J A Langendijk

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Radiotherapy of squamous cell carcinoma of the nasal vestibule
    Johannes A Langendijk
    Department of Radiation Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 59:1319-25. 2004
  2. ncbi request reprint The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature
    J A Langendijk
    Department of Radiation Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Oncol 22:4604-12. 2004
  3. ncbi request reprint Postoperative radiotherapy in squamous cell carcinoma of the oral cavity: the importance of the overall treatment time
    J A Langendijk
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 57:693-700. 2003
  4. ncbi request reprint Quality of life after curative radiotherapy in Stage I non-small-cell lung cancer
    Johannes A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    Int J Radiat Oncol Biol Phys 53:847-53. 2002
  5. ncbi request reprint Quality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study
    J A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    Int J Radiat Oncol Biol Phys 47:149-55. 2000
  6. ncbi request reprint Risk-group definition by recursive partitioning analysis of patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy
    Johannes A Langendijk
    Department of Radiation Oncology, Vrije University Medical Center, Amsterdam, The Netherlands
    Cancer 104:1408-17. 2005
  7. ncbi request reprint Prospective study on quality of life before and after radical radiotherapy in non-small-cell lung cancer
    J A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    J Clin Oncol 19:2123-33. 2001
  8. ncbi request reprint A phase II study of primary reirradiation in squamous cell carcinoma of head and neck
    Johannes A Langendijk
    Department of Radiation Oncology, V U University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 78:306-12. 2006
  9. ncbi request reprint External validation of a risk group defined by recursive partitioning analysis in patients with head and neck carcinoma treated with surgery and postoperative radiotherapy
    Xavier Leon
    Department of Otolaryngology Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Head Neck 29:815-21. 2007
  10. ncbi request reprint Quality of life after surgical treatment for oral and oropharyngeal cancer: a prospective longitudinal assessment of patients reconstructed by a microvascular flap
    Pepijn A Borggreven
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Oral Oncol 43:1034-42. 2007

Detail Information

Publications84

  1. ncbi request reprint Radiotherapy of squamous cell carcinoma of the nasal vestibule
    Johannes A Langendijk
    Department of Radiation Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 59:1319-25. 2004
    ..To evaluate the results of primary radiotherapy (RT) for squamous cell carcinoma of the nasal vestibule...
  2. ncbi request reprint The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: a meta-analysis of the published literature
    J A Langendijk
    Department of Radiation Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Oncol 22:4604-12. 2004
    ....
  3. ncbi request reprint Postoperative radiotherapy in squamous cell carcinoma of the oral cavity: the importance of the overall treatment time
    J A Langendijk
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 57:693-700. 2003
    ....
  4. ncbi request reprint Quality of life after curative radiotherapy in Stage I non-small-cell lung cancer
    Johannes A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    Int J Radiat Oncol Biol Phys 53:847-53. 2002
    ..The aim of this study was to investigate changes in quality of life (QOL) among medically inoperable Stage I non-small-cell lung cancer (NSCLC) patients treated with curative radiotherapy...
  5. ncbi request reprint Quality of life after palliative radiotherapy in non-small cell lung cancer: a prospective study
    J A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    Int J Radiat Oncol Biol Phys 47:149-55. 2000
    ..Additionally, the correlation between the level of symptom relief and objective tumor response was investigated...
  6. ncbi request reprint Risk-group definition by recursive partitioning analysis of patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy
    Johannes A Langendijk
    Department of Radiation Oncology, Vrije University Medical Center, Amsterdam, The Netherlands
    Cancer 104:1408-17. 2005
    ..The objective of this study was to define different prognostic groups with regard to locoregional control (LRC) derived from recursive partitioning analysis (RPA)...
  7. ncbi request reprint Prospective study on quality of life before and after radical radiotherapy in non-small-cell lung cancer
    J A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    J Clin Oncol 19:2123-33. 2001
    ..Additionally, the association between the level of symptom relief and objective tumor response, as well as with radiation-induced pulmonary changes, was investigated...
