Sonja I Gringhuis

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. pmc Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
    Mol Cell Biol 25:6454-63. 2005
  2. ncbi request reprint DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Postbus 7057, 1007MB Amsterdam, The Netherlands
    Mol Immunol 45:2359-69. 2008
  3. doi request reprint Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
    Nat Immunol 10:203-13. 2009
  4. doi request reprint Innate signaling by the C-type lectin DC-SIGN dictates immune responses
    Jeroen den Dunnen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
    Cancer Immunol Immunother 58:1149-57. 2009
  5. ncbi request reprint Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genes
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    J Cell Physiol 206:203-10. 2006
  6. doi request reprint Pathogen recognition by DC-SIGN shapes adaptive immunity
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MC Amsterdam, The Netherlands
    Future Microbiol 4:879-90. 2009
  7. ncbi request reprint Gene expression analysis of glycosylation-related genes by real-time polymerase chain reaction
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, Free University Medical Center, Amsterdam, The Netherlands
    Methods Mol Biol 347:187-209. 2006
  8. pmc Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cells
    Johanna G I van Rietschoten
    Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Rm 7341, Los Angeles, CA 90089 9181, USA
    Blood 108:2143-9. 2006
  9. ncbi request reprint Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilization
    Juan Jesús García-Vallejo
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands
    J Biol Chem 280:12676-82. 2005
  10. ncbi request reprint C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007

Collaborators

Detail Information

Publications17

  1. pmc Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
    Mol Cell Biol 25:6454-63. 2005
    ..Thus, a key mechanism regulating mRNA binding and function of the destabilizing AUBP TTP involves the phosphorylation status of 14-3-3beta...
  2. ncbi request reprint DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Postbus 7057, 1007MB Amsterdam, The Netherlands
    Mol Immunol 45:2359-69. 2008
    ..The identification of Le(Y) as the carbohydrate ligand of DC-SIGN in endothelial cells opens new possibilities for the manipulation of DC migration...
  3. doi request reprint Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
    Nat Immunol 10:203-13. 2009
    ..Thus, dectin-1 activates two independent signaling pathways, one through Syk and one through Raf-1, to induce immune responses...
  4. doi request reprint Innate signaling by the C-type lectin DC-SIGN dictates immune responses
    Jeroen den Dunnen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
    Cancer Immunol Immunother 58:1149-57. 2009
    ..In this review we will discuss in detail the current knowledge about DC-SIGN signaling and its implications on immunity...
  5. ncbi request reprint Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genes
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
    J Cell Physiol 206:203-10. 2006
    ....
  6. doi request reprint Pathogen recognition by DC-SIGN shapes adaptive immunity
    Teunis B H Geijtenbeek
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MC Amsterdam, The Netherlands
    Future Microbiol 4:879-90. 2009
    ..In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens...
  7. ncbi request reprint Gene expression analysis of glycosylation-related genes by real-time polymerase chain reaction
    Juan J Garcia-Vallejo
    Department of Molecular Cell Biology and Immunology, Free University Medical Center, Amsterdam, The Netherlands
    Methods Mol Biol 347:187-209. 2006
    ....
  8. pmc Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cells
    Johanna G I van Rietschoten
    Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Rm 7341, Los Angeles, CA 90089 9181, USA
    Blood 108:2143-9. 2006
    ..Taken together, these results suggest that allele-specific expression of IL-1alpha in CD4+ cells is achieved, at least in part, by differential methylation of the promoter...
  9. ncbi request reprint Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilization
    Juan Jesús García-Vallejo
    Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands
    J Biol Chem 280:12676-82. 2005
    ..These data strongly demonstrate that TNFalpha modulates the glycosylation of endothelial cells by a mechanism that directly enhances the stability of beta4GalT-1 mRNA transcripts...
  10. ncbi request reprint C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB
    Sonja I Gringhuis
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Immunity 26:605-16. 2007
    ..Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens...
  11. ncbi request reprint Innate signaling and regulation of Dendritic cell immunity
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
    Curr Opin Immunol 19:435-40. 2007
    ..Notably, members within one family of PRRs can trigger opposite signalling features, indicating that the ultimate outcome of pathogen-induced immune responses depends on the pathogen signature and the collective PRRs involved...
  12. pmc TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo
    Marein A W P de Jong
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    J Clin Invest 118:3440-52. 2008
    ..Our data demonstrate a decisive role for LCs in HIV-1 transmission during genital coinfections and suggest antiinflammatory therapies as potential strategies to prevent HIV-1 transmission...
  13. ncbi request reprint Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45
    Sandra J van Vliet
    Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands
    Nat Immunol 7:1200-8. 2006
    ..Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases...
  14. ncbi request reprint Oxidants and tyrosine phosphorylation: role of acute and chronic oxidative stress in T-and B-lymphocyte signaling
    Cornelis L Verweij
    Department of Molecular and Cellular Biology, VU Medical Center, Amsterdam, The Netherlands
    Antioxid Redox Signal 4:543-51. 2002
    ..In this report, the redox regulation of signaling involving protein tyrosine kinase activity, in particular in T- and B-lymphocyte signaling, is reviewed...
  15. ncbi request reprint Linker for activation of T cells: sensing redox imbalance
    Sonja I Gringhuis
    Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Methods Enzymol 352:248-57. 2002
  16. pmc Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization
    Joppe W R Hovius
    Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
    PLoS Pathog 4:e31. 2008
    ..Insight into the molecular mechanism of immunosuppression by tick salivary proteins might provide innovative strategies to combat Lyme disease and could lead to the development of novel anti-inflammatory or immunosuppressive agents...
  17. pmc Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways
    Sonja I Gringhuis
    Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 22:400-11. 2002
    ..Conclusively, the data suggest a role for LAT as a crucial intermediate in the sensitivity of TCR signaling and hence T lymphocytes toward chronic oxidative stress...