Jeroen J G Geurts

Summary

Affiliation: VU University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Grey matter pathology in multiple sclerosis
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Neurol 7:841-51. 2008
  2. ncbi request reprint Extensive hippocampal demyelination in multiple sclerosis
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 66:819-27. 2007
  3. doi request reprint Measurement and clinical effect of grey matter pathology in multiple sclerosis
    Jeroen J G Geurts
    Department of Anatomy and Neurosciences, Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, Netherlands
    Lancet Neurol 11:1082-92. 2012
  4. doi request reprint Postmortem verification of MS cortical lesion detection with 3D DIR
    A Seewann
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 78:302-8. 2012
  5. doi request reprint Consensus recommendations for MS cortical lesion scoring using double inversion recovery MRI
    J J G Geurts
    VU University Medical Center, Department of Anatomy and Neuroscience, MF G 116, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Neurology 76:418-24. 2011
  6. ncbi request reprint Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging
    Jeroen J G Geurts
    Department of Radiology, Neurology, MR Center for MS Research, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands
    Radiology 236:254-60. 2005
  7. doi request reprint Gray matter pathology in (chronic) MS: modern views on an early observation
    Jeroen J G Geurts
    Dept of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Sci 282:12-20. 2009
  8. doi request reprint Does high-field MR imaging improve cortical lesion detection in multiple sclerosis?
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    J Neurol 255:183-91. 2008
  9. ncbi request reprint MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis
    Jeroen J G Geurts
    MS Research Center, Dept of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Magn Reson Med 55:478-83. 2006
  10. doi request reprint Functional connectivity changes in multiple sclerosis patients: a graph analytical study of MEG resting state data
    Menno M Schoonheim
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 34:52-61. 2013

Detail Information

Publications58

  1. ncbi request reprint Grey matter pathology in multiple sclerosis
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Neurol 7:841-51. 2008
    ..These hypotheses remain to be validated over the coming years, and could substantially affect our current views on MS pathogenesis...
  2. ncbi request reprint Extensive hippocampal demyelination in multiple sclerosis
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 66:819-27. 2007
    ..Our results indicate that hippocampal demyelination is frequent and extensive in MS and that anatomical localization, size, and inflammatory activity vary for different lesion types...
  3. doi request reprint Measurement and clinical effect of grey matter pathology in multiple sclerosis
    Jeroen J G Geurts
    Department of Anatomy and Neurosciences, Section of Clinical Neuroscience, VU University Medical Center, Amsterdam, Netherlands
    Lancet Neurol 11:1082-92. 2012
    ..By focusing on the latest insights into the in-vivo measurement of grey matter lesions and atrophy, we can assess their clinical effects...
  4. doi request reprint Postmortem verification of MS cortical lesion detection with 3D DIR
    A Seewann
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 78:302-8. 2012
    ..To assess the sensitivity and specificity of 3D double inversion recovery (DIR) MRI for detecting multiple sclerosis (MS) cortical lesions (CLs) using a direct postmortem MRI to histopathology comparison...
  5. doi request reprint Consensus recommendations for MS cortical lesion scoring using double inversion recovery MRI
    J J G Geurts
    VU University Medical Center, Department of Anatomy and Neuroscience, MF G 116, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Neurology 76:418-24. 2011
    ..This study aimed to formulate consensus recommendations for scoring cortical lesions in patients with MS, using DIR images acquired in 6 European centers according to local protocols...
  6. ncbi request reprint Intracortical lesions in multiple sclerosis: improved detection with 3D double inversion-recovery MR imaging
    Jeroen J G Geurts
    Department of Radiology, Neurology, MR Center for MS Research, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, Netherlands
    Radiology 236:254-60. 2005
    ....
  7. doi request reprint Gray matter pathology in (chronic) MS: modern views on an early observation
    Jeroen J G Geurts
    Dept of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    J Neurol Sci 282:12-20. 2009
    ..Also, the use and reliability of MRI atrophy measures as a monitoring tool for GM damage in the therapeutic setting will be reviewed...
  8. doi request reprint Does high-field MR imaging improve cortical lesion detection in multiple sclerosis?
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands
    J Neurol 255:183-91. 2008
    ..Therefore, in this post mortem study, the sensitivity of high field-strength MRI (4.7 T) for cortical lesions was investigated, and compared to that of standard field-strength (1.5 T)...
