P Lips

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Vitamin D physiology
    P Lips
    Department of Endocrinology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, Netherlands
    Prog Biophys Mol Biol 92:4-8. 2006
  2. pmc Multifactorial evaluation and treatment of persons with a high risk of recurrent falling was not cost-effective
    G M E E Peeters
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 22:2187-96. 2011
  3. pmc Sunlight exposure or vitamin D supplementation for vitamin D-deficient non-western immigrants: a randomized clinical trial
    I S Wicherts
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 22:873-82. 2011
  4. pmc Bone pain and extremely low bone mineral density due to severe vitamin D deficiency in celiac disease
    Noortje M Rabelink
    Endocrine Section, Department of Internal Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Arch Osteoporos 6:209-13. 2011
  5. ncbi request reprint Interaction between vitamin D and calcium
    Paul Lips
    Department of Internal Medicine, Endocrine Section, VU University Medical Center, Amsterdam, The Netherlands
    Scand J Clin Lab Invest Suppl 243:60-4. 2012
  6. pmc Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence
    Janneke P van Wijngaarden
    Department of Human Nutrition, Wageningen University, P, O, Box 8129 6700 EV Wageningen, The Netherlands
    BMC Geriatr 11:80. 2011
  7. pmc Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents
    V Chel
    Verpleeghuis Marienhave, Warmond, The Netherlands
    Osteoporos Int 19:663-71. 2008
  8. pmc [Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study)
    Klaas A Hartholt
    Department of Internal Medicine Section Geriatric Medicine, Erasmus MC, University Medical Rotterdam, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Geriatr 11:48. 2011
  9. pmc Prevention of fall incidents in patients with a high risk of falling: design of a randomised controlled trial with an economic evaluation of the effect of multidisciplinary transmural care
    Geeske M E E Peeters
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    BMC Geriatr 7:15. 2007
  10. ncbi request reprint Relative value of 25(OH)D and 1,25(OH)2D measurements
    Paul Lips
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Bone Miner Res 22:1668-71. 2007

Detail Information

Publications158 found, 100 shown here

  1. ncbi request reprint Vitamin D physiology
    P Lips
    Department of Endocrinology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, Netherlands
    Prog Biophys Mol Biol 92:4-8. 2006
    ..Bone mineralization mainly depends on ambient calcium concentration. Vitamin D metabolites may play a role in the prevention of auto-immune disease and cancer...
  2. pmc Multifactorial evaluation and treatment of persons with a high risk of recurrent falling was not cost-effective
    G M E E Peeters
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 22:2187-96. 2011
    ..The intervention and usual care groups did not differ in fall risk or costs. The multifactorial approach was not cost-effective compared to usual care in this group...
  3. pmc Sunlight exposure or vitamin D supplementation for vitamin D-deficient non-western immigrants: a randomized clinical trial
    I S Wicherts
    EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 22:873-82. 2011
    ..Vitamin D supplementation was more effective than advised sunlight exposure in improving vitamin D status and lowering parathyroid hormone levels...
  4. pmc Bone pain and extremely low bone mineral density due to severe vitamin D deficiency in celiac disease
    Noortje M Rabelink
    Endocrine Section, Department of Internal Medicine, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
    Arch Osteoporos 6:209-13. 2011
    ..Furthermore, she was treated with high oral doses of vitamin D and a gluten-free diet. After a few weeks of treatment, her bone pain decreased, and her muscle strength improved...
  5. ncbi request reprint Interaction between vitamin D and calcium
    Paul Lips
    Department of Internal Medicine, Endocrine Section, VU University Medical Center, Amsterdam, The Netherlands
    Scand J Clin Lab Invest Suppl 243:60-4. 2012
    ..Trials in institutionalized persons had better results than in independently living elderly. These results confirm that an interaction exists between calcium and vitamin D...
  6. pmc Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence
    Janneke P van Wijngaarden
    Department of Human Nutrition, Wageningen University, P, O, Box 8129 6700 EV Wageningen, The Netherlands
    BMC Geriatr 11:80. 2011
    ....
  7. pmc Efficacy of different doses and time intervals of oral vitamin D supplementation with or without calcium in elderly nursing home residents
    V Chel
    Verpleeghuis Marienhave, Warmond, The Netherlands
    Osteoporos Int 19:663-71. 2008
    ..A daily dose was more effective than a weekly dose, and a monthly dose was the least effective...
