P Kenemans

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Tibolone increases bone mineral density but also relapse in breast cancer survivors: LIBERATE trial bone substudy
    Nigel J Bundred
    Department of Surgery, University of Manchester, Southmoor Road, Manchester, M23 9LT, UK
    Breast Cancer Res 14:R13. 2012
  2. doi request reprint Androgens and breast cancer risk
    Peter Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    Gynecol Endocrinol 28:46-9. 2012
  3. ncbi request reprint Postmenopausal hormone therapy and breast cancer: what is the problem?
    Peter Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 51:75-82. 2005
  4. ncbi request reprint Oncogenic pathways in hereditary and sporadic breast cancer
    P Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 61:141-50. 2008
  5. ncbi request reprint Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial
    Peter Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 10:135-46. 2009
  6. ncbi request reprint Oncogenic pathways in hereditary and sporadic breast cancer
    P Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 49:34-43. 2004
  7. ncbi request reprint Tibolone: clinical recommendations and practical guidelines. A report of the International Tibolone Consensus Group
    P Kenemans
    VU University Medical Center, Department of Obstetrics and Gynaecology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 51:21-8. 2005
  8. ncbi request reprint Breast cancer and post-menopausal hormone therapy
    P Kenemans
    Department of Obstetrics and Gynaecology, Free University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 17:123-37. 2003
  9. ncbi request reprint Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours
    S von Mensdorff-Pouilly
    Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, Netherlands
    Eur J Cancer 32:1325-31. 1996
  10. ncbi request reprint An enzyme-linked immunosorbent assay for the measurement of circulating antibodies to polymorphic epithelial mucin (MUC1)
    S von Mensdorff-Pouilly
    Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Tumour Biol 19:186-95. 1998

Detail Information

Publications103 found, 100 shown here

  1. pmc Tibolone increases bone mineral density but also relapse in breast cancer survivors: LIBERATE trial bone substudy
    Nigel J Bundred
    Department of Surgery, University of Manchester, Southmoor Road, Manchester, M23 9LT, UK
    Breast Cancer Res 14:R13. 2012
    ..40 (95% CI, 1.14 to 1.70; P = 0.001). A subgroup of women was entered into a study of bone mineral density (BMD)...
  2. doi request reprint Androgens and breast cancer risk
    Peter Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    Gynecol Endocrinol 28:46-9. 2012
    ..The evidence available so far makes counselling women interested in testosterone supplementation for distressful low sexual desire, more of an art than science...
  3. ncbi request reprint Postmenopausal hormone therapy and breast cancer: what is the problem?
    Peter Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 51:75-82. 2005
    ..So, we have a problem and not a firm basis for undisputable statements...
  4. ncbi request reprint Oncogenic pathways in hereditary and sporadic breast cancer
    P Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 61:141-50. 2008
    ..As mutations acquired early during tumorigenesis will be present in all later stages, large-scale gene expression profiling using DNA microarray analysis techniques can help to classify breast cancers into clinically relevant subtypes...
  5. ncbi request reprint Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial
    Peter Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Oncol 10:135-46. 2009
    ..The aim of this study was to show non-inferiority of tibolone to placebo regarding risk of recurrence in breast-cancer patients with climacteric complaints...
  6. ncbi request reprint Oncogenic pathways in hereditary and sporadic breast cancer
    P Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 49:34-43. 2004
    ..As mutations acquired early during tumorigenesis will be present in all later stages, large-scale gene expression profiling using DNA microarray analysis techniques can help to classify breast cancers into clinically relevant subtypes...
  7. ncbi request reprint Tibolone: clinical recommendations and practical guidelines. A report of the International Tibolone Consensus Group
    P Kenemans
    VU University Medical Center, Department of Obstetrics and Gynaecology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 51:21-8. 2005
    ....
  8. ncbi request reprint Breast cancer and post-menopausal hormone therapy
    P Kenemans
    Department of Obstetrics and Gynaecology, Free University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 17:123-37. 2003
    ..not increased while morbidity is? And is HRT contraindicated for women with a positive family history for breast cancer or in those women who have been treated for breast cancer? And finally, are there alternative options for these women?..
  9. ncbi request reprint Humoral immune response to polymorphic epithelial mucin (MUC-1) in patients with benign and malignant breast tumours
    S von Mensdorff-Pouilly
    Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, Netherlands
    Eur J Cancer 32:1325-31. 1996
    ....
  10. ncbi request reprint An enzyme-linked immunosorbent assay for the measurement of circulating antibodies to polymorphic epithelial mucin (MUC1)
    S von Mensdorff-Pouilly
    Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Tumour Biol 19:186-95. 1998
    ..The objective of this study was to develop a reliable assay for the accurate determination of circulating free antibodies to MUC1...
  11. ncbi request reprint Cellular and humoral immune responses to MUC1 mucin and tandem-repeat peptides in ovarian cancer patients and controls
    F G Snijdewint
    Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Cancer Immunol Immunother 48:47-55. 1999
    ....
  12. ncbi request reprint A randomized placebo-controlled study of the effect of transdermal vs. oral estradiol with or without gestodene on homocysteine levels
    R G V Smolders
    Department of Obstetrics and Gynecology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Fertil Steril 79:261-7. 2003
    ..To assess the effect of transdermal vs. oral administration of E2 on plasma homocysteine levels and to evaluate the impact of adding a progestogen to these regimens...
