J J M Hoozemans

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Curr Pharm Des 14:1419-27. 2008
  2. pmc Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease
    Piet Eikelenboom
    Valeriuskliniek, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Alzheimers Res Ther 4:15. 2012
  3. doi request reprint Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Biochem Cell Biol 44:1295-8. 2012
  4. pmc Microglia activation in sepsis: a case-control study
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neuroinflammation 4:4. 2007
  5. ncbi request reprint The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain Res 951:218-26. 2002
  6. ncbi request reprint Activation of the unfolded protein response in Parkinson's disease
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 354:707-11. 2007
  7. pmc The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus
    Jeroen J M Hoozemans
    VU University Medical Center, Department of Pathology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Pathol 174:1241-51. 2009
  8. ncbi request reprint Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    CNS Neurol Disord Drug Targets 10:57-67. 2011
  9. pmc Neuroinflammation in Alzheimer's disease wanes with age
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroinflammation 8:171. 2011
  10. ncbi request reprint Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
    Jeroen J M Hoozemans
    Department of Psychiatry, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 15:492-9. 2004

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Cyclooxygenase-1 and -2 in the different stages of Alzheimer's disease pathology
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Curr Pharm Des 14:1419-27. 2008
    ..Understanding the physiological and pathological role of cyclooxygenase in AD pathology may facilitate the design of therapeutics for the treatment or prevention of AD...
  2. pmc Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease
    Piet Eikelenboom
    Valeriuskliniek, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    Alzheimers Res Ther 4:15. 2012
    ..The view that peripheral inflammation can increase the risk of dementia in older people provides scope for prevention...
  3. doi request reprint Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Int J Biochem Cell Biol 44:1295-8. 2012
    ..Increased understanding of the crosstalk between signaling pathways involved in protein quality control in the ER and tau phosphorylation will support the development of new therapeutic targets that promote neuronal survival...
  4. pmc Microglia activation in sepsis: a case-control study
    Afina W Lemstra
    Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
    J Neuroinflammation 4:4. 2007
    ..The aim of this study was to investigate whether activation of microglia can be detected in patients who died of sepsis...
  5. ncbi request reprint The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain Res 951:218-26. 2002
    ....
  6. ncbi request reprint Activation of the unfolded protein response in Parkinson's disease
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Biochem Biophys Res Commun 354:707-11. 2007
    ..These data show that the UPR is activated in PD and that UPR activation is closely associated with the accumulation and aggregation of alpha-synuclein...
  7. pmc The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus
    Jeroen J M Hoozemans
    VU University Medical Center, Department of Pathology, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Am J Pathol 174:1241-51. 2009
    ....
  8. ncbi request reprint Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology
    J J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    CNS Neurol Disord Drug Targets 10:57-67. 2011
    ....
  9. pmc Neuroinflammation in Alzheimer's disease wanes with age
    Jeroen J M Hoozemans
    Department of Pathology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Neuroinflammation 8:171. 2011
    ..However, the age-dependent relationship between inflammation and clinical phenotype of AD has never been investigated...
  10. ncbi request reprint Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
    Jeroen J M Hoozemans
    Department of Psychiatry, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 15:492-9. 2004
    ..These results suggest that p38 MAPK does not mediate COX-2 expression and pRb inactivation, which are involved in cellular changes in pyramidal neurons early in AD pathogenesis...
  11. ncbi request reprint Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Curr Drug Targets 4:461-8. 2003
    ..Understanding the role of COX in AD pathogenesis could contribute to the development of an anti-inflammatory therapy for the treatment or prevention of AD...
  12. ncbi request reprint The pathological cascade of Alzheimer's disease: the role of inflammation and its therapeutic implications
    Jeroen J M Hoozemans
    Department of Pathology, Graduate School of Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit, VU University Medical Center, The Netherlands
    Drugs Today (Barc) 38:429-43. 2002
    ..This review will outline several pathological mechanisms in Alzheimer's disease as well as some means of therapeutic intervention following the amyloid cascade hypothesis...
  13. ncbi request reprint The unfolded protein response is activated in Alzheimer's disease
    J J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, University of Amsterdam, P O Box 22660, 1100 DD, Amsterdam, The Netherlands
    Acta Neuropathol 110:165-72. 2005
    ..Although the initial participation of the UPR in AD pathogenesis might be neuroprotective, sustained activation of the UPR in AD might initiate or mediate neurodegeneration...
  14. ncbi request reprint Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress
    W Scheper
    Neurogenetics Laboratory, Academic Medical Center, Amsterdam, The Netherlands
    Neuropathol Appl Neurobiol 33:523-32. 2007
    ..Our data suggest that ER and post-ER protein quality control mechanisms are activated early in the pathology of AD...
  15. ncbi request reprint Neuroinflammation in Alzheimer's disease and prion disease
    P Eikelenboom
    Department of Psychiatry, Graduate School of Neurosciences, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Glia 40:232-9. 2002
    ....
  16. pmc Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease
    D A T Nijholt
    Department of Genome Analysis, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Cell Death Differ 18:1071-81. 2011
    ..Our data suggest that autophagy is the major degradational pathway following UPR activation in neuronal cells and indicate a connection between UPR activation and autophagic pathology in AD brain...
  17. ncbi request reprint The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis
    Jeroen J M Hoozemans
    Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Gerontol 41:380-6. 2006
    ..These data suggest that activation of the UPR affects cell cycle protein expression in neurons during neurodegeneration in AD...
  18. doi request reprint Quantification of amyloid-beta 40 in cerebrospinal fluid
    Nicolaas A Verwey
    Department of Neurology, VU University Medical Center, Alzheimer Center Amsterdam, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Immunol Methods 348:57-66. 2009
    ..Reliable methods to detect these biomarkers in CSF are of great importance for understanding the disease mechanisms and for diagnostic purposes...
