J M Middeldorp

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Noninvasive diagnosis of nasopharyngeal carcinoma: nasopharyngeal brushings reveal high Epstein-Barr virus DNA load and carcinoma-specific viral BARF1 mRNA
    Servi J C Stevens
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands, and Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Int J Cancer 119:608-14. 2006
  2. doi request reprint Evaluation of commercial EBV RecombLine assay for diagnosis of nasopharyngeal carcinoma
    Dewi K Paramita
    Department of Histology and Cell Biology, Gadjah Mada University, Yogyakarta, Indonesia
    J Clin Virol 42:343-52. 2008
  3. pmc Variable EBV DNA load distributions and heterogeneous EBV mRNA expression patterns in the circulation of solid organ versus stem cell transplant recipients
    A E Greijer
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Dev Immunol 2012:543085. 2012
  4. pmc Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation
    Marlinda Adham
    Department of Otorhinolaryngology, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Chin J Cancer 31:185-96. 2012
  5. pmc EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomas
    Abdelmajid Khabir
    Laboratoire d anatomie et de cytologie pathologiques, hôpital universitaire Habib Bourguiba, 3029 Sfax, Tunisia
    Virol J 2:39. 2005
  6. pmc Can an online clinical data management service help in improving data collection and data quality in a developing country setting?
    Maarten A Wildeman
    Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Trials 12:190. 2011
  7. pmc Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population
    Susanna H Hutajulu
    Faculty of Medicine Dr Sardjito Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia
    Mol Cancer 10:48. 2011
  8. pmc Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study
    Amolo S Asito
    SUNY Upstate Medical University, Syracuse, NY, USA
    Infect Agent Cancer 5:13. 2010
  9. pmc Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30
    Colleen Pelser
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Infect Agent Cancer 5:18. 2010
  10. pmc Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9
    Cecile Keryer-Bibens
    UMR 8126 CNRS Institut Gustave Roussy, Villejuif, France
    BMC Cancer 6:283. 2006

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Noninvasive diagnosis of nasopharyngeal carcinoma: nasopharyngeal brushings reveal high Epstein-Barr virus DNA load and carcinoma-specific viral BARF1 mRNA
    Servi J C Stevens
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands, and Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Int J Cancer 119:608-14. 2006
    ..This procedure may be useful for confirmatory diagnosis in large serological NPC screening programs and has potential as prognostic tool...
  2. doi request reprint Evaluation of commercial EBV RecombLine assay for diagnosis of nasopharyngeal carcinoma
    Dewi K Paramita
    Department of Histology and Cell Biology, Gadjah Mada University, Yogyakarta, Indonesia
    J Clin Virol 42:343-52. 2008
    ..Specific reactivity patterns to these proteins have been described for infectious mononucleosis (IM), nasopharyngeal carcinoma (NPC), various types of lymphoma, and healthy EBV carriers...
  3. pmc Variable EBV DNA load distributions and heterogeneous EBV mRNA expression patterns in the circulation of solid organ versus stem cell transplant recipients
    A E Greijer
    Department of Pathology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Dev Immunol 2012:543085. 2012
    ..In SOT, expression of BARTs was detected in all leukocyte samples. LMP2 and EBNA1 mRNA was found in 5/15 and 2/15, respectively, but LMP1 mRNA in only 1, coinciding with severe PTLD and high EBV DNA...
  4. pmc Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation
    Marlinda Adham
    Department of Otorhinolaryngology, Faculty of Medicine, University of Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia
    Chin J Cancer 31:185-96. 2012
    ..Increased medical awareness of prevailing early stage signs and symptoms coupled to use of EBV-related diagnostic tumor markers may lead to down-staging and timely treatment to improve survival of patients with this aggressive disease...
  5. pmc EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomas
    Abdelmajid Khabir
    Laboratoire d anatomie et de cytologie pathologiques, hôpital universitaire Habib Bourguiba, 3029 Sfax, Tunisia
    Virol J 2:39. 2005
    ..We and others have previously shown that the juvenile form of NPC has distinct biological characteristics including a low amount of p53 and Bcl2 in the tumor tissue and a low level of anti-EBV IgG and IgA in the peripheral blood...