  8. pmc [Cost] effectiveness of withdrawal of fall-risk increasing drugs versus conservative treatment in older fallers: design of a multicenter randomized controlled trial (IMPROveFALL-study)
    Klaas A Hartholt
    Department of Internal Medicine Section Geriatric Medicine, Erasmus MC, University Medical Rotterdam, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Geriatr 11:48. 2011
    ....
  9. pmc Prevention of fall incidents in patients with a high risk of falling: design of a randomised controlled trial with an economic evaluation of the effect of multidisciplinary transmural care
    Geeske M E E Peeters
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    BMC Geriatr 7:15. 2007
    ....
  10. ncbi request reprint Relative value of 25(OH)D and 1,25(OH)2D measurements
    Paul Lips
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Bone Miner Res 22:1668-71. 2007
  11. doi request reprint The effect of vitamin D on bone and osteoporosis
    Paul Lips
    Endocrine Section, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 25:585-91. 2011
    ..These subjects are discussed in detail in this review. Finally, the knowledge gaps and research agenda are discussed...
  12. ncbi request reprint Statins and bone turnover
    P Lips
    Department of Endocrinology, VU Medical Centre, Amsterdam, The Netherlands
    Eur J Clin Invest 32:543-4. 2002
  13. ncbi request reprint [Vitamin D deficiency in a multicultural setting]
    P Lips
    VU Medisch Centrum, Afd Endocrinologie, Postbus 7057, 1007 MB Amsterdam
    Ned Tijdschr Geneeskd 145:2060-2. 2001
    ..In a multicultural society such as in the Netherlands, advice regarding vitamin D (for example that provide by the Dutch Health Council) should take into account the above-mentioned risk factors...
  14. ncbi request reprint Vitamin D status and nutrition in Europe and Asia
    P Lips
    VU University Medical Center, Department of Endocrinology, P O Box 7057, 1007 MB Amsterdam, Netherlands
    J Steroid Biochem Mol Biol 103:620-5. 2007
    ..Risk groups are young children, the elderly, pregnant women and non-western immigrants in Europe. Important determinants are skin type, sex, clothing, nutrition, food fortification, supplement use, BMI and degree of urbanization...
  15. doi request reprint Reducing fracture risk with calcium and vitamin D
    Paul Lips
    Department of Endocrinology and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 73:277-85. 2010
    ....
  16. doi request reprint Worldwide status of vitamin D nutrition
    P Lips
    VU University Medical Center, Department of Internal Medicine, Section Endocrinology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Steroid Biochem Mol Biol 121:297-300. 2010
    ..In conclusion, vitamin D deficiency and insufficiency are globally still very common especially in risk groups such as young children, pregnant women, elderly and immigrants...
  17. ncbi request reprint Which circulating level of 25-hydroxyvitamin D is appropriate?
    Paul Lips
    Department of Endocrinology, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Steroid Biochem Mol Biol 89:611-4. 2004
    ..While a low calcium intake may aggravate Vitamin D deficiency, a high calcium intake may have a Vitamin D sparing effect. With current knowledge, a global estimate for the appropriate serum 25(OH)D is 50 nmol/l...
  18. doi request reprint Once-weekly dose of 8400 IU vitamin D(3) compared with placebo: effects on neuromuscular function and tolerability in older adults with vitamin D insufficiency
    Paul Lips
    Department of Endocrinology, Vrije Universiteit Medisch Centrum, Amsterdam, The Netherlands
    Am J Clin Nutr 91:985-91. 2010
    ..Vitamin D insufficiency, which is prevalent in older individuals, is associated with bone and muscle weakness and falls...
  19. ncbi request reprint Quality of life in patients with osteoporosis
    Paul Lips
    Department of Endocrinology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Osteoporos Int 16:447-55. 2005
    ..In conclusion, suitable instruments exist for measuring quality of life in patients with osteoporotic fractures. These instruments are useful for clinical trials and for assessment of the burden of disease...
  20. pmc Validation of the IOF quality of life questionnaire for patients with wrist fracture
    P Lips
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 21:61-70. 2010
    ..This questionnaire, including 12 questions, was validated in a multicentre study and compared with an osteoporosis-specific questionnaire (Qualeffo-41) and a generic questionnaire (EQ-5D)...
  21. ncbi request reprint Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons
    Natalia O Kuchuk
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 94:1244-50. 2009
    ..Serum 25-hydroxyvitamin D [25(OH)D] may influence serum PTH and other parameters of bone health up to a threshold concentration, which may be between 25 and 80 nmol/liter...