  13. ncbi request reprint Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin
    S von Mensdorff-Pouilly
    Departments of Obstetrics and Gynecology, Clinical Chemistry, Pathology, and Surgery, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Clin Oncol 18:574-83. 2000
    ..The present study analyzes the incidence of naturally occurring MUC1 antibodies in early breast cancer patients and relates the presence of these antibodies in pretreatment serum to outcome of disease...
  14. ncbi request reprint Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer
    J M Piek
    Department of Obstetrics and Gynaecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    J Pathol 195:451-6. 2001
    ....
  15. ncbi request reprint Oral, more than transdermal, oestrogen therapy lowers asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study
    M O Verhoeven
    Department of Obstetrics and Gynaecology, Project Ageing Women and Institute for Cardiovascular Research Vrije Universiteit, Amsterdam, Netherlands
    J Intern Med 259:199-208. 2006
    ..To compare the effects of oral and transdermal hormone therapy (HT) on asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, in postmenopausal women...
  16. ncbi request reprint No increase in C-reactive protein levels during intranasal compared to oral hormone therapy in healthy post-menopausal women
    M Hemelaar
    Project Ageing Women and Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Reprod 21:1635-42. 2006
    ..This study compared the effects of intranasal and oral administration of 17beta-estradiol (E2) combined with norethisterone acetate (NETA) on markers of inflammation in healthy post-menopausal women...
  17. ncbi request reprint Autoantibodies to p53 in ovarian cancer patients and healthy women: a comparison between whole p53 protein and 18-mer peptides for screening purposes
    C J Vennegoor
    Department of Obstetrics and Gynecology, University Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Cancer Lett 116:93-101. 1997
    ..IgG2 antibodies against p53 suggest p53-specific CD4+ T helper 1 cell activity in some of the ovarian cancer patients...
  18. ncbi request reprint Effects of transdermal and oral oestrogen replacement therapy on C-reactive protein levels in postmenopausal women: a randomised, placebo-controlled trial
    M S Post
    Project Ageing Women and the Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Thromb Haemost 88:605-10. 2002
    ..In conclusion, oral E(2) significantly increased CRP levels. This change was larger than the increase found during oral E(2) + G. Transdermal E(2) did not affect CRP levels...
  19. ncbi request reprint Reactivity of natural and induced human antibodies to MUC1 mucin with MUC1 peptides and n-acetylgalactosamine (GalNAc) peptides
    S von Mensdorff-Pouilly
    Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Int J Cancer 86:702-12. 2000
    ..Therefore, our results indicate that a MUC1 glycopeptide would be a better vaccine than a naked peptide...
  20. ncbi request reprint Hormone replacement influences homocysteine levels in the methionine-loading test: a randomized placebo controlled trial in postmenopausal women
    R G V Smolders
    Project Aging Women, Department of Obstetrics and Gynaecology, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, PO Box 7057, Amsterdam 1007 MB, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 117:55-9. 2004
    ..To investigate the mechanism by which exogenous oestrogen influences the homocysteine metabolism in postmenopausal women...
  21. ncbi request reprint Oral estradiol decreases plasma homocysteine, vitamin B6, and albumin in postmenopausal women but does not change the whole-body homocysteine remethylation and transmethylation flux
    R G V Smolders
    Project Aging Women, Vrije Universiteit University Medical Center, Department of Obstetrics and Gynecology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 90:2218-24. 2005
    ....
  22. ncbi request reprint Survival analysis in familial ovarian cancer, a case control study
    R P Zweemer
    Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 98:219-23. 2001
    ..This may have important implications for the management and prevention of familial ovarian cancer...
  23. ncbi request reprint Effects of 15 months of 17 beta-estradiol and dydrogesterone on systolic cardiac function according to quantitative and Doppler echocardiography in healthy postmenopausal women
    H Kessel
    Project Ageing Women and the Institute for Cardiovascular Research-Vrije Universiteit, Amsterdam, The Netherlands
    Am J Obstet Gynecol 184:910-6. 2001
    ..It is suggested that 15 months of treatment probably is too short a period for detection of direct effects on the heart itself...
  24. ncbi request reprint Expression of differentiation and proliferation related proteins in epithelium of prophylactically removed ovaries from women with a hereditary female adnexal cancer predisposition
    J M J Piek
    Department of Obstetrics and Gynaecology, VU University Medical Centre, 1007 MB Amsterdam, The Netherlands
    Histopathology 43:26-32. 2003
    ....
  25. ncbi request reprint Raloxifene reduces impedance to flow within the uterine artery in early postmenopausal women: a 2-year randomized, placebo-controlled, comparative study
    M S Post
    Ageing Women Project and the Institute for Cardiovascular Research-Vrije Universiteit (ICaR-VU, Department of Obstetrics and Gynecology, VU University Medical Centre, Amsterdam, The Netherlands
    Am J Obstet Gynecol 185:557-62. 2001
    ..CONCLUSION: Long-term use of 150 mg of raloxifene daily or ccHRT reduces impedance to flow within the uterine artery. This indicates that high-dose raloxifene may exert cardiovascular protection...