  6. pmc Can an online clinical data management service help in improving data collection and data quality in a developing country setting?
    Maarten A Wildeman
    Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Trials 12:190. 2011
    ..This study assesses whether the introduction of a clinical trial data management service (CTDMS) composed of electronic case report forms (eCRF) can result in effective data collection and treatment monitoring...
  7. pmc Epigenetic markers for early detection of nasopharyngeal carcinoma in a high risk population
    Susanna H Hutajulu
    Faculty of Medicine Dr Sardjito Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia
    Mol Cancer 10:48. 2011
    ..This study determined methylation status of multiple TSGs and evaluated whether it may improve early detection...
  8. pmc Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study
    Amolo S Asito
    SUNY Upstate Medical University, Syracuse, NY, USA
    Infect Agent Cancer 5:13. 2010
    ..abstract:..
  9. pmc Risk of classical Kaposi sarcoma by plasma levels of Epstein-Barr virus antibodies, sCD26, sCD23 and sCD30
    Colleen Pelser
    Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Infect Agent Cancer 5:18. 2010
    ..To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV)...
  10. pmc Exosomes released by EBV-infected nasopharyngeal carcinoma cells convey the viral latent membrane protein 1 and the immunomodulatory protein galectin 9
    Cecile Keryer-Bibens
    UMR 8126 CNRS Institut Gustave Roussy, Villejuif, France
    BMC Cancer 6:283. 2006
    ..Although this report suggested that NPC cells could also produce exosomes carrying immunosuppressive proteins, this hypothesis has remained so far untested...
  11. ncbi request reprint Molecular diagnosis of viral infections in renal transplant recipients
    Jaap M Middeldorp
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Curr Opin Nephrol Hypertens 11:665-72. 2002
    ..To discuss biological and methodological aspects of virus infection monitoring in the renal transplant setting...
  12. doi request reprint Multiple roles of LMP1 in Epstein-Barr virus induced immune escape
    J M Middeldorp
    VU University Medical Center, Department of Pathology and Cancer Center Amsterdam, The Netherlands
    Semin Cancer Biol 18:388-96. 2008
    ..Herein we discuss current knowledge regarding the role of LMP1 in immune evasion of EBV and how this strategy for establishment of persistence contributes to immune escape of EBV+ tumors...
  13. ncbi request reprint Pathogenic roles for Epstein-Barr virus (EBV) gene products in EBV-associated proliferative disorders
    Jaap M Middeldorp
    Department of Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Crit Rev Oncol Hematol 45:1-36. 2003
    ..EBV gene expression patterns and possible pathogenic mechanisms are discussed. In addition, expression of the cellular genes upregulated by EBV in vitro is discussed, and a comparison with the in vivo situation is made...
  14. pmc Conserved mutation of Epstein-Barr virus-encoded BamHI-A Rightward Frame-1 (BARF1) gene in Indonesian nasopharyngeal carcinoma
    Susanna H Hutajulu
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Infect Agent Cancer 5:16. 2010
    ....
  15. ncbi request reprint Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases
    P Meij
    Department of Pathology, Academic Hospital, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    J Infect Dis 179:1108-15. 1999
    ..From this study, it can be concluded that LMP1 is a protein with a very low immunogenicity for the humoral immune response in humans...
  16. ncbi request reprint Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients
    S J Stevens
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Blood 97:1165-71. 2001
    ..Furthermore, it is shown that EBV and CMV can reactivate independently in LTx recipients and that EBV DNA load monitoring may be useful in discriminating PTLD from rejection...
  17. ncbi request reprint Direct immunosuppressive effects of EBV-encoded latent membrane protein 1
    D F Dukers
    Department of Pathology, Academic Hospital, Vrije Universiteit, Amsterdam, The Netherlands
    J Immunol 165:663-70. 2000
    ..Moreover, we demonstrate, for the first time, that transmembrane protein-mediated immunosuppression is not solely restricted to RNA tumor viruses, but can also be found in DNA tumor viruses...