  8. ncbi request reprint A phase II study of primary reirradiation in squamous cell carcinoma of head and neck
    Johannes A Langendijk
    Department of Radiation Oncology, V U University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 78:306-12. 2006
    ....
  9. ncbi request reprint External validation of a risk group defined by recursive partitioning analysis in patients with head and neck carcinoma treated with surgery and postoperative radiotherapy
    Xavier Leon
    Department of Otolaryngology Head and Neck Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Head Neck 29:815-21. 2007
    ..The objective of the present study was to carry out an external validation of this RPA-derived classification system...
  10. ncbi request reprint Quality of life after surgical treatment for oral and oropharyngeal cancer: a prospective longitudinal assessment of patients reconstructed by a microvascular flap
    Pepijn A Borggreven
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Oral Oncol 43:1034-42. 2007
    ..These results, obtained in a homogenous group of patients, may serve as HRQOL benchmarks for future studies investigating surgical and other treatment modalities...
  11. pmc 2-Deoxy-2[F-18]FDG-PET for detection of recurrent laryngeal carcinoma after radiotherapy: interobserver variability in reporting
    L van der Putten
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Mol Imaging Biol 10:294-303. 2008
    ..To evaluate accuracy and interobserver variability in the assessment of 2-deoxy-2[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET) for detection of recurrent laryngeal carcinoma after radiotherapy...
  12. ncbi request reprint Swallowing after major surgery of the oral cavity or oropharynx: a prospective and longitudinal assessment of patients treated by microvascular soft tissue reconstruction
    Pepijn A Borggreven
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Head Neck 29:638-47. 2007
    ..The aim of this study was to analyze swallowing outcome in advanced oral/oropharyngeal cancer patients treated with microvascular reconstructive surgery and adjuvant radiotherapy...
  13. doi request reprint FADD expression is associated with regional and distant metastasis in squamous cell carcinoma of the head and neck
    W J Pattje
    Department of Radiation Oncology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Histopathology 63:263-70. 2013
    ..3 is associated with increased metastasis in HNSCC and breast cancer. The aim of this study was to investigate the association between FADD protein expression in advanced-stage HNSCC and clinicopathological features and outcome...
  14. ncbi request reprint A review on re-irradiation for recurrent and second primary head and neck cancer
    N Kasperts
    Department of Radiation Oncology, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Oral Oncol 41:225-43. 2005
    ....
  15. doi request reprint Postoperative elective nodal irradiation for squamous cell carcinoma of the head and neck: outcome and prognostic factors for regional recurrence
    M R Vergeer
    Department of Radiation Oncology, Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Oncol 22:2489-94. 2011
    ..Materials and methods: Between 1985 and 2000, 785 cN0 or pN0 necks were treated with elective nodal irradiation in 619 head and neck squamous cell carcinoma patients...
  16. ncbi request reprint Reirradiation in squamous cell head and neck cancer: recent developments and future directions
    Johannes A Langendijk
    Department of Radiation Oncology, University Medical Center Groningen University of Groningen, Groningen, The Netherlands
    Curr Opin Oncol 19:202-9. 2007
    ....
  17. ncbi request reprint Multicenter validation of recursive partitioning analysis classification for patients with squamous cell head and neck carcinoma treated with surgery and postoperative radiotherapy
    Anja Jonkman
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 68:119-25. 2007
    ..To validate the recursive partitioning analysis (RPA) classification system for squamous cell head and neck cancer as recently reported by the VU University Medical Center...
  18. ncbi request reprint The efficacy of voice therapy in patients after treatment for early glottic carcinoma
    Christine D L van Gogh
    Department of Otorhinolaryngology, Head and Neck Surgery, Vrije Universitet Medical Center, Amsterdam, The Netherlands
    Cancer 106:95-105. 2006
    ..The objective of this randomized and controlled study was to assess the efficacy of voice therapy in these patients...