  9. ncbi request reprint MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis
    Jeroen J G Geurts
    MS Research Center, Dept of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Magn Reson Med 55:478-83. 2006
    ..In conclusion, thalamic and hippocampal GM pathology are important features of (progressive) MS...
  10. doi request reprint Functional connectivity changes in multiple sclerosis patients: a graph analytical study of MEG resting state data
    Menno M Schoonheim
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 34:52-61. 2013
    ..This indicates the value of graph analysis beyond traditional structural and functional measures, with possible implications for diagnostic and/or prognostic purposes in MS...
  11. doi request reprint Diffusely abnormal white matter in chronic multiple sclerosis: imaging and histopathologic analysis
    Alexandra Seewann
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Arch Neurol 66:601-9. 2009
    ..Underlying pathologic and MRI characteristics of DAWM are largely unknown...
  12. doi request reprint Clinical application of multi-contrast 7-T MR imaging in multiple sclerosis: increased lesion detection compared to 3 T confined to grey matter
    Wolter L de Graaf
    Department of Radiology, VU University Medical Center, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Radiol 23:528-40. 2013
    ..However, a clinical MRI protocol at 7 T has never been investigated. We evaluated the clinical value of 7-T MRI by investigating the sensitivity of lesion detection compared with 3 T...
  13. doi request reprint Subcortical atrophy and cognition: sex effects in multiple sclerosis
    Menno M Schoonheim
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:1754-61. 2012
    ..Understanding the exact relationship between atrophy and cognition requires further investigation. The aim of this study was to investigate the relationship between subcortical GM atrophy and cognition in early relapsing onset MS...
  14. doi request reprint Improved detection of active multiple sclerosis lesions: 3D subtraction imaging
    Bastiaan Moraal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 255:154-63. 2010
    ....
  15. doi request reprint Multi-contrast, isotropic, single-slab 3D MR imaging in multiple sclerosis
    Bastiaan Moraal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Eur Radiol 18:2311-20. 2008
    ..A selection of single-slab 3D contrasts, for example, 3D-FLAIR and 3D-DIR, could replace 2D sequences in the radiological practice...
  16. doi request reprint Use of ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI to demonstrate diffuse inflammation in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) patients: an exploratory study
    Machteld M Vellinga
    Department of Neurology, MS Centre Amsterdam, Amsterdam, The Netherlands
    J Magn Reson Imaging 29:774-9. 2009
    ..USPIO have been shown to visualize the cellular component of inflammation in focal MS lesions. In this study, we aimed to explore USPIO as a marker for the more diffuse inflammation in MS NAWM, using quantitative MRI...
  17. ncbi request reprint Glutamate gene polymorphisms predict brain volumes in multiple sclerosis
    Eva M M Strijbis
    Department of Neurology, VU University Medical Centre, Amsterdam, The Netherlands
    Mult Scler 19:281-8. 2013
    ..The most common approach in imaging genetics is based on mass-univariate linear modelling (MULM), which faces several limitations...
  18. doi request reprint Imaging the tip of the iceberg: visualization of cortical lesions in multiple sclerosis
    Alexandra Seewann
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 17:1202-10. 2011
    ..Here, we investigated whether CLs that are visible on conventional MRI differ from MRI-invisible CLs in terms of underlying histopathology and quantitative MRI (qMRI) measures...
  19. doi request reprint Long-interval T2-weighted subtraction magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials
    Bastiaan Moraal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Ann Neurol 67:667-75. 2010
    ....
  20. doi request reprint Structural and functional hippocampal changes in multiple sclerosis patients with intact memory function
    Stefan D Roosendaal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands
    Radiology 255:595-604. 2010
    ..To investigate changes in hippocampal functional connectivity and structural measures of hippocampal damage in multiple sclerosis (MS) patients with intact spatial memory, a cognitive domain frequently affected in progressive MS...
  21. doi request reprint Cognitive impairment in MS: impact of white matter integrity, gray matter volume, and lesions
    Hanneke E Hulst
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 80:1025-32. 2013
    ..To investigate whether extent and severity of white matter (WM) damage, as measured with diffusion tensor imaging (DTI), can distinguish cognitively preserved (CP) from cognitively impaired (CI) multiple sclerosis (MS) patients...
  22. pmc Cognitive dysfunction in early multiple sclerosis: altered centrality derived from resting-state functional connectivity using magneto-encephalography
    Martin Hardmeier
    Department of Clinical Neurophysiology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 7:e42087. 2012
    ..Cognitive dysfunction in multiple sclerosis (MS) is frequent. Insight into underlying mechanisms would help to develop therapeutic strategies...