  18. ncbi request reprint Expression dynamics of human cytomegalovirus immune evasion genes US3, US6, and US11 in the blood of lung transplant recipients
    A E Greijer
    Department of Pathology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Infect Dis 184:247-55. 2001
    ..Interestingly, immune evasion RNA remained detectable after clinical recovery, often independently of IE1 RNA expression, indicating persistent viral activity, which may have implications for long-term control of HCMV...
  19. pmc Purified hexameric Epstein-Barr virus-encoded BARF1 protein for measuring anti-BARF1 antibody responses in nasopharyngeal carcinoma patients
    E K Hoebe
    VU University Medical Center, Department of Pathology, Amsterdam, Netherlands
    Clin Vaccine Immunol 18:298-304. 2011
    ..The presence of antibodies against native BARF1 in the blood of NPC patients provides evidence that the protein is expressed and secreted as a hexameric protein in NPC patients...
  20. pmc Dried-blood sampling for epstein-barr virus immunoglobulin G (IgG) and IgA serology in nasopharyngeal carcinoma screening
    J Fachiroh
    Department of Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Microbiol 46:1374-80. 2008
    ..3 filter paper is a more economical yet diagnostically comparable alternative to S&S no. 903 filter paper. Finger prick DB sampling is proposed for NPC diagnosis, particularly for remote hospitals and field screening studies...
  21. ncbi request reprint Bioreactor-scale production and one-step purification of Epstein-Barr nuclear antigen 1 expressed in baculovirus-infected insect cells
    P Meij
    Department of Pathology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Protein Expr Purif 20:324-33. 2000
    ..A >200-fold specific enrichment was reached and yields of bEBNA1 with an estimated purity of >95%...
  22. pmc Toward standardization of Epstein-Barr virus DNA load monitoring: unfractionated whole blood as preferred clinical specimen
    S J Stevens
    Department of Pathology, University Hospital Vrije Universiteit, 1081 HV Amsterdam, The Netherlands
    J Clin Microbiol 39:1211-6. 2001
    ..Unfractionated whole blood is strongly preferred since it combines all blood compartments that may harbor EBV and it best reflects the absolute viral burden in the patient's circulation...
  23. ncbi request reprint Production monitoring and purification of EBV encoded latent membrane protein 1 expressed and secreted by recombinant baculovirus infected insect cells
    P Meij
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Virol Methods 90:193-204. 2000
    ..Although the overall yields (20 microg purified LMP1 from 100 ml culture supernatant) and protein concentrations were low, higher concentrations of >95% purified BLMP1 could be reached after freeze drying...
  24. pmc Diagnostic value of measuring Epstein-Barr virus (EBV) DNA load and carcinoma-specific viral mRNA in relation to anti-EBV immunoglobulin A (IgA) and IgG antibody levels in blood of nasopharyngeal carcinoma patients from Indonesia
    Servi J C Stevens
    Department of Pathology, Vrije Universiteit Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Microbiol 43:3066-73. 2005
    ..The circulating EBV DNA load is independent of serological parameters and does not reflect intact tumor cells. The primary diagnostic value of the EBV DNA load for the detection of NPC is limited...
  25. ncbi request reprint All infiltrating T-lymphocytes in Hodgkin's disease express immunohistochemically detectable T-cell receptor zeta-chains in situ
    D F Dukers
    Department of Pathology, Academic Hospital, Vrije Universiteit Amsterdam, The Netherlands
    Histopathology 36:544-50. 2000
    ....
  26. pmc Comparison of quantitative competitive PCR with LightCycler-based PCR for measuring Epstein-Barr virus DNA load in clinical specimens
    Servi J C Stevens
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Microbiol 40:3986-92. 2002
    ..To avoid false negativity or underestimation of viral load, future internal calibration of the LightCycler is recommended. This would also enhance EBV load assay standardization and interinstitute comparisons...
  27. ncbi request reprint High Epstein-Barr virus (EBV) DNA loads in HIV-infected patients: correlation with antiretroviral therapy and quantitative EBV serology
    Servi J C Stevens
    Department of Pathology, University Hospital Vrije Universiteit, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    AIDS 16:993-1001. 2002
    ....