  19. doi request reprint Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy
    Johannes A Langendijk
    Department of Radiation Oncology, VU University Medical Center, Groningen, The Netherlands
    J Clin Oncol 26:3770-6. 2008
    ....
  20. doi request reprint Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 74:1-8. 2009
    ....
  21. ncbi request reprint Health status and voice outcome after treatment for T1a glottic carcinoma
    A Jeanne G E Peeters
    Department of Otorhinolaryngology and Head and Neck Surgery, Vrije University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur Arch Otorhinolaryngol 261:534-40. 2004
    ..Patients selected for endoscopic laser surgery on average report fewer voice-related problems than those who underwent radiotherapy...
  22. ncbi request reprint Supraglottic carcinoma treated with curative radiation therapy: identification of prognostic groups with MR imaging
    Redina Ljumanovic
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 232:440-8. 2004
    ..To retrospectively assess the prognostic meaning of tumor characteristics depicted on pretreatment magnetic resonance (MR) images for local outcome in supraglottic squamous cell carcinoma treated with definitive radiation therapy...
  23. ncbi request reprint Cordectomy by CO2 laser or radiotherapy for small T1a glottic carcinomas: costs, local control, survival, quality of life, and voice quality
    Kim M Goor
    Erasmus MC, University Medical Center Rotterdam, Institute for Medical Technology Assessment Department of Health Policy and Management, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Head Neck 29:128-36. 2007
    ..Therefore, we retrospectively evaluated the costs, voice quality, quality of life, and clinical results of both treatments...
  24. doi request reprint Radiation dose associated with local control in advanced anal cancer: retrospective analysis of 129 patients
    Joachim Widder
    Department of Radiotherapy, Medical University of Vienna, Austria
    Radiother Oncol 87:367-75. 2008
    ..To retrospectively analyse a large consecutive cohort of patients with anal cancer for treatment-related factors influencing local control and survival...
  25. ncbi request reprint Screening for distant metastases in patients with head and neck cancer: what is the current clinical practice?
    J Brouwer
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Clin Otolaryngol 30:438-43. 2005
    ..There is no consensus on the diagnostic technique that has to be used nor on the subgroup of HNSCC patients that may benefit from screening...
  26. doi request reprint Radiotherapy on the neck nodes predicts severe weight loss in patients with early stage laryngeal cancer
    Jacqueline A E Langius
    Department of Nutrition and Dietetics, VU University Medical Center, Amsterdam, The
    Radiother Oncol 97:80-5. 2010
    ..The objective of this study was to evaluate weight loss and nutrition-related symptoms in patients with T1/T2 LC during RT and to select predictive factors for early identification of malnourished patients...
  27. doi request reprint Ipsilateral irradiation for oral and oropharyngeal carcinoma treated with primary surgery and postoperative radiotherapy
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 78:682-8. 2010
    ..Late radiation-induced morbidity was also evaluated...
  28. ncbi request reprint The prevalence of hypothyroidism after treatment for laryngeal and hypopharyngeal carcinomas: are autoantibodies of influence?
    Annalisa M Lo Galbo
    Department of Otorinolaryngology Head and Neck Surgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Acta Otolaryngol 127:312-7. 2007
    ..The incidence rate of hypothyroidism after treatment for laryngeal and hypopharyngeal cancer is high, especially after combination treatment. An association between hypothyroidism and autoantibodies was found...
  29. ncbi request reprint Unilateral versus bilateral irradiation in squamous cell head and neck cancer in relation to patient-rated xerostomia and sticky saliva
    Anke Petra Jellema
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 85:83-9. 2007
    ..To investigate the association between radiation technique with patient-rated moderate and severe xerostomia and sticky saliva...
  30. ncbi request reprint MR imaging predictors of local control of glottic squamous cell carcinoma treated with radiation alone
    Redina Ljumanovic
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 244:205-12. 2007
    ....