  23. doi request reprint Gender-related differences in functional connectivity in multiple sclerosis
    Menno M Schoonheim
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    Mult Scler 18:164-73. 2012
    ..Functional reorganization of neural activity may contribute to limit disability, and possible gender differences in this process may have important clinical implications...
  24. doi request reprint Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany Departments of Neurology, Radiology, Epidemiology and Biostatistics, Anatomy and Neurosciences, Section of Clinical Neuroscience, and Physics and Medical Technology, MS Center Amsterdam, VU University Medical Center, Amsterdam, the Netherlands Fraunhofer MEVIS, Institute for Medical Image Computing, Bremen, Germany
    Radiology 269:542-52. 2013
    ..To determine whether spinal cord atrophy differs among disease subtypes in multiple sclerosis (MS) and whether it offers diagnostic and clinical correlative information beyond that provided by other magnetic resonance (MR) imaging markers...
  25. doi request reprint Functional adaptive changes within the hippocampal memory system of patients with multiple sclerosis
    Hanneke E Hulst
    Department of Radiology, VU University Medical Center, The Netherlands
    Hum Brain Mapp 33:2268-80. 2012
    ..These findings are important for future cognitive therapeutic studies, since cognitive intervention might be most effective before cognitive impairment is present and when adaptive changes of the brain are most prominent...
  26. ncbi request reprint Quantitative 1H-MRS of healthy human cortex, hippocampus, and thalamus: metabolite concentrations, quantification precision, and reproducibility
    Jeroen J G Geurts
    Department of Radiology, MR Center for MS Research, VU University Medical Center, Amsterdam, The Netherlands
    J Magn Reson Imaging 20:366-71. 2004
    ....
  27. ncbi request reprint Cortical lesions in multiple sclerosis: combined postmortem MR imaging and histopathology
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 26:572-7. 2005
    ..The aim of this study was to determine the proportion of intracortical and mixed gray matter (GM)-white matter (WM) lesions that can be visualized with postmortem MR imaging...
  28. doi request reprint Meningeal inflammation is not associated with cortical demyelination in chronic multiple sclerosis
    Evert Jan Kooi
    Departments of Pathology Neuropathology University Medical Center, Amsterdam, The Netherlands
    J Neuropathol Exp Neurol 68:1021-8. 2009
    ..In addition, no follicle-like structures were found in the MS samples. Our data suggest that the occurrence of cortical lesions is not related to the presence of meningeal inflammation in a large number of chronic MS patients...
  29. pmc Lesion detection at seven Tesla in multiple sclerosis using magnetisation prepared 3D-FLAIR and 3D-DIR
    Wolter L de Graaf
    Department of Radiology, VU University Medical Center Amsterdam, De Boelelaan 1117, NL 1081 HV, Amsterdam, The Netherlands
    Eur Radiol 22:221-31. 2012
    ..To examine the feasibility and value of 7 T 3D T2-weighted Fluid Attenuated Inversion Recovery (FLAIR) and Double Inversion Recovery (DIR) MR sequences for lesion detection in multiple sclerosis (MS)...
  30. ncbi request reprint Altered diffusion tensor in multiple sclerosis normal-appearing brain tissue: cortical diffusion changes seem related to clinical deterioration
    Hugo Vrenken
    Department of Radiology, MR Center for MS Research, VU University Medical Center, Amsterdam, The Netherlands
    J Magn Reson Imaging 23:628-36. 2006
    ..To investigate normal-appearing white (NAWM) and cortical gray (NAGM) matter separately in multiple sclerosis (MS) in vivo using diffusion tensor imaging (DTI)...
  31. ncbi request reprint Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis
    Lars Bö
    Department of Pathology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Arch Neurol 64:76-80. 2007
    ..Histopathologic studies have shown that subpial cortical demyelination is extensive in chronic multiple sclerosis (MS)...
  32. doi request reprint In vivo MR imaging of hippocampal lesions in multiple sclerosis
    Stefan D Roosendaal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, The Netherlands
    J Magn Reson Imaging 27:726-31. 2008
    ..To investigate whether a recently improved version of the three-dimensional double inversion-recovery (3D-DIR) technique enables the in vivo detection of hippocampal lesions in multiple sclerosis (MS)...
  33. ncbi request reprint Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability
    Stefan D Roosendaal
    Department of Radiology, VU University Medical Centre, Amsterdam, The Netherlands
    Mult Scler 17:1098-106. 2011
    ..Although grey matter damage in multiple sclerosis is currently recognized, determinants of grey matter volume and its relationship with disability are not yet clear...
