L J G Gooren

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Diagnostic approach to the aging male
    Louis J G Gooren
    Department of Endocrinology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    World J Urol 20:17-22. 2002
  2. ncbi request reprint Recent insights into androgen action on the anatomical and physiological substrate of penile erection
    Louis J G Gooren
    Department of Endocrinology, Andrology Section, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Asian J Androl 8:3-9. 2006
  3. ncbi request reprint Transsexuals and competitive sports
    Louis J G Gooren
    Department of Endocrinology, Section of Andrology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 151:425-9. 2004
  4. ncbi request reprint Androgen replacement therapy: present and future
    Louis J G Gooren
    Department of Endocrinology, Section of Andrology, VU University Medical Center, Amsterdam, The Netherlands
    Drugs 64:1861-91. 2004
  5. ncbi request reprint Transdermal testosterone delivery: testosterone patch and gel
    Louis J G Gooren
    Section of Andrology, Department of Endocrinology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Urol 21:316-9. 2003
  6. ncbi request reprint New long-acting androgens
    Louis J Gooren
    Department of Endocrinology, Section of Andrology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Urol 21:306-10. 2003
  7. ncbi request reprint Androgen deficiency in the aging male: benefits and risks of androgen supplementation
    Louis Gooren
    Department of Endocrinology, Vrije Universiteit Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Steroid Biochem Mol Biol 85:349-55. 2003
  8. ncbi request reprint Significance of oestrogens in male (patho)physiology
    L J G Gooren
    Department of Endocrinology, section Andrologie, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Endocrinol (Paris) 64:126-35. 2003
  9. ncbi request reprint Hormone treatment of the adult transsexual patient
    Louis Gooren
    Department of Endocrinology, VU Medical Center, Amsterdam, The Netherlands
    Horm Res 64:31-6. 2005
  10. ncbi request reprint Androgens and male behavior
    Louis J G Gooren
    Department of Endocrinology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Cell Endocrinol 198:31-40. 2002

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Diagnostic approach to the aging male
    Louis J G Gooren
    Department of Endocrinology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    World J Urol 20:17-22. 2002
    ..Of great importance is the need to raise awareness in aging men of the possibilities modern medicine offers to improve quality of life, and to encourage these men to utilize them for their benefit...
  2. ncbi request reprint Recent insights into androgen action on the anatomical and physiological substrate of penile erection
    Louis J G Gooren
    Department of Endocrinology, Andrology Section, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Asian J Androl 8:3-9. 2006
    ..The above invites a re-examination of the merits of giving testosterone to aging men with ED. The beneficial effects of PDE5 inhibitors may only be optimally expressed in a eugonadal environment...
  3. ncbi request reprint Transsexuals and competitive sports
    Louis J G Gooren
    Department of Endocrinology, Section of Andrology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 151:425-9. 2004
    ....
  4. ncbi request reprint Androgen replacement therapy: present and future
    Louis J G Gooren
    Department of Endocrinology, Section of Andrology, VU University Medical Center, Amsterdam, The Netherlands
    Drugs 64:1861-91. 2004
    ..With increasing age the risk of adverse effects on the prostate, the cardiovascular system and erythropoiesis increases. Consequently, short-acting testosterone preparations are better suited for aging androgen-deficient men...
  5. ncbi request reprint Transdermal testosterone delivery: testosterone patch and gel
    Louis J G Gooren
    Section of Andrology, Department of Endocrinology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Urol 21:316-9. 2003
    ..In conclusion, both the testosterone patch and testosterone gel are valuable contributions to androgen replacement treatment meeting the requirements specified for testosterone replacement treatment...
  6. ncbi request reprint New long-acting androgens
    Louis J Gooren
    Department of Endocrinology, Section of Andrology, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    World J Urol 21:306-10. 2003
    ..This method requires minor surgery. Injectable testosterone undecanoate maintains plasma testosterone in the normal range for 12 weeks...
  7. ncbi request reprint Androgen deficiency in the aging male: benefits and risks of androgen supplementation
    Louis Gooren
    Department of Endocrinology, Vrije Universiteit Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    J Steroid Biochem Mol Biol 85:349-55. 2003
    ..It seems a defensible practice to treat aging men with androgens if and when they are testosterone-deficient, but long-term studies including sufficient numbers of men are needed...
