Coen A C Ottenheijm

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam
    J Appl Physiol 112:1157-65. 2012
  2. pmc Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading?
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU Univ Medical Center, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 300:L161-6. 2011
  3. pmc Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    Hum Mol Genet 20:2015-25. 2011
  4. doi request reprint Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction
    Emmy Manders
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 303:L1070-8. 2012
  5. pmc Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy
    Coen A C Ottenheijm
    1 Department of Physiology, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 136:1718-31. 2013
  6. pmc Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2)
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    J Struct Biol 170:334-43. 2010
  7. doi request reprint Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations
    Josine Marieke de Winter
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Dr Coen Ottenheijm, Department of Physiology, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    J Med Genet 50:383-92. 2013
  8. pmc New insights into the structural roles of nebulin in skeletal muscle
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands
    J Biomed Biotechnol 2010:968139. 2010
  9. doi request reprint Diaphragm muscle fiber weakness in pulmonary hypertension
    Frances S de Man
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 183:1411-8. 2011
  10. pmc The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Netherlands
    Front Physiol 3:37. 2012

Collaborators

Detail Information

Publications11

  1. pmc Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam
    J Appl Physiol 112:1157-65. 2012
    ..We hypothesized that in response to the increased compliance of the extracellular matrix in TNX-deficient EDS patients, intracellular adaptations take place in the elastic properties of the giant muscle protein titin...
  2. pmc Titin-based mechanosensing and signaling: role in diaphragm atrophy during unloading?
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU Univ Medical Center, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 300:L161-6. 2011
    ..Here, we provide a novel perspective on how titin, and its biomechanical sensing and signaling, might be involved in the development of mechanical unloading-induced diaphragm weakness...
  3. pmc Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    Hum Mol Genet 20:2015-25. 2011
    ..These findings provide a scientific basis for differential therapeutics aimed at restoring contractile performance in patients with TPM3-based versus NEB-based myopathy...
  4. doi request reprint Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction
    Emmy Manders
    Department of Pulmonology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 303:L1070-8. 2012
    ..Together, these findings indicate that diaphragm weakness in PH is at least partly caused by sarcomeric dysfunction, which appears to be specific for the diaphragm...
  5. pmc Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy
    Coen A C Ottenheijm
    1 Department of Physiology, VU University Medical Centre, Amsterdam, The Netherlands
    Brain 136:1718-31. 2013
    ....
  6. pmc Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2)
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    J Struct Biol 170:334-43. 2010
    ..Thus, the present study provides important novel insights into the pathogenesis of muscle weakness in nebulin-based NM...
  7. doi request reprint Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations
    Josine Marieke de Winter
    Department of Physiology, University of Arizona, Tucson, AZ 85724, USA Dr Coen Ottenheijm, Department of Physiology, VU University Medical Center, Amsterdam 1081 BT, The Netherlands
    J Med Genet 50:383-92. 2013
    ..Here, we studied the ability of the novel fast skeletal muscle troponin activator, CK-2066260, to augment force generation at submaximal calcium levels in muscle cells from nemaline myopathy patients with nebulin mutations...
  8. pmc New insights into the structural roles of nebulin in skeletal muscle
    Coen A C Ottenheijm
    Laboratory for Physiology, Institute for Cardiovascular Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands
    J Biomed Biotechnol 2010:968139. 2010
    ..When these functions of nebulin are absent, muscle weakness ensues, as is the case in patients with nemaline myopathy with mutations in nebulin. Here we review these new insights in the role of nebulin in skeletal muscle structure...
  9. doi request reprint Diaphragm muscle fiber weakness in pulmonary hypertension
    Frances S de Man
    Department of Pulmonology, VU University Medical Center Institute for Cardiovascular Research, Amsterdam, The Netherlands
    Am J Respir Crit Care Med 183:1411-8. 2011
    ..Recently it was suggested that patients with pulmonary hypertension (PH) suffer from inspiratory muscle dysfunction. However, the nature of inspiratory muscle weakness in PH remains unclear...
  10. pmc The sarcomeric protein nebulin: another multifunctional giant in charge of muscle strength optimization
    Coen A C Ottenheijm
    Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Netherlands
    Front Physiol 3:37. 2012
    ..Here, we discuss these important novel insights into the role of nebulin in skeletal muscle function...
  11. doi request reprint Diaphragm muscle fiber function and structure in humans with hemidiaphragm paralysis
    W N Welvaart
    Department of Surgery, Vrije Universiteit University Medical Center Institute for Cardiovascular Research, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 301:L228-35. 2011
    ..Diaphragm muscle fiber atrophy and weakness following hemidiaphragm paralysis develops slowly and takes months to occur...