  31. doi request reprint Pre- and post-radiotherapy MRI results as a predictive model for response in laryngeal carcinoma
    Redina Ljumanovic
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, P O Box 7057, 1007 MB, Amsterdam The Netherlands
    Eur Radiol 18:2231-40. 2008
    ..Pre- and post-RT MRI evaluation of the larynx can identify patients at high risk for developing local failure...
  32. doi request reprint Delineation guidelines for organs at risk involved in radiation-induced salivary dysfunction and xerostomia
    Tara A van de Water
    Department of Radiation Oncology, University Medical Center Groningen University of Groningen, The Netherlands
    Radiother Oncol 93:545-52. 2009
    ..The aim of this paper is to introduce computed tomography (CT)-based delineation guidelines for organs at risk (OARs) in the head and neck area, associated with radiation-induced salivary dysfunction and xerostomia...
  33. doi request reprint The psychometric and clinical validity of the SWAL-QOL questionnaire in evaluating swallowing problems experienced by patients with oral and oropharyngeal cancer
    Rico N Rinkel
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Oral Oncol 45:e67-71. 2009
    ..It can be used in future comparative studies for oral and oropharyngeal cancer and in clinical practice to identify patients in need of further diagnostics and/or swallowing rehabilitation services...
  34. doi request reprint Quantifying local radiation-induced lung damage from computed tomography
    Ghazaleh Ghobadi
    Department of Radiation Oncology, University Medical Center Groningen University of Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 76:548-56. 2010
    ..Therefore, the aim of the present study was to develop a method for quantification of local radiation-induced lung tissue damage using CT...
  35. ncbi request reprint Prognostic factors in adult soft tissue sarcomas of the head and neck: a single-centre experience
    Remco de Bree
    Department of Otolaryngology Head and Neck Surgery, Vrije Universiteit University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Oral Oncol 42:703-9. 2006
    ..Negative surgical margins are an important prognostic factor, but are difficult to obtain in head and neck sarcomas...
  36. ncbi request reprint Results of postoperative reirradiation for recurrent or second primary head and neck carcinoma
    Nicolien Kasperts
    Department of Radiation Oncology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Cancer 106:1536-47. 2006
    ....
  37. ncbi request reprint Speech outcome after surgical treatment for oral and oropharyngeal cancer: a longitudinal assessment of patients reconstructed by a microvascular flap
    Pepijn A Borggreven
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Head Neck 27:785-93. 2005
    ..The aim of the study was to analyze speech outcome for patients with advanced oral/oropharyngeal cancer treated with reconstructive surgery and adjuvant radiotherapy...
  38. ncbi request reprint Detecting recurrent laryngeal carcinoma after radiotherapy: room for improvement
    Jolijn Brouwer
    Department of Otolaryngology and Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Arch Otorhinolaryngol 261:417-22. 2004
    ..Too many unnecessary laryngoscopies are performed. New imaging techniques such as FDG-PET or new applications of CT or MRI may improve the yield of direct laryngoscopy...
  39. ncbi request reprint The significance of anemia in squamous cell head and neck cancer treated with surgery and postoperative radiotherapy
    Sandrine M G van de Pol
    Department of Radiation Oncology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Oral Oncol 42:131-8. 2006
    ..Hb level between surgery and radiotherapy is an important prognostic factor for both LRC and OS among patients with SCCHN treated with surgery and postoperative radiotherapy...
  40. ncbi request reprint Severe comorbidity negatively influences prognosis in patients with oral and oropharyngeal cancer after surgical treatment with microvascular reconstruction
    Pepijn A Borggreven
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Oral Oncol 41:358-64. 2005
    ..No multivariate influences on the effects of comorbidity were found. Improved knowledge of the effect of comorbidity on survival may lead to better patient selection and counselling for major surgery and microvascular reconstruction...