  22. ncbi request reprint Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications
    P Lips
    Department of Endocrinology, Institute for Endocrinology, Reproduction and Metabolism, EVM Institute, Vrije Universiteit Medical Center, 1007 MB Amsterdam, The Netherlands
    Endocr Rev 22:477-501. 2001
    ..Vitamin D3 is recommended in housebound elderly, and it may be cost-effective in hip fracture prevention in selected risk groups...
  23. ncbi request reprint Skeletal muscle mass and muscle strength in relation to lower-extremity performance in older men and women
    M Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Am Geriatr Soc 48:381-6. 2000
    ..We tested the hypothesis that persons with lower muscle mass or muscle strength have poorer lower-extremity performance (LEP)...
  24. doi request reprint Homocysteine and the methylenetetrahydrofolate reductase 677C-->T polymorphism in relation to muscle mass and strength, physical performance and postural sway
    K M A Swart
    Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 67:743-8. 2013
    ....
  25. ncbi request reprint A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the multiple outcomes of raloxifene evaluation clinical trial
    P Lips
    Department of Endocrinology, Academic Hospital Vrije Universiteit, 1007 M B Amsterdam, The Netherlands
    J Clin Endocrinol Metab 86:1212-21. 2001
    ..Treatment with vitamin D(3) and calcium increased serum 25OHD and decreased serum PTH significantly; the effect was greater for lower baseline serum 25OHD...
  26. ncbi request reprint Positive effect of alendronate on bone mineral density and markers of bone turnover in patients with rheumatoid arthritis on chronic treatment with low-dose prednisone: a randomized, double-blind, placebo-controlled trial
    W F Lems
    VU University Medical Centre, Department of Rheumatology, 4A 42, P O Box 7057, 1007 MB, and Slotervaart Hospital, Department of Rheumatology, Amsterdam, The Netherlands
    Osteoporos Int 17:716-23. 2006
    ....
  27. doi request reprint Does frailty predict increased risk of falls and fractures? A prospective population-based study
    O J de Vries
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 24:2397-403. 2013
    ..The predictive ability of frailty is not superior to falls history...
  28. ncbi request reprint Peak expiratory flow rate shows a gender-specific association with vitamin D deficiency
    N M van Schoor
    EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Clin Endocrinol Metab 97:2164-71. 2012
    ..To our knowledge, no previous studies examined the longitudinal relationship between vitamin D status and pulmonary function in a population-based sample of older persons...
  29. ncbi request reprint A risk profile for identifying community-dwelling elderly with a high risk of recurrent falling: results of a 3-year prospective study
    S M F Pluijm
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center VUmc, Amsterdam, The Netherlands
    Osteoporos Int 17:417-25. 2006
    ..The aim of the prospective study reported here was to develop a risk profile that can be used to identify community-dwelling elderly at a high risk of recurrent falling...
  30. doi request reprint Vitamin D status is associated with functional limitations and functional decline in older individuals
    E Sohl
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Clin Endocrinol Metab 98:E1483-90. 2013
    ..Vitamin D is known to influence muscle health. A reduction in muscle mass increases the risk of functional limitations among older individuals...
  31. ncbi request reprint Effects of the selective estrogen receptor modulator, raloxifene, on the somatotropic axis and insulin-glucose homeostasis
    A M Oleksik
    Department of Endocrinology, Academic Hospital Vrije Universiteit, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 86:2763-8. 2001
    ..The results of this small cross-sectional study need confirmation by longitudinal studies...
  32. doi request reprint Vitamin D status is associated with physical performance: the results of three independent cohorts
    E Sohl
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 24:187-96. 2013
    ..However, vitamin D status does not predict a decline in physical performance in individuals aged 55-65 years...
  33. ncbi request reprint Determinants of bone mineral density in older men and women: body composition as mediator
    S M Pluijm
    Institute for Research in Extramural Medicine, EMGO-lnstitute, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Bone Miner Res 16:2142-51. 2001
    ..It can be concluded that (1) FM and MM are strong independent determinants of total hip BMD and that (2) FM possibly plays a mediating role in the association of weight change, walking activity, and SHBG with total hip BMD in women...
  34. doi request reprint The relationship between cortisol, muscle mass and muscle strength in older persons and the role of genetic variations in the glucocorticoid receptor
    G M E E Peeters
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 69:673-82. 2008
    ..This study examines the relationship between cortisol, muscle mass and muscle strength in community-dwelling older persons and the role of genetic variations in the glucocorticoid receptor (GR)...
  35. doi request reprint Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons
    K M A Swart
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Nutr Health Aging 17:578-84. 2013
    ..The current study aimed to examine homocysteine in relation to different aspects of physical functioning...