  26. ncbi request reprint Women's expectations and acceptance of cyclic induced HRT bleeds
    P H van de Weijer
    Department of Obstetrics and Gynaecology, Menopause Research Project Ageing Women, Free University Hospital, Amsterdam, The Netherlands
    Maturitas 30:257-63. 1998
    ..To assess women's expectations and acceptance of cyclic induced HRT bleeds before and after their participation in a 1-year study and to compare the impact of these cyclic bleeds with that of previous menstrual bleeds...
  27. ncbi request reprint Antibody-dependent cell-mediated cytotoxicity can be induced by MUC1 peptide vaccination of breast cancer patients
    F G Snijdewint
    Department of Obstetrics and Gynaecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Int J Cancer 93:97-106. 2001
    ..MUC1 Ab-dependent cell-mediated tumor cell killing may occur in vivo and the ADCC assay can be applied to monitor MUC1 vaccination trials...
  28. ncbi request reprint Humoral immune responses to MUC1 in women with a BRCA1 or BRCA2 mutation
    B B J Hermsen
    Department of Obstetrics and Gynaecology, VU University Medical Centre, De Boelenlaan 1117, 1081 HV Amsterdam, The Netherlands
    Eur J Cancer 43:1556-63. 2007
    ..The aim of the study was to evaluate humoral immune responses to MUC1 in women at hereditary high risk of breast cancer to investigate whether this immune response could play a role in the prevention of disease...
  29. ncbi request reprint Estrogens, homocysteine, vasodilatation and menopause: basic mechanisms, interactions and clinical implications
    R G V Smolders
    Project Aging Women, Institute for Cardiovascular Research, Vrije Universiteit, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Gynecol Endocrinol 17:339-54. 2003
    ....
  30. ncbi request reprint Effects of hormone replacement therapy on blood platelets
    A Thijs
    Department of General Internal Medicine, VU Academic Medical Center, Amsterdam, The Netherlands
    Eur J Clin Invest 32:613-8. 2002
    ..We studied the effect of short-term oral hormone replacement therapy (unopposed oestradiol or sequentially combined oestradiol and trimegestone or dydrogesterone) on platelet activation parameters in healthy postmenopausal women...
  31. pmc Differences in MHC and TAP-1 expression in cervical cancer lymph node metastases as compared with the primary tumours
    F V Cromme
    Institute for Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 69:1176-81. 1994
    ..Furthermore, the lack of class II MHC expression in metastasised cells either reflects a different local lymphokine production or indicates that these cells may have escaped CD4+ cytotoxic T-lymphocyte (CTL)-mediated killing...
  32. ncbi request reprint Sentinel node detection in cervical cancer
    R H Verheijen
    Department of Obstetrics and Gynecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Obstet Gynecol 96:135-8. 2000
    ..Sentinel node detection has not yet proved feasible in tumors, such as cervical cancer, that drain to deep pelvic lymph nodes...
  33. ncbi request reprint Comparative genomic hybridization of microdissected familial ovarian carcinoma: two deleted regions on chromosome 15q not previously identified in sporadic ovarian carcinoma
    R P Zweemer
    Department of Obstetrics and Gynaecology, VU Medical Center, Amsterdam, The Netherlands
    Lab Invest 81:1363-70. 2001
    ..These and other yet unknown suppressor genes may be involved in a specific carcinogenic pathway for familial ovarian cancer and may explain the distinct clinical presentation and behavior of familial ovarian cancer...
  34. pmc Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients
    M M Gourevitch
    Department of Obstetrics and Gynaecology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 72:934-8. 1995
    ..Most antibodies in PEM-CICs were of IgG class, suggesting their specific nature to the PEM epitopes...
  35. ncbi request reprint Perspectives in hormone replacement therapy
    P Kenemans
    Department of Obstetrics and Gynaecology, Free University Hospital, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
    Maturitas 38:S41-8. 2001
    ..The prospects for safe and effective postmenopausal HRT with either estrogens or estrogen-like drugs are very promising when these drugs are used in a patient-tailored, risk profile-based manner...
  36. pmc Analysis of MHC class I and II expression in relation to presence of HPV genotypes in premalignant and malignant cervical lesions
    F V Cromme
    Institute for Pathology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 67:1372-80. 1993
    ..The results indicate that local differences may exist in the type of cellular immune response to HPV induced lesions...
  37. ncbi request reprint T cell infiltration and MHC I and II expression in the presence of tumor antigens: An immunohistochemical study in patients with serous epithelial ovarian cancer
    H W Nijman
    Department of Obstetrics and Gynaecology, University Hospital Vrije Universteit, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 94:114-20. 2001
    ..The immune escape mechanism by MHC class I and beta2m downregulation seems to be of minor importance. Our data support the view that immunotherapy may offer new possibilities with high specificity in ovarian cancer...
  38. ncbi request reprint Relationship of estradiol levels to breakthrough bleeding during continuous combined hormone replacement therapy
    P H van de Weijer
    Department of Obstetrics and Gynaecology, Free University Hospital, Amsterdam, The Netherlands
    Obstet Gynecol 93:551-7. 1999
    ..To determine whether serum estradiol and dydrogesterone concentrations are associated with the occurrence of breakthrough bleeding...
  39. ncbi request reprint The Million Women Study: a licence to kill other investigations?