  41. ncbi request reprint Protection of salivary function by concomitant pilocarpine during radiotherapy: a double-blind, randomized, placebo-controlled study
    Fred R Burlage
    Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 70:14-22. 2008
    ..To investigate the effect of concomitant administration of pilocarpine during radiotherapy for head-and-neck squamous cell carcinoma (HNSCC) on postradiotherapy xerostomia...
  42. ncbi request reprint A screening questionnaire for voice problems after treatment of early glottic cancer
    Christine D L van Gogh
    Department of Otorhinolaryngology, Head and Neck Surgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 62:700-5. 2005
    ..A 5-item screening questionnaire was designed for detection of voice impairment. The purpose of this study is to assess psychometric properties of this questionnaire in clinical practice...
  43. ncbi request reprint Distant metastases in head and neck carcinoma: identification of prognostic groups with MR imaging
    Redina Ljumanovic
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Amsterdam, The Netherlands
    Eur J Radiol 60:58-66. 2006
    ..To evaluate retrospectively the prognostic significance of lymph node parameters assessed on pretreatment magnetic resonance (MR) images for development of distant metastases in patients with head and neck squamous cell carcinomas...
  44. ncbi request reprint Does radiation dose to the salivary glands and oral cavity predict patient-rated xerostomia and sticky saliva in head and neck cancer patients treated with curative radiotherapy?
    Anke Petra Jellema
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 77:164-71. 2005
    ..To investigate the association between the mean salivary gland and oral cavity dose, with patient-rated moderate and severe xerostomia and sticky saliva...
  45. ncbi request reprint Control of nodal metastases in squamous cell head and neck cancer treated by radiation therapy or chemoradiation
    Marije R Vergeer
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 79:39-44. 2006
    ..In the present study, prognostic values of several CT-based pre-treatment nodal and treatment-related characteristics were evaluated among patients with squamous cell head and neck cancer treated with non-surgical modalities...
  46. ncbi request reprint Recent changes in the treatment of patients with advanced laryngeal cancer
    Eric M Genden
    Department of Otolaryngology Head and Neck Surgery, The Mount Sinai Medical Center, New York, NY, USA
    Head Neck 30:103-10. 2008
    ..This article reviews the current options available for a patient with advanced laryngeal cancer and discusses the impact of therapy...
  47. ncbi request reprint Options for salvage after failed initial treatment of anterior vocal commissure squamous carcinoma
    Patrick J Bradley
    Department of Otorhinolaryngology Head and Neck Surgery, Queens Medical Centre, Nottingham, UK
    Eur Arch Otorhinolaryngol 263:889-94. 2006
    ..However, total laryngectomy may remain the only treatment option for advanced or aggressive first time recurrence, or in patients who develop subsequent recurrence following previous less aggressive surgery (endoscopic or external)...
  48. pmc The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer
    W J Pattje
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Br J Cancer 102:1778-85. 2010
    ..Presently, no markers exist to accurately predict treatment outcome. Expression of proteins in the human epidermal growth factor receptor (EGFR) pathway has been reported as a prognostic marker in several types of cancer...
  49. ncbi request reprint Pretreatment quality of life of inoperable non-small cell lung cancer patients referred for primary radiotherapy
    J A Langendijk
    Radiotherapeutisch Instituut Limburg, Heerlen, The Netherlands
    Acta Oncol 39:949-58. 2000
    ....
  50. ncbi request reprint Has the degree of contrast enhancement with MR imaging in laryngeal carcinoma added value to anatomic parameters regarding prediction of response to radiation therapy?
    R Ljumanovic
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 28:1540-6. 2007
    ....
  51. doi request reprint A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer
    Johannes A Langendijk
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 90:189-95. 2009
    ..The purpose of this study was to design a predictive model for swallowing dysfunction after curative radiotherapy or chemoradiation...
  52. ncbi request reprint Radiotherapy alone, versus radiotherapy with amifostine 3 times weekly, versus radiotherapy with amifostine 5 times weekly: A prospective randomized study in squamous cell head and neck cancer
    Anke Petra Jellema
    Department of Radiation Oncology, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Cancer 107:544-53. 2006
    ....