  36. doi request reprint High long-term cortisol levels, measured in scalp hair, are associated with a history of cardiovascular disease
    L Manenschijn
    Department of Internal Medicine, Erasmus MC, Room Ee 542, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:2078-83. 2013
    ..Our aim was to study whether long-term cortisol levels, measured in scalp hair, are associated with cardiovascular diseases...
  37. ncbi request reprint Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons
    N M van Schoor
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 66:174-81. 2012
    ..The objective of this study was to examine whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance, both cross-sectionally and longitudinally...
  38. ncbi request reprint Additional weight bearing during exercise and estrogen in the rat: the effect on bone mass, turnover, and structure
    A M Tromp
    Department of Endocrinology, Vrije Universiteit Medical Center, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Calcif Tissue Int 79:404-15. 2006
    ..The effects of mechanical loading on the trabecular bone of the femoral head were not significant. This study suggests that the effect of mechanical loading in the rat-with-backpack model mainly occurs at cortical bone sites...
  39. ncbi request reprint The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women
    Natalia O Kuchuk
    Department of Endocrinology, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 67:295-303. 2007
    ..Our objective was to examine whether serum oestradiol (E2) and testosterone (T) are associated with quantitative ultrasound (QUS), bone mineral density (BMD), bone turnover markers and fracture incidence...
  40. pmc Is there a U-shaped association between physical activity and falling in older persons?
    G M E E Peeters
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 21:1189-95. 2010
    ..Among 1,337 community-dwelling older persons, no evidence for a nonlinear association was found. If all older persons increase their physical activity level with 100 units, 4% may be prevented to become recurrent fallers...
  41. ncbi request reprint Development of the Qualeffo-31, an osteoporosis-specific quality-of-life questionnaire
    N M van Schoor
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 17:543-51. 2006
    ..The objectives of this study were: (1) to develop a shorter version of the Qualeffo-41 by removing redundant questions; and (2) to investigate the scale characteristics, reliability, and validity of this shorter version...
  42. ncbi request reprint Serum fasting cortisol in relation to bone, and the role of genetic variations in the glucocorticoid receptor
    N M van Schoor
    EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 67:871-8. 2007
    ..To examine the relationship between endogenous cortisol and bone, and the role of genetic variations in the glucocorticoid receptor (GR)...
  43. ncbi request reprint Positron emission tomography for the detection of metastases of differentiated thyroid carcinoma
    P Lips
    Department of Endocrinology, Academic Hospital Vrije Universiteit, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Neth J Med 57:150-6. 2000
    ..To show the value of positron emission tomography (PET) with 18-F-fluorodeoxyglucose (18-FDG) for the detection of metastases of differentiated thyroid carcinoma in selected patients...
  44. ncbi request reprint A fifteen-year longitudinal study in young adults on the relation of physical activity and fitness with the development of the bone mass: The Amsterdam Growth And Health Longitudinal Study
    H C Kemper
    Institute for Research in Extramural Medicine EMGO, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Bone 27:847-53. 2000
    ..Only neuromotor fitness and not cardiopulmonary fitness during adolescence and young adulthood is related to the BMD of males and females at age 28 years...
  45. ncbi request reprint Static and dynamic measures of frailty predicted decline in performance-based and self-reported physical functioning
    M T E Puts
    LASA, Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam Amsterdam, The Netherlands
    J Clin Epidemiol 58:1188-98. 2005
    ..To determine the effect of frailty on decline in physical functioning and to examine if chronic diseases modify this effect...
  46. ncbi request reprint Functional limitations and poor physical performance as independent risk factors for self-reported fractures in older persons
    V S Stel
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 15:742-50. 2004
    ..This study examined whether three aspects of functioning (i.e., functional limitations, physical performance, and physical activity) were associated with fractures in older men and women...
  47. ncbi request reprint Impact of prevalent and incident vertebral fractures on utility: results from a patient-based and a population-based sample
    N M van Schoor
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Qual Life Res 17:159-67. 2008
    ..030). In conclusion, utility is lower among persons with prevalent and incident VFX, especially in a patient-based sample. Utility loss was not significantly different between women without and with incident VFX...
  48. ncbi request reprint Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, 1081 BT Amsterdam, The Netherlands
    J Clin Endocrinol Metab 88:5766-72. 2003
    ..05-5.28) based on muscle mass. The associations were similar in men and women. The results of this prospective, population-based study show that lower 25-OHD and higher PTH levels increase the risk of sarcopenia in older men and women...
