Research Topics
Genomes and Genes | Sonja I GringhuisSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolinSonja I Gringhuis
Department of Molecular Cell Biology and Immunology, VU Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
Mol Cell Biol 25:6454-63. 2005..Thus, a key mechanism regulating mRNA binding and function of the destabilizing AUBP TTP involves the phosphorylation status of 14-3-3beta...
DC-SIGN mediates adhesion and rolling of dendritic cells on primary human umbilical vein endothelial cells through LewisY antigen expressed on ICAM-2Juan J Garcia-Vallejo
Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Postbus 7057, 1007MB Amsterdam, The Netherlands
Mol Immunol 45:2359-69. 2008..The identification of Le(Y) as the carbohydrate ligand of DC-SIGN in endothelial cells opens new possibilities for the manipulation of DC migration...
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and SykSonja I Gringhuis
Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, 1007 MC Amsterdam, The Netherlands
Nat Immunol 10:203-13. 2009..Thus, dectin-1 activates two independent signaling pathways, one through Syk and one through Raf-1, to induce immune responses...- Innate signaling by the C-type lectin DC-SIGN dictates immune responsesJeroen den Dunnen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, P O Box 7057, 1007 MC Amsterdam, The Netherlands
Cancer Immunol Immunother 58:1149-57. 2009..In this review we will discuss in detail the current knowledge about DC-SIGN signaling and its implications on immunity... - Activation of human endothelial cells by tumor necrosis factor-alpha results in profound changes in the expression of glycosylation-related genesJuan J Garcia-Vallejo
Department of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam, The Netherlands
J Cell Physiol 206:203-10. 2006.... - Gene expression analysis of glycosylation-related genes by real-time polymerase chain reactionJuan J Garcia-Vallejo
Department of Molecular Cell Biology and Immunology, Free University Medical Center, Amsterdam, The Netherlands
Methods Mol Biol 347:187-209. 2006.... - Pathogen recognition by DC-SIGN shapes adaptive immunityTeunis B H Geijtenbeek
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MC Amsterdam, The Netherlands
Future Microbiol 4:879-90. 2009..In this article, we will discuss the signaling pathways induced by DC-SIGN and its central role in the regulation of adaptive immunity to bacterial, fungal and viral pathogens... - Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilizationJuan Jesús García-Vallejo
Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical Centre, 1007 MB Amsterdam, The Netherlands
J Biol Chem 280:12676-82. 2005..These data strongly demonstrate that TNFalpha modulates the glycosylation of endothelial cells by a mechanism that directly enhances the stability of beta4GalT-1 mRNA transcripts... - Differentially methylated alleles in a distinct region of the human interleukin-1alpha promoter are associated with allele-specific expression of IL-1alpha in CD4+ T cellsJohanna G I van Rietschoten
Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, Rm 7341, Los Angeles, CA 90089 9181, USA
Blood 108:2143-9. 2006..Taken together, these results suggest that allele-specific expression of IL-1alpha in CD4+ cells is achieved, at least in part, by differential methylation of the promoter... - C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaBSonja I Gringhuis
Department of Molecular Cell Biology and Immunology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
Immunity 26:605-16. 2007..Thus, this pathway is involved in regulation of adaptive immunity by DCs to bacterial, fungal, and viral pathogens... - Innate signaling and regulation of Dendritic cell immunitySandra J van Vliet
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands
Curr Opin Immunol 19:435-40. 2007..Notably, members within one family of PRRs can trigger opposite signalling features, indicating that the ultimate outcome of pathogen-induced immune responses depends on the pathogen signature and the collective PRRs involved... - TNF-alpha and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivoMarein A W P de Jong
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
J Clin Invest 118:3440-52. 2008..Our data demonstrate a decisive role for LCs in HIV-1 transmission during genital coinfections and suggest antiinflammatory therapies as potential strategies to prevent HIV-1 transmission... - Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45Sandra J van Vliet
Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands
Nat Immunol 7:1200-8. 2006..Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases... - Oxidants and tyrosine phosphorylation: role of acute and chronic oxidative stress in T-and B-lymphocyte signalingCornelis L Verweij
Department of Molecular and Cellular Biology, VU Medical Center, Amsterdam, The Netherlands
Antioxid Redox Signal 4:543-51. 2002..In this report, the redox regulation of signaling involving protein tyrosine kinase activity, in particular in T- and B-lymphocyte signaling, is reviewed... - Linker for activation of T cells: sensing redox imbalanceSonja I Gringhuis
Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Methods Enzymol 352:248-57. 2002 - Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilizationJoppe W R Hovius
Center for Experimental and Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands
PLoS Pathog 4:e31. 2008..Insight into the molecular mechanism of immunosuppression by tick salivary proteins might provide innovative strategies to combat Lyme disease and could lead to the development of novel anti-inflammatory or immunosuppressive agents... - Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathwaysSonja I Gringhuis
Department of Rheumatology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
Mol Cell Biol 22:400-11. 2002..Conclusively, the data suggest a role for LAT as a crucial intermediate in the sensitivity of TCR signaling and hence T lymphocytes toward chronic oxidative stress...