    M J van der Mooren
    Project Ageing Women, Department of Obstetrics and Gynaecology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 113:3-5. 2004
    ..It is concluded that the hormone fear that was caused by the MWS, and augmented by some professionals and the media, was unjustifiable...
  40. ncbi request reprint Influence of the route of administration on targeting of ovarian cancer with the chimeric monoclonal antibody MOv18: i.v. vs. i.p
    I van Zanten-Przybysz
    Department of Obstetrics and Gynecology, University Hospital, Vrije Universiteit, Amsterdam, The Netherlands
    Int J Cancer 92:106-14. 2001
    ..The i.p. route could be advantageous with respect to bone marrow toxicity since the AUC was significantly lower for the i.p. route. However, within 2 days post-injection, the blood clearance followed the same pattern for both routes...
  41. ncbi request reprint Experience with hormonal therapy in advanced epithelial ovarian cancer
    N van der Vange
    Department of Medical Oncology, Free University Hospital, Amsterdam, The Netherlands
    Acta Oncol 34:813-20. 1995
    ..It is suggested to further study this in patients who do not reach a complete response after standard induction chemotherapy, particularly in those with well-differentiated tumors...
  42. pmc CA 125 half-life in ovarian cancer: a multivariate survival analysis
    C A Yedema
    Department of Obstetrics and Gynaecology, Free University Hospital, Amsterdam, The Netherlands
    Br J Cancer 67:1361-7. 1993
    ..A CA 125 half-life < or = 20 days vs > 20 days calculated using this formula, provides an independent prognostic factor for survival in stage III-IV patients early in the course of therapy (P = 0.04)...
  43. ncbi request reprint Prospective multicenter evaluation of the morphometric D-score for prediction of the outcome of endometrial hyperplasias
    J P Baak
    Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands
    Am J Surg Pathol 25:930-5. 2001
    ..S. $50 per case)...
  44. ncbi request reprint Pulsed estrogen exposure selectively modulates tissue response: a hypothesis
    P Kenemans
    Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    Gynecol Endocrinol 18:159-64. 2004
    ..In addition, pulsed estrogen exposure also increases local concentration of 2-methoxyestradiol, a specific estradiol metabolite with proven anti-tumor properties...
  45. ncbi request reprint Endocervical curettage by Vabra aspiration as part of colposcopic evaluation
    T J Helmerhorst
    Department of Obstetrics and Gynecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Gynecol Oncol 36:312-6. 1990
    ..Vabra ECC is considered an efficient, safe, and well-tolerated diagnostic outpatient method and recommended as a standard part of colposcopic evaluation...
  46. ncbi request reprint Oral oestradiol/trimegestone replacement reduces procarboxypeptidase U (TAFI): a randomized, placebo- controlled, 12-week study in early postmenopausal women
    M S Post
    Project Ageing Women and the Institute for Cardiovascular Research Vrije Universiteit ICaR VU, Amsterdam, The Netherlands
    J Intern Med 251:245-51. 2002
    ..4.17.20), an inhibitor of fibrinolysis, in healthy early postmenopausal women...
  47. ncbi request reprint Maternal serum Ca125 and Ca15-3 antigen levels in normal and pathological pregnancy
    G G Bon
    Department of Obstetrics and Gynecology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
    Fetal Diagn Ther 16:166-72. 2001
    ..CA15-3 maternal serum levels are higher during the third trimester compared to the first and second trimester. Maternal CA125 and CA15-3 serum levels showed no relation with a pathological outcome of pregnancy...
  48. pmc Molecular evidence for putative tumour suppressor genes on chromosome 13q specific to BRCA1 related ovarian and fallopian tube cancer
    A P M Jongsma
    Department of Obstetrics and Gynaecology, 1007 MB, Amsterdam, The Netherlands
    Mol Pathol 55:305-9. 2002
    ..The aim of this study was to define regions on chromosome 13 that may harbour additional tumour suppressor genes involved in the tumorigenesis of BRCA1 related ovarian and fallopian tube cancer...
  49. pmc Intraperitoneal photodynamic therapy of the rat CC531 adenocarcinoma
    R B Veenhuizen
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Br J Cancer 73:1387-92. 1996
    ..Repeated treatments resulted in increased tumour response...
  50. ncbi request reprint Intranasal continuous combined 17 beta-estradiol/norethisterone therapy improves the lipid profile in healthy postmenopausal women
    Majoie Hemelaar
    Department of Obstetrics and Gynecology, Project Aging Women, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands
    Fertil Steril 85:979-88. 2006
    ..To compare the effects of continuous combined 17beta-estradiol (E2) plus norethisterone (acetate) [NET(A)] therapy by either intranasal or oral administration on the lipid profile in postmenopausal women...
  51. pmc The effects of tibolone in older postmenopausal women
    Steven R Cummings
    San Francisco Coordinating Center and the California Pacific Medical Center Research Institute, San Francisco, USA
    N Engl J Med 359:697-708. 2008
    ..Tibolone has estrogenic, progestogenic, and androgenic effects. Although tibolone prevents bone loss, its effects on fractures, breast cancer, and cardiovascular disease are uncertain...