  34. pmc Subtraction MR images in a multiple sclerosis multicenter clinical trial setting
    Bastiaan Moraal
    Departments of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Radiology 250:506-14. 2009
    ....
  35. ncbi request reprint Whole-brain T1 mapping in multiple sclerosis: global changes of normal-appearing gray and white matter
    Hugo Vrenken
    Departments of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 240:811-20. 2006
    ..To prospectively investigate whether T1 changes in normal-appearing white matter (WM) and normal-appearing gray matter (GM) in multiple sclerosis (MS) are global or regional and their relationship to disease type...
  36. doi request reprint Shifting imaging targets in multiple sclerosis: from inflammation to neurodegeneration
    René M Vigeveno
    VU University Medical Center, Department of Radiology, Amsterdam, The Netherlands
    J Magn Reson Imaging 36:1-19. 2012
    ....
  37. doi request reprint Enhanced number and activity of mitochondria in multiple sclerosis lesions
    Maarten E Witte
    Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 219:193-204. 2009
    ..Together, these findings support a mechanism whereby enhanced density of mitochondria in MS lesions might contribute to the formation of free radicals and subsequent tissue damage...
  38. doi request reprint Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla
    Iris D Kilsdonk
    Department of Radiology, VU University Medical Center, De Boelelaan 1118, 1081, hz, Amsterdam, The Netherlands
    Eur Radiol 24:841-9. 2014
    ..To investigate whether a new magnetic resonance image (MRI) technique called T2*-weighted fluid attenuation inversion recovery (FLAIR*) can differentiate between multiple sclerosis (MS) and vascular brain lesions, at 7 Tesla (T)...
  39. ncbi request reprint Sex-specific extent and severity of white matter damage in multiple sclerosis: implications for cognitive decline
    Menno M Schoonheim
    Department of Radiology, VU University Medical Center, Amsterdam, The Netherlands Department of Anatomy and Neuroscience, VU University Medical Center, Amsterdam, The Netherlands
    Hum Brain Mapp 35:2348-58. 2014
    ..The extent of WM FA changes, especially in the thalamus, was associated with cognitive performance in this cohort of early MS patients...
  40. ncbi request reprint Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis
    Catharina M P Vos
    Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neurobiol Dis 20:953-60. 2005
    ..This study shows for the first time that in MS brain changes in the vasculature take place not only in focal lesions but also in DAWM as detected by postmortem MRI...
  41. doi request reprint Diagnostic imaging of patients in a memory clinic: comparison of MR imaging and 64-detector row CT
    Mike P Wattjes
    Department of Radiology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Radiology 253:174-83. 2009
    ....
  42. ncbi request reprint Resting state networks change in clinically isolated syndrome
    Stefan D Roosendaal
    VU University Medical Centre, Department of Radiology, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Brain 133:1612-21. 2010
    ..These changes are lost in patients with relapsing remitting multiple sclerosis with increasing brain damage, indicating that cortical reorganization of resting state networks is an early and finite phenomenon in multiple sclerosis...
  43. doi request reprint Mitochondrial dysfunction: a potential link between neuroinflammation and neurodegeneration?
    Maarten E Witte
    Department of Pathology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Mitochondrion 10:411-8. 2010
    ..Here we describe the involvement of mitochondrial (dys)function in various neurological disorders and discuss the putative link between mitochondrial function and neuroinflammation...
  44. pmc Clusters of activated microglia in normal-appearing white matter show signs of innate immune activation
    Jack van Horssen
    Department of Molecular Cell Biology and Immunology Neuropathology, VU University Medical Center, Van der Boechorststraat 7, 1081, BT, Amsterdam, The Netherlands
    J Neuroinflammation 9:156. 2012
    ..The aim of this study was to gain more insight into the frequency, distribution and cellular architecture of preactive lesions using a large cohort of well-characterized MS brain samples...
  45. pmc Grey matter damage in multiple sclerosis: a pathology perspective
    Roel Klaver
    Deptartment of Anatomy and Neurosciences, Clinical Neuroscience, VU University Medical Centre, Amsterdam, The Netherlands
    Prion 7:66-75. 2013
    ..This paper provides an overview of GM damage in MS with a focus on its topology and histopathology...
