Rik Ossenkoppele

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint [Amyloid-plaque imaging of the brain using PET]
    Rik Ossenkoppele
    VU Medisch Centrum, Afd Nucleaire Geneeskunde and PET Research, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A2981. 2011
  2. pmc Is verbal episodic memory in elderly with amyloid deposits preserved through altered neuronal function?
    Rik Ossenkoppele
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, the Netherlands Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Cereb Cortex 24:2210-8. 2014
  3. ncbi request reprint Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions
    Rik Ossenkoppele
    From the Department of Radiology and Nuclear Medicine R O, S C J V, H V, A V, R A v S, S M A, M D Z, R B, A D W, F B, A A L, B N M v B, Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam R O, W M v d F, S A S, S M A, M D Z, P S, and Department of Epidemiology and Biostatistics W M v d F, S A S, J T, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 82:1768-75. 2014
  4. doi request reprint Impact of molecular imaging on the diagnostic process in a memory clinic
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:414-21. 2013
  5. doi request reprint Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 80:359-65. 2013
  6. doi request reprint Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 135:2115-25. 2012
  7. doi request reprint Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, Netherlands
    Eur J Nucl Med Mol Imaging 39:990-1000. 2012
  8. pmc Amyloid imaging in prodromal Alzheimer's disease
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, 1007 MB Amsterdam, The Netherlands
    Alzheimers Res Ther 3:26. 2011
  9. doi request reprint Longitudinal amyloid imaging using 11C-PiB: methodologic considerations
    Bart N M van Berckel
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:1570-6. 2013
  10. ncbi request reprint The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease
    Sofie M Adriaanse
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 41:1190-8. 2014

Detail Information

Publications12

  1. ncbi request reprint [Amyloid-plaque imaging of the brain using PET]
    Rik Ossenkoppele
    VU Medisch Centrum, Afd Nucleaire Geneeskunde and PET Research, Amsterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A2981. 2011
    ..In the future, amyloid imaging could also be useful for selecting patients for clinical trials and in evaluating the effects of disease modifying agents tailored at lowering Aβ burden...
  2. pmc Is verbal episodic memory in elderly with amyloid deposits preserved through altered neuronal function?
    Rik Ossenkoppele
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, the Netherlands Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Cereb Cortex 24:2210-8. 2014
    ..This preliminary study suggests that neural compensation, as a manifestation of brain reserve, enables elderly supposedly on the path to AD, at least temporarily, to preserve cognitive function. ..
  3. ncbi request reprint Long-term effects of amyloid, hypometabolism, and atrophy on neuropsychological functions
    Rik Ossenkoppele
    From the Department of Radiology and Nuclear Medicine R O, S C J V, H V, A V, R A v S, S M A, M D Z, R B, A D W, F B, A A L, B N M v B, Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam R O, W M v d F, S A S, S M A, M D Z, P S, and Department of Epidemiology and Biostatistics W M v d F, S A S, J T, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 82:1768-75. 2014
    ..To assess how amyloid deposition, glucose hypometabolism, and cerebral atrophy affect neuropsychological performance in patients with Alzheimer disease (AD) dementia, patients with mild cognitive impairment (MCI), and controls over time...
  4. doi request reprint Impact of molecular imaging on the diagnostic process in a memory clinic
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Alzheimers Dement 9:414-21. 2013
    ..We evaluated the impact of these tracers on the diagnostic process in a memory clinic population...
  5. doi request reprint Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 80:359-65. 2013
    ..To examine the relationships between apolipoprotein E (APOE) ε4 dose and in vivo distributions of both fibrillary amyloid burden and glucose metabolism in the same Alzheimer disease dementia patients, selected for abnormal amyloid imaging...
  6. doi request reprint Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 135:2115-25. 2012
    ..As such, increased amyloid burden, together with metabolic dysfunction, in the parietal lobe of younger patients with Alzheimer's disease may contribute to the distinct cognitive profile in these patients...
  7. doi request reprint Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, PO Box 7057, 1007MB, Amsterdam, Netherlands
    Eur J Nucl Med Mol Imaging 39:990-1000. 2012
    ..18)F]FDG is a glucose analogue and its uptake reflects metabolic activity. The purpose of this study was to examine longitudinal changes in these tracers in patients with AD or mild cognitive impairment (MCI) and in healthy controls...
  8. pmc Amyloid imaging in prodromal Alzheimer's disease
    Rik Ossenkoppele
    Department of Neurology and Alzheimer Center, VU University Medical Center, Amsterdam, 1007 MB Amsterdam, The Netherlands
    Alzheimers Res Ther 3:26. 2011
    ..These findings may have important implications for the design of future clinical trials aimed at preventing progression to Alzheimer's disease by lowering the brain amyloid-beta burden in patients with mild cognitive impairment...
  9. doi request reprint Longitudinal amyloid imaging using 11C-PiB: methodologic considerations
    Bart N M van Berckel
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 54:1570-6. 2013
    ..Several methods are in use for analyzing (11)C-Pittsburgh compound-B ((11)C-PiB) data. The objective of this study was to identify the method of choice for measuring longitudinal changes in specific (11)C-PiB binding...
  10. ncbi request reprint The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease
    Sofie M Adriaanse
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 41:1190-8. 2014
    ..The present multimodal neuroimaging study examined whether amyloid pathology and glucose metabolism are related to cortical volume loss over time in Alzheimer's disease (AD) patients and healthy elderly controls...
  11. ncbi request reprint Amyloid and its association with default network integrity in Alzheimer's disease
    Sofie M Adriaanse
    Department of Nuclear Medicine and PET Research, Alzheimer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 35:779-91. 2014
    ..Longitudinal studies are needed to examine if amyloid depositions precede aberrant functional connectivity in the DMN. Hum Brain Mapp 35:779-791, 2014. © 2012 Wiley Periodicals, Inc. ..