  52. ncbi request reprint Breast cancer and climacteric complaints: weighing up risks of hormone therapy against quality of life
    Henk R Franke
    Department of Obstetrics and Gynecology, Medisch Spectrum Twente Hospital Group, Enschede, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 134:143-6. 2007
    ..If the quality of life is seriously affected in these often-young women with these iatrogenic climacteric complaints, then careful consideration must be given to the various treatment modalities...
  53. ncbi request reprint Increased resistance to activated protein C after short-term oral hormone replacement therapy in healthy post-menopausal women
    Marinka S Post
    Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    Br J Haematol 119:1017-23. 2002
    ..In contrast, hormone replacement therapy had no effect on FVIII:Ag. Oral E2 and E2 + D had a small, favourable effect on FXI:Ag...
  54. ncbi request reprint The effects of 12 weeks of HMR 3339, a novel selective estrogen receptor modulator, on markers of coagulation and fibrinolysis: a randomized, placebo-controlled, double-blind, dose-ranging study in healthy postmenopausal women
    Tatjana E Vogelvang
    Project Aging Women, The Institute for Cardiovascular Research Vrije Universiteit, Amsterdam, The Netherlands
    Am J Obstet Gynecol 193:1384-94. 2005
    ..To investigate the short-term effects of HMR 3339, a novel selective estrogen receptor modulator, on markers of coagulation and fibrinolysis...
  55. ncbi request reprint Effects of transdermal and oral postmenopausal hormone therapy on vascular function: a randomized, placebo-controlled study in healthy postmenopausal women
    Majoie Hemelaar
    Project Aging Women, Department of Obstetrics, VU University Medical Center Amsterdam, The Netherlands
    Menopause 12:526-35. 2005
    ....
  56. ncbi request reprint Breast cancer risk in postmenopausal women using testosterone in combination with hormone replacement therapy
    Johannes Bitzer
    University Women s Hospital Basel, Department of Gynecological Social Medicine and Psychosomatic, Spitalstrasse 21, 4031 Basel, Switzerland
    Maturitas 59:209-18. 2008
    ..The purpose of this study is to review the available clinical data on the impact of exogenous testosterone containing postmenopausal hormone therapy on breast cancer risk...
  57. ncbi request reprint Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review
    Majoie Hemelaar
    Project Aging Women and Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Fertil Steril 90:642-72. 2008
    ..Non-oral postmenopausal HT appears not to increase venous thromboembolic risk, whereas the effect on coronary heart disease risk is less clear...
  58. ncbi request reprint High level of MUC1 in serum of ovarian and breast cancer patients inhibits huHMFG-1 dependent cell-mediated cytotoxicity (ADCC)
    Maria Moreno
    Department of Obstetrics and Gynaecology, VU Universiteit Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cancer Lett 257:47-55. 2007
    ....
  59. ncbi request reprint Effects of a supplement containing isoflavones and Actaea racemosa L. on asymmetric dimethylarginine, lipids, and C-reactive protein in menopausal women
    Marieke O Verhoeven
    Department of Obstetrics and Gynecology, Project Aging Women, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Fertil Steril 87:849-57. 2007
    ..To investigate the effects of a supplement containing soy isoflavones and Actaea racemosa L. on several coronary heart disease (CHD) risk markers in menopausal women...
  60. ncbi request reprint Serum CA-125 in relation to adnexal dysplasia and cancer in women at hereditary high risk of ovarian cancer
    Brenda B J Hermsen
    Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 25:1383-9. 2007
    ..The aim of this study was to investigate whether CA-125 concentrations are indicative of adnexal dysplasia and cancer in women at hereditary high risk of ovarian/tubal cancer...
  61. ncbi request reprint Effects on asymmetric dimethylarginine of HMR 3339, a novel selective estrogen receptor modulator: a 12-week, randomized, placebo-controlled, double-blind, dose-ranging study in healthy postmenopausal women
    Marieke O Verhoeven
    Project Aging Women, Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Menopause 14:235-42. 2007
    ..To investigate the short-term effects of three different doses of the selective estrogen receptor modulator HMR 3339 in comparison with placebo and raloxifene on asymmetric dimethylarginine (ADMA), a nitric oxide synthase inhibitor...
  62. ncbi request reprint Effects of intranasal versus oral hormone therapy on asymmetric dimethylarginine in healthy postmenopausal women: a randomized study
    Marieke O Verhoeven
    Project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Atherosclerosis 195:181-8. 2007
    ..This study was conducted to compare the effect on ADMA between intranasal and oral 17beta-estradiol (E2) combined with norethisterone (acetate) (NET(A)) administration in postmenopausal women...
  63. ncbi request reprint Hemostatic markers in healthy postmenopausal women during intranasal and oral hormone therapy: a randomized trial
    Majoie Hemelaar
    Vrije Universiteit, Amsterdam, The Netherlands
    Menopause 15:248-55. 2008
    ..A wide range of markers of coagulation and fibrinolysis associated with coronary artery disease was tested...
  64. ncbi request reprint BRCA1 and p53 protein expression in cultured ovarian surface epithelial cells derived from women with and without a BRCA1 germline mutation
    Jurgen M J Piek
    Department of Obstetrics and Gynaecology, VU University Medical Center, De Boelelaan 1117, 1081HV, NH, Amsterdam, The Netherlands
    Arch Gynecol Obstet 274:327-31. 2006
    ..Therefore, we have assessed whether differences in the expression of BRCA1 and p53 proteins in cultured OSE cells could contribute to these observations...