  8. ncbi request reprint Significance of oestrogens in male (patho)physiology
    L J G Gooren
    Department of Endocrinology, section Andrologie, Vrije Universiteit Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Endocrinol (Paris) 64:126-35. 2003
    ..Sources of estrogens in men are endogenous androgens, or in case of androgen deficiency, exogenous androgens. Dietary phytoestrogens or selective estrogen receptor modulators, as drugs, may be significant as well...
  9. ncbi request reprint Hormone treatment of the adult transsexual patient
    Louis Gooren
    Department of Endocrinology, VU Medical Center, Amsterdam, The Netherlands
    Horm Res 64:31-6. 2005
    ..The principal hormonal treatment is a testosterone preparation. Hormone-dependent tumours have been encountered and surveillance is necessary...
  10. ncbi request reprint Androgens and male behavior
    Louis J G Gooren
    Department of Endocrinology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Mol Cell Endocrinol 198:31-40. 2002
    ..But clinical observations show compellingly that other, largely unidentified, factors may modulate, or even override the effects of androgens...
  11. ncbi request reprint Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people
    A W F T Toorians
    Departments of Endocrinology Andrology, Vrije Universiteit University Medical Center, 1007 MB Amsterdam, The Netherlands
    J Clin Endocrinol Metab 88:5723-9. 2003
    ..Testosterone administration to female-to-male transsexuals had an antithrombotic effect...
  12. ncbi request reprint [Some new aspects of the Klinefelter syndrome]
    L J G Gooren
    VU Medisch Centrum, Afd Endocrinologie, De Boelelaan III7, 108I HV Amsterdam
    Ned Tijdschr Geneeskd 150:2693-6. 2006
    ..New reproductive techniques no longer automatically mean that men with KS will remain infertile. Treatment with testosterone is in principle life-long to prevent osteoporosis and loss of muscle mass and strength...
  13. ncbi request reprint Established risk factors for coronary heart disease are unrelated to androgen-induced baldness in female-to-male transsexuals
    E J Giltay
    Department of Endocrinology, Andrology Unit, Vrije University Medical Center, Amsterdam, The Netherlands
    J Endocrinol 180:107-12. 2004
    ..Therefore, our findings do not support the idea that MPB serves as an indicator of increased CHD risk through androgenic effects on classic CHD risk factors...
  14. ncbi request reprint Calculation of bioavailable and free testosterone in men: a comparison of 5 published algorithms
    Willem de Ronde
    Department of Endocrinology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Clin Chem 52:1777-84. 2006
    ..Estimation of serum concentrations of free testosterone (FT) and bioavailable testosterone (bioT) by calculation is an inexpensive and uncomplicated method. We compared results obtained with 5 different algorithms...
  15. ncbi request reprint Effect of testosterone administration on serum and urine kallikrein concentrations in female-to-male transsexuals
    Margrita H Slagter
    Department of Endocrinology, Vrije Universiteit University Medical Centre, Amsterdam, The Netherlands, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Chem 52:1546-51. 2006
    ..To gain insight into in vivo kallikrein regulation we measured kallikrein concentrations in serum and urinary tissue in female-to-male transsexuals before and after testosterone administration...
  16. ncbi request reprint Serum and urine tissue kallikrein concentrations in male-to-female transsexuals treated with antiandrogens and estrogens
    Margrita H Slagter
    Department of Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Chem 52:1356-65. 2006
    ..Our purpose was to examine serum and urinary tissue kallikrein concentration changes in male-to-female transsexuals before and after treatment with antiandrogens and estrogens...
  17. ncbi request reprint Effects of long-term androgen administration on breast tissue of female-to-male transsexuals
    Margrita H Slagter
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada
    J Histochem Cytochem 54:905-10. 2006
    ..These changes are similar to those observed at the end-stage of menopausal mammary involution...
  18. ncbi request reprint The effects of the aromatase inhibitor anastrozole on bone metabolism and cardiovascular risk indices in ovariectomized, androgen-treated female-to-male transsexuals
    Mathijs C M Bunck
    Department of Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Endocrinol 154:569-75. 2006
    ..The aim of this study was to investigate the effects of estrogen deprivation on bone metabolism and vascular parameters without the interference of counter-regulatory effects as seen in eugonadal men...