  53. doi request reprint Objective acoustic-phonetic speech analysis in patients treated for oral or oropharyngeal cancer
    Marieke J de Bruijn
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Folia Phoniatr Logop 61:180-7. 2009
    ..The goal of the present study is to investigate the role of objective acoustic-phonetic analyses in a multidimensional speech assessment protocol...
  54. doi request reprint Consequences of additional use of PET information for target volume delineation and radiotherapy dose distribution for esophageal cancer
    Christina T Muijs
    Department of Radiation Oncology, University Medical Centre Groningen University of Groningen, Groningen, The Netherlands
    Radiother Oncol 93:447-53. 2009
    ..To determine the consequences of target volume (TV) modifications, based on the additional use of PET information, on radiation planning, assuming PET/CT-imaging represents the true extent of the tumour...
  55. doi request reprint Minimising contralateral breast dose in post-mastectomy intensity-modulated radiotherapy by incorporating conformal electron irradiation
    Hans Paul van der Laan
    Department of Radiation Oncology, University Medical Center Groningen University of Groningen, Groningen, The Netherlands
    Radiother Oncol 94:235-40. 2010
    ..To assess the potential benefit of incorporating conformal electron irradiation in intensity-modulated radiotherapy (IMRT) for loco-regional post-mastectomy RT...
  56. ncbi request reprint The importance of immunohistochemical expression of EGFr in squamous cell carcinoma of the oral cavity treated with surgery and postoperative radiotherapy
    Ernst J Smid
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 65:1323-9. 2006
    ..The aim of this study was to investigate the prognostic significance of epidermal growth factor (EGFr) expression in oral cavity squamous cell carcinoma (OCSCC) treated with curative surgery and postoperative radiotherapy...
  57. doi request reprint Improved detection of recurrent laryngeal tumor after radiotherapy using (18)FDG-PET as initial method
    Jolijn Brouwer
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Radiother Oncol 87:217-20. 2008
    ..18)FDG-PET is interpreted visually so that observer variation may affect clinical practice. In the present study, we therefore investigated this aspect of reproducibility...
  58. ncbi request reprint Primary treatment of the anterior vocal commissure squamous carcinoma
    Patrick J Bradley
    Department of Otorhinolaryngology Head and Neck Surgery, Queens Medical Centre, Nottingham, UK
    Eur Arch Otorhinolaryngol 263:879-88. 2006
    ..The use of the above recommendations would allow for more meaningful results to be reported and for cause specific analysis of failure of treatment techniques applied...
  59. ncbi request reprint Compliance and efficiency before and after implementation of a clinical practice guideline for laryngeal carcinomas
    Michel van Agthoven
    Department of Health Policy and Management, Institute for Medical Technology Assessment, Erasmus MC, University Medical Centre Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Eur Arch Otorhinolaryngol 263:729-37. 2006
    ..Balanced against the equal costs before and after the guideline's implementation, we conclude that the efficiency of the care process improved...
  60. ncbi request reprint Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer
    S M De Lange
    Department of Medical Oncology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Eur J Cancer 38:1212-7. 2002
    ..Although the toxicity of this treatment was occasionally severe, the response and survival are encouraging and warrant further studies of this combination...
  61. ncbi request reprint Impact of radiation-induced xerostomia on quality of life after primary radiotherapy among patients with head and neck cancer
    Anke Petra Jellema
    Department of Radiation Oncology, University Medical Center, Utrecht, The Netherlands
    Int J Radiat Oncol Biol Phys 69:751-60. 2007
    ..To investigate the impact of xerostomia on overall quality of life (QoL) outcome and related dimensions among head and neck cancer patients treated with primary radiotherapy...
  62. ncbi request reprint Screening for distant metastases in patients with head and neck cancer: is chest computed tomography sufficient?
    Jolijn Brouwer
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Laryngoscope 115:1813-7. 2005
    ..Different clinical risk factors in patients with head and neck squamous cell carcinoma for the development of distant metastases were identified...