  28. pmc Activity of the EBNA1 promoter associated with lytic replication (Fp) in Epstein-Barr virus associated disorders
    A A Brink
    Department of Pathology, University Hospital Vrije Universiteit, HV Amsterdam, The Netherlands
    Mol Pathol 54:98-102. 2001
    ..CONCLUSIONS: These results confirm the previously proposed "housekeeping" function of the Qp promoter...
  29. ncbi request reprint Morphological evidence of an activated cytotoxic T-cell infiltrate in EBV-positive gastric carcinoma preventing lymph node metastases
    Josine van Beek
    Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Am J Surg Pathol 30:59-65. 2006
    ..018). At present, the antigenic target has to be determined. These data support the notion that local triggering of cellular immune responses in EBV-positive GC prevents lymph node metastasis formation...
  30. ncbi request reprint Epstein-Barr virus (EBV) serology for predicting distant metastases in a white juvenile patient with nasopharyngeal carcinoma and no clinical response to EBV lytic induction therapy
    Servi J C Stevens
    Department of Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Head Neck 28:1040-5. 2006
    ..This resulted in the first detectable EBV DNA levels in the blood but did not result in clinical response...
  31. ncbi request reprint Role of Epstein-Barr virus DNA load monitoring in prevention and early detection of post-transplant lymphoproliferative disease
    Servi J C Stevens
    Department of Pathology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Leuk Lymphoma 43:831-40. 2002
    ..Finally, a standardization of methodology, clinical specimen type, and cut-off values is proposed. This is essential for comparisons between different institutes and more adequate patient management...
  32. ncbi request reprint Aberrant Epstein-Barr virus persistence in HIV carriers is characterized by anti-Epstein-Barr virus IgA and high cellular viral loads with restricted transcription
    Servi J C Stevens
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    AIDS 21:2141-9. 2007
    ..We aimed to characterize the nature of this EBV DNA and to determine the transcriptional phenotype of EBV in blood, in relation to serological parameters...
  33. pmc Functional delivery of viral miRNAs via exosomes
    D Michiel Pegtel
    Department of Pathology, Cancer Center Amsterdam, Vrije Universiteit University Medical Center, 1081HV Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 107:6328-33. 2010
    ..Taken together our findings are consistent with miRNA-mediated gene silencing as a potential mechanism of intercellular communication between cells of the immune system that may be exploited by the persistent human gamma-herpesvirus EBV...
  34. ncbi request reprint High numbers of granzyme B/CD8-positive tumour-infiltrating lymphocytes in nasopharyngeal carcinoma biopsies predict rapid fatal outcome in patients treated with curative intent
    Joost J Oudejans
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Pathol 198:468-75. 2002
    ..It is concluded that the presence of many granzyme B-positive TILs in a selected group of Indonesian NPC patients is a strong and stage-independent marker for a rapid fatal clinical outcome...
  35. pmc Single-assay combination of Epstein-Barr Virus (EBV) EBNA1- and viral capsid antigen-p18-derived synthetic peptides for measuring anti-EBV immunoglobulin G (IgG) and IgA antibody levels in sera from nasopharyngeal carcinoma patients: options for field scr
    J Fachiroh
    Dept Pathology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    J Clin Microbiol 44:1459-67. 2006
    ..2%, respectively, in the Indonesian NPC samples. The use of these combined methods for seroepidemiological screening studies is proposed...
  36. pmc Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation
    E K Hoebe
    VU University Medical Center, Department of Pathology, Amsterdam, The Netherlands
    J Virol 86:11322-32. 2012
    ..The early kinetics of BARF1 upon transactivation by R confirm its status as an early gene and emphasize the necessity of early immune modulation during lytic reactivation...
  37. ncbi request reprint Functional CD4(+) and CD8(+) T-cell responses induced by autologous mitomycin C treated Epstein-Barr virus transformed lymphoblastoid cell lines
    P Meij
    Department of Pathology, University Hospital Vrije Universiteit, 1007 MB Amsterdam, The Netherlands
    Cell Immunol 208:25-33. 2001
    ..Thus, ex vivo T-cell activation with cryopreserved McLCL results in activation of both CD4(+) and CD8(+) T-cells producing a Th1-like cytokine profile, making this a suitable protocol for adoptive therapy of PTLD...