  49. doi request reprint The impact of medication on vitamin D status in older individuals
    E Sohl
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Room A517, 1081 BT Amsterdam, The Netherlands
    Eur J Endocrinol 166:477-85. 2012
    ..The aim of this study was to (better) define the associations between the use of specific medicines and serum 25(OH)D...
  50. ncbi request reprint Effects of the selective oestrogen receptor modulator-raloxifene-on calcium and PTH secretory dynamics in women with osteoporosis
    A Oleksik
    Department of Endocrinology, Vrije Universiteit, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 54:575-82. 2001
    ..CONCLUSION: Raloxifene did not have any detectable effect on the PTH set-point. An effect on non-suppressible PTH secretion cannot be excluded...
  51. ncbi request reprint Vitamin D deficiency as a risk factor for osteoporotic fractures
    N M van Schoor
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Bone 42:260-6. 2008
    ..The relatively low cut point of serum 25(OH)D in our population is possibly caused by high calcium intake in the Netherlands...
  52. ncbi request reprint Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in older men and women
    M B Snijder
    Institute of Health Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    J Intern Med 261:558-65. 2007
    ..Effects of poor vitamin D status on blood pressure may be mediated by elevated parathyroid hormone (PTH) levels...
  53. ncbi request reprint Impact of vertebral deformities, osteoarthritis, and other chronic diseases on quality of life: a population-based study
    N M van Schoor
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Osteoporos Int 16:749-56. 2005
    ..After adjustment for age, sex, and other chronic diseases, severe osteoporosis of the vertebrae, cardiac disease, peripheral arterial disease, and diabetes mellitus significantly reduced quality of life in the general population...
  54. ncbi request reprint Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO). Working Party for Quality of Life of the European Foundation for Osteoporosis
    P Lips
    Department of Endocrinology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Osteoporos Int 10:150-60. 1999
    ..In conclusion, QUALEFFO is repeatable, coherent and discriminates well between patients with vertebral fractures and control subjects. The results of this study confirm the decreased quality of life in patients with vertebral fractures...
  55. ncbi request reprint The effect of exercise on systemic and bone concentrations of growth factors in rats
    N Bravenboer
    Department of Endocrinology, Research Institute for Endocrinology, Reproduction and Metabolism, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Orthop Res 19:945-9. 2001
    ..The effects in bone caused by mechanical stimulation cannot be explained by changes in serum IGF-I and IGF-I produced in the liver. The concentrations of IGF-I and TGFbeta in bone appeared to be modulated by running exercise...
  56. pmc Collagen type I alpha1 Sp1 polymorphism, osteoporosis, and intervertebral disc degeneration in older men and women
    S M F Pluijm
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Centre, Amsterdam, The Netherlands
    Ann Rheum Dis 63:71-7. 2004
    ..To examine whether collagen type I alpha1 (COLIA1) Sp1 polymorphism is associated with osteoporosis and/or intervertebral disc degeneration in older people...
  57. doi request reprint Relationships between cortisol level, mortality and chronic diseases in older persons
    R M M Schoorlemmer
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 71:779-86. 2009
    ..High cortisol level is known to be associated with osteoporosis, hypertension, diabetes mellitus (DM), susceptibility to infections and depression and may protect against chronic obstructive pulmonary disease...
  58. pmc In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes
    C M A Reijnders
    Department of Endocrinology, Vrye Universiteit University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Calcif Tissue Int 80:137-43. 2007
    ..Mechanical stimulation modulates IGFBP-2 mRNA expression in endocortical osteocytes. We suggest that IGFBP-2 plays a role in the lamellar bone formation process...
  59. ncbi request reprint The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation
    P Lips
    Vrije Universiteit Medical Center, Amsterdam, The Netherlands, and Nottingham City Hospital, David Evans Medical Research Centre, UK
    J Intern Med 260:245-54. 2006
    ..A high prevalence of inadequacy has been reported in many studies but the prevalence of inadequacy amongst women with osteoporosis in different regions of the world has not been well characterized...
  60. ncbi request reprint Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission
    Marjolein Visser
    Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije University, Amsterdam, Netherlands
    Am J Clin Nutr 84:616-22; quiz 671-2. 2006
    ..The prevalence of vitamin D deficiency in nursing home patients is high...
  61. ncbi request reprint A classification tree for predicting recurrent falling in community-dwelling older persons
    Vianda S Stel
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    J Am Geriatr Soc 51:1356-64. 2003
    ..To develop a classification tree for predicting the risk of recurrent falling in community-dwelling older persons using tree-structured survival analysis (TSSA)...