  63. doi request reprint Bath and shower effects in the rat parotid gland explain increased relative risk of parotid gland dysfunction after intensity-modulated radiotherapy
    Peter van Luijk
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 74:1002-5. 2009
    ..To assess in a rat model whether adding a subtolerance dose in a region adjacent to a high-dose irradiated subvolume of the parotid gland influences its response (bath-and-shower effect)...
  64. doi request reprint Quality assurance in head and neck surgical oncology: EORTC 24954 trial on larynx preservation
    C R Leemans
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands Electronic address
    Eur J Surg Oncol 39:1013-8. 2013
    ..The need for a quality assurance program is the evaluation and prevention of differences in treatments between centres in this multidisciplinary study...
  65. pmc Critical weight loss is a major prognostic indicator for disease-specific survival in patients with head and neck cancer receiving radiotherapy
    J A E Langius
    Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Br J Cancer 109:1093-9. 2013
    ..2-2.4; P=0.004).Conclusion:Weight loss both before and during radiotherapy are important prognostic indicators for 5-year DSS in HNC patients. Randomised studies into the prognostic effect of nutritional intervention are needed. ..
  66. doi request reprint Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension
    G Ghobadi
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    Thorax 67:334-41. 2012
    ..Recent data suggest that vascular damage plays an important role in the development of radiation-induced pulmonary toxicity. Therefore, the authors investigated whether irradiation of the lung also induces pulmonary hypertension...
  67. ncbi request reprint Voice in early glottic cancer compared to benign voice pathology
    C D L van Gogh
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur Arch Otorhinolaryngol 264:1033-8. 2007
    ..The VHI proved to be an adequate tool for baseline and effectiveness measurement of voice...
  68. ncbi request reprint Radiotherapy-induced cerebral abnormalities in patients with low-grade glioma
    T J Postma
    Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Neurology 59:121-3. 2002
    ..White matter abnormalities were observed in six patients, all of whom were treated with prior radiotherapy. These radiologic cerebral abnormalities correlated with cognitive performance...
  69. doi request reprint Cardiovascular morbidity after radiotherapy or chemoradiation in patients with cervical cancer
    John H Maduro
    Department of Radiation Oncology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 78:1337-44. 2010
    ..To evaluate the risk of cardiovascular events (CVE) in patients with cervical cancer treated with radiotherapy or chemoradiation...
  70. ncbi request reprint Immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma: beneficial effect on local control without additional negative impact on pituitary function and life expectancy
    Alfons C M van den Bergh
    Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 67:863-9. 2007
    ..To demonstrate the benefit of immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma (NFA) in perspective to the need for hormonal substitution and life expectancy...
  71. ncbi request reprint Low levels of circulating invariant natural killer T cells predict poor clinical outcome in patients with head and neck squamous cell carcinoma
    Johan W Molling
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 25:862-8. 2007
    ..It has been reported that iNKT cells are reduced in peripheral blood of cancer patients compared with healthy controls. Here, we investigated whether the extent of this deficiency affected disease outcome in HNSCC patients...
  72. doi request reprint Optimizing dose prescription in stereotactic body radiotherapy for lung tumours using Monte Carlo dose calculation
    Joachim Widder
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700RB Groningen, The Netherlands
    Radiother Oncol 94:42-6. 2010
    ..To define a method of dose prescription employing Monte Carlo (MC) dose calculation in stereotactic body radiotherapy (SBRT) for lung tumours aiming at a dose as low as possible outside of the PTV...
  73. ncbi request reprint Optimum dose range for the amelioration of long term radiation-induced hyposalivation using prophylactic pilocarpine treatment
    Fred Ronald Burlage
    Department of Radiation Oncology, University of Groningen, The Netherlands
    Radiother Oncol 86:347-53. 2008
    ..To determine dose and time dependency of pilocarpine pre-treatment protection from late damage after unilateral irradiation of the rat parotid gland...