  38. ncbi request reprint In vivo transcription of the Epstein-Barr virus (EBV) BamHI-A region without associated in vivo BARF0 protein expression in multiple EBV-associated disorders
    Josine van Beek
    Department of Pathology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Gen Virol 84:2647-59. 2003
    ..It is concluded that the BARF0 protein is unlikely to play a role in vivo in EBV-positive malignancies...
  39. ncbi request reprint A rapid and reliable enzyme immunoassay PCR-based screening method to identify EBV-carrying gastric carcinomas
    Josine van Beek
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Mod Pathol 15:870-7. 2002
    ..Only these samples and those with poor DNA quality will require testing in the EBER1/2-RISH, thereby reducing the amount of laborious RISH assays with 85%...
  40. ncbi request reprint EBV-positive gastric adenocarcinomas: a distinct clinicopathologic entity with a low frequency of lymph node involvement
    Josine van Beek
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Oncol 22:664-70. 2004
    ..In the present study, we analyzed a large cohort of EBV-positive and EBV-negative gastric adenocarcinomas for their clinicopathologic features to determine whether they constitute a different clinical entity...
  41. ncbi request reprint Antibody responses to Epstein-Barr virus-encoded latent membrane protein-1 (LMP1) and expression of LMP1 in juvenile Hodgkin's disease
    Pauline Meij
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    J Med Virol 68:370-7. 2002
    ..Interestingly, all patients with the strongest antibody responses to LMP1 had EBV-negative tumors, suggesting immunological selection in vivo...
  42. ncbi request reprint Detection of late pp67-mRNA by NASBA in peripheral blood for the diagnosis of human cytomegalovirus disease in AIDS patients
    B S N Blank
    Department of Internal Medicine, National AIDS Therapy Evaluation Centre, Academic Medical Centre, University of Amsterdam, Bouwdeel T, Meibergdreef 9, 1100 DD, Amsterdam, The Netherlands
    J Clin Virol 25:29-38. 2002
    ..To evaluate the value of late-pp67-mRNA nucleic acid sequence-based amplification (NASBA) in comparison to DNA-PCR, blood culture and pp65-antigenemia assay for the detection of human cytomegalovirus (HCMV) disease in HIV-infected patients...
  43. ncbi request reprint Profiling of Epstein-Barr virus latent RNA expression in clinical specimens by gene-specific multiprimed cDNA synthesis and PCR
    Servi J C Stevens
    Department of Pathology, VU Medical Centre, Amsterdam, The Netherlands
    Methods Mol Biol 292:27-38. 2005
    ....
  44. ncbi request reprint Multiplex real-time NASBA for monitoring expression dynamics of human cytomegalovirus encoded IE1 and pp67 RNA
    Astrid E Greijer
    Organon Teknika, Boxtel, Amsterdam, The Netherlands
    J Clin Virol 24:57-66. 2002
    ..The monitoring for HCMV mRNA expression in whole blood provides an accurate and informative diagnostic approach...
  45. ncbi request reprint Quantitative detection of Epstein-Barr virus DNA in clinical specimens by rapid real-time PCR targeting a highly conserved region of EBNA-1
    Servi J C Stevens
    Department of Pathology, VU Medical Centre, Amsterdam, The Netherlands
    Methods Mol Biol 292:15-26. 2005
    ..The "closed-tube" system eliminates the risk of PCR contamination by product carryover and also the need for post-PCR detection...
  46. ncbi request reprint Identification and prevalence of CD8(+) T-cell responses directed against Epstein-Barr virus-encoded latent membrane protein 1 and latent membrane protein 2
    Pauline Meij
    Department of Pathology, VU Medical Center, Amsterdam, The Netherlands
    Int J Cancer 99:93-9. 2002
    ..These results demonstrate that CD8(+) memory T cell responses to LMP1 and especially to LMP2 do exist in Caucasians, albeit at low levels and could potentially be exploited for therapeutic use...
  47. pmc Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo
    Donna Hochberg
    Department of Pathology, Tufts University School of Medicine, Jaharis Building, 150 Harrison Avenue, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 101:239-44. 2004
    ..It suggests that BL may be a tumor of a latently infected memory B cell that is stuck proliferating because it is a tumor and, therefore, constitutively expressing only EBNA1...
