Reina E Mebius

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Development and function of the splenic marginal zone
    Reina E Mebius
    VU Medical Center, Department of Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
    Crit Rev Immunol 24:449-64. 2004
  2. ncbi request reprint Structure and function of the spleen
    Reina E Mebius
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Nat Rev Immunol 5:606-16. 2005
  3. ncbi request reprint Blockade of IDO inhibits nasal tolerance induction
    Arnold P J van der Marel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 179:894-900. 2007
  4. ncbi request reprint Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis
    Trieneke C G Timmer
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Arthritis Rheum 56:2492-502. 2007
  5. doi request reprint Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner
    Mark F R Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Leukoc Biol 84:152-61. 2008
  6. pmc A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp
    Martijn A Nolte
    Department of Molecular Cell Biology, VUMC, Amsterdam, Netherlands
    J Exp Med 198:505-12. 2003
  7. pmc Mesenchymal stem cells are mobilized from the bone marrow during inflammation
    Jasper J Koning
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Netherlands
    Front Immunol 4:49. 2013
  8. pmc Colonic patch and colonic SILT development are independent and differentially regulated events
    A P Baptista
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mucosal Immunol 6:511-21. 2013
  9. doi request reprint Lymphoid organs for peritoneal cavity immune response: milky spots
    Reina E Mebius
    Department of Molecular Cell Biology and Immunology, VUMC, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Immunity 30:670-2. 2009
  10. pmc Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
    Serge A van de Pavert
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 10:1193-9. 2009

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Development and function of the splenic marginal zone
    Reina E Mebius
    VU Medical Center, Department of Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
    Crit Rev Immunol 24:449-64. 2004
    ..The developmental pathways that lead to the formation of the marginal zone are described, and the function of the marginal zone is discussed in relation to the function of the spleen as the major blood-filtering organ of the body...
  2. ncbi request reprint Structure and function of the spleen
    Reina E Mebius
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, v d Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Nat Rev Immunol 5:606-16. 2005
    ..A better understanding of the function of this complex organ has been gained from recent studies, as outlined in this Review article...
  3. ncbi request reprint Blockade of IDO inhibits nasal tolerance induction
    Arnold P J van der Marel
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Immunol 179:894-900. 2007
    ....
  4. ncbi request reprint Inflammation and ectopic lymphoid structures in rheumatoid arthritis synovial tissues dissected by genomics technology: identification of the interleukin-7 signaling pathway in tissues with lymphoid neogenesis
    Trieneke C G Timmer
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Arthritis Rheum 56:2492-502. 2007
    ..To gain more insight into this specific disease process, we sought to identify the genes expressed in RA tissues with ectopic lymphoid structures...
  5. doi request reprint Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner
    Mark F R Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Leukoc Biol 84:152-61. 2008
    ..The postnatal development of the splenic white pulp, involving the influx of T cells, depends on LTalpha1beta2 expressed by B cells...
  6. pmc A conduit system distributes chemokines and small blood-borne molecules through the splenic white pulp
    Martijn A Nolte
    Department of Molecular Cell Biology, VUMC, Amsterdam, Netherlands
    J Exp Med 198:505-12. 2003
    ..Therefore, the conduit plays a role in distribution of both blood-borne and locally produced molecules and provides a framework for directing lymphocyte migration and organization of the splenic white pulp...
  7. pmc Mesenchymal stem cells are mobilized from the bone marrow during inflammation
    Jasper J Koning
    Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Netherlands
    Front Immunol 4:49. 2013
    ..These data provide a mechanism by which MSCs can be mobilized from the bone marrow in order to contribute to tissue repair at a distant location...
  8. pmc Colonic patch and colonic SILT development are independent and differentially regulated events
    A P Baptista
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Mucosal Immunol 6:511-21. 2013
    ..In conclusion, our data demonstrate that different mechanisms, mediated mainly by programmed stimuli, induce the formation of distinct colonic lymphoid tissues, therefore suggesting that these tissues may have different functions...
  9. doi request reprint Lymphoid organs for peritoneal cavity immune response: milky spots
    Reina E Mebius
    Department of Molecular Cell Biology and Immunology, VUMC, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Immunity 30:670-2. 2009
    ..In this issue of Immunity, Rangel-Moreno et al. (2009) provide compelling data to consider them as unique secondary lymphoid organs...
  10. pmc Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
    Serge A van de Pavert
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 10:1193-9. 2009
    ..Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons...
  11. pmc LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 182:5439-45. 2009
    ..Furthermore, the same signals may regulate lymphangiogenesis to the lymph node through induction of VEGF-C...