  19. ncbi request reprint Transgender feminization of the facial skeleton
    Alfred G Becking
    Department of Oral and Maxillofacial Surgery and Oral Pathology, Vrije Universiteit University Medical Center and Academic Center for Dentistry, Amsterdam, The Netherlands
    Clin Plast Surg 34:557-64. 2007
    ....
  20. ncbi request reprint The sex difference of plasma homovanillic acid is unaffected by cross-sex hormone administration in transsexual subjects
    Erik J Giltay
    Geestelijke Gezondheidszorg Delfland, Institute of Mental Health, PO Box 5016, 2600 GA Delft, The Netherlands
    J Endocrinol 187:109-16. 2005
    ....
  21. ncbi request reprint Psychological consequences
    Louis J G Gooren
    Department of Endocrinology Andrology, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Semin Reprod Med 20:285-96. 2002
    ..Children in this predicament must receive guidance well into adulthood. It may be difficult to engage in sexual relations when the anatomy of the genitalia (often operated upon) is not fully normal...
  22. ncbi request reprint Organizing and activating effects of sex hormones in homosexual transsexuals
    Stephanie H M van Goozen
    Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands
    Behav Neurosci 116:982-8. 2002
    ..Homosexual transsexuals, who prior to hormone treatment scored in the direction of the opposite sex, may have reached a ceiling in performance and therefore do not benefit from activating hormonal effects...
  23. ncbi request reprint Effects of sex steroids on components of the insulin resistance syndrome in transsexual subjects
    Jolanda M H Elbers
    Department of Endocrinology, Andrology Unit, Wageningen University, The Netherlands
    Clin Endocrinol (Oxf) 58:562-71. 2003
    ..These differences are attributed to sex-specific sex steroid profiles, but the effects of sex steroids on the individual components of the insulin resistance syndrome remain incompletely understood...
  24. ncbi request reprint Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals
    Erik J Giltay
    Department of Human Nutrition and Epidemiology, Wageningen University, P O Box 8129, Netherlands
    Atherosclerosis 168:139-46. 2003
    ..Thus, oral and transdermal estrogens decrease plasma tHcy to a similar degree (by geometric mean -26%), which suggests that a hepatic mechanism is unlikely to play an important role in the decline of tHcy levels...
  25. ncbi request reprint Associations of sex-hormone-binding globulin (SHBG) with non-SHBG-bound levels of testosterone and estradiol in independently living men
    Willem de Ronde
    Department of Internal Medicine, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:157-62. 2005
    ..Therefore, we conclude that in eugonadal men, higher SHBG levels are associated with lower levels of non-SHBG-E2 but slightly higher levels of non-SHBG-T. This means that SHBG cannot be regarded as an estrogen amplifier in eugonadal men...
  26. ncbi request reprint Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects
    Erik J Giltay
    Psychiatric Center GGZ Delfland, Delft, Netherlands
    Am J Clin Nutr 80:1167-74. 2004
    ..During pregnancy there is a high demand for docosahexaenoic acid (DHA), which is needed for formation of the fetal brain. Women who do not consume marine foods must synthesize DHA from fatty acid precursors in vegetable foods...
  27. ncbi request reprint Serum levels of sex hormone-binding globulin (SHBG) are not associated with lower levels of non-SHBG-bound testosterone in male newborns and healthy adult men
    Willem de Ronde
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 62:498-503. 2005
    ..In in vitro experiments increased levels of SHBG will be associated with decreased levels of non-SHBG bound testosterone (non-SHBG-T). However, in vivo SHBG can alter both production and clearance rates and thus plasma levels of T...
  28. ncbi request reprint The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women
    Laura A Schaap
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Clin Endocrinol (Oxf) 63:152-60. 2005
    ..The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population-based sample of older men and women...
  29. ncbi request reprint Review of studies of androgen treatment of female-to-male transsexuals: effects and risks of administration of androgens to females
    Louis J G Gooren
    Department of Endocrinology, Andrology Unit, VU University Medical Center, Amsterdam, The Netherlands
    J Sex Med 5:765-76. 2008
    ..Naturally, androgens may have virilizing effects in women. It is often believed that androgens have deleterious effects on cardiovascular risks...