Jan Hendrik Hooijberg

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells
    Yehuda G Assaraf
    Department of Biology, The Technion, Haifa 32000, Israel
    J Biol Chem 278:6680-6. 2003
  2. ncbi request reprint The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis
    Jan Hendrik Hooijberg
    Department of Pediatric Hematology Oncology, VU University Medical Center VUmc, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Biochem Pharmacol 65:765-71. 2003
  3. ncbi request reprint Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1)
    Jan Hendrik Hooijberg
    Department of Pediatric Hematology Oncology, VU University Medical Center VUmc, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Biochem Pharmacol 67:1541-8. 2004
  4. ncbi request reprint Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis
    Ilan Ifergan
    Department of Biology, The Technion, Haifa 32000, Israel
    J Biol Chem 279:25527-34. 2004
  5. ncbi request reprint The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates
    Peter Wielinga
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 65:4425-30. 2005
  6. ncbi request reprint Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia
    Robert de Jonge
    Department of Clinical Chemistry and Pediatric Oncology Hematology, Erasmus MC, Rm L 102, POB 2040, 3000 CA Rotterdam, The Netherlands
    Blood 106:717-20. 2005

Collaborators

  • Godefridus J Peters
  • Yehuda G Assaraf
  • G Jansen
  • P Borst
  • Peter Wielinga
  • Robert de Jonge
  • Ilan Ifergan
  • Yaddanapudi Ravindranath
  • Rob Pieters
  • Christina H van Zantwijk
  • Christine H van Zantwijk
  • Bertrand D van Zelst
  • Marcel de Haas
  • Glen Reid
  • Gertjan Kaspers
  • Ingrid van der Heijden
  • Jan Wijnholds
  • Gertjan J L Kaspers
  • Ietje Kathmann
  • Noam Zelcer
  • Gert Jan L Kaspers
  • Frits G J Peters
  • Kasper van der Born
  • Sjofn Gunnarsdottir
  • Jan Lindemans
  • Assaf Shafran
  • George L Scheffer

Detail Information

Publications6

  1. ncbi request reprint Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells
    Yehuda G Assaraf
    Department of Biology, The Technion, Haifa 32000, Israel
    J Biol Chem 278:6680-6. 2003
    ..These findings suggest a functional role for MRP1 in the maintenance of cellular folate homeostasis...
  2. ncbi request reprint The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis
    Jan Hendrik Hooijberg
    Department of Pediatric Hematology Oncology, VU University Medical Center VUmc, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Biochem Pharmacol 65:765-71. 2003
    ..These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated...
  3. ncbi request reprint Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1)
    Jan Hendrik Hooijberg
    Department of Pediatric Hematology Oncology, VU University Medical Center VUmc, De Boelelaan 1117, 1007 MB, Amsterdam, The Netherlands
    Biochem Pharmacol 67:1541-8. 2004
    ..These results have potentially important implications in the understanding of the (patho-)physiological roles of MRP1/ABCC1, and possibly other ABC transporter proteins in cellular folate homeostasis and drug resistance...
  4. ncbi request reprint Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis
    Ilan Ifergan
    Department of Biology, The Technion, Haifa 32000, Israel
    J Biol Chem 279:25527-34. 2004
    ..This is the first evidence for the possible role of BCRP in the maintenance of cellular folate homeostasis...
  5. ncbi request reprint The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates
    Peter Wielinga
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 65:4425-30. 2005
    ..These results show the potential of MRP5 to mediate transport of (anti)folates and contribute to resistance against antifolate drugs...
  6. ncbi request reprint Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia
    Robert de Jonge
    Department of Clinical Chemistry and Pediatric Oncology Hematology, Erasmus MC, Rm L 102, POB 2040, 3000 CA Rotterdam, The Netherlands
    Blood 106:717-20. 2005
    ..SHMT1 1420TT homozygotes only showed decreased MTX sensitivity in the TSI(50, cont). In conclusion, polymorphisms in the folate-related genes MTHFR, MTRR, and SHMT1 are related to MTX resistance in pediatric patients with ALL...