  62. ncbi request reprint Which types of activities are associated with risk of recurrent falling in older persons?
    G M E E Geeske Peeters
    Department of Internal Medicine, Section Endocrinology, VU University Medical Center, Postbus 7057, 1007 MB Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 65:743-50. 2010
    ..This study explored the associations between various types of activities, their underlying physical components, and recurrent falling in community-dwelling older persons...
  63. doi request reprint Assessing the prevalence of modifiable risk factors in older patients visiting an ED due to a fall using the CAREFALL Triage Instrument
    Roos C van Nieuwenhuizen
    Department of Traumatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Emerg Med 28:994-1001. 2010
    ....
  64. ncbi request reprint The Amsterdam Hip Protector Study: compliance and determinants of compliance
    N M van Schoor
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Osteoporos Int 14:353-9. 2003
    ..Although, the compliance percentages were moderately high during the unannounced visits in this study, not everyone was wearing the protector correctly and most participants did not wear the hip protector during the night...
  65. ncbi request reprint Cross-geographic region differences in quality of life in women with and without vertebral fracture
    N M van Schoor
    EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Osteoporos Int 20:1759-66. 2009
    ..QoL differed between continents, countries, and ethnicities. The observed differences in QoL mostly appeared larger than the difference in QoL between women with or without mild to moderate VFX...
  66. ncbi request reprint The association between plasma homocysteine levels and bone quality and bone mineral density parameters in older persons
    A W Enneman
    Department of Internal Medicine, Erasmus MC, University Medical Centre Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Bone 63:141-6. 2014
    ..Therefore, we wanted to investigate whether plasma homocysteine levels are associated with bone quality parameters, rather than with bone mineral density...
  67. doi request reprint The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review
    Y H M Krul-Poel
    Department of Internal Medicine, Medical Centre Alkmaar, PO Box 501, 1800 AM Alkmaar, The Netherlands
    Eur J Endocrinol 169:853-65. 2013
    ..Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS...
  68. ncbi request reprint Homocysteine and the risk of nursing home admission and mortality in older persons
    K M A Swart
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Clin Nutr 66:188-95. 2012
    ..This study aimed to investigate whether higher homocysteine and lower vitamin B12 concentrations increase the risk of future nursing home (NH) admission and all-cause mortality in independently living older persons...
  69. ncbi request reprint What does quality of life mean to older frail and non-frail community-dwelling adults in the Netherlands?
    M T E Puts
    LASA, Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Qual Life Res 16:263-77. 2007
    ..Moreover, the health of the frail limited the amount and scope of activities that they performed. This led to a lower quality of life perceived by the frail compared to the non-frail...
  70. ncbi request reprint Body mass index, body composition, and leptin at onset of puberty in male and female rats after intrauterine growth retardation and after early postnatal food restriction
    M J Engelbregt
    Department of Clinical Chemistry, the Research Institute for Endocrinology, Reproduction and Metabolism, VU Medical Center, 1081 HV Amsterdam, The Netherlands
    Pediatr Res 50:474-8. 2001
    ....
  71. ncbi request reprint Fall-risk screening test: a prospective study on predictors for falls in community-dwelling elderly
    A M Tromp
    Institute for Research in Extramural Medicine (EMGO Institute, Amsterdam, The Netherlands
    J Clin Epidemiol 54:837-44. 2001
    ..0-5.4%) to 46.8% (95% CI: 43.0-50.6%). Our study provides a fall-risk screening test based on four easily measurable predictors that can be used for fall-risk stratification in community-dwelling elderly...
  72. doi request reprint Vitamin D status, parathyroid function, bone turnover, and BMD in postmenopausal women with osteoporosis: global perspective
    Natalia O Kuchuk
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Bone Miner Res 24:693-701. 2009
    ..Along with latitude, affluence seems to be an important factor for serum 25(OH)D level, especially in Europe, where it is strongly correlated with latitude...
  73. ncbi request reprint Serum insulin-like growth factor-I and body composition in community dwelling older people
    Sigridur Jakobsdóttir
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 73:173-80. 2010
    ..We conducted a study to investigate serum IGF-I levels across different age categories and a possible association between serum IGF-I and measurements of body composition in older people...
  74. ncbi request reprint The effects of the aromatase inhibitor anastrozole on bone metabolism and cardiovascular risk indices in ovariectomized, androgen-treated female-to-male transsexuals
    Mathijs C M Bunck
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 154:569-75. 2006
    ..The aim of this study was to investigate the effects of estrogen deprivation on bone metabolism and vascular parameters without the interference of counter-regulatory effects as seen in eugonadal men...