  12. ncbi request reprint Secretory leukoprotease inhibitor in mucosal lymph node dendritic cells regulates the threshold for mucosal tolerance
    Janneke N Samsom
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 179:6588-95. 2007
    ..As such, it regulates the quality of the ensuing Ag-specific immune response in the mucosa draining LN...
  13. doi request reprint Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase
    Rogier M Reijmers
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 184:3656-64. 2010
    ....
  14. pmc Lymph sacs are not required for the initiation of lymph node formation
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Development 136:29-34. 2009
    ..5 Prox1 conditional mutant embryos, which have defective lymph sacs. However, subsequent clustering of hematopoietic cells within these developing lymph nodes is less efficient...
  15. doi request reprint Lymph node stromal cells support dendritic cell-induced gut-homing of T cells
    Rosalie Molenaar
    Department of Molecular Cell Biology and Immunology, VU Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    J Immunol 183:6395-402. 2009
    ..Therefore, cooperation of sessile lymph node stromal cells with mobile dendritic cells warrants the imprinting of tissue specific homing receptors on activated T cells...
  16. ncbi request reprint Fc gamma RIIB regulates nasal and oral tolerance: a role for dendritic cells
    Janneke N Samsom
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Faculteit der Geneeskunde, MB Amsterdam, The Netherlands
    J Immunol 174:5279-87. 2005
    ....
  17. ncbi request reprint Initiation of cellular organization in lymph nodes is regulated by non-B cell-derived signals and is not dependent on CXC chemokine ligand 13
    Tom Cupedo
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Immunol 173:4889-96. 2004
    ....
  18. doi request reprint A crucial role for retinoic acid in the development of Notch-dependent murine splenic CD8- CD4- and CD4+ dendritic cells
    Marieke R Beijer
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 43:1608-16. 2013
    ..These data demonstrate that vitamin A stimulates the development of Notch-dependent splenic DCs and indicate that inefficient generation of DCs may contribute to the immune deficits observed during vitamin A deficiency. ..
  19. ncbi request reprint B cells are crucial for both development and maintenance of the splenic marginal zone
    Martijn A Nolte
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Academic Medical Center, Amsterdam, The Netherlands
    J Immunol 172:3620-7. 2004
    ..This direct correlation between circulating B cells and the function of the spleen implies an increased risk for B cell lymphopenic patients with bacterial infections...
  20. ncbi request reprint Induction of secondary and tertiary lymphoid structures in the skin
    Tom Cupedo
    Department of Molecular Cell Biology and Immunology, VU Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Immunity 21:655-67. 2004
    ....
  21. doi request reprint The conduit system of the lymph node
    Ramon Roozendaal
    Department of Molecular Cell Biology and Immunology, Vrije University VU Medical Center, PO Box 7057, 1007MB Amsterdam, The Netherlands
    Int Immunol 20:1483-7. 2008
    ..The conduit system is also important for fluid distribution between afferent lymphatics and blood, but the mechanisms are not yet established...
  22. ncbi request reprint Organogenesis of lymphoid tissues
    Reina E Mebius
    Department of Molecular Cell Biology, VU University Medical Center, v d Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Nat Rev Immunol 3:292-303. 2003
    ....
  23. doi request reprint Stromal cell-immune cell interactions
    Ramon Roozendaal
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Annu Rev Immunol 29:23-43. 2011
    ..The cells that form these microenvironments are collectively called stromal cells. Here, we focus on the stromal cells present within secondary lymphoid organs and discuss their importance for various aspects of the immune system...
  24. ncbi request reprint Effects of fluorescent and nonfluorescent tracing methods on lymphocyte migration in vivo
    Martijn A Nolte
    Department of Molecular Cell Biology, VU Medical Center, Amsterdam, The Netherlands
    Cytometry A 61:35-44. 2004
    ..The use of fluorescent dyes to monitor in vivo cellular migration and proliferation has greatly expanded, but little is known about their potential influence on cell migration...
  25. ncbi request reprint Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
    Serge A van de Pavert
    1 Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands 2 Hubrecht Institute KNAW Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT Utrecht, Netherlands 3
    Nature 508:123-7. 2014
    ..Our results reveal a molecular link between maternal nutrients and the formation of immune structures required for resistance to infection in the offspring. ..
  26. doi request reprint Interdependence of stromal and immune cells for lymph node function
    Jasper J Koning
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Trends Immunol 33:264-70. 2012
    ..We propose that during immune reactions, the interactions of stromal and immune cells are similarly important for controlling the expanding lymphocyte pool...
  27. ncbi request reprint Lymphoid organogenesis in brief
    Mark F R Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Immunol 37:S46-52. 2007
    ..Future research will identify additional molecules and cells required for the formation of the various lymphoid organs, because the picture is not complete yet...