  46. ncbi request reprint Heterogeneity of cortical lesions in multiple sclerosis: clinical and pathologic implications
    Evert Jan Kooi
    Department of Pathology Neuropathology, VU University Medical Center, Amsterdam, The Netherlands
    Neurology 79:1369-76. 2012
    ..Here, we assessed the clinical significance of microglia activation in CLs in a large autopsy sample, and we investigated possible interrelationships with other pathologic characteristics...
  47. pmc Cholinergic imbalance in the multiple sclerosis hippocampus
    Evert Jan Kooi
    Department of Pathology Neuropathology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands
    Acta Neuropathol 122:313-22. 2011
    ..Our findings reveal an MS-specific cholinergic imbalance in the hippocampus, which may be instrumental in terms of future treatment options for memory problems in this disease...
  48. doi request reprint Pluriformity of inflammation in multiple sclerosis shown by ultra-small iron oxide particle enhancement
    Machteld M Vellinga
    Department of Neurology, University Medical Centre, Amsterdam, The Netherlands
    Brain 131:800-7. 2008
    ..The use of USPIO-enhanced MRI is likely to lead to more insight in the pluriformity of inflammation in multiple sclerosis...
  49. ncbi request reprint Longitudinal absolute metabolite quantification of white and gray matter regions in healthy controls using proton MR spectroscopic imaging
    Oliver T Wiebenga
    Department of Radiology and Nuclear Medicine, Neuroscience Campus Amsterdam and VU University Medical Center, Amsterdam, The Netherlands Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam and VU University Medical Center, Amsterdam, The Netherlands
    NMR Biomed 27:304-11. 2014
    ..This may serve as a background for longitudinal clinical studies in adult patients...
  50. doi request reprint Cortical imaging in multiple sclerosis: recent findings and 'grand challenges'
    Marita Daams
    Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
    Curr Opin Neurol 26:345-52. 2013
    ..This review summarizes recent advancements in cortical imaging in multiple sclerosis (MS)...
  51. ncbi request reprint Multiple sclerosis patients show a highly significant decrease in alpha band interhemispheric synchronization measured using MEG
    Keith S Cover
    MEG Centre, VU University Medical Centre, 1 OBC, K2, Reception C, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Neuroimage 29:783-8. 2006
    ..The IHCM was found to be reproducible in controls over a period of more than 15 months. Further studies should investigate whether MEG derived synchronization measures may be useful as markers for MS disease load...
  52. ncbi request reprint Gray and normal-appearing white matter in multiple sclerosis: an MRI perspective
    Hugo Vrenken
    MS Center Amsterdam, VU University Medical Center, Department of Physics and Medical Technology, De Boelelaan, Amsterdam, The Netherlands
    Expert Rev Neurother 7:271-9. 2007
    ....
  53. doi request reprint Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex
    Karin Boer
    Department of Neuro Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Neuropathology 28:577-90. 2008
    ..Autopsy findings confirm the complexity of the brain abnormalities encountered in TSC patients and proved useful in clarifying certain aspects of the pathogenesis, epileptogenesis and pharmacoresistance of TSC lesions...
  54. doi request reprint Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations
    Alida A Gouw
    VU University Medical Centre, Department of Neurology, De Boelelaan 1117, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:126-35. 2011
    ..By reviewing studies that directly correlated postmortem MRI and histopathology, this paper aimed to characterise the pathological substrates of SVD in order to create more understanding as to its heterogeneous clinical manifestation...
  55. ncbi request reprint Preactive multiple sclerosis lesions offer novel clues for neuroprotective therapeutic strategies
    Johannes M van Noort
    Delta Crystallon BV Zernikedreef 9, 2333 CK Leiden, The Netherlands
    CNS Neurol Disord Drug Targets 10:68-81. 2011
    ....
  56. pmc Gray matter imaging in multiple sclerosis: what have we learned?
    Hanneke E Hulst
    Department of Radiology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    BMC Neurol 11:153. 2011
    ..In this review, we provide an overview of what has been learned about imaging of gray matter damage in MS, and offer a brief perspective with regards to future developments in this field...
  57. doi request reprint HLA-DRB1*1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis
    Madeleine H Sombekke
    Department of Neurology, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Arch Neurol 66:1531-6. 2009
    ..Multiple sclerosis (MS) is a heterogeneous neurologic disease with extensive variation with respect to the most affected central nervous system region (brain vs spinal cord)...
  58. ncbi request reprint Is progressive multiple sclerosis a gray matter disease?
    Jeroen J G Geurts
    Ann Neurol 64:230-2. 2008