However, recent findings also implicate glutamate and cannabinoid neurotransmission in impulsivity. In this review, we will discuss some of the recent developments in the neuropharmacological manipulation of impulsive behaviour... - On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonistsTommy Pattij
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
Psychopharmacology (Berl) 219:327-40. 2012..Nonetheless, it is unclear which adrenoceptor subtypes are involved in these effects... - Dopamine receptor D1/D5 gene expression in the medial prefrontal cortex predicts impulsive choice in ratsMaarten Loos
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
Cereb Cortex 20:1064-70. 2010..Together, these data indicate that this class of dopamine receptors in the mPFC plays a pivotal role in impulsive choice, and aberrancies thereof might contribute to ADHD symptomatology... - Activity and impulsive action are controlled by different genetic and environmental factorsM Loos
Departments of Molecular and Cellular Neurobiology, VU University, Amsterdam, The Netherlands
Genes Brain Behav 8:817-28. 2009.... - Long-lasting cognitive deficits resulting from adolescent nicotine exposure in ratsDanielle S Counotte
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit, Amsterdam, The Netherlands
Neuropsychopharmacology 34:299-306. 2009..Together, these data suggest that adolescence is a time window during which the brain is vulnerable to long-lasting cognitive disturbances resulting from nicotine exposure... - Independent genetic loci for sensorimotor gating and attentional performance in BXD recombinant inbred strainsM Loos
Department of Molecular and Cellular Neurobiology Anatomy and Neurosciences, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University and VU University Medical Center, Amsterdam, The Netherlands
Genes Brain Behav 11:147-56. 2012..Therefore, it is worth pursuing the causative genes residing in both attention and PPI QTL, as these may contribute to separate molecular pathways implicated in neuropsychiatric diseases, such as schizophrenia... - Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male ratsTrynke R de Jong
Department of Anatomy, Radboud University Nijmegen Medical Centre, Intern Mail Nr 230 Postbus 9101 6500 HB, Nijmegen, The Netherlands
Eur Neuropsychopharmacol 16:39-48. 2006..No differences between the groups were found in the other tests. Apparently, chronic treatment with SSRIs during adolescence may cause mild changes in adult behavior... - The role of CB1 receptors in psychostimulant addictionJoost Wiskerke
Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
Addict Biol 13:225-38. 2008..Together, these findings suggest that modulators of the eCB system represent a promising novel type of therapy to treat drug addiction... - Trait impulsivity predicts escalation of sucrose seeking and hypersensitivity to sucrose-associated stimuliLeontien Diergaarde
Department of Anatomy and Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
Behav Neurosci 123:794-803. 2009..As such, elevated impulsivity might constitute a risk factor for the initiation and maintenance of addictive behaviors... - Impulsive-like behavior in differential-reinforcement-of-low-rate 36 s responding in mice depends on training historyTommy Pattij
Department of Anatomy, University Medical Center St Radboud, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
Neurosci Lett 354:169-71. 2004..Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history... - Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in ratsLeontien Diergaarde
Center for Neurogenomics and Cognitive Research, Department of Anatomy and Neurosciences, VU Medical Center, Amsterdam, The Netherlands
Biol Psychiatry 63:301-8. 2008..Although heavy smoking has been associated with impulsivity in humans, it is not clear whether poor impulse control represents a risk factor in the etiology of nicotine dependence... - Effects of chronic paroxetine pretreatment on (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin induced c-fos expression following sexual behaviorT R de Jong
Department of Anatomy, Radboud University Nijmegen Medical Centre, The Netherlands
Neuroscience 134:1351-61. 2005.... - Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5-choice serial reaction time task and strain-specific responsivity to amphetamineMaarten Loos
Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, Amsterdam, The Netherlands
Behav Brain Res 214:216-24. 2010.... - Effects of acute and chronic apomorphine on sex behavior and copulation-induced neural activation in the male ratJocelien D A Olivier
Department of Anatomy, UMC St Radboud, University of Nijmegen, The Netherlands
Eur J Pharmacol 576:61-76. 2007.... - Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT-induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetineTrynke R de Jong
Department of Anatomy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Psychopharmacology (Berl) 179:509-15. 2005..The involvement of 5-HT1A receptors is likely, since 5-HT1A receptor agonists accelerate ejaculation and chronic SSRI treatment is thought to desensitize 5-HT1A receptors... - Operant learning and differential-reinforcement-of-low-rate 36-s responding in 5-HT1A and 5-HT1B receptor knockout miceTommy Pattij
Department of Anatomy, University Medical Center St Radboud, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands
Behav Brain Res 141:137-45. 2003..In contrast, 5-HT(1A) receptors appear to be involved in facilitation of autoshaping, but their role in impulsivity and prefrontal cortex-dependent learning and memory appears to be limited... - Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivityTrynke R de Jong
Department of Anatomy, University Medical Centre St Radboud, Nijmegen, The Netherlands
Eur J Pharmacol 509:49-59. 2005..Citalopram reduced Fos-immunoreactivity in the arcuate hypothalamic nucleus, an area that might link serotonergic neurotransmission to ejaculation... - Autonomic changes associated with enhanced anxiety in 5-HT(1A) receptor knockout miceTommy Pattij
Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Neuropsychopharmacology 27:380-90. 2002..The present findings show that 5-HT(1A) receptor KO mice display a more "anxious-like" phenotype not only at a behavioral, but also at autonomic levels... - Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibilityJudith R Homberg
Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Eur J Neurosci 26:2066-73. 2007.... - Activation of the brain 5-HT2C receptors causes hypolocomotion without anxiogenic-like cardiovascular adjustments in miceOliver Stiedl
Center for Neurogenomics and Cognitive Research CNCR and Institute of Neurosciences INW, Vrije Universiteit Amsterdam, The Netherlands
Neuropharmacology 52:949-57. 2007..In summary, in view of lack of autonomic effects, and the lack of hypoactivity upon forebrain stimulation, the hypolocomotion induced by systemic mCPP cannot be explained by an enhanced anxiety-like state... - 5-HT1A receptor knockout mice and mice overexpressing corticotropin-releasing hormone in models of anxietyLucianne Groenink
Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, The Netherlands
Eur J Pharmacol 463:185-97. 2003..Rather than studying the direct consequences of alterations in the targeted gene, 1AKO and CRH-OE mice seem very valuable to study compensatory processes that seem to have taken place in reaction to life-long changes in gene expression... - GABA(A)-benzodiazepine receptor complex sensitivity in 5-HT(1A) receptor knockout mice on a 129/Sv backgroundTommy Pattij
Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, Netherlands
Eur J Pharmacol 447:67-74. 2002..The anxious phenotype of 1AKO mice seems to occur independent of the GABA(A)-benzodiazepine receptor complex functioning... - The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatmentMarcel D Waldinger
Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences and Utrecht Institute for Parmaceutical Sciences, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands
Psychopharmacology (Berl) 160:283-9. 2002..The mechanisms whereby paroxetine and fluvoxamine, both being selective serotonin uptake inhibitors, differentially inhibit sexual behavior are unclear...