  48. ncbi request reprint Treatment of posttransplant lymphoproliferative disease with rituximab: the remission, the relapse, and the complication
    Erik A M Verschuuren
    Dept of Internal Medicine, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Transplantation 73:100-4. 2002
    ..Thus far, no major complications have been described. We treated three lung transplant recipients with Rituximab because of PTLD...
  49. ncbi request reprint Role of sexual behavior in the acquisition of asymptomatic Epstein-Barr virus infection: a longitudinal study
    Ciaran B J Woodman
    Cancer Research UK Institute for Cancer Studies, University of Birmingham
    Pediatr Infect Dis J 24:498-502. 2005
    ..We report the prevalence and subsequent incidence of EBV infection in a cohort of sexually active young women and explore the social and sexual determinants of incident infections...
  50. ncbi request reprint Epstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controls
    Silvia de Sanjose
    Servei d Epidemiologia and Registre del Cancer, IDIBELL, Institut Catala d Oncologia, Gran Via Km 2 7, 08907 L Hospitalet, Barcelona, Spain
    Int J Cancer 121:1806-12. 2007
    ..Ab_EBV is a useful tool to explore EBV imbalances preceding or paralleling possible EBV associated oncogenic events...
  51. ncbi request reprint Native early antigen of Epstein-Barr virus, a promising antigen for diagnosis of nasopharyngeal carcinoma
    Dewi K Paramita
    Department of Histology and Cell Biology, Faculty of Medicine Gadjah Mada University, Yogyakarta, Indonesia
    J Med Virol 79:1710-21. 2007
    ..The use of a defined native EBV EA-specific antigen opens the way to further improve serological diagnosis of NPC...
  52. ncbi request reprint Molecular diversity of Epstein-Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects
    Jajah Fachiroh
    Gadjah Mada University, Yogyakarta, Indonesia
    J Infect Dis 190:53-62. 2004
    ..Our results reveal dissimilarity between EBV polypeptides recognized by IgG and IgA antibodies, which suggests independent B cell triggering events...
  53. pmc Molecular evidence for rhesus lymphocryptovirus infection of epithelial cells in immunosuppressed rhesus macaques
    Jeffery L Kutok
    Department of Pathology, BrighamWomen s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 78:3455-61. 2004
    ..These studies demonstrate that the rhesus LCV has tropism for epithelial cells, in addition to B cells, and is a relevant animal model system for studying the role of epithelial cell infection in EBV pathogenesis...
  54. doi request reprint Monitoring of EBV reactivation is justified in patients with aplastic anemia treated with rabbit ATG as a second course of immunosuppression
    Marielle J Wondergem
    Blood 111:1739; author reply 1739-40. 2008
  55. ncbi request reprint Cytomegalovirus (CMV) inactivation in breast milk: reassessment of pasteurization and freeze-thawing
    Klaus Hamprecht
    Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital of Tubingen, Elfriede Aulhorn Strasse 6, 72076 Tubingen, Germany
    Pediatr Res 56:529-35. 2004
    ..Further studies are necessary to evaluate short-term heat treatment below 72 degrees Celsius as an effective tool for prevention of CMV transmission...
  56. ncbi request reprint EBV-positive cutaneous B-cell lymphoproliferative disease after imatinib mesylate
    Marcel W Bekkenk
    Blood 102:4243. 2003
  57. ncbi request reprint Generation of an adenoviral vector containing an addition of a heterologous ligand to the serotype 3 fiber knob
    Taco G Uil
    Department of Medicine, Division of Human Gene Therapy, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Cancer Gene Ther 10:121-4. 2003
    ..The heterologous tag proved to be accessible for binding in the context of the virion and, moreover, had rendered the modified vector capable of mediating gene transfer through an artificial, non-Ad3 receptor...
  58. pmc The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function
    Jianmin Zuo
    Division of Cancer Studies, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Virol 82:2385-93. 2008
    ..These data provide further evidence that EBV has multiple mechanisms to modulate HLA class I-restricted T-cell responses, thus enabling the virus to replicate and persist in the immune-competent host...