  28. ncbi request reprint Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype
    Rogier M Thurlings
    Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Arthritis Rheum 58:1582-9. 2008
    ..To investigate the relationship between lymphoid neogenesis in the synovium of patients with rheumatoid arthritis (RA) and characteristics of inflammation and disease severity...
  29. ncbi request reprint Role of chemokines in the development of secondary and tertiary lymphoid tissues
    Tom Cupedo
    VU Medical Center, Department of Molecular Cell Biology, Van der Boechorststraat 7, Amsterdam, BT 1081, The Netherlands
    Semin Immunol 15:243-8. 2003
    ..During adult life, similar processes might also be at the basis of development of organized tertiary lymphoid structures often seen in inflammatory lesions...
  30. doi request reprint Retinoic acid induces blood-brain barrier development
    Mark R Mizee
    Blood Brain Barrier Research Group, Department of Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Neurosci 33:1660-71. 2013
    ..Together, our results point to an important role for RA in the induction of the BBB during human and mouse development...
  31. ncbi request reprint Presumptive lymph node organizers are differentially represented in developing mesenteric and peripheral nodes
    Tom Cupedo
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands
    J Immunol 173:2968-75. 2004
    ..These findings provide a possible explanation for the well-known differences in developmental requirements for nodes at peripheral or mesenteric locations...
  32. ncbi request reprint Cellular interactions in lymph node development
    Tom Cupedo
    Department of Cell Biology and Histology, Academic Medical Center of the University of Amsterdam, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    J Immunol 174:21-5. 2005
    ..This review will focus on these cellular interactions between organizing and inducing cell populations leading to the formation of lymph nodes or organized inflammatory infiltrates...
  33. ncbi request reprint The importance of regional lymph nodes for mucosal tolerance
    Georg Kraal
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Immunol Rev 213:119-30. 2006
    ..Here, we discuss the way regional lymph nodes contribute to the direction of immune responses and what is known about the local factors and cell behavior that form the basis for these differences...
  34. ncbi request reprint The role of CD45+CD4+CD3- cells in lymphoid organ development
    Tom Cupedo
    VU Medical Center, Department of Molecular Cell Biology, Amsterdam, The Netherlands
    Immunol Rev 189:41-50. 2002
    ..Here we will focus on CD45+CD4+CD3- cells that are the early colonizing cells in lymph nodes and Peyer's patches and develop a hypothetical model of their contribution to the creation of organized lymphoid structures...
  35. doi request reprint Expression of retinaldehyde dehydrogenase enzymes in mucosal dendritic cells and gut-draining lymph node stromal cells is controlled by dietary vitamin A
    Rosalie Molenaar
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Immunol 186:1934-42. 2011
    ..Our results show that RA-dependent signaling within the intestine is indispensable for RALDH activity in the draining MLN...
  36. pmc The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors
    Martijn A Nolte
    Department of Molecular Cell Biology, VU University Medical Centre, Amsterdam, The Netherlands
    Immunology 106:299-307. 2002
    ....
  37. ncbi request reprint Innate lymphoid cells--a proposal for uniform nomenclature
    Hergen Spits
    Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Nat Rev Immunol 13:145-9. 2013
    ..Here, we propose that ILCs should be categorized into three groups based on the cytokines that they can produce and the transcription factors that regulate their development and function...
  38. doi request reprint New insights into the development of lymphoid tissues
    Serge A van de Pavert
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Nat Rev Immunol 10:664-74. 2010
    ..In addition, we discuss the differing requirements for the postnatal formation of mucosa-associated lymphoid tissues and tertiary lymphoid structures that develop at sites of chronic inflammation...
  39. pmc Stromal cells of the mouse spleen
    Joke M den Haan
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands
    Front Immunol 3:201. 2012
    ..In this review, the features of stromal cells of both white and red pulp will be described in light of the function of the spleen...
  40. ncbi request reprint Expression of the murine CD27 ligand CD70 in vitro and in vivo
    Kiki Tesselaar
    Laboratory for Experimental Immunology, Academic Medical Center, Leiden, The Netherlands
    J Immunol 170:33-40. 2003
    ..Thus, expression of CD70 in the mouse is highly regulated at the transcriptional and posttranslational level. This most likely serves to limit excessive effector cell formation after antigenic stimulation...
  41. pmc Arginine deficiency affects early B cell maturation and lymphoid organ development in transgenic mice
    Wouter J de Jonge
    Department of Anatomy and Embryology, University of Amsterdam, The Netherlands
    J Clin Invest 110:1539-48. 2002
    ..We conclude that arginine deficiency impairs early B cell maturation...
  42. ncbi request reprint Vitamins in control of lymphocyte migration
    Reina E Mebius
    Nat Immunol 8:229-30. 2007