Affiliation: VU University Medical Center
Country: The Netherlands
- Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activationAtoosa Familian
Department of Psychiatry, Institute for Clinical and Experimental Neurosciences VU ICEN VU, VU University Medical Center, Amsterdam, The Netherlands
Glia 53:233-40. 2006..Our data suggest that minocycline and tetracycline at tolerable doses can inhibit human microglial activation. This activity in part is exerted by inhibition of (SAP and C1q enhanced) Abeta fibril formation...
- Minocycline does not affect amyloid beta phagocytosis by human microglial cellsAtoosa Familian
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
Neurosci Lett 416:87-91. 2007..Here, we demonstrate that minocycline down-regulates the production of pro-inflammatory cytokines by human microglia without affecting their beneficial activity, phagocytosis of amyloid beta fibrils...
- Neuroinflammation in plaque and vascular beta-amyloid disorders: clinical and therapeutic implicationsPiet Eikelenboom
Department of Neurology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Neurodegener Dis 5:190-3. 2008..The cerebral beta-amyloid (Abeta) disorders show a great variability in the distribution of parenchymal and vascular amyloid deposits...