  19. doi request reprint Presence of tissue transglutaminase in granular endoplasmic reticulum is characteristic of melanized neurons in Parkinson's disease brain
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center, The Netherlands
    Brain Pathol 21:130-9. 2011
    ..Moreover, as also α-synuclein aggregates were observed in tTG granule positive neurons, these results provide a clue to the cellular site of interaction between α-synuclein and tTG...
  20. doi request reprint Transglutaminases and transglutaminase-catalyzed cross-links colocalize with the pathological lesions in Alzheimer's disease brain
    Micha M M Wilhelmus
    Department of Anatomy and Neurosciences, Institute for Clinical and Experimental Neurosciences, VU University Medical Center, Amsterdam, The Netherlands
    Brain Pathol 19:612-22. 2009
    ..We conclude that these TGs demonstrate cross-linking activity in AD lesions, which suggests that both TG1 and TG2 are likely involved in the protein aggregation processes underlying the formation of SPs, CAA and/or NFTs in AD brain...
  21. ncbi request reprint Adult human microglia secrete cytokines when exposed to neurotoxic prion protein peptide: no intermediary role for prostaglandin E2
    Robert Veerhuis
    Research Institute Neurosciences Vrije Universiteit, Department of Psychiatry, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Brain Res 925:195-203. 2002
    ..Furthermore, PrP105-132 did not stimulate microglial PGE(2) synthesis. We conclude that, unlike IL-1beta-induced IL-6 synthesis in astrocytes, the PrP-induced IL-6 synthesis in human adult microglia is not PGE2 mediated...
  22. ncbi request reprint Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q
    Robert Veerhuis
    Institute for Clinical and Experimental Neurosciences VU ICEN VU, Department of Psychiatry, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands
    Neurobiol Dis 19:273-82. 2005
    ..Combined, ultrastructural and thioflavin assays, together with microglial cytokine release measurements, provide a test system to screen potential, fibrillarity impeding therapeutics for prion disease...
  23. doi request reprint Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implications
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 5:190-3. 2008
    ..The cerebral beta-amyloid (Abeta) disorders show a great variability in the distribution of parenchymal and vascular amyloid deposits...
  24. ncbi request reprint Cyclin D1 and cyclin E are co-localized with cyclo-oxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
    Jeroen J M Hoozemans
    Graduate School Neurosciences Amsterdam, Research Institute Neurosciences, Vrije Universiteit, Department of Pathology, VU University Medical Center, The Netherlands
    J Neuropathol Exp Neurol 61:678-88. 2002
    ..Our findings suggest a relationship between the neuronal expression of COX-2 and cell cycle markers, which may be involved early in AD pathology...
  25. ncbi request reprint Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner
    Sidhartha M Chafekar
    Neurogenetics Laboratory, University of Amsterdam, Amsterdam, The Netherlands
    Antioxid Redox Signal 9:2245-54. 2007
    ..Because UPR activation is observed in AD brain at a stage that precedes the massive fibrillar Abeta deposition and tangle formation, this may indicate a role for nonfibrillar Abeta in the induction of the UPR in AD neurons...
  26. doi request reprint Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease
    Piet Eikelenboom
    Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neurodegener Dis 7:38-41. 2010
    ..Objectives: To show that the interest in inflammation in Alzheimer's disease (AD) is not only an early event in the history of AD but that inflammation is also an early event in the pathogenesis of AD...
  27. ncbi request reprint The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs
    Jeroen J M Hoozemans
    Neurogenetics Laboratory, Academic Medical Center, 1100 DE Amsterdam, The Netherlands
    Curr Drug Targets CNS Neurol Disord 4:307-15. 2005
    ..Understanding the pathological, physiological and neuroprotective role of cyclooxygenase will contribute to the development of a therapy for the treatment or prevention of AD...
  28. ncbi request reprint The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death
    Agata Copani
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Biochim Biophys Acta 1772:409-12. 2007
    ..The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders...
  29. doi request reprint Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity
    Giuseppe Pollio
    Siena Biotech SpA, Discovery Research, Via Fiorentina 1, 53100 Siena, Italy
    Neurobiol Dis 31:145-58. 2008
    ....
  30. ncbi request reprint Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes
    Michael Hull
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Hauptstrasse 5, D 79104 Freiburg, Germany
    Neurochem Int 48:663-72. 2006
    ..The potential role of astroglial cells in the phagocytosis of amyloid and the involvement of PGs in this process suggests that a modulation of PGs synthesis may be a putative target in the prevention of amyloid deposition...
  31. ncbi request reprint DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid
    Agata Copani
    Department of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
    J Neurosci 26:10949-57. 2006
    ..Accordingly, by investigating the neuronal expression of DNA pol-beta, along with phosphorylated retinoblastoma protein and neurofibrillary changes in AD brain, we show an early involvement of DNA pol-beta in the pathogenesis of AD...
  32. ncbi request reprint Pin1 levels are downregulated during ER stress in human neuroblastoma cells
    Yolanda S Kap
    Neurogenetics Laboratory, Academic Medical Center, PO Box 22700, Amsterdam, 1100 DE, The Netherlands
    Neurogenetics 8:21-7. 2007
    ..This study creates a starting point to investigate whether modulation of the ER stress response may prevent or delay tau pathology in AD...
  33. ncbi request reprint Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB
    Anne Waschbisch
    Department of Psychiatry, University of Freiburg Medical School, Freiburg, Germany
    J Neurochem 96:680-93. 2006
    ....