  74. ncbi request reprint Grading-system-dependent volume effects for late radiation-induced rectal toxicity after curative radiotherapy for prostate cancer
    Hans Paul van der Laan
    Department of Radiation Oncology, University Medical Center Groningen University of Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 70:1138-45. 2008
    ..0 graded rectal toxicity among patients with prostate cancer treated with RT...
  75. ncbi request reprint Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer
    Johan H Gibcus
    Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin Cancer Res 13:6257-66. 2007
    ..Recently, we reported that the amplicon size in 30 laryngeal and pharyngeal carcinomas with 11q13 amplification is determined by unique genomic structures, resulting in the amplification of a set of genes rather than a single gene...
  76. ncbi request reprint Evaluating adherence to the Dutch guideline for diagnosis, treatment and follow-up of laryngeal carcinomas
    Michel van Agthoven
    Department of Health Policy and Management, Institute for Medical Technology Assessment, Erasmus MC, University Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Radiother Oncol 74:337-44. 2005
    ..We retrospectively evaluated whether clinical practice changed according to the recommendations of this guideline and whether it succeeded in its aim...
  77. pmc Dosimetric consequences of the shift towards computed tomography guided target definition and planning for breast conserving radiotherapy
    Hans Paul van der Laan
    Department of Radiation Oncology, University Medical Center Groningen University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Radiat Oncol 3:6. 2008
    ....
  78. ncbi request reprint Comparison of normal tissue dose with three-dimensional conformal techniques for breast cancer irradiation including the internal mammary nodes
    Hans P van der Laan
    Department of Radiation Oncology, University Medical Center Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 63:1522-30. 2005
    ..To compare the Para Mixed technique for irradiation of the internal mammary nodes (IMN) with three commonly used strategies, by analyzing the dose to the heart and other organs at risk...
  79. ncbi request reprint Patient position verification with oblique radiation beams
    Nanna M Sijtsema
    Department of Radiation Oncology, University Medical Center Groningen University of Groningen, Groningen, The Netherlands
    Radiother Oncol 85:126-31. 2007
    ..Currently applied additional anterior posterior (AP) and lateral verification beams could then be abandoned...
  80. ncbi request reprint The impact of heart irradiation on dose-volume effects in the rat lung
    Peter van Luijk
    Department of Radiation Oncology, University Medical Center, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 69:552-9. 2007
    ..To test the hypothesis that heart irradiation increases the risk of a symptomatic radiation-induced loss of lung function (SRILF) and that this can be well-described as a modulation of the functional reserve of the lung...
  81. ncbi request reprint Permanent unilateral hearing loss after radiotherapy for parotid gland tumors
    Lisa van der Putten
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Head Neck 28:902-8. 2006
    ..The purpose of this retrospective study was to determine the long-term effects of radiotherapy on hearing function in patients who underwent parotidectomy and postoperative radiotherapy for unilateral tumors of the parotid gland...
  82. doi request reprint Limited benefit of inversely optimised intensity modulation in breast conserving radiotherapy with simultaneously integrated boost
    Hans Paul van der Laan
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands
    Radiother Oncol 94:307-12. 2010
    ....
  83. ncbi request reprint Peripheral blood IFN-gamma-secreting Valpha24+Vbeta11+ NKT cell numbers are decreased in cancer patients independent of tumor type or tumor load
    Johan W Molling
    Department of Pathology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Int J Cancer 116:87-93. 2005
    ..g., by hampering efficient tumor immunosurveillance...
  84. ncbi request reprint Radiotherapy is not associated with reduced quality of life and cognitive function in patients treated for nonfunctioning pituitary adenoma
    Andre P van Beek
    Department of Endocrinology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 68:986-91. 2007
    ..To assess the influence of different treatment modalities on long-term health-related quality of life (HR-QoL) and cognitive problems among patients who had been treated for nonfunctioning pituitary adenoma (NFA)...