  65. ncbi request reprint Less effect of intranasal than oral hormone therapy on factors associated with venous thrombosis risk in healthy postmenopausal women
    Majoie Hemelaar
    Project Aging Women and Institute for Cardiovascular Research Vrije Universiteit ICaR VU, Department of Obstetrics and Gynecology, VU University Medical Center, De Boelelaan 1117, 1081 HV, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 26:1660-6. 2006
    ....
  66. ncbi request reprint Low prevalence of (pre) malignant lesions in the breast and high prevalence in the ovary and Fallopian tube in women at hereditary high risk of breast and ovarian cancer
    Brenda B J Hermsen
    Department of Obstetrics and Gynaecology, VU University Medical Centre, Amsterdam, The Netherlands
    Int J Cancer 119:1412-8. 2006
    ..The high frequency of (pre) malignant lesions in the adnexal tissue stresses further the importance of pBSO from the age of 40 onwards in women at hereditary high risk...
  67. ncbi request reprint HMR 3339, a novel selective estrogen receptor modulator, reduces total cholesterol, low-density lipoprotein cholesterol, and homocysteine in healthy postmenopausal women
    Tatjana E Vogelvang
    Project Aging Women and the Department of Obstetrics and Gynecology, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Fertil Steril 82:1540-9. 2004
    ..To investigate the short-term effects of HMR 3339 in comparison with raloxifene and placebo on cardiovascular risk factors...
  68. ncbi request reprint Effects of oral and transdermal low-dose estrogen therapy on echocardiographic parameters of cardiac function
    Tatjana E Vogelvang
    Department of Obstetrics and Gynecology, The Project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Fertil Steril 80:546-53. 2003
    ..To investigate the effects of transdermal 17 beta-estradiol (E(2)) compared with oral unopposed as well as opposed E(2) on echocardiographic parameters of left ventricular (LV) systolic and diastolic function...
  69. ncbi request reprint Postmenopausal hormone therapy: impact on menopause-related symptoms, chronic disease and quality of life
    Marius Jan van der Mooren
    Department of Obstetrics and Gynecology, Project Aging Women, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Drugs 64:821-36. 2004
    ..Therefore, doctors involved in the care of climacteric women in the 21st century are much more able to meet the specific needs of individual patients and improve health and quality of life...
  70. ncbi request reprint Effects of low-dose oral and transdermal estrogen replacement therapy on hemostatic factors in healthy postmenopausal women: a randomized placebo-controlled study
    Marinka S Post
    Project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Am J Obstet Gynecol 189:1221-7. 2003
    ..This study was undertaken to investigate the effect of transdermal and oral estrogen replacement therapy in healthy postmenopausal women on markers of coagulation and fibrinolysis associated with coronary artery disease...
  71. ncbi request reprint Raloxifene reduces procarboxypeptidase U, an antifibrinolytic marker. A 2-year randomized, placebo-controlled study in healthy early postmenopausal women
    Tatjana E Vogelvang
    project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit ICaR VU Department of Obstetrics and Gynecology, Vrije University Medical Center, Amsterdam, The Netherlands
    Menopause 11:110-5. 2004
    ..The aim of this study was to compare the long-term effects of two dosages of raloxifene with oral hormone therapy (HT; conjugated equine estrogens combined with medroxyprogesterone acetate) on procarboxypeptidase U...
  72. ncbi request reprint Cellular and humoral responses after multiple injections of unconjugated chimeric monoclonal antibody MOv18 in ovarian cancer patients: a pilot study
    Iwona van Zanten-Przybysz
    Dept of Obstetrics and Gynaecology, Vrije Universiteit Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Cancer Res Clin Oncol 128:484-92. 2002
    ..Chimeric antibody MOv18 (c-MOv18) mediates antibody-dependent cellular cytotoxicity (ADCC) in vitro. To study the toxicity of c-MOv18 and its immunological effects, five ovarian cancer patients received intravenous injections for 4 weeks...
  73. ncbi request reprint Oral, more than transdermal, estrogen therapy improves lipids and lipoprotein(a) in postmenopausal women: a randomized, placebo-controlled study
    Majoie Hemelaar
    Project Ageing Women and the Institute for Cardiovascular Research, The Department of Obstetrics and Gynecology, VU Medical Center, Amsterdam, The Netherlands
    Menopause 10:550-8. 2003
    ..To assess the effects of low-dose oral and transdermal estrogen therapy on the lipid profile and lipoprotein(a) [Lp(a)] levels in healthy, postmenopausal women and to study the additional influence of gestodene administration...
  74. ncbi request reprint The effects of 17 beta-oestradiol plus dydrogesterone compared with conjugated equine oestrogens plus medroxyprogesterone acetate on lipids, apolipoproteins and lipoprotein(a)
    Alyde T de Kraker
    Project Ageing Women, Department of Obstetrics, Diakonessenhuis Utrecht, VU University Medical Center Amsterdam, The Netherlands
    Maturitas 49:253-63. 2004
    ..To compare the effects of 17 beta-oestradiol plus dydrogesterone with conjugated equine oestrogens plus medroxyprogesterone acetate on serum lipids, apolipoproteins and lipoprotein(a) in postmenopausal women...