  75. ncbi request reprint Vitamin D status predicts physical performance and its decline in older persons
    Ilse S Wicherts
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 92:2058-65. 2007
    ..Vitamin D deficiency is common among older people and can cause mineralization defects, bone loss, and muscle weakness...
  76. ncbi request reprint Effects of gender and age on the association of apolipoprotein E epsilon4 with bone mineral density, bone turnover and the risk of fractures in older people
    S M F Pluijm
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Osteoporos Int 13:701-9. 2002
    ....
  77. pmc Reproducibility of bone mineral density measurement in daily practice
    M C Lodder
    Department of Rheumatology, VU University Medical Centre, Amsterdam, The Netherlands
    Ann Rheum Dis 63:285-9. 2004
    ..Bone mineral density (BMD) measurements are frequently performed repeatedly for each patient. Subsequent BMD measurements allow reproducibility to be assessed...
  78. doi request reprint Vitamin D and gestational diabetes: a systematic review and meta-analysis
    Y H M Poel
    Department of Internal Medicine, Gynaecology and Reproductive Medicine, Medical Centre Alkmaar, Alkmaar, The Netherlands
    Eur J Intern Med 23:465-9. 2012
    ..The role of maternal vitamin D status in gestational diabetes mellitus (GDM) is not clear. This meta-analysis aimed to examine this role in women with GDM compared with normal glucose tolerance (NGT)...
  79. doi request reprint Self-reported loss of consciousness after head trauma does not predispose to hypopituitarism in an older population
    N M Rabelink
    Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Head Trauma Rehabil 26:90-7. 2011
    ..This population study examines the prevalence of hypopituitarism and low bone mineral density (BMD) in older persons reporting loss of consciousness after head trauma (HT)...
  80. ncbi request reprint Relationship between cortisol and physical performance in older persons
    G M E E Peeters
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 67:398-406. 2007
    ..Hypercortisolism is associated with muscle weakness. This study examines the relationship between cortisol and physical performance in older persons...
  81. ncbi request reprint Biomechanical comparison of hard and soft hip protectors, and the influence of soft tissue
    N M van Schoor
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, D4, 1081 BT Amsterdam, The Netherlands
    Bone 39:401-7. 2006
    ..Both hard hip protectors, which primarily shunt away energy, and soft hip protectors, which primarily absorb energy, were included...
  82. doi request reprint Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women
    Jj Kragt
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 15:9-15. 2009
    ..The geographical distribution of MS is striking with a prevalence that increases with latitude. For this reason, vitamin D deficiency is considered a possible pathogenic co-factor in MS...
  83. ncbi request reprint [Bisphosphonate-associated osteonecrosis of the jaws 1]
    R H B Allard
    Afdeling Mondziekten en Kaak en aangezichtschirurgie van het VU medisch centrum in Amsterdam Academisch Centrum Tandheelkunde Amsterdam ACTA
    Ned Tijdschr Tandheelkd 114:423-7. 2007
    ..Bisphosphonate-associated osteonecrosis is very difficult to treat. Therefore, dental preventive measures and treatment of dental foci and other inflammations are recommended before starting bisphosphonate therapy...
  84. pmc Sentinel node detection in patients with thyroid carcinoma: a meta-analysis
    P G H M Raijmakers
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    World J Surg 32:1961-7. 2008
    ....
  85. ncbi request reprint Ongoing thyroiditis
    Suat Simsek
    Department of Endocrinology Diabetes Center, VU University Medical Center, Boelelaan 1117, Amsterdam, The Netherlands
    Thyroid 17:1153-4. 2007
  86. ncbi request reprint Determination of fibroblast growth factor 23
    Annemieke C Heijboer
    Department of Clinical Chemistry, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Ann Clin Biochem 46:338-40. 2009
    ..Fibroblast growth factor 23 (FGF-23) is a recently discovered hormone, which plays a key role in phosphate regulation. To investigate whether FGF-23 can be determined reliably, we validated the three available FGF-23 assays...
  87. doi request reprint The need for patients' endocrine function vigilance following treatment of head and neck cancer
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Curr Opin Otolaryngol Head Neck Surg 16:154-7. 2008
    ..The aim of this article is to examine the need for screening of endocrine dysfunction following treatment of head and neck cancer...