  75. ncbi request reprint Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women
    Marinka S Post
    Project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, Amsterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 23:1116-21. 2003
    ....
  76. ncbi request reprint Laparoscopic detection of sentinel lymph nodes followed by lymph node dissection in patients with early stage cervical cancer
    Marrije R Buist
    Department of Obstetrics, Nuclear Medicine, and Pathology, VU Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Gynecol Oncol 90:290-6. 2003
    ..Furthermore, the results of laparoscopic pelvic lymph node dissection were studied, validated by subsequent laparotomy...
  77. ncbi request reprint The sentinel node in cervical cancer: scintigraphy and laparoscopic gamma probe-guided biopsy
    Rik Pijpers
    Department of Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 31:1479-86. 2004
    ..Based on SN histology, the treatment was altered in nine patients (26%). We conclude that laparoscopic SN biopsy is feasible in cervical cancer and may result in custom-designed treatment strategies with a reduction in morbidity...
  78. ncbi request reprint Our history
    Goran Samsioe
    Maturitas 42:S3-4. 2002
  79. ncbi request reprint Quality of life in breast cancer patients
    Peter Kenemans
    Gynecol Endocrinol 23:366-7. 2007
  80. ncbi request reprint The differential diagnostic potential of a panel of tumor markers (CA 125, CA 15-3, and CA 72-4 antigens) in patients with a pelvic mass
    Eltjo M J Schutter
    Department of Obstetrics and Gynecology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Am J Obstet Gynecol 187:385-92. 2002
    ..The purpose of this study was to assess the differential diagnostic potential of a combination of CA 125, CA 15-3, and CA 72-4 antigens in the definition of malignant disease, especially ovarian carcinoma in patients with a pelvic mass...
  81. ncbi request reprint 17 beta-Estradiol induces a rapid, endothelium-dependent, sex-specific vasodilatation in spontaneous constricted rat arterioles
    Ramon G V Smolders
    Project Aging Women, and the Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Am J Obstet Gynecol 187:375-81. 2002
    ..Our purpose was to resolve the apparent contradiction between the endothelium-dependent and endothelium-independent vasodilator effects of 17 beta-estradiol reported in different studies...
  82. doi request reprint A combination of serum tumor markers identifies high-risk patients with early-stage squamous cervical cancer
    Elvira M Davelaar
    Department of Obstetrics and Gynecology, Free University Medical Center, Amsterdam, The Netherlands
    Tumour Biol 29:9-17. 2008
    ..In conclusion, a combination of SCC-Ag and CYFRA 21-1 may help to identify early-stage cervical cancer patients with occult disease requiring adjuvant therapy...
  83. ncbi request reprint Expression of multidrug resistance-associated markers, their relation to quantitative pathologic tumour characteristics and prognosis in advanced ovarian cancer
    Mariël Brinkhuis
    Department of Pathology, Free University Medical Center, Amsterdam, The Netherlands
    Anal Cell Pathol 24:17-23. 2002
    ..Further studies are required to elucidate the biological background of the strong prognostic value of mean nuclear area in advanced ovarian cancer...
  84. ncbi request reprint Endometrial effects of tibolone in elderly, osteoporotic women
    Bruce Ettinger
    University of California, San Francisco, San Francisco, California, USA
    Obstet Gynecol 112:653-9. 2008
    ..To investigate endometrial effects of tibolone administered to postmenopausal women for 3 years...
  85. ncbi request reprint Neither long-term treatment with raloxifene nor hormone replacement therapy modulate cardiac function in healthy postmenopausal women: two randomized, placebo-controlled, 2-year studies
    Tatjana E Vogelvang
    Project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit ICaR VU, Department of Obstetrics and Gynecology, VU University Medical Centre, Amsterdam, The Netherlands
    Am J Obstet Gynecol 186:729-36. 2002
    ..A total of 157 women were studied in 2 randomized, double-blind, placebo-controlled, 2-year studies...
  86. ncbi request reprint Our history
    Goran Samsioe
    Maturitas 41:169-70. 2002
  87. ncbi request reprint A 2-year, randomized, comparative, placebo-controlled study on the effects of raloxifene on lipoprotein(a) and homocysteine
    Raimond G V Smolders
    Department of Obstetrics and Gynecology, Institute for Cardiovascular Research, VU University Medical Centre, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Maturitas 41:105-14. 2002
    ..In this 2-year study, the long-term effects of raloxifene (Rlx) in two doses, on Lp(a) and Hcy, were studied and compared with the effects of continuously combined hormone replacement therapy (ccHRT)...
  88. ncbi request reprint Effect of HMR 3339, a novel selective estrogen receptor modulator, on C-reactive protein levels in healthy postmenopausal women
    Tatjana E Vogelvang
    Project Aging Women and the Institute for Cardiovascular Research Vrije Universiteit ICaR VU, Amsterdam, The Netherlands
    Am J Cardiol 94:1205-8. 2004
    ..A dose-dependent reduction in C-reactive protein was observed, the largest reduction with HMR 3339 50 mg...