  88. ncbi request reprint Fall risk: the clinical relevance of falls and how to integrate fall risk with fracture risk
    G Peeters
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Best Pract Res Clin Rheumatol 23:797-804. 2009
    ..Challenges for future research include further validation of existing prediction tools and evaluation of the cost-effectiveness of treatment after screening...
  89. ncbi request reprint Low testosterone levels and decline in physical performance and muscle strength in older men: findings from two prospective cohort studies
    Laura A Schaap
    EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 68:42-50. 2008
    ..We examined whether levels of testosterone were associated with 3-year decline in physical performance and muscle strength in older men...
  90. doi request reprint Validation of the LASA fall risk profile for recurrent falling in older recent fallers
    G M E E Geeske Peeters
    Department of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Epidemiol 63:1242-8. 2010
    ..This study assessed the predictive validity of this profile in older persons seeking care after a fall...
  91. doi request reprint The association of serum insulin-like growth factor-I with mortality, cardiovascular disease, and cancer in the elderly: a population-based study
    Christa C van Bunderen
    VU University Medical Center, Department of Internal Medicine, Amsterdam, The Netherlands
    J Clin Endocrinol Metab 95:4616-24. 2010
    ..g. cardiovascular disease (CVD) and cancer. Decreased as well as increased levels have been reported to be associated with reduced life expectancy in humans...
  92. doi request reprint Multifactorial intervention to reduce falls in older people at high risk of recurrent falls: a randomized controlled trial
    Oscar J de Vries
    Department of Internal Medicine, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
    Arch Intern Med 170:1110-7. 2010
    ..Guidelines recommend multifactorial, targeted fall prevention. We evaluated the effectiveness of a multifactorial intervention in older persons with a high risk of recurrent falls...
  93. pmc Effect of raloxifene treatment on osteocyte apoptosis in postmenopausal women
    Huib W van Essen
    Department of Endocrinology, VU University Medical Center, 1007 MB, Amsterdam, The Netherlands
    Calcif Tissue Int 81:183-90. 2007
    ..The percent of apoptotic osteocytes was dependent on the level of bone remodeling in an individual...
  94. doi request reprint Lipid levels: a link between cardiovascular disease and osteoporosis?
    Petra J Buizert
    Department of Internal Medicine, Section Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    J Bone Miner Res 24:1103-9. 2009
    ..e., high levels of HDL-c and low TC/HDL-c ratio) is unfavorable for QUS. These results indicate that HDL-c levels do not explain the association between osteoporosis and CVD...
  95. doi request reprint Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals
    Renate T de Jongh
    Department of Internal Medicine and Endocrinology EMGO Institute for Health and Care Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Endocrinol 164:75-82. 2011
    ..Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality...
  96. ncbi request reprint Effect of long-term growth hormone treatment on bone mass and bone metabolism in growth hormone-deficient men
    Nathalie Bravenboer
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    J Bone Miner Res 20:1778-84. 2005
    ..Long-term GH treatment in GH-deficient men resulted in a continuous increase in bone turnover as shown by histomorphometry. BMD continuously increased in all regions of interest, but more in the regions with predominantly cortical bone...
  97. ncbi request reprint Effects of 10 years of growth hormone (GH) replacement therapy in adult GH-deficient men
    Lucia I Arwert
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 63:310-6. 2005
    ..GH-deficient adults have changes in body composition, bone mineral density (BMD) and lipid profile that can be altered by GH substitution. However, long-term data on GH substitution (up to 10 years of follow-up) are limited...
  98. ncbi request reprint The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women
    Laura A Schaap
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 63:152-60. 2005
    ..The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population-based sample of older men and women...
  99. ncbi request reprint Sex differences in the risk of frailty for mortality independent of disability and chronic diseases
    Martine T E Puts
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Am Geriatr Soc 53:40-7. 2005
    ..To determine the effect of static and dynamic frailty on mortality in older men and women...
  100. ncbi request reprint Smoking and quantitative ultrasound parameters in the calcaneus in 36-year-old men and women
    Claire M Bernaards
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Osteoporos Int 15:735-41. 2004
    ..However, since BMD parameters and QUS parameters were not measured at the same sites, our results may also simply suggest that the calcaneus is affected by smoking at an earlier stage than the lumbar spine, hip, and total body...
  101. ncbi request reprint Different aspects of visual impairment as risk factors for falls and fractures in older men and women
    Michiel R de Boer
    Department of Ophthalmology, VU University Medical Center, Amsterdam 1007 MB, The Netherlands
    J Bone Miner Res 19:1539-47. 2004
    ..The analyses showed that impaired vision is an independent risk factor for both recurrent falling and fractures...