  89. ncbi request reprint BRCA1/2-related ovarian cancers are of tubal origin: a hypothesis
    Jurgen M J Piek
    Gynecol Oncol 90:491. 2003
  90. ncbi request reprint Effect of hormone replacement therapy on plasma levels of the cardiovascular risk factor asymmetric dimethylarginine: a randomized, placebo-controlled 12-week study in healthy early postmenopausal women
    Marinka S Post
    Project Aging Women and the Institute for Cardiovascular Research, Vrije Universiteit, Department of Obstetrics and Gynecology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 88:4221-6. 2003
    ..Whether the reduction of the NOS substrate arginine in the E(2)+T group counteracts the potentially beneficial effect of ADMA reduction or reflects increased NO production remains to be investigated...
  91. ncbi request reprint Endothelium-dependent dilatory effects of 3alpha-OH-tibolone in gracilis muscle arterioles of the female Wistar rat
    Iolente J M Korstjens
    Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands
    Menopause 12:340-7. 2005
    ..We investigated the direct vasodilatory effects of the major active tibolone metabolite 3alpha-OH-tibolone and its sulfated form on female rat skeletal muscle arterioles, which play an important role in the control of blood pressure...
  92. ncbi request reprint Lobulitis is a frequent finding in prophylactically removed breast tissue from women at hereditary high risk of breast cancer
    Brenda B J Hermsen
    Department of Obstetrics and Gynaecology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 206:220-3. 2005
    ..This novel finding implies an immune reaction to an as yet unidentified antigen frequently present in women at hereditary high risk of breast cancer, possibly as part of an early carcinogenic event...
  93. ncbi request reprint Women's health after WHI
    Peter Kenemans
    Maturitas 51:1-3. 2005
  94. ncbi request reprint Intraperitoneal serous adenocarcinoma: a critical appraisal of three hypotheses on its cause
    Jurgen M J Piek
    Department of Obstetrics and Gynecology, Vrije University Medical Center, Amsterdam, The Netherlands
    Am J Obstet Gynecol 191:718-32. 2004
    ..In 3 hypotheses, 3 possible tissues of origin are proposed: the ovarian surface epithelium, the Fallopian tube epithelium, and the secondary Mullerian system...
  95. ncbi request reprint Effect of a combination of isoflavones and Actaea racemosa Linnaeus on climacteric symptoms in healthy symptomatic perimenopausal women: a 12-week randomized, placebo-controlled, double-blind study
    Marieke O Verhoeven
    Project Ageing Women, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Menopause 12:412-20. 2005
    ..To investigate the effects of a novel dietary supplement containing soy isoflavones and Actaea racemosa Linnaeus (formerly called Cimicifuga racemosa L.) on climacteric symptoms in healthy perimenopausal women...
  96. ncbi request reprint Clinical and technical evaluation of the ACS:OV serum assay and comparison with three other CA125-detecting assays
    Elvira M Davelaar
    Department of Obstetrics and Gynaecology, Vrije Universiteit Medical Center, 1081 HV Amsterdam, The Netherlands
    Ann Clin Biochem 40:663-73. 2003
    ..In this study the clinical and technical performance of the CA125- detecting Bayer ACS:OV immunoluminometric serum assay was compared with three other well-established CA125-detecting assays...
  97. ncbi request reprint Tibolone: how does its mechanism of action translate into clinical effects
    Peter Kenemans
    Maturitas 48:S1-3. 2004
  98. ncbi request reprint Emerging selective estrogen receptor modulators: special focus on effects on coronary heart disease in postmenopausal women
    Tatjana Elène Vogelvang
    Department of Obstetrics and Gynecology, Project Aging Women, Institute for Cardiovascular Research Vrije Universiteit, VU University Medical Center, Amsterdam, The Netherlands
    Drugs 66:191-221. 2006
    ..Currently, limited data are available with regard to these next-generation SERMs and CHD. Nevertheless, some of these novel agents provide arguments for continuing the search for an ideal SERM...
  99. ncbi request reprint Cultures of ovarian surface epithelium from women with and without a hereditary predisposition to develop female adnexal carcinoma
    Jurgen M J Piek
    Department of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    Gynecol Oncol 92:819-26. 2004
    ..This study aims to detect differences in growth potential and morphology that are maintained or specifically expressed in vitro...
  100. ncbi request reprint Homocysteine impairs estrogen-induced vasodilation in isolated rat arterioles
    Raimond G V Smolders
    Aging Women Project, Institute for Cardiovascular Research, Vrije University, Amsterdam, The Netherland
    Menopause 11:98-103. 2004
    ..Moreover, homocysteine has also been shown to influence vasoreactivity. We investigated the influence of homocysteine on the rapid vasodilatory effects of estradiol in an isolated vessel setup...
  101. ncbi request reprint Histopathological characteristics of BRCA1- and BRCA2-associated intraperitoneal cancer: a clinic-based study
    Jurgen M J Piek
    Departments of Obstetrics and Gynaecology, VU University Medical Center, Amsterdam, The Netherlands
    Fam Cancer 2:73-8. 2003
    ..This suggests, therefore, that serous tumors may be the only subtype related to a BRCA1 or BRCA2 mutation. Furthermore, fallopian tube carcinoma occurred more often in BRCA mutation